2394 results about "Glycoside" patented technology

The invention relates to the field of preparation of novel compounds, and discloses a glycoside group-containing compound as well as a preparation method and application thereof. The glycoside group-containing compound has a structure as shown in a formula (1). The polymer obtained by polymerizing the compound can improve the water-drive recovery efficiency of conventional oil reservoirs and common heavy oil reservoirs. # imgabs0 #

The invention provides a pharmaceutical composition for intranasal administration comprising a salt of sumatriptan or a physiologically acceptable solvate thereof, an alkyl glycoside or saccharide alkyl ester and optionally at least one pharmaceutically acceptable excipient, wherein the said composition provides Tmax value of less than 30 minutes upon said administration. Other aspects and embodiments are contemplated and described.The invention also provides a pharmaceutical composition for intranasal administration comprising a triptan, a pharmaceutically acceptable vehicle and a mucosal permeation enhancer, wherein upon said administration said composition provides a Tmax substantially equivalent to subcutaneous administration of said triptan. Other aspects and embodiments are contemplated and described.

The invention belongs to the field of biological fermentation synthetic medicines, and particularly relates to tocopherol glucoside and a preparation process thereof. The synthesis method comprises the following steps: (1) preparing an enzyme catalyst; (2) carrying out enzymatic conversion reaction; (3) purifying ion resin; (4) removing impurities; the synthesis process provided by the invention is simple in route and strong in operability, the prepared tocopherol glucoside is high in purity, the total yield of the product is greater than 30%, and the purity is greater than 95.0%.

The invention provides an application of citrus flavonoid glycosyl transferase CitUGT73A78 in biosynthesis of flavonoid glycoside, and belongs to the technical field of gene engineering and enzyme engineering. According to the present invention, the function of the CitUGT73A78 gene is cloned and verified, and the in vitro enzyme activity test proves that the CitUGT73A78 recombinant protein has broad-spectrum catalytic activity, and can efficiently catalyze the glucosylation of a variety of flavonoids so as to generate the corresponding flavonoids 7-O-glucoside and / or flavonoids 4 '-O-glucoside. An in-vivo transient overexpression test also proves that the CitUGT73A78 gene has a promoting effect on the accumulation of the content of the citrus flavonoid 7-O-glucoside. The invention not only provides a preparation method for the production of flavonoid 4 '-O-glucoside, has the advantages of simplicity, convenience, high catalytic efficiency, low cost, greenness and safety, but also can be applied to nutritional quality improvement and germplasm innovation of citrus fruits.

The invention provides an acne-removing and relapse-preventing composition suitable for acne sensitive skin and application of the acne-removing and relapse-preventing composition, and belongs to the technical field of cosmetics. The epigallocatechin gallic acid glucoside, the brazilin, the roselle flower extract, the jujube bark extract, the linseed oil unsaponifiable matter and the guaiacol extract are selected as active ingredients of the acne-removing and relapse-preventing composition and interact with one another, growth of acne-related pathogenic bacteria can be rapidly inhibited, and the skin micro-ecology can be adjusted; skin inflammation in the whole process of acne is effectively inhibited, the effects of preventing and inhibiting inflammation are achieved, the skin barrier is effectively repaired, redness is reduced, meanwhile, the effect of adjusting skin grease balance is achieved, and acne recurrence is prevented; in addition, the acne-removing and relapse-preventing composition also has the effects of removing yellow gas, uniformizing skin color and improving skin roughness, is mild and non-irritating, can be used for sensitive skin, and expands the application range of the acne-removing and relapse-preventing composition.

The invention relates to the technical field of microorganisms, in particular to a culture medium and a method for culturing Ackermania muciniphila for activating Amuc-1260 by using lambda-carrageenan as a carbon source, according to the culture method, the lambda-carrageenan is used for replacing a traditional carbon source, thallus growth and proliferation can be remarkably promoted, the effect is optimal under the condition of 2.00 g / L, and the culture cost is low. Compared with the conventional carbon source (glucose), the carbon source is improved by 92.91%. Further research finds that the lambda-carrageenan can induce the Akk bacteria to up-regulate the expression of glycoside hydrolase such as Amuc-1260 and enhance the activity of pathways such as glycosaminoglycan degradation, amino acid metabolism and insulin signals, so that the metabolic adaptability and energy utilization efficiency of the bacteria are improved. Meanwhile, the Akk bacteria secrete more functional short-chain fatty acids such as acetic acid, propionic acid and the like under the condition, and have the effects of regulating intestinal health and maintaining metabolic homeostasis. The invention provides a new theoretical basis and technical support for large-scale culture of Akk bacteria and development of a metabiotic product.

The invention belongs to the field of cosmetics, and discloses a composition which comprises a pepper fruit extract, epigallocatechin gallyl glucoside, diacetylboldine, a sanguisorba officinalis root extract and nicotinamide. The composition is detected by a DPPH method to have an excellent antioxidant effect. Meanwhile, the invention also discloses a composition capable of resisting thermal stimulation and UV stimulation, which can obviously inhibit the lipofuscin generation level of nematodes after thermal stimulation and UV stimulation by adopting nematode model detection. And after the composition is used together with the withanolaria nipponensis root extract, the composition has a remarkable synergistic effect on inhibition of lipofuscin generation of nematodes subjected to thermal stimulation and ultraviolet light stimulation. The composition provided by the invention has very good anti-wrinkle effects of light aging resistance and thermal aging resistance, and can effectively prevent the generation of color spots.

The invention provides an amino acid frosted cleaning composition as well as a preparation method and application thereof. The amino acid frosted cleaning composition comprises a surfactant, an amino acid composition, a thickening agent, a humectant, an antioxidant, a pH regulator and water, the surfactant is a combination of cocoyl glycinate, cocamidopropyl hydroxy sulfobetaine, sodium cocoyl methyl taurine taurate, sulfonic acid hydroxypropyl ester lauryl glucoside cross-linked polymer sodium and glycolipid. According to the invention, a mild surfactant system with amino acid as a main component is adopted, so that the shampoo has rich and fine foam, quick foaming performance and easy washing performance, and the skin feeling is smooth and soft after washing. In addition, the system contains suspended crystal frosted particles formed by self-assembly of the amino acid composition, the appearance is novel, the better efficacy performance is achieved, and meanwhile the cleaning effect and the use comfort are improved.

The invention discloses astragalus polysaccharide processed by different processing technologies and application thereof, self-weight polysaccharides of RAPSs, SAPSs, WAPSs and HAPSs are extracted from crude products and processed products obtained by salt processing, wine processing and honey processing, and the influence of different processing methods on the structure and bidirectional immunomodulatory activity of the astragalus polysaccharide is discussed. Results show that different processing methods change the properties and structural characteristics of the astragalus polysaccharide so as to influence the bidirectional immunomodulatory activity of the astragalus polysaccharide; the extraction rate, chemical composition, molecular weight, monosaccharide composition, chain conformation and surface morphology, Zeta potential and particle size, immunity enhancement and anti-inflammatory activity and the like of the four polysaccharides are remarkably different, but the four polysaccharides have the same typical crystal interior, main glycoside residues and O-glucosidic bonds. In a test concentration range, the honey-processed polysaccharide has a relatively strong immunity enhancing capability, and the wine-processed polysaccharide has a relatively strong anti-inflammatory capability.

The invention discloses a composition with tightening, wrinkle fading, soothing and repairing effects and application of the composition. The composition with the effects of tightening and fading wrinkles and relieving and repairing is prepared from a lactobacillus fermentation product, hexanediol, fully human collagen, glycosylglycerol, a citrus peel extract, a palmitoyl tripeptide-5 solution, a chrysanthemum extract and SPG beta-glucan. According to the invention, seven active material raw materials including the lactobacillus fermentation product, the fully human collagen, the glycosylglycerol, the citrus peel extract, the palmitoyl tripeptide-5 solution, the chrysanthemum extract and the SPG beta-glucan are creatively combined for use, and the seven raw materials supplement each other and have a synergistic effect; the effects of lightening skin wrinkles, improving skin barriers and relieving skin sensitivity are achieved from multiple dimensions, and cosmetics prepared from the composition have the effects of repairing, relieving, tightening and resisting wrinkles.

The invention relates to an endonuclease S2 mutant, a preparation method of the endonuclease S2 mutant and application of the endonuclease S2 mutant in antibody glycosylation transformation. The glycosidase S2 mutant comprises a carbohydrate binding module (CBM) defined by M677-D843 in SEQ ID NO: 1, and the amino acid sequence of the glycosidase S2 mutant comprises SEQ ID NO: 3, SEQ ID NO: 4 or SEQ ID NO: 5.

The invention relates to the technical field of pineapple planting, in particular to a management and control method for reducing malformed fruits caused by non-development of pineapple kernels. The management and control method comprises the steps of regulating and controlling nutrition before a flowering period, optimizing a microenvironment in a flowering period, strengthening management in a young fruit period and comprehensively preventing and controlling diseases and insect pests. The operation of regulating and controlling the nutrition before the flowering stage comprises the following steps: supplying a water-dispersible slow-release fertilizer by adopting a drip irrigation system from a seedling stage to a flowering accelerating stage; the mass ratio of nitrogen to phosphorus to potassium in the water dispersible slow-release fertilizer is 1: (1.1-1.3): (1.4-1.6); the operation of optimizing the microenvironment in the flower forcing period comprises the following steps: forcing flowers in cloudy days at the temperature of 18-25 DEG C or at dusk; after the inflorescence develops, a mixed solution of ethephon and gibberellic acid is adopted for core filling; the operation of strengthening young fruit stage management comprises the following steps: in a young fruit stage, spraying a mixed aqueous solution of sugar alcohol calcium and monopotassium phosphate to leaf surfaces; the operation of comprehensively preventing and controlling diseases and insect pests comprises the following steps: covering with breathable insect-preventing fruit bags 20 days after flowers wither, and releasing natural enemies to control the cardinal number of pests.

The present disclosure provides enzymes and methods of using those enzymes to transfer sugar moieties to the substrate steviol glycosides. The designed beta-1, 3-glycosyltransferase can be used for adding a glucose monomer connected with beta-1, 3 to steviol glycosides. In particular, the designed beta-1, 3-glycosyltransferase is used in a one-pot reaction together with a beta-1, 2-glycosyltransferase and a sucrose synthase to convert stevioside and / or Reb A to Reb M.

The invention relates to a corrosion and scale inhibitor for TRT and a preparation method of the corrosion and scale inhibitor, and relates to the technical field of chemical reagents. The corrosion and scale inhibitor is prepared from the following components in percentage by mass: 15 to 20 percent of morpholine, 25 to 30 percent of aminoethyl ethanolamine, 15 to 20 percent of 1-hydroxyethyl-2-undecylimidazoline onium salt, 12 to 18 percent of sodium polyaspartate, 8 to 12 percent of itaconic acid-allylsulfonic acid copolymer, 1 to 3 percent of alkyl glycoside and the balance of a mixture of water and glycerol in a mass ratio of 1 to (1 to 3). The corrosion and scale inhibitor disclosed by the invention can synchronously inhibit corrosion of an acid medium and scale deposition of salts such as NH4Cl and the like, and the corrosion inhibition rate and the scale inhibition rate are effectively improved.

The present application relates to the technical field of daily chemical cleaning products, and discloses a kind of wormwood leaf, enzyme laundry detergent, including the following components, by weight percentage: wormwood leaf enzyme: 30-50wt%, environmental protection enzyme: 10-20wt%, composite surfactant: 5-10wt%, including fatty alcohol polyoxyethylene ether sulfate and alkyl glycoside, wherein fatty alcohol polyoxyethylene ether sulfate accounts for 60-80wt% of the total amount of composite surfactant, and alkyl glycoside accounts for 20-40wt% of the total amount of composite surfactant; Dispersant: 0.3-1wt%; Enzyme-surfactant composite catalyst: 1-5wt%. The present invention adopts the technical scheme of combining wormwood leaf enzyme with environmental protection enzyme, extracts active enzyme and natural functional ingredients by fermentation, and realizes efficient decomposition of organic stains such as grease and protein. Compared with the scheme of using only chemical surfactant in the prior art, the problem of environmental pollution and skin irritation of chemical detergent is solved, and the safety and environmental protection of washing are significantly improved.

The invention relates to a method for producing glycosylglycerol. The method comprises the following steps: S1, culturing trichocephalus microcoleus to a logarithmic phase; and S2, adding glycerol and glucose into the culture environment of the coleus microcoleus to induce the coleus microcoleus to accumulate the glycosylglycerol. According to the invention, by optimizing the culture of the coleus microcoleus BL0902, the production of the glycosylglycerol by using the strain is realized, and on the basis, the strain is subjected to metabolic engineering transformation, so that the yield of the glycosylglycerol is greatly improved by the obtained engineering strain.

The invention provides a preparation composition of a glucagon-like peptide-1 receptor agonist for nasal mucosa administration, and particularly relates to the technical field of biological medicine materials. The preparation composition mainly comprises a glucagon-like peptide-1 receptor stimulant, alkyl glycoside and phospholipid, wherein the ratio of the glucagon-like peptide-1 receptor stimulant to the alkyl glycoside to the phospholipid is (0.25-17.5): (0.25-10): (0.1-10) by mass. The active pharmaceutical ingredients in the preparation composition provided by the invention are delivered through nasal mucosa, directly enter blood circulation from an absorption part, can take effect quickly, have higher bioavailability, and improve the compliance of patients.

The invention belongs to the field of daily chemicals, and discloses a mitochondrial energy improving composition based on plant stem cells, application and cosmetics, the composition comprises the following components by weight: 0.0005-1 part of sunflower bud extract; 0.0005 to 1 part of a melissa officinalis extract; and 0.0005 to 1 part of epigallocatechin gallo glucoside or epigallocatechin gallate. According to the composition disclosed by the invention, the sunflower bud extract, the melissa officinalis extract, the epigallocatechin gallyl glucoside or the epigallocatechin gallate are combined, and the combination of the sunflower bud extract, the melissa officinalis extract, the epigallocatechin gallyl glucoside and the epigallocatechin gallate has the effects of obviously improving the cell mitochondrial dysfunction, improving the mitochondrial energy and increasing the content of I-type collagen; the composition can be used as a potential optional scheme of anti-wrinkle active ingredients in cosmetics.

The invention discloses a preparation method and application of chlorine dioxide preservative paper.The preparation method comprises the steps that starch, nanocellulose, hydrogen peroxide, ferric sulfate, distilled water and sodium hydroxide are mixed to obtain gelatinized starch, and then the gelatinized starch is mixed with water-based acrylic resin, casein, alkyl glycoside and ammonium persulfate to obtain composite starch glue; mixing sodium chlorite and composite starch glue to obtain fresh-keeping coating liquid A, and then coating the fresh-keeping coating liquid A on fresh-keeping base paper to obtain fresh-keeping coating liquid A paper; citric acid and distilled water are mixed to obtain fresh-keeping coating liquid B, and then fresh-keeping base paper is soaked in the fresh-keeping coating liquid B to obtain fresh-keeping coating liquid B paper; the fresh-keeping coating liquid A paper and the fresh-keeping coating liquid B paper are attached to obtain the chlorine dioxide fresh-keeping paper. The chlorine dioxide fresh-keeping paste is pasted on the inner side of the blueberry packaging box cover to keep the blueberries fresh. The chlorine dioxide preservative paper prepared by the invention can solve the problems of burst release and short retention time of chlorine dioxide, can reduce the problems of easy softening, rot and deterioration of picked blueberries, prolongs the shelf life of the blueberries, and improves the commodity value of the blueberries.

The invention belongs to the technical field of pesticide compositions, and particularly provides a weeding composition containing topramezone or salt thereof, which comprises topramezone or salt thereof, agriculturally acceptable auxiliaries and biostimulant, the biostimulant is complex enzyme glycoside. The topramezone composition does not cause phytotoxicity to crops such as corn when used under the high-temperature condition, the use environment of topramezone is widened, and the topramezone composition can be used as a safe herbicide composition for field crops such as corn under the high-temperature condition in summer. Through further screening of auxiliaries, the weeding composition provided by the invention can improve the mixing performance of the preparation, has strong hard water resistance, is beneficial to plant absorption, improves the weeding effect, and is a safe and efficient herbicide preparation.

The invention belongs to the field of personal care, and particularly relates to a glycoside derivative flexible liposome and a preparation method and application thereof, the glycoside derivative flexible liposome comprises a main shell material, a humectant, a wrapped raw material, an auxiliary shell material, a preservative and a solvent; the main shell material is phosphatidylcholine, and the auxiliary shell material is polyquaternium-51; the preservative is any one or more of 1, 2-hexanediol, p-hydroxyacetophenone, methylparaben, phenoxyethanol and caprylyl glycol; the moisturizing agent is butanediol; the wrapped raw material is hydroxypropyl tetrahydrofurantriol; the solvent is deionized water. According to the invention, the permeability and penetration depth of the glassine and the concentration of the glassine at a target position are improved by utilizing a flexible liposome wrapping technology, the bioavailability of the glassine is improved, and the addition amount is reduced under the condition of realizing the same tightening and anti-wrinkle effects, so that the cost is reduced.

The invention discloses an anti-aging herba epimedii extract. The anti-aging herba epimedii extract is prepared by performing microbial fermentation on herba epimedii powder. The invention further discloses a preparation method of the anti-aging herba epimedii extract and application of the anti-aging herba epimedii extract in preparation of anti-aging drugs, food and health care products. According to the invention, through special plant lactobacillus and a fermentation process, efficient conversion of main glycoside components in herba epimedii is realized, the contents of icariin and epimedin C are reduced, the contents of secondary glycoside I and secondary glycoside II are remarkably increased, and new icaritin is generated. The herba epimedii extract disclosed by the invention has the effects of resisting aging and prolonging the service life.

The present invention discloses a culture medium, a fermentation method and an application of Streptomyces for producing pieridian glycosides. Through this fermentation method, the Streptomyces can produce abundant pieridian glycosides, and its effective part contains more than 8 types of pieridian glycosides at the same time, and the content of the four types of pieridian glycosides, namely compound 4, compound 5, compound 6 and compound 8, is greater than 5%. The extract obtained by the strain through this fermentation method and its effective part can be used to prepare drug lead compounds for treating renal cancer, organ fibrosis, acute kidney injury and chronic kidney disease, and can provide drug source guarantee for China's marine drug research and development.

The invention belongs to the field of concrete admixtures and relates to a concrete foaming agent as well as a preparation method and application thereof. The concrete foaming agent contains a foaming component, a reinforcing agent, a conditioning agent, water and an optional foam stabilizer, wherein the foaming component is organic amine modified sulfonated alkyl glycoside; the organic amine modified sulfonated alkyl glycoside is prepared according to the following method: carrying out hydroxyamination reaction on polyether alkyl glycoside and organic amine, carrying out sulfonation reaction on the obtained hydroxyamination reaction product, and filtering, washing and drying the obtained crude product to obtain the organic amine modified sulfonated alkyl glycoside. The key point of the invention is that the organic amine modified sulfonated alkyl glycoside is introduced into the concrete foaming agent as a foaming component, and the organic amine modified sulfonated alkyl glycoside can enhance the temperature resistance of the concrete foaming agent and endow the concrete foaming agent with good weather resistance, so that the concrete foaming agent still has good foaming and foam stabilizing properties under a relatively high temperature condition.

The invention discloses a composition for treating prostatitis and a preparation method and application thereof. The composition is prepared from the following components in parts by weight: 5 to 15 parts of ergothioneine, 10 to 20 parts of cistanche total glycosides, 25 to 45 parts of phytosterol, 450 to 550 parts of pumpkin seed oil, 180 to 250 parts of fructus cannabis oil and 250 to 350 parts of auxiliary materials. Through the synergistic effect of various natural active components, the composition maintains the balance of overall metabolism of a body while reducing inflammation and inhibiting prostate cell proliferation, side effect risks possibly brought by a traditional single-component treatment scheme are avoided, and the composition has higher clinical application potential. The composition disclosed by the invention has a wide market application prospect and popularization value by virtue of good safety and compliance.

The invention provides a viscosity-controllable and low-toxicity polysaccharide-based antibacterial detergent and a preparation method thereof, and belongs to the technical field of daily chemical sterilization. The detergent comprises the following raw materials in percentage by mass: 0.5-6% of a polysaccharide thickener, 10% of a bacteriostatic agent, 10% of a glycoside nonionic surfactant and the balance of water, the polysaccharide thickening agent is a mixture of chitosan, chitosan hydrochloride and quaternized chitosan. The polysaccharide is applied to viscosity regulation and control of a surfactant system without a petroleum-based thickening agent for the first time, application of the polysaccharide in the field of daily chemical washing is expanded, and compared with other antibacterial hand sanitizer competitive products containing benzene rings and phenol bacteriostatic agents and 6501 thickening agents, the antibacterial hand sanitizer competitive products have the remarkable advantages of high biocompatibility, high antibacterial property, easiness in degradability and the like.

The invention discloses a glucosyltransferase and a preparation method and application of a mutant of the glucosyltransferase. The amino acid sequence of the glucosyltransferase comprises a sequence as shown in SEQ ID NO. 1 or SEQ ID NO. 2. The glucosyltransferase and the mutant thereof can efficiently catalyze the generation of the tocopherol glucoside, the enzyme activity can reach 0.34 U / mg, a new way of synthesizing the tocopherol glucoside by a biological method is developed, the glucosyltransferase and the mutant thereof can be widely applied to the fields of medicines, cosmetics and the like, the industrial production of tocopherol derivatives is promoted, and the production cost is reduced. The requirements of the market on high bioavailability and high stability tocopherol derivatives are met, and the technical progress and industrial upgrading of related industries are promoted.

Cleaning compositions that include a non-functionalized alkyl polyglycoside, a nonionic surfactant system, and water. In certain embodiments, the cleaning compositions are substantially free of alkyl phenol ethoxylates. Additionally, some embodiments of the invention are substantially free of butyl cellosolve. The cleaning composition is capable of removing both proteinaceous food soils and hydrocarbon-based oily soils. The cleaning compositions include a biorenewable, environmentally friendly alternative to nonyl phenol ethoxylates and exhibit superior cleaning of food soils.

The invention discloses a high-temperature-resistant drilling fluid lubricant and a production process thereof, and relates to the field of lubricants, and the high-temperature-resistant drilling fluid lubricant comprises the following raw materials in parts by weight: 90-100 parts of biodiesel, 0.8-1.0 part of a surfactant, 0.8-1.0 part of an emulsifier, 12-16 parts of modified alkyl glycoside, 4-6 parts of modified microspheres, and 0.5-0.7 part of a dispersant. The synthesized modified alkyl glycoside comprises an imidazole quaternary ammonium cation, an ester group and a hindered phenol structure, and the oxidation resistance, the high temperature resistance and the corrosion resistance of the drilling fluid lubricant are improved. The synthesized modified microspheres comprise silicon dioxide microspheres and a polymerized carbodiimide structure, so that the hydrolysis resistance, high temperature resistance and wear resistance of the drilling fluid lubricant are improved.

The invention provides a method for detecting medicinal components of a traditional Chinese medicine composition UPLC-MS / MS. The detection method can be used for identifying 14 medicinal components of the traditional Chinese medicine composition, namely saikoside A, saikoside D, naringin, paeoniflorin, hesperidin, chicoric acid, chlorogenic acid, salvianolic acid B, narcissoside, kaempferitrin, lobetyolin, amygdalin, hyperoside and rutin. And a reference is provided for evaluating the internal quality of the traditional Chinese medicine composition.