27 results about "Hinokitiol" patented technology

Disclosed is a method for treating a disease or condition characterized by neurodegeneration by administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of hinokitiol, a hinokitiol derivative, and an iron-transporting tropolone.

Disclosed is a method of treating a disease or condition characterized by neurodegeneration via administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of hinokitiol, hinokitiol derivatives, and iron-transporting tropolones.

The present application relates to a kind of composition of synergistic inhibition porphyromonas gingivalis, belong to oral care technical field.The present application provides a kind of composition of synergistic inhibition porphyromonas gingivalis, the composition is composed of peach geniposide and hinokitiol.The present application selects peach geniposide and hinokitiol from numerous existing components, finds that the composition formed by the combination of the two has synergistic effect, can improve the bacteriostatic efficacy of the composition, especially for the bacteriostatic effect of porphyromonas gingivalis, its inhibitory effect is stronger.

The invention relates to a composition for resisting oxidation and inhibiting porphyromonas gingivalis and application of the composition, and belongs to the technical field of oral care. The invention provides a composition for resisting oxidation and inhibiting porphyromonas gingivalis. The composition is prepared from a mangnolia officinalis bark extract and hinokiol. The mangnolia officinalis bark extract and hinokiol are screened from numerous existing components, it is found that the composition formed by combining and compounding the mangnolia officinalis bark extract and hinokiol has a synergistic interaction effect, the antibacterial effect of the composition can be improved, especially the antibacterial effect on porphyromonas gingivalis can be improved, and the inhibition effect is higher.

The invention belongs to the technical field of cosmetics, and discloses a plant source antimicrobial composition as well as a preparation method and application thereof. The botanical antimicrobial composition disclosed by the invention is prepared from the following components in parts by weight: 0.05 to 5 parts of cacumen biotae extract, 10 to 30 parts of raspberry ketone and 0.05 to 5 parts of hinokiol. According to the plant source antimicrobial composition disclosed by the invention, a multi-target and all-around antibacterial and antiseptic system is constructed through a synergistic effect of natural plant components, rapid and broad-spectrum inhibition on bacteria, fungi and propionibacterium acnes is realized, and excellent physical and chemical stability can be kept in an extreme environment; the preservative effect is not affected by a complex formula system, and the function of instantly killing acne pathogenic bacteria is achieved. Meanwhile, the plant-derived antimicrobial composition can also be perfectly compatible with active ingredients of various cosmetics, can be flexibly applied to various product types, and provides a natural, efficient, reliable and low-irritation preservative solution for users.

To provide an oral composition that has a high astringent effect and high storage stability of berberine. [Solution] An oral composition comprising (A) component: berberine, (B) component: hinokitiol, and (C) component: isopropylmethylphenols, wherein the content of component (B) is 0.001 to 0.5% by mass relative to the total mass of the oral composition, and the ratio of the mass of component (C) to the mass of component (B), expressed as component (C) / component (B), is 0.01 to 10.

The invention belongs to the technical field of microbial fertilizers, and particularly relates to a novel multifunctional zinc-silicon bacterial fertilizer which comprises a microbial agent, and the microbial agent is formed by compounding bacillus velezensis and piperlongumine or hinokitiol according to the mass ratio of (1-150): (150-1). The novel multifunctional zinc-silicon bacterial fertilizer can effectively prevent and control crop diseases so as to achieve the biological control effect, can supplement elements such as zinc and silicon required by crop growth, is beneficial to crop production, has the effect of multiple effects after one application, and can provide support for green and healthy development of crops.

The invention relates to a composition for synergistically inhibiting porphyromonas gingivalis, and belongs to the technical field of oral care. The invention provides a composition for synergistically inhibiting porphyromonas gingivalis. The composition is prepared from totarol and hinokiol. The totarol and the hinokiol are screened from numerous existing components, it is found that the composition formed by combining and compounding the totarol and the hinokiol has the synergistic interaction effect, the antibacterial effect of the composition can be improved, especially the antibacterial effect on porphyromonas gingivalis can be improved, and the inhibition effect of the composition is higher.

A cosmetic composition is disclosed comprising i) a scalp health agent; and ii) a natural active selected from cotoin, isoliquiritigenin, xanthohumol, pinostrobin chalcone, and a mixture thereof; wherein the scalp health agent is selected from a group consisting of polyvalent metal salts of pyrithione, hydroxamic acid, hinokitiol, azole compound and selenium sulfide; wherein the weight ratio of the amount of said active to that of said scalp health agent is from 1:100 to 100:1.

