10 results about "Isoliquiritigenin" patented technology

The invention provides a cough-relieving and phlegm-eliminating composition and a preparation method thereof. The cough-relieving and phlegm-eliminating composition is prepared from the following raw materials: anhydrous morphine, anhydrous codeine phosphate, apigenin, liquiritin, isoliquiritin, liquiritigenin, isoliquiritigenin, glycyrrhizic acid, trans-anethole, camphor and sodium benzoate. The composition further comprises a luffa stem extract, an atractylodes lancea rhizome extract and a radix ranunculi ternati bark extract. The cough-relieving and phlegm-eliminating composition provided by the invention has the advantages of few impurities, clear and remarkable drug effect and small side effect. Under the action of the core antitussive drug, three plant extracts of luffa stem, Atractylodes lancea and Ranunculus ternatus Thunb. Are creatively added, so that the phlegm eliminating capacity and the overall antitussive effect of the whole formula are remarkably enhanced. The cough-relieving and phlegm-eliminating composition disclosed by the invention realizes the synergistic interaction of '1 + 1 + 1gt, 3' on the core indexes of inhibiting the cough frequency, prolonging the cough latency period, promoting sputum excretion and the like, and realizes the cough-relieving and phlegm-eliminating effects of treating both symptoms and root causes through the multi-target-point and multi-mechanism synergistic effect.

A small molecule composition, comprising licochalcone A, licochalcone C, licochalcone D, licochalcone E, echinatin, isoliquiritigenin, formononetin, liquiritigenin, licoflavone C, glabrol, licoisoflavone A and licoisoflavone B, and the use thereof in preparing anticancer or antitumor drugs, anti-ferroptosis drugs, or drugs for sensitization of anticancer or antitumor drugs. The small molecule composition can also be used in combination with other antitumor drugs.

The invention discloses application of isoliquiritigenin in preparation of a medicine for treating 5-FU induced cardiotoxicity, and belongs to the technical field of biomedicine.The medicine comprises the isoliquiritigenin, and the isoliquiritigenin improves 5-FU induced oxidative stress and apoptosis by regulating an AhR-CYP1A1 pathway, so that the 5-FU induced cardiotoxicity is improved; the invention systematically reveals the action mechanism of the isoliquiritigenin for improving the 5-FU-induced cardiotoxicity by inhibiting an AhR-CYP1A1 signal channel for the first time from the animal overall level and the cell molecule level to mechanism analysis, and proves the application value of the isoliquiritigenin in preparation of the medicine for treating the 5-FU-induced cardiotoxicity; based on complete analysis of the mechanism, the invention provides a brand new active ingredient and a technical scheme for preparing the medicine for resisting 5-FU cardiotoxicity, lays a theoretical and experimental foundation for research and development of the medicine for relieving the side effect of 5-FU chemotherapy, and has an important medicine development value.

The invention discloses a method for screening anti-inflammatory heart protection active components of Siji decoction. The method comprises the following steps: 1, finding eicosanoic acid related to the drug effect of the Siji decoction and measuring the content of eicosanoic acid; 2, identification of components absorbed into blood by the Siji decoction and determination of relative peak intensity; and 3, analyzing the correlation between the content of the eicosanoic acid metabolite related to the drug effect of the Siji decoction and the relative peak intensity of the component absorbed into blood by the Siji decoction, and screening the anti-inflammatory heart protection active component of the Siji decoction. The method comprises the following steps: by taking an eicosanoic acid metabolic profile as a drug effect target, constructing a correlation model of quantitative information of eicosanoic acid metabolites in a rat with heart failure at different time points and blood-entering component intensities of Siji decoction at different time points; through screening, it is determined that the four components of songorine, neoline, talasamine and isoliquiritigenin have the definite anti-inflammatory heart protection effect, and the method is accurate and efficient.

The application discloses a kind of based on isoliquiritigenin biological base temperature-resistant antibacterial foam cotton material and preparation method and application thereof, the foam cotton material is obtained by foaming based on the main chain type benzoxazine resin of isoliquiritigenin biological base, with maleic anhydride, foaming agent master batch, the main chain type benzoxazine resin of based on isoliquiritigenin biological base molecular formula as shown below.The application is prepared with the main chain type benzoxazine resin of isoliquiritigenin biological base as organism to obtain the benzoxazine foam with temperature-resistant antibacterial property of body.The foam cotton material of the application has the following advantages: based on the molecular structure of isoliquiritigenin, product has excellent antibacterial property;High crosslinking density benzoxazine gives product excellent temperature resistance;The product thermal conductivity is as low as 0.033W / (m·K), and the product has wide application in medical equipment, electronic equipment, new energy automobile and other fields.

The present invention relates to a composition of paeoniflorin and isoliquiritigenin and application thereof. The composition according to the present invention is rich in raw materials, and has the effects of anti-inflammation, antioxidant, inhibiting collagen deposition, etc., and can be effectively used to treat diffuse interstitial pulmonary fibrosis with high economic and social benefits.

This invention belongs to the field of biomedical technology, specifically relating to an isoliquiritigenin composition for improving depression and its preparation method. The isoliquiritigenin composition for improving depression comprises the following raw materials in parts by weight: 22-40 parts isoliquiritigenin, 10-17 parts N-acetyl-D-glucosamine, and 15-20 parts β-lapaquinone. Isoliquiritigenin, N-acetyl-D-glucosamine, and β-lapaquinone constitute a multi-target synergistic isoliquiritigenin composition for improving depression. Experimental results show that by taking the isoliquiritigenin composition prepared according to this invention, it can systematically exert its effects and comprehensively improve the pathological state of depression, showing broad application prospects.

The invention discloses an application of isoliquiritigenin and / or glabridin in preparation of a medicine for treating acanthamoeba infection. The research finds that the isoliquiritigenin and the glabridin are adopted to treat the acanthamoeba trophoblast cells, proliferation of the acanthamoeba trophoblast cells can be remarkably inhibited, toxicity to host cells is small, and the inhibition effect of the isoliquiritigenin and the glabridin on the acanthamoeba is more remarkable when the isoliquiritigenin and the glabridin are matched. Therefore, the isoliquiritigenin and / or glabridin can be used for preparing medicines or preparations for preventing and / or treating diseases caused by acanthamoeba infection, removing acanthamoeba cells or inhibiting acanthamoeba cell proliferation.

The invention belongs to the technical field of biology, and discloses application of isoliquiritigenin in preparation of a product for preventing and / or treating fish infected with a siniperca chuatsi and frog iridovirus (MRV), the EC50 of the isoliquiritigenin is 3.08 mu M, and the isoliquiritigenin has a remarkable in-vivo and in-vitro anti-MRV effect, so that the treatment administration effect is the best, the premixing administration is the second time, and the effect of preventing and / or treating the fish infected with the siniperca chuatsi and frog iridovirus is achieved. The result shows that the isoliquiritigenin possibly has a direct damage effect on MRV virus particles and inhibits MRV virus proliferation; besides, excessive inflammation and cell apoptosis caused by MRV infection can cause fish tissue damage and can promote virus proliferation and escape, and isoliquiritigenin can relieve tissue damage caused by MRV virus, inhibit virus proliferation and play a comprehensive antiviral role through anti-inflammatory and anti-apoptosis effects; meanwhile, the invention also provides a medicine containing isoliquiritigenin, a fish feed and a fish feed additive.