34 results about "Hinokitiol" patented technology

Disclosed is a method for treating a disease or condition characterized by neurodegeneration by administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of hinokitiol, a hinokitiol derivative, and an iron-transporting tropolone.

Disclosed is a method of treating a disease or condition characterized by neurodegeneration via administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of hinokitiol, hinokitiol derivatives, and iron-transporting tropolones.

The present invention provides a composition for improving recurrent dandruff, as well as its preparation method and application, relating to the technical field of shampoo products. The composition comprises tropone and hinokitiol, wherein the weight ratio of tropone and hinokitiol is 2 to 8:1. The composition has synergistic antibacterial and synergistic antioxidant effects; can effectively remove mature biofilms, reduce the ability of bacterial species to form biofilms, and avoid the drug resistance problem of antidandruff agents; has low cytotoxicity, and reduces the irritation problem of antidandruff agents; the composition effectively inhibits the occurrence of recurrent dandruff by taking a multi-pathway strategy of reducing drug resistance and repairing oxidative barrier damage, thereby achieving a long-lasting and highly effective effect, and solves the technical problem that long-term use of antidandruff agents can damage the scalp barrier and cause drug resistance in the resident scalp flora, thereby triggering an inflammatory response and exacerbating dandruff or causing a sensitive scalp, further deepening dandruff, and causing recurring dandruff.

The present application relates to a kind of composition of synergistic inhibition porphyromonas gingivalis, belong to oral care technical field.The present application provides a kind of composition of synergistic inhibition porphyromonas gingivalis, the composition is composed of peach geniposide and hinokitiol.The present application selects peach geniposide and hinokitiol from numerous existing components, finds that the composition formed by the combination of the two has synergistic effect, can improve the bacteriostatic efficacy of the composition, especially for the bacteriostatic effect of porphyromonas gingivalis, its inhibitory effect is stronger.

The invention relates to a composition for resisting oxidation and inhibiting porphyromonas gingivalis and application of the composition, and belongs to the technical field of oral care. The invention provides a composition for resisting oxidation and inhibiting porphyromonas gingivalis. The composition is prepared from a mangnolia officinalis bark extract and hinokiol. The mangnolia officinalis bark extract and hinokiol are screened from numerous existing components, it is found that the composition formed by combining and compounding the mangnolia officinalis bark extract and hinokiol has a synergistic interaction effect, the antibacterial effect of the composition can be improved, especially the antibacterial effect on porphyromonas gingivalis can be improved, and the inhibition effect is higher.

The invention belongs to the technical field of cosmetics, and discloses a plant source antimicrobial composition as well as a preparation method and application thereof. The botanical antimicrobial composition disclosed by the invention is prepared from the following components in parts by weight: 0.05 to 5 parts of cacumen biotae extract, 10 to 30 parts of raspberry ketone and 0.05 to 5 parts of hinokiol. According to the plant source antimicrobial composition disclosed by the invention, a multi-target and all-around antibacterial and antiseptic system is constructed through a synergistic effect of natural plant components, rapid and broad-spectrum inhibition on bacteria, fungi and propionibacterium acnes is realized, and excellent physical and chemical stability can be kept in an extreme environment; the preservative effect is not affected by a complex formula system, and the function of instantly killing acne pathogenic bacteria is achieved. Meanwhile, the plant-derived antimicrobial composition can also be perfectly compatible with active ingredients of various cosmetics, can be flexibly applied to various product types, and provides a natural, efficient, reliable and low-irritation preservative solution for users.

To provide an oral composition that has a high astringent effect and high storage stability of berberine. [Solution] An oral composition comprising (A) component: berberine, (B) component: hinokitiol, and (C) component: isopropylmethylphenols, wherein the content of component (B) is 0.001 to 0.5% by mass relative to the total mass of the oral composition, and the ratio of the mass of component (C) to the mass of component (B), expressed as component (C) / component (B), is 0.01 to 10.

The invention belongs to the technical field of microbial fertilizers, and particularly relates to a novel multifunctional zinc-silicon bacterial fertilizer which comprises a microbial agent, and the microbial agent is formed by compounding bacillus velezensis and piperlongumine or hinokitiol according to the mass ratio of (1-150): (150-1). The novel multifunctional zinc-silicon bacterial fertilizer can effectively prevent and control crop diseases so as to achieve the biological control effect, can supplement elements such as zinc and silicon required by crop growth, is beneficial to crop production, has the effect of multiple effects after one application, and can provide support for green and healthy development of crops.

The invention relates to a composition for synergistically inhibiting porphyromonas gingivalis, and belongs to the technical field of oral care. The invention provides a composition for synergistically inhibiting porphyromonas gingivalis. The composition is prepared from totarol and hinokiol. The totarol and the hinokiol are screened from numerous existing components, it is found that the composition formed by combining and compounding the totarol and the hinokiol has the synergistic interaction effect, the antibacterial effect of the composition can be improved, especially the antibacterial effect on porphyromonas gingivalis can be improved, and the inhibition effect of the composition is higher.

The present invention discloses an anti-dandruff, oil-control and anti-hair loss shampoo containing hinokitiol and a preparation method thereof, belonging to the daily chemical technology field. Cocamidopropyl betaine, sodium cocoyl glycinate, modified selenium disulfide powder, sodium lauryl polyether sulfate, polydimethylsiloxane, glycerin, preservative, sodium chloride, zinc pyrrolidone carboxylate and deionized water are added to a stirring kettle, stirred evenly at 60-80 °C, cooled to 35-45 °C, and natural extract and hinokitiol are added to the stirring kettle and stirred evenly to obtain an anti-dandruff, oil-control and anti-hair loss shampoo containing hinokitiol. The modified selenium disulfide and hinokitiol are used in combination to synergistically improve the anti-dandruff effect of the shampoo. The modified selenium disulfide uses zeolite powder particles as the matrix and has a unique porous structure, which can effectively adsorb oils, dirt, etc. on the scalp, making the scalp more refreshing. Then, a layer of polydopamine is coated on the outer layer, which helps to reduce the irritation to the scalp and improve the hydrophilicity and dispersion stability of the modified selenium disulfide.

Disclosed is a method of treating a disease or condition characterized by neurodegeneration via administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of hinokiol, hinokiol derivatives, and iron transporter palmitol ketones.

The present invention belongs to the technical field of plant disease control, and specifically relates to an application in preventing and / or controlling plant bacterial diseases. Through screening, the present invention discovers that hinokitiol has an inhibitory effect on Ralstonia solanacearum LS2020, Pseudomonas syringae pv. tomato DC3000, and Xanthomonas campestris pv. vesicatoria 85-10, thereby effectively preventing and controlling plant bacterial wilt and leaf spot diseases. The present invention discloses the lethal concentration of hinokitiol for inhibiting Ralstonia solanacearum and the pathogen of tomato leaf spot disease, providing a new approach for the control of plant bacterial diseases.

A cosmetic composition is disclosed comprising i) a scalp health agent; and ii) a natural active selected from cotoin, isoliquiritigenin, xanthohumol, pinostrobin chalcone, and a mixture thereof; wherein the scalp health agent is selected from a group consisting of polyvalent metal salts of pyrithione, hydroxamic acid, hinokitiol, azole compound and selenium sulfide; wherein the weight ratio of the amount of said active to that of said scalp health agent is from 1:100 to 100:1.