An object of the present invention is to provide an oral composition having a good antibacterial effect, flavor expression, and smooth skin.SOLUTION: A composition for oral cavity, a dentifrice composition, a composition for external use, and a composition for oral cavity for treatment or prevention of periodontal disease, comprising a component (A): a fluorine-containing compound, a component (B): hinokitiol and / or thymol, and a component (C): a nonionic surfactant, wherein the content of the component (A) is 3000 to 20000 ppm in terms of fluoride ion concentration.SELECTED DRAWING: None

The invention discloses a preparation method and a detection method of hinokitiol, and belongs to the technical field of synthesis of medical intermediates, the preparation method comprises the following steps: S1, carrying out a reaction on cyclopentadiene, ethyl magnesium bromide and isopropyl p-toluenesulfonate to obtain cyclopentadiene; the preparation method comprises the following steps: carrying out an addition reaction on 1-isopropyl cyclopentadiene and dichloroacetyl chloride in a solvent to prepare 7, 7-dichloro-3-isopropyl-bicyclo [3, 2, 0] hept-2-ene-6-one, and carrying out a reaction on the 7, 7-dichloro-3-isopropyl-bicyclo [3, 2, 0] hept-2-ene-6-one and 1-isopropyl cyclopentadiene in the solvent to prepare 7, 7-dichloro-3-isopropyl-bicyclo [3, 2, 0] hept-2-ene-6-one; s3, the 7, 7-dichloro-3-isopropyl-bicyclo [3, 2, 0] hept-2-ene-6-ketone, a mixed solution containing tert-butyl alcohol, acetic acid and water and triethylamine are subjected to a ring expansion reaction, and a crude product of hinokitiol is prepared; and S4, carrying out alkali extraction and acid precipitation on the hinokitiol crude product, and recrystallizing to obtain hinokitiol. The method greatly simplifies the post-treatment process, has the advantages of low cost, high purity, high yield and the like, and is suitable for large-scale industrial production.

To provide a hair growth or hair care agent composition containing hinokitiol, salicylic acid, edetic acid salt, and ethanol, which does not produce precipitates over time.SOLUTION: The above problems are solved by a hair growth or hair care agent composition containing at least hinokitiol, salicylic acid, edetic acid salt, and ethanol, a content of the edetic acid salt being 0.02 mass / volume% or more relative to the total volume of the composition, and a content of the ethanol being 30 to 70 vol.%, and pH is 3.7 or more and less than 6.0.SELECTED DRAWING: None

Disclosed herein is a cosmetic composition comprising i) hinokitiol and ii) hydroxamic acid wherein the weight ratio of the amount of hydroxamic acid to the amount of hinokitiol is 2: 1 to 15: 1 wherein the hydroxamic acid is capryloyl hydroxamic acid, benzoyl hydroxamic acid or a mixture thereof.

An accord composition for improving the scalp microbiome is provided. Such accord compositions comprise hinokitiol and at least one synergistic compound. Consumer products and methods of use for the consumer products are also provided.

The invention discloses a hinokiol pH response release nanoemulsion composition and a preparation method thereof. The hinokiol pH response release nanoemulsion composition comprises the following components in percentage by mass: 0.5%-5% of hinokiol related extract, 0.1%-3% of a pH sensing emulsifier, 0.5%-10% of a pH sensing synergist, 2%-10% of an emulsion stabilizer, 5%-20% of an active matter solubilizer, 0.002%-0.01% of an active matter antioxidant stabilizer, 4%-9% of an auxiliary component and the balance of filler, wherein the sum of the mass fractions of the components does not exceed 100%. The malassezia inhibitor can be quickly released at a scurf affected part with a high pH value so as to strongly inhibit malassezia, and can be slowly released in a weak acid environment of healthy scalp so as to maintain flora balance and play an oil control role.

The present invention provides a preservative for an external preparation for skin and a use thereof. The preservative comprises: hinokitiol; and one or more solvents selected from the group consisting of alkantriol having 3 to 6 carbon atoms, dipropylene glycol, glycerol caprylate, ethylhexylglycerin, and phenoxyethanol. According to one aspect of the present invention, the preservative for an external preparation for skin can be stably held in a liquid state at room temperature and under cold storage conditions, and can exhibit an excellent antibacterial effect after being formed into a dosage form.

A cosmetic composition comprising hinokitiol and an organic UVA filter selected from butyl methoxydibenzoylmethane, bis-ethylhexyloxyphenol methoxyphenyl triazine, diethylamino hydroxybenzoyl hexyl benzoate, methylene bis-benzotriazolyl tetramethylbutylphenol and mixtures thereof is disclosed. It has proven to improve the stability of hinokitiol.

The application discloses a bactericidal composition containing hinokitiol and plant essential oil and main components thereof, and effective components are hinokitiol and oregano essential oil, clove essential oil, thyme essential oil, carvacrol, eugenol and thymol. The mass fraction ratio of the hinokitiol and the oregano essential oil, the clove essential oil, the thyme essential oil, the carvacrol, the eugenol and the thymol is 1:1, 1:10, 1:30 and 1:50. The bactericidal composition can be used for preventing and treating rhynchosporium, sclerotinia sclerotiorum, tomato gray mold, wheat scab, rice blast, cotton wilt and aspergillus flavus. The components of the application are all natural products and harmless to the environment. The application can reduce the influence of pesticides on the environment, reduce the cost of using pesticides, delay or overcome the generation of disease resistance, prolong the service life of the pesticides, and is beneficial to the comprehensive management of diseases.

This scheme provides a highly stable multi-encapsulated cypress phenol liposome and its preparation method and application. Cypress phenol is emulsified with a special glycolipid emulsifier to obtain a nano-cypress phenol emulsion, and then the nano-cypress phenol is further encapsulated with a phospholipid bilayer of phospholipids and emulsified esters to obtain a multi-encapsulated cypress phenol liposome with a special double-shell three-layer structure. The cypress phenol active substance is encapsulated by glycolipids and sandwiched between the phospholipid bilayers, which improves the water solubility and stability of the multi-encapsulated cypress phenol liposome, and has a good antibacterial effect, and can be widely used in the cosmetics field.

The invention relates to the technical field of health-care food, in particular to a vagina probiotic composition which comprises the following raw materials: 10-20 parts of probiotic compound bacteria, 20-40 parts of prebiotics, 10-20 parts of traditional Chinese medicine powder and pharmaceutically acceptable auxiliary materials, wherein the probiotic compound bacteria are composed of lactobacillus reuteri strain GR-1, lactobacillus rhamnosus strain RC-14 and lactobacillus bulgaricus, and the traditional Chinese medicine powder is prepared from shikonin, hinokitiol and cicada slough extract. Three probiotics and traditional Chinese medicine powder are used in a combined mode, and the probiotics composite bacterial powder is used for balancing vaginal flora and preventing vaginitis from developing to urethritis; the shikonin, the hinokitiol and the cicada slough extract assist in improving urinary tract infection, inhibiting growth of pathogenic bacteria and avoiding further deterioration of vaginal flora; the prebiotics are used for proliferation of beneficial bacteria.

The present invention relates to the use of a compound of formula (I), wherein - R is: ○ a (C1–C20)alkyl, a heteroalkyl, a (C1–C20)alkenyl, a (C1–C20)alkynyl, the alkyl, heteroalkyl, alkenyl or alkynyl optionally being substituted with one or more substituents chosen from a halogen atom, an oxo group, a (C1–C8)alkyl, an OH group, a (C1–C6)alkoxy and a C1–C6)haloalkyl; ○ a saturated or unsaturated and non-aromatic hydrocarbon-based cyclic or polycyclic system, each ring comprising 3 to 7, preferably 5 or 6 ring members, and optionally substituted by one or more (C1–C8)alkyls; ○ a saturated or unsaturated and non-aromatic heterocycle, each ring comprising 3 to 7, preferably 5 or 6 ring members, and comprising one or more, in particular 1 or 2, heteroatoms selected from oxygen, sulphur and nitrogen, and optionally substituted by one or more (C1–C8)alkyls, or an aryl, aryl-(C1–C6)alkyl, heteroaryl, or heteroaryl-(C1–C6)alkyl group, the group being optionally substituted with one or more substituents selected from a halogen atom, a (C1–C8)alkyl, (C1–C6)alkoxy and (C1–C6)haloalkyl; - X is an oxygen atom or an NR' group, with R' a hydrogen atom or a (C1–C4)alkyl; and - n is equal to 0 or 1, for its fungicidal and / or bactericidal activity on fungi and / or oomycetes and / or pathogenic bacteria of plants and crop seeds.

The invention discloses a sodium hyaluronate-coated hinokiol microbead stable anti-dandruff composition and a preparation method thereof, and the sodium hyaluronate-coated hinokiol microbead stable anti-dandruff composition comprises the following components by mass: 2%-6% of sodium hyaluronate-coated hinokiol microbeads, 10%-20% of a surfactant, 0.1%-5% of a humectant, 0.01%-3% of a thickener, 0.01%-3% of a pH regulator, 0.001%-0.5% of a preservative, and the balance of water. The sum of the mass fractions of the components does not exceed 100%, and the balance is filler. According to the method, hinokiol is prevented from being influenced by illumination and free radicals, meanwhile, hinokiol is effectively isolated from formula materials, it is guaranteed that hinokiol stably exists in the transparent packaging material for a long time, and the antibacterial rate is increased.

To remove senescent cells, and / or to prevent, suppress, or improve skin aging phenomena such as age spots, wrinkles, sagging, dullness, thinning of the skin, weakening of the skin, decreased skin barrier function, and dryness by removing senescent cells. [Solution] A composition containing lactic acid, indole lactic acid, phenyl lactic acid, catechin, caffeic acid, umbelliferone, parthenolide, pyridoxine hydrochloride, arbutin, hinokitiol, oxaloacetate, tocotrienol, tocopherol, γ-oryzanol, retinol acetate, retinyl palmitate, riboflavin, and pantothenyl ethyl ether, as well as chemically possible salts thereof, and at least one selected from the group consisting of Enterococcus bacteria and Lactobacillus bacteria.

To provide a composition for oral cavity hardly causing separation during preservation while containing a slightly water-soluble medicinal component.SOLUTION: This composition for the oral cavity comprises (A) sodium fluoride, (B) a water-soluble calcium salt, (C) one or more kinds selected from the group consisting of condensed phosphoric acids and their alkali metal salts and (D) one or more kinds selected from the group consisting of tocopherol, glycyrrhetinic acid, Phellodendron amurense RUPRECHT extract and hinokitiol.SELECTED DRAWING: None

An object of the present invention is to provide a novel glycation stress inhibitor having an activity of inhibiting glycation stress occurring in vivo.SOLUTION: The glycation stress inhibitor, the glycation reaction inhibitor or the inflammatory reaction inhibitor for inhibiting the inflammatory reaction caused by AGEs contains one or more kinds selected from the group consisting of glycyrrhizic acids, allantoins, azulenes, pyridoxine hydrochloride, hinokitiols, copper chlorophylls, lysozyme chloride and epsilon-aminocaproic acid. Each agent is useful as an external preparation, an agent for oral cavity, a gingival care agent, and a periodontal disease preventive agent.SELECTED DRAWING: None

This invention discloses a shower gel with antibacterial function, specifically relating to the technical field of shower gels. This shower gel aims to solve the problems of existing shower gels being unsuitable for damaged skin and hindering wound healing with long-term use. The shower gel of this invention contains the following components by weight percentage: 0.05%-0.2% hinoki alcohol; 1.0%-5.0% psoralen extract; 1.0%-8.0% Tween 20; 3.0%-10.0% propylene glycol; 0.5%-3.0% phospholipids; 0.01%-0.15% benzalkonium chloride; appropriate amount of pH adjuster; and the balance being purified water. This invention achieves a gentle and non-irritating cleansing effect through the selection and proportioning of specific components, while also exhibiting a significant inhibitory effect on common pathogenic bacteria. It is particularly suitable for the cleansing and care of skin around postoperative wounds and sensitive skin. This shower gel does not contain alcohol, fragrance, pigments, or irritating surfactants, avoiding secondary damage to damaged skin caused by traditional products. It has good system stability and biocompatibility, providing a safe and effective whole-body cleansing solution for postoperative patients.

To provide a solid cleaning preparation.SOLUTION: A solid cleaning preparation for cleaning an intraoral appliance such as a denture or an orthodontic retainer, the solid cleaning preparation containing (A) at least one selected from the group consisting of a dichloroisocyanurate salt, a quaternary ammonium salt, isopropylmethylphenol, a fluoride, thymol, hinokitiol, cetylpyridinium chloride, benzethonium chloride, chlorhexidine acetate, chlorhexidine gluconate, sodium monofluorophosphate, triclosan, lysozyme chloride, and chlorhexidine hydrochloride, (B) an oxygen-based bleaching agent, (C) a foaming agent, and (D) at least one selected from the group consisting of calcium silicate, dextrin, lactose, starch, gum arabic, gelatin, casein, and talc, wherein an amount of the component (D) is 0.2 pt.mass or more and 5 pts.mass or less with respect to 1 pt.mass of the component (A).SELECTED DRAWING: None