56 results about "Hinokitiol" patented technology

A flavor and fragrance composition possessing an antibacterial activity effective against periodontal disease-causing bacteria and/or a halitosis-inhibition action capable of controlling production of volatile sulfides, which is safe for the human body, and containing at least one or more substances selected from food fragrance materials such as hexylaldehyde, caryophyllene alcohol, cinnamicaldehyde, dihydroeugenol, farnesol, dihydrofarnesol, hinokitiol, isoeugenol, γ-undecalactone, d-limonene, o-methoxycinnamicaldehyde, β-pinene, γ-terpinene, terpinolene, orange oil, nutmeg oil, and grapefruit oil, and an oral care composition containing the same.

The invention belongs to the field of daily use chemicals, and particularly relates to hair nourishing and restoring liquid with sophora flavescens extracts. The hair nourishing and restoring liquid which is a composition comprises, by weight, 0.0001%-10% of the sophora flavescens extracts, 0.001%-5% of hinokitiol and 0.01%-10% of nicotinamide. The hair nourishing and restoring liquid has the advantages that three active substances are combined with one another, so that effects of activating and strengthening hair roots, promoting hair growth and preventing hair loss can be realized; effects of collaboratively promoting the hair growth and preventing the hair loss can be realized by the three active components, and excellent hair nourishing and restoring effects can be realized as compared with a single active component.

A composition for a bactericidal, disinfecting, and cleansing foam agent contains, as essential components, (a) at least one nonionic surfactant selected from polyalkylene glycol ethers and fatty acid esters of polyglycerin, (b) a bactericidal component, and (c) water. In a preferable embodiment, the nonionic surfactant has a HLB of 10 or greater and is selected from fatty acid esters of polyglycerin. The bactericidal component is selected from hinokitiol, hinokitiol salts, and hinokitiol complexes. This composition is free from a lower alcohol, and further free from an anionic surfactant, an amphoteric surfactant and a cationic surfactant. This composition is particularly suitable for a pump foam-type product. This invention can provide a composition suitable for a bactericidal, disinfecting, and cleansing agent wherein the composition turns into foam sufficiently to give an easy-to-use foam agent.

The invention relates to a waterborne hinokitiol wood preservative and a preparation method thereof, and is used for solving the problems that hinokitiol giving a natural corrosion resistance to wood has poor water solubility and is difficult to use. The wood preservative comprises the components according to mol ratio: 0.2-2 mol of hinokitiol, 1 mol of a solubility promoter, and 0.01-1 mol of a tannin extract (the molar ratio calculated according to the content of phenolic hydroxyl group). The wood preservative is used for processing the wood, and when the mass concentration of hinokitiol is about 1%, the resistance of the processed wood to Aspergillus niger, Penicillium citrinum, Trichoderma is up to 100%, and the fungal growth is completely inhibited; and moreover, the molding resistance of the processed wood to Coriolus versicolor and Gloeophyllum trabeum can achieve strong molding resistance level.

An antimicrobial adhesive sheet containing an antimicrobial agent which exerts the antimicrobial activity not only on an attached site but also in the space in the vicinity of the attached site, and an antimicrobial method using the sheet. The antimicrobial adhesive sheet has a moisture permeability of at least 1,000 g/m²·24 hrs as the whole sheet, where a non-aqueous adhesive layer containing a vaporizable antimicrobial agent is formed on one side of the support. As the support, non-woven fabric and porous plastic sheet are preferable. In case of non-porous plastic sheet, polyurethane resins and polyamide resins are preferably used. As the vaporizable antimicrobial agent, hinokitiol is preferable and inclusion compounds thereof may also be used. As the adhesive, an acrylic adhesive prepared by polymerizing a (meth)acrylic acid alkyl ester as the main component is preferably used.

Babassuamadopropalkonium chloride is quaternary ammonium compounds obtained from natural babassu oil that contains a high level of lauric acid, and it has been used as mild conditioner. We found that babassuamadopropalkonium chloride has strong and broad-spectrum antimicrobial activity especially with bisabolol. Bisabolol is the active component of Chamomile, one of the most used medical plants, and has been used as anti-irritant. We found that there is a synergistic effect of bisabolol on hinokitiol, when combined with ethylhexylglycerin or caprylyl glycol. This synergistic effect of composition of bisabolol and ethylhexylglycerin can reduce the required amount of hinokitiol, which if used in high amount can be unstable by more than 100 times. Self-preserving personal care cleansing compositions that include bisabolol, alkyl or alkylamidopropyl betaines, amphoteric surfactants, acyl sarcosinates and optionally fatty acids and(or) acyl lactylate and(or) acyl glucoside and(or) babassuamadopropalkonium chloride and colloidal silver have also broad-spectrum antimicrobial activity.

A therapeutic approach to prevent drug resistance and chemotherapy-related secondary cancer associated with DNA mismatch repair (MMR) deficiency is disclosed based on screening antioxidants for reducing microsatellite instability (MSI) while enhancing the cytotoxicity of chemotherapeutic agents. The work is based on experiments using antioxidants to target reactive oxygen species generated by oxaliplatin, a commonly used chemotherapeutic agent, and is applicable to other chemotherapeutic agent, and in particular 5-fluorouracil, methotrexate, CCNU, etoposide and vinblastine. In particular oxaliplatin is co-treated with an antioxidant, including CDC, CAPE, ciclopirox ethanolamine, hinokitiol, gossypol, n-Octyl caffeate, baicalein, or curcumin.

The invention provides a Cypress oleic alcoholic metallic compound due to the strong antibiotic activity of the compound against infectious pathogenicbacteria and vegetable pathogenicbacteria. The compound can be applied to blocking the infection of infectious pathogenicbacteria for materials by the bacteriostasis or antibiotic functional characteristic, as well as to the environmental cleaning and disease control in farming industry and agricultural plant disease control, thus expanding the application of the Cypress oleic alcoholic metallic compound.

The biological catalyst as one kind of composite biological functional material includes two reagent components packed separately, the reagent A consists of metal ion 0.5-1 wt%, 2D resin 7-9 wt%, titania 66.3-71.7 wt% and zinc oxide 1.3-13.3 wt%; and the reagent B consists of L-serine 0.2-0.5 wt%, cystine 0.2-0.5 wt%, acetylcholine 0.5-0.7 wt% and hinokitiol 12-16 wt%. It can distinguish pathogenetic microbes fast and accurately and kill pathogenetic microbes only, and has no irritation to human body, no side effect, no influence on human body immunity, high physical and chemical stability, wash resistance, and no influence on the characteristics and indexes of fabric.

An antibacterial or anti-acne formulation containing (a) tropone or a substituted tropone and (b) a metal or metal salt selected from copper, copper salts, bismuth, bismuth salts, silver, silver salts, and mixtures thereof, for use in the treatment of either acne or body odour. The substituted tropone may be for example tropolone or hinokitiol.

The invention relates to hinokitiol clathrate compound and a preparation method thereof and specifically relates to the hinokitiol clathrate compound which can obviously improve hinokitiol water solubility and completely solve illumination color change and degradation of the hinokitol and the preparation method thereof. The hinokitiol clathrate compound disclosed by the invention is preferably clathrate compound prepared from the hinokitiol and cyclodextrin or derivative of the cyclodextrin, wherein the cyclodextrin or the derivative thereof is chosen from alpha-cyclodextrin or derivative thereof, beta-cyclodextrin or derivative thereof and gamma-cyclodextrin or derivative thereof, and a mass ratio of the hinokitiol to the cyclodextrin or the derivative thereof is (1 to 8) to (1 to 1000).The preparation method of the hinokitiol clathrate compound is chosen from a precipitation and coprecipitation method, a grinding method, an ultrasonic method, a freeze drying method, a spray drying method, a liquid-liquid method or a liquid-gas method, a solid phase clathration method and the like.

The invention belongs to the technical field of synthesis of pharmaceutical intermediates, and relates to a method for preparing high-purity hinokitiol and a coordination complex thereof. The method comprises the steps that 1-perchlorocyclopentadiene is generated by using cyclopentadiene, sodium hydroxide and NCS and reacts with dichloracetyl chloride, barium hydroxide is added, dilute sulphuric acid and chloroform are added after the reaction, and 1-chloro cyclopentadiene 4,4-dichloro cyclobutyl5-ketone is obtained through a final reaction; 1-chloro cyclopentadiene 4,4-dichloro cyclobutyl5-ketone is mixed with a mixed solution of acetic acid, acetone and water, then barium hydroxide is added, and 2-hydroxyl-4-chloro-2,4,6-cycloheptatrien-1-ketone is obtained through a final reaction; 2-hydroxyl-4-chloro-2,4,6-cycloheptatrien-1-ketone is added to THF, potassium phosphate and isopropylboronic acid are added, and the mixture after the reaction is added to a mixed solution of methanol, HCl/1 and 4-dioxane to obtain hinokitiol at last. The method has the advantages that the process is simple, the cost is low, and the product purity is high.

The invention belongs to the technical field of functional polymer materials, and particularly relates to self-antibacterial lactic acid-based waterborne polyurethane as well as a preparation method and an emulsion thereof. Water-based chitosan and hinokitiol structures are introduced to a side chain of a large polyurethane long chain by self-antibacterial lactic acid-based waterborne polyurethane and are uniformly distributed, so that two substances with different antibacterial and bactericidal mechanisms mutually generate a bactericidal and antibacterial synergistic effect, the drug resistance of bacterial organisms can be effectively reduced, and meanwhile, the two substances are grafted on a polyurethane long chain in a chemical bond manner, so that the antibacterial property is lasting.

The invention relates to an anti-hair-loss hair-growth scalp care essence containing hinokitiol, and a preparation method and application of the anti-hair-loss hair-growth scalp care essence. The anti-hair-loss hair-growth scalp care essence comprises the following preparation raw materials: the hinokitiol, Swertia Japonica extracts, cacumen platycladi extracts, polygoni multiflori radix extracts, ginseng radix extracts and polyglycerol-10 lauric acid esters, and meanwhile, the anti-hair-loss hair-growth scalp care essence does not contain ethyl alcohol. The hinokitiol mainly improves the autophagy activity of human hair papilla cells and the autophagy activity of mitochondria, the Swertia Japonica extracts mainly can expand peripheral blood vessels and accelerate scalp blood circulation, and the cacumen platycladi extracts, the polygoni multiflori radix extracts and the ginseng radix extracts mainly improve the cell activity of hair follicle. Five ingredients jointly accelerate growth of hair from multiple dimensions from different mechanism angles so as to have an unexpected synergistic interaction function for an anti-hair-loss hair-growth effect. Meanwhile, the polyglycerol-10 lauric acid esters are taken as a solvent for dissolving the hinokitiol, no ethyl alcohol is contained, and a formula is moderate and is free from stimulation.

The invention discloses a bactericidal composition containing hinokitiol, plant essential oil and main components of the hinokitiol and the plant essential oil, wherein the active components of the bactericidal composition are hinokitiol, origanum essential oil, clove essential oil, thyme essential oil, carvacrol, eugenol and thymol, and the mass part ratio of the hinokitiol to the origanum essential oil to the clove essential oil to the thyme essential oil to the carvacrol to the eugenol to the thyme is 1:1, 1:10, 1:30 and 1:50. According to the invention, the bactericidal composition can be used for preventing and treating rhizoctonia solani, sclerotinia rot of colza, botrytis cinerea, wheat scab, rice blast, fusarium wilt of cotton and aspergillus flavus; the components are all natural products and are harmless to the environment; and the influence of pesticides on the environment is expected to be reduced, the pesticide use cost is reduced, the generation of pesticide resistance of diseases can be delayed or overcome, the service life of the pesticide is prolonged, and the comprehensive management of the diseases is facilitated.

Cleansing compositions can include hinokitiol; and a 2-pyridinol N-oxide material; wherein the ratio by weight of the 2-pyridinol N-oxide material to the hinokitiol is about 1:4 to about 2:1 and the combination of the 2-pyridinol N-oxide material and hinokitiol includes about 9 ppm or more by weight of the cleansing composition.

The invention discloses a method for preparing hinokitiol. The method includes the steps of conducting an addition reaction on bromoform and an initial raw material compound, namely cyclohexene, to obtain a first compound, namely 7,7-dibromo bicyclo[4.1.0]heptane; the first compound is subjected to an oxidization reaction to obtain a second compound, namely 3,7,7-tribromo bicyclo[4.1.0]heptyl-2-ketone; the second compound is subjected to a substitution reaction to obtain a third compound, namely 7,7-dibromo-3-hydroxy bicyclo[4.1.0] heptyl-3-alkene-2-ketone; the third compound is subjected to aring enlargement reaction to obtain a fourth compound, namely 4-bromo-2-hydroxy cycloheptyl-2,4,6-triene-1-ketone; the fourth compound is subjected to an alkylation reaction to obtain hinokitiol.