An object of the present invention is to provide an oral composition having a good antibacterial effect, flavor expression, and smooth skin.SOLUTION: A composition for oral cavity, a dentifrice composition, a composition for external use, and a composition for oral cavity for treatment or prevention of periodontal disease, comprising a component (A): a fluorine-containing compound, a component (B): hinokitiol and / or thymol, and a component (C): a nonionic surfactant, wherein the content of the component (A) is 3000 to 20000 ppm in terms of fluoride ion concentration.SELECTED DRAWING: None

The invention discloses a preparation method and a detection method of hinokitiol, and belongs to the technical field of synthesis of medical intermediates, the preparation method comprises the following steps: S1, carrying out a reaction on cyclopentadiene, ethyl magnesium bromide and isopropyl p-toluenesulfonate to obtain cyclopentadiene; the preparation method comprises the following steps: carrying out an addition reaction on 1-isopropyl cyclopentadiene and dichloroacetyl chloride in a solvent to prepare 7, 7-dichloro-3-isopropyl-bicyclo [3, 2, 0] hept-2-ene-6-one, and carrying out a reaction on the 7, 7-dichloro-3-isopropyl-bicyclo [3, 2, 0] hept-2-ene-6-one and 1-isopropyl cyclopentadiene in the solvent to prepare 7, 7-dichloro-3-isopropyl-bicyclo [3, 2, 0] hept-2-ene-6-one; s3, the 7, 7-dichloro-3-isopropyl-bicyclo [3, 2, 0] hept-2-ene-6-ketone, a mixed solution containing tert-butyl alcohol, acetic acid and water and triethylamine are subjected to a ring expansion reaction, and a crude product of hinokitiol is prepared; and S4, carrying out alkali extraction and acid precipitation on the hinokitiol crude product, and recrystallizing to obtain hinokitiol. The method greatly simplifies the post-treatment process, has the advantages of low cost, high purity, high yield and the like, and is suitable for large-scale industrial production.

To provide a hair growth or hair care agent composition containing hinokitiol, salicylic acid, edetic acid salt, and ethanol, which does not produce precipitates over time.SOLUTION: The above problems are solved by a hair growth or hair care agent composition containing at least hinokitiol, salicylic acid, edetic acid salt, and ethanol, a content of the edetic acid salt being 0.02 mass / volume% or more relative to the total volume of the composition, and a content of the ethanol being 30 to 70 vol.%, and pH is 3.7 or more and less than 6.0.SELECTED DRAWING: None

Disclosed herein is a cosmetic composition comprising i) hinokitiol and ii) hydroxamic acid wherein the weight ratio of the amount of hydroxamic acid to the amount of hinokitiol is 2: 1 to 15: 1 wherein the hydroxamic acid is capryloyl hydroxamic acid, benzoyl hydroxamic acid or a mixture thereof.

An accord composition for improving the scalp microbiome is provided. Such accord compositions comprise hinokitiol and at least one synergistic compound. Consumer products and methods of use for the consumer products are also provided.

The invention discloses a hinokiol pH response release nanoemulsion composition and a preparation method thereof. The hinokiol pH response release nanoemulsion composition comprises the following components in percentage by mass: 0.5%-5% of hinokiol related extract, 0.1%-3% of a pH sensing emulsifier, 0.5%-10% of a pH sensing synergist, 2%-10% of an emulsion stabilizer, 5%-20% of an active matter solubilizer, 0.002%-0.01% of an active matter antioxidant stabilizer, 4%-9% of an auxiliary component and the balance of filler, wherein the sum of the mass fractions of the components does not exceed 100%. The malassezia inhibitor can be quickly released at a scurf affected part with a high pH value so as to strongly inhibit malassezia, and can be slowly released in a weak acid environment of healthy scalp so as to maintain flora balance and play an oil control role.

The present invention provides a preservative for an external preparation for skin and a use thereof. The preservative comprises: hinokitiol; and one or more solvents selected from the group consisting of alkantriol having 3 to 6 carbon atoms, dipropylene glycol, glycerol caprylate, ethylhexylglycerin, and phenoxyethanol. According to one aspect of the present invention, the preservative for an external preparation for skin can be stably held in a liquid state at room temperature and under cold storage conditions, and can exhibit an excellent antibacterial effect after being formed into a dosage form.

The present invention discloses the application of a hinokitiol composition in the preparation of a Staphylococcus aureus inhibitor. After adding hinokitiol, the survival rate of Staphylococcus aureus drug-resistant bacteria significantly decreases when treated with tetracycline, tigecycline, and chlortetracycline, indicating that these two substances can improve the sensitivity of Staphylococcus aureus drug-resistant bacteria to tetracycline, tigecycline, and chlortetracycline and have a synergistic effect. Animal experiments show that the combination of hinokitiol and tetracycline can significantly reduce the Staphylococcus aureus load colonized in the nasal cavity of mice. The hinokitiol provided by the present invention can be combined with tetracycline antibiotics to have a strong synergistic antibacterial effect both in vivo and in vitro, providing a brand-new technical method for the prevention and treatment of diseases in humans and farm animals.

A cosmetic composition comprising hinokitiol and an organic UVA filter selected from butyl methoxydibenzoylmethane, bis-ethylhexyloxyphenol methoxyphenyl triazine, diethylamino hydroxybenzoyl hexyl benzoate, methylene bis-benzotriazolyl tetramethylbutylphenol and mixtures thereof is disclosed. It has proven to improve the stability of hinokitiol.

The application discloses a bactericidal composition containing hinokitiol and plant essential oil and main components thereof, and effective components are hinokitiol and oregano essential oil, clove essential oil, thyme essential oil, carvacrol, eugenol and thymol. The mass fraction ratio of the hinokitiol and the oregano essential oil, the clove essential oil, the thyme essential oil, the carvacrol, the eugenol and the thymol is 1:1, 1:10, 1:30 and 1:50. The bactericidal composition can be used for preventing and treating rhynchosporium, sclerotinia sclerotiorum, tomato gray mold, wheat scab, rice blast, cotton wilt and aspergillus flavus. The components of the application are all natural products and harmless to the environment. The application can reduce the influence of pesticides on the environment, reduce the cost of using pesticides, delay or overcome the generation of disease resistance, prolong the service life of the pesticides, and is beneficial to the comprehensive management of diseases.

This scheme provides a highly stable multi-encapsulated cypress phenol liposome and its preparation method and application. Cypress phenol is emulsified with a special glycolipid emulsifier to obtain a nano-cypress phenol emulsion, and then the nano-cypress phenol is further encapsulated with a phospholipid bilayer of phospholipids and emulsified esters to obtain a multi-encapsulated cypress phenol liposome with a special double-shell three-layer structure. The cypress phenol active substance is encapsulated by glycolipids and sandwiched between the phospholipid bilayers, which improves the water solubility and stability of the multi-encapsulated cypress phenol liposome, and has a good antibacterial effect, and can be widely used in the cosmetics field.

The invention relates to the technical field of health-care food, in particular to a vagina probiotic composition which comprises the following raw materials: 10-20 parts of probiotic compound bacteria, 20-40 parts of prebiotics, 10-20 parts of traditional Chinese medicine powder and pharmaceutically acceptable auxiliary materials, wherein the probiotic compound bacteria are composed of lactobacillus reuteri strain GR-1, lactobacillus rhamnosus strain RC-14 and lactobacillus bulgaricus, and the traditional Chinese medicine powder is prepared from shikonin, hinokitiol and cicada slough extract. Three probiotics and traditional Chinese medicine powder are used in a combined mode, and the probiotics composite bacterial powder is used for balancing vaginal flora and preventing vaginitis from developing to urethritis; the shikonin, the hinokitiol and the cicada slough extract assist in improving urinary tract infection, inhibiting growth of pathogenic bacteria and avoiding further deterioration of vaginal flora; the prebiotics are used for proliferation of beneficial bacteria.

The present invention discloses a plant activator and its application, belonging to the technical field of plant growth regulation. The active ingredients in the plant activator include hinokitiol and rape pollen extract. The present invention first combines hinokitiol and rape pollen extract as the active ingredients of the plant activator. The two cooperate with each other and jointly play a role in promoting the self-growth of crops, and can significantly improve the yield and quality of crops such as tomatoes. At the same time, it can reduce the use of chemical drugs, which is of great significance for improving the quality and efficiency of crops and the sustainable development of agriculture.

The present invention relates to the use of a compound of formula (I), wherein - R is: ○ a (C1–C20)alkyl, a heteroalkyl, a (C1–C20)alkenyl, a (C1–C20)alkynyl, the alkyl, heteroalkyl, alkenyl or alkynyl optionally being substituted with one or more substituents chosen from a halogen atom, an oxo group, a (C1–C8)alkyl, an OH group, a (C1–C6)alkoxy and a C1–C6)haloalkyl; ○ a saturated or unsaturated and non-aromatic hydrocarbon-based cyclic or polycyclic system, each ring comprising 3 to 7, preferably 5 or 6 ring members, and optionally substituted by one or more (C1–C8)alkyls; ○ a saturated or unsaturated and non-aromatic heterocycle, each ring comprising 3 to 7, preferably 5 or 6 ring members, and comprising one or more, in particular 1 or 2, heteroatoms selected from oxygen, sulphur and nitrogen, and optionally substituted by one or more (C1–C8)alkyls, or an aryl, aryl-(C1–C6)alkyl, heteroaryl, or heteroaryl-(C1–C6)alkyl group, the group being optionally substituted with one or more substituents selected from a halogen atom, a (C1–C8)alkyl, (C1–C6)alkoxy and (C1–C6)haloalkyl; - X is an oxygen atom or an NR' group, with R' a hydrogen atom or a (C1–C4)alkyl; and - n is equal to 0 or 1, for its fungicidal and / or bactericidal activity on fungi and / or oomycetes and / or pathogenic bacteria of plants and crop seeds.

The invention discloses a sodium hyaluronate-coated hinokiol microbead stable anti-dandruff composition and a preparation method thereof, and the sodium hyaluronate-coated hinokiol microbead stable anti-dandruff composition comprises the following components by mass: 2%-6% of sodium hyaluronate-coated hinokiol microbeads, 10%-20% of a surfactant, 0.1%-5% of a humectant, 0.01%-3% of a thickener, 0.01%-3% of a pH regulator, 0.001%-0.5% of a preservative, and the balance of water. The sum of the mass fractions of the components does not exceed 100%, and the balance is filler. According to the method, hinokiol is prevented from being influenced by illumination and free radicals, meanwhile, hinokiol is effectively isolated from formula materials, it is guaranteed that hinokiol stably exists in the transparent packaging material for a long time, and the antibacterial rate is increased.

To remove senescent cells, and / or to prevent, suppress, or improve skin aging phenomena such as age spots, wrinkles, sagging, dullness, thinning of the skin, weakening of the skin, decreased skin barrier function, and dryness by removing senescent cells. [Solution] A composition containing lactic acid, indole lactic acid, phenyl lactic acid, catechin, caffeic acid, umbelliferone, parthenolide, pyridoxine hydrochloride, arbutin, hinokitiol, oxaloacetate, tocotrienol, tocopherol, γ-oryzanol, retinol acetate, retinyl palmitate, riboflavin, and pantothenyl ethyl ether, as well as chemically possible salts thereof, and at least one selected from the group consisting of Enterococcus bacteria and Lactobacillus bacteria.

To provide a minoxidil-containing composition for external use which suppresses discoloration of a preparation with time in a minoxidil-containing composition for external use obtained by blending at least one active ingredient selected from the group consisting of glycyrrhetinic acid and / or a salt thereof, a pantothenyl ethyl ether, panthenol, hinokitiol and diphenhydramine and / or a salt thereof.SOLUTION: There is provided a composition for external use which suppresses discoloration of a preparation with time by using a specific polyhydric alcohol, that is, there is provided a composition for external use which comprises: at least one active ingredient selected from the group consisting of minoxidil, glycyrrhetinic acid and / or a salt thereof, a pantothenyl ethyl ether, panthenol, hinokitiol and diphenhydramine and / or a salt thereof; propylene glycol; and an acid.SELECTED DRAWING: None