51 results about "White Mulberry" patented technology

The present application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for relieving cough and asthma, and a preparation method and application thereof. The traditional Chinese medicine composition comprises, in mass parts, perilla seed 5-15 parts, radish seed 5-15 parts, white mulberry bark 5-15 parts, orange red or processed orange red 5-15 parts, and cassia 5-15 parts. The traditional Chinese medicine composition has the effect of relieving cough and asthma, can effectively improve the clinical symptoms such as cough, expectoration and wheezing of patients with chronic obstructive pulmonary disease, promote lung rehabilitation, improve the dyspnea condition of the patients, and improve the life quality of the patients.

The invention relates to the technical field of traditional Chinese medicine compositions, and discloses a traditional Chinese medicine composition for wound healing and a preparation method thereof.The traditional Chinese medicine composition used in the early stage comprises 10-12 parts of rheum officinale, 5-6 parts of coptis chinensis, 10-12 parts of scutellaria baicalensis, 10-12 parts of golden cypress, 10-12 parts of corydalis tuber, 6-7 parts of pseudo-ginseng, 5-6 parts of pollen typhae, 4-5 parts of dragon's blood, 10-12 parts of sanguisorba officinalis, 10-13 parts of ramulus mori and 10-12 parts of gallnut; the traditional Chinese medicine composition used in the middle stage is prepared from 10-12 parts of radix astragali, 10-12 parts of radix angelicae sinensis, 10-12 parts of radix salviae miltiorrhizae, 10-12 parts of talc, 10-12 parts of ramulus mori, 10-12 parts of gallnut, 10-12 parts of rhizoma chuanxiong, 4-5 parts of resina draconis, 10-12 parts of frankincense and 10-12 parts of myrrh; the traditional Chinese medicine composition used in the later period comprises 10-12 parts of radix astragali, 10-12 parts of radix dipsaci, 10-12 parts of radix angelicae sinensis, 10-12 parts of rhizoma chuanxiong, 10-12 parts of gallnut, 10-12 parts of ramulus mori, 10-12 parts of radix codonopsis, 10-12 parts of radix salviae miltiorrhizae, 10-12 parts of radix morindae officinalis and 10-12 parts of talc. Wound treatment is divided into three stages, the cure rate of chronic refractory wounds (CRW) can be remarkably increased, inflammatory factors are inhibited, and tissue regeneration is promoted.

The application relates to the technical field of cough-relieving medicines, and discloses a high-efficiency cough-relieving loquat particle composition which is composed of the following components in parts by weight: loquat leaf extract 30-40 parts; white front extract 10-15 parts; platycodon grandiflorum extract 6-10 parts; white mulberry bark extract 18-25 parts; stemona sessiliflora extract 7-10 parts; menthol 0.1-0.5 part; polyethylene glycol 2-5 parts; mannitol 8-12 parts; ethyl cellulose 3-6 parts; hydroxypropyl methyl cellulose 1-3 parts; phosphatidylcholine 1-3 parts; polysorbate 80 1-3 parts; cross-linked sodium carboxymethyl cellulose 4-6 parts; and sucrose 40-60 parts. The double dispersion system combining the immediate-release component and the sustained-release component is adopted, the solubility and the initial release speed of the traditional Chinese medicine extract are remarkably improved through the addition of polyethylene glycol and mannitol, and the technical effect that the drug effect appearing time is remarkably shortened is achieved. Compared with the technical scheme relying on only a single release mode in the prior art, the deficiency that the drug effect is slow and the symptoms of the patient cannot be timely relieved is solved.

The application belongs to the technical field of traditional Chinese medicines, and particularly relates to a preparation method of a traditional Chinese medicine composition for intractable chronic cough and application thereof; and particularly discloses a traditional Chinese medicine composition for treating intractable chronic cough, which comprises, by weight fraction, 10-40 parts of Poria cocos, 3-25 parts of fried licorice, 3-20 parts of Schisandra chinensis, 1-20 parts of dried ginger, 1-12 parts of Asarum, 3-20 parts of prepared pinellia, 3-20 parts of bitter apricot kernel, 5-40 parts of white mulberry bark, 3-25 parts of bupleurum, 3-25 parts of wind-protecting plant, 5-40 parts of north-sand peony and 1-5 pieces of centipede. The application is a pure traditional Chinese medicine prescription, has high safety and good efficacy, and can quickly relieve symptoms of intractable chronic cough patients, and is suitable for clinical popularization and application due to wide drug source.

