The invention belongs to the technical field of
traditional Chinese medicine fermentation, and provides
astragalus membranaceus
fermentation liquor as well as a preparation method and application thereof. The preparation process comprises the following steps of soaking
astragalus membranaceus slices in water, decocting, and filtering to obtain
medicine residues and first
medicine liquid, adding water into the
medicine residues, and decocting to obtain second medicine liquid, combining the first medicine liquid and the second medicine liquid, and concentrating to obtain an
astragalus membranaceus water extract, mixing
lactobacillus plantarum LZU-S-ZCJ with LZU-J-TSL6, and inoculating the mixture into the astragalus membranaceus water extract for
fermentation, so as to obtain the astragalus membranaceus fermentation liquor. The astragalus membranaceus fermentation liquor obtained by the method disclosed by the invention can relieve the
edema degree of mouse lungs, relieve the
inflammatory cell infiltration state caused by
lipopolysaccharide (LPS), reduce the accumulation of
protein liquid in the mouse lungs, reduce the concentration of
inflammatory factors in BALF of mice with acute
lung injury, regulate the frontal intestinal
flora of the mice with acute
lung injury and the like, can be used for treating acute
lung injury, and has a good effect of relieving mouse acute
lung injury.