The present invention relates to a fingerprint construction method and detection method of an Mahuang Dingchuan Decoction composition. The fingerprint construction method of the present invention comprises the following steps: taking a reference substance and an Mahuang Dingchuan Decoction composition, and preparing a reference substance solution and a test solution respectively; using high performance liquid chromatography to detect the reference substance solution and the test solution, and obtaining corresponding detection patterns and reference patterns; importing the detection patterns into a traditional Chinese medicine chromatographic fingerprint similarity evaluation system for analysis, and obtaining a fingerprint of the Mahuang Dingchuan Decoction composition with identification. The present invention constructs a fingerprint of the Mahuang Dingchuan Decoction composition, which has rich chromatographic peaks and contains effective ingredients belonging to multiple medicinal materials such as ephedra, bitter almond, scutellaria, white mulberry bark, ophiopogon, platycodon, coltsfoot flower, radish seed, ginkgo, etc., which can more comprehensively reflect the overall chemical composition of the Mahuang Dingchuan Decoction composition, provide an effective means for the overall quality control and evaluation of the Mahuang Dingchuan Decoction preparation, can better monitor and evaluate the quality of this product, and has a high application value.

The invention provides a traditional Chinese medicine composition for treating pulmonary arterial hypertension right heart failure, which is characterized in that the traditional Chinese medicine composition is prepared from the following raw material medicines: safflower carthamus, polygonum cuspidatum, semen lepidii, white mulberry root-bark and astragalus membranaceus. Various components in the traditional Chinese medicine composition are scientific in compatibility and play a synergistic effect, the cardio-pulmonary function of a right heart failure rat suffering from pulmonary arterial hypertension can be improved, the hemodynamics of pulmonary artery can be improved, the pathological damage and fibrosis degree of cardiac muscle tissue can be relieved, the inflammation level can be reduced, and the remarkable treatment effect on the right heart failure suffering from pulmonary arterial hypertension can be achieved; the clinical application value is higher, and the medical application prospect is wide.

The invention belongs to the technical field of solid beverages, and particularly discloses a functional solid beverage and a preparation method thereof.The solid beverage is composed of superfine mixed powder formed by conducting low-temperature baking, wall breaking treatment and screening on components in percentage by mass: 15% of sea-buckthorn, 15% of white mulberry, 12% of dandelion, 12% of radix polygonati officinalis, 12% of rhizoma polygonati, 30% of black fruit small molecule peptide, 1% of riboflavin and 3% of monosaccharide. The low-temperature baking is a treatment process in which each component is independently performed under the condition of 40-60 DEG C and the duration time is longer than 24 hours, and a synergistic technical scheme of differential pretreatment and accurate low-temperature baking effectively solves the technical problem that active components are degraded due to high-temperature and non-protection treatment in traditional solid beverage processing; in the raw material pretreatment stage, plant-derived raw materials such as hippophae rhamnoides and white mulberries are pre-dried at the temperature of 50-60 DEG C for humidity control, and polygonatum kingianum is steamed for 2-3 hours to convert irritant components.

The invention discloses a composition with a cough relieving effect as well as a preparation method and application thereof, and relates to the technical field of traditional Chinese medicines. The method comprises the following steps: crushing fritillaria, adding ethanol for infiltration, and performing percolation extraction to obtain fritillaria percolation liquid; adding water into gypsum, decocting and extracting to obtain gypsum decoction; the preparation method comprises the following steps: crushing semen armeniacae amarae, pinellia ternate and ginkgo kernels, putting into a frying bag, mixing with ephedra, lumbricus, white mulberry root-bark, thesium chinense, liquorice, fructus perillae and semen lepidii, adding ethanol, heating, refluxing and extracting to obtain a mixed extracting solution 1; decocting and extracting radix scutellariae to obtain radix scutellariae decoction, and preparing radix scutellariae extract fine powder; adding water into honeysuckle and tussilago farfara, decocting and extracting to obtain a mixed extracting solution 2; mixing and concentrating the products to obtain clear paste; and uniformly mixing the clear paste with the scutellaria baicalensis extract fine powder to obtain the composition with the cough relieving effect. By improving an extraction method and a concentration method of the traditional Chinese medicine composition, the transfer rate of effective components in the obtained extract is higher, and the traditional Chinese medicine composition has a better effect on treating cough.

The invention discloses a method for extracting flavonoid substances from white mulberry root-bark and application of the flavonoid substances, and belongs to the technical field of natural medicine extraction. The method comprises the following steps: 1, weighing white mulberry root-bark, and carrying out pretreatment to obtain white mulberry root-bark powder; 2, weighing the white mulberry root-bark powder, adding an ethanol water solution, stirring and extracting at constant temperature, and carrying out solid-liquid separation to obtain a first filtrate and a first filter residue; 3, adding a mixed solution of ethyl acetate and acetone into the first filter residue, carrying out ultrasonic treatment assisted extraction, and carrying out solid-liquid separation to obtain a second filtrate and a second filter residue; and 4, mixing the first filtrate and the second filtrate, carrying out reduced pressure distillation concentration, and drying to obtain the white mulberry root-bark flavonoid extract. Through step-by-step extraction and optimization of extraction conditions and process sequence, the extraction rate and purity of the flavonoid substances are remarkably improved, operation is performed under mild conditions, the structure and activity of the flavonoid substances are protected, and the method is easy and convenient to operate, efficient, environmentally friendly and good in application prospect.

The invention discloses an external nursing cream containing white muscardine silkworm and gentiana macrophylla and a preparation method thereof, the nursing cream takes white muscardine silkworm and gentiana macrophylla as main raw materials, the main raw materials are extracted by ethanol with the concentration of 20-99%, and the ethanol can be edible wine, health care medicinal liquor or medical ethanol; and the finished product is mild for external use after being blended by a matrix, and the irritation is controllable. Auxiliary materials such as artificial musk, ground beeltle, mirabilite, myrrh and angelica sinensis can be selectively added, and the ointment is prepared by extracting, concentrating and adding an external matrix. The invention has the advantages of simple and mild formula, flexible and simple process, easily available raw materials and wide application range, and is suitable for daily external skin care.

The invention discloses a natural extract preparation for promoting lactation of a human body and a preparation method of the natural extract preparation, and relates to the technical field of postpartum rehabilitation. Turmeric, pine needles, sea-buckthorn, pawpaw and radix puerariae have the effects of clearing and activating the channels and collaterals and promoting blood circulation to remove blood stasis; dandelion, clinacanthus nutans and white mulberry root-bark have the effects of diminishing swelling and removing stasis; the astragalus membranaceus and the pericarpium citri reticulatae have the effects of strengthening the spleen and middle warmer; liquorice and folium mori have the effects of cooling blood and diminishing swelling; the sea-buckthorn and the hawthorn have the effects of promoting the circulation of qi, dissipating stasis, invigorating stomach and promoting digestion; the willow bark has the effects of dispelling wind and arresting itching; and particularly, the traditional Chinese medicine composition has a good improvement effect on insufficient milk, milk caking and blocking, pain and the like after delivery.

The invention relates to the technical field of traditional Chinese medicine shampoo and production thereof, in particular to traditional Chinese medicine shampoo with the effects of preventing hair loss, removing dandruff and relieving itching and an automatic preparation device of the traditional Chinese medicine shampoo. The traditional Chinese medicine shampoo comprises the following raw materials in parts by weight: 20-30 parts of Chinese honeylocust fruit, 20-30 parts of Chinese soapberry fruit, 10-20 parts of radix sophorae flavescentis, 10-20 parts of white mulberry root-bark, 8-16 parts of Chinese arborvitae twig and leaf, 8-16 parts of radix angelicae, 8-16 parts of mulberry leaf, 8-16 parts of garden balsam stem, 8-16 parts of tea bran, 4-12 parts of polygonum multiflorum, 4-12 parts of rhizoma polygonati, 4-12 parts of lucid ganoderma, 4-12 parts of mint, 2-5 parts of dried ginger, 2-5 parts of broadleaf holly leaf, 40-60 parts of ginger, 40-60 parts of edible salt and 240-360 parts of purified water. According to the present invention, the shampoo has the effective hair loss prevention, dandruff removing and itching relieving functions, can avoid the damage of the chemical components to the hair, has good hair maintenance effect, and can effectively extract the components in the raw materials through the mode of fumigation first and boiling second so as to improve the efficacy of the shampoo.

The invention relates to a traditional Chinese medicine composition for treating chronic obstructive pulmonary disease. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 5-15 parts of flos farfarae, 35-45 parts of cortex mori, 5-15 parts of shaved cinnamon bark, 5-15 parts of ginseng, 5-15 parts of radix asteris, 5-15 parts of white quartz, 10-20 parts of stalactite, 10-20 parts of schisandra chinensis, 15-25 parts of radix ophiopogonis, 3-13 parts of ginger, 3-13 parts of jujube and 3-13 parts of polished round-grained rice. The invention further provides application of the traditional Chinese medicine composition. The formula has the main effects of warming yang, tonifying lung, relieving cough and dissolving phlegm. In the formula, ginseng is used for invigorating spleen, lung and heart meridians, reinforcing vital energy, tonifying lung and spleen, white quartz is used for invigorating lung and kidney meridians, warming lung and tonifying qi, and tonifying kidney and strengthening yang, and the ginseng and the white quartz are used as monarch drugs; stalactite belongs to lung and kidney meridians, and has the effects of warming lung, tonifying qi, invigorating kidney and strengthening yang. Flos farfarae and radix asteris are used as ministerial drugs for warming lung and relieving cough, descending qi and reducing phlegm, and cortex cinnamomi is used for warming meridians and dredging collaterals, and supporting yang and transforming qi; the formula combines dynamic and static, and tonifies without stagnation; warmth and moisture are both considered, and warm is not dry; the effects of warming yang, tonifying the lung, relieving cough and dissolving phlegm are achieved.

The invention belongs to the technical field of traditional Chinese medicine compositions and cosmetics, and discloses a repairing type Chinese herbal medicine compound lip mask and a preparation method and application thereof. The lip mask is prepared by compounding fifteen Chinese herbal medicines including wintersweet flowers, honeysuckle flowers, cortex lycii radicis, poria peel, white mulberry root-bark, wild chrysanthemum flowers, almonds, angelica sinensis, radix arnebiae seu lithospermi, radix semiaquilegiae, dandelions, herba violae, gypsum, fructus forsythiae and rhizoma cimicifugae with an aloe extracting solution and performing precipitation and refining through chitosan. The lip care solution is suitable for dry, sensitive and damaged lip skin care.

The invention belongs to the technical field of medicines, relates to a cis-trans Diels-Alder adduct extracted from the root bark of white mulberry, and discloses a method for preparing the Diels-Alder adduct and application of the Diels-Alder adduct. The specific preparation process comprises the following steps: performing alcohol extraction on white mulberry root-bark coarse powder, collecting a fraction containing a target compound through macroporous adsorption resin column adsorption chromatography and thin-layer chromatography detection, and performing silica gel column reduced pressure chromatography, polyamide column chromatography, ODS column chromatography and high performance liquid chromatography separation and purification on the fraction containing the target compound to obtain the white mulberry root-bark extract. The cis-trans Diels-Alder adduct is subjected to a reaction in the presence of a catalyst; according to the present invention, the Ellman method determination results show that the compound has significant inhibition effect on cholinesterase; the method for preparing the cis-trans Diels-Alder adduct is clear and controllable in operation, and the obtained compound is few in impurity and high in purity and has the potential of being developed into an anti-Alzheimer disease medicine.

The present invention provides a traditional Chinese medicine ointment for treating hand-foot syndrome and a preparation method thereof. The ointment is made from the following ingredients: sesame oil, lithospermum erythrorhizon, angelica dahurica, bletilla striata, white mulberry, angelica sinensis, rhubarb, knotweed, honeysuckle, siler, raw rehmannia root, pearl powder, dragon's blood, borneol, radix trichosanthis, frankincense, myrrh, rosin, lard, beeswax, and quicklime. This ointment enhances the original Ziyun ointment by adding bletilla striata, rhubarb, knotweed, honeysuckle, pearl powder, dragon's blood, borneol, radix trichosanthis, frankincense, myrrh, and other ingredients, thereby enhancing its yin-nourishing, blood-cooling, and detoxifying effects. The ointment exhibits excellent effects in alleviating pain, removing rotten flesh, stopping bleeding, promoting tissue regeneration, and providing antibacterial and anti-inflammatory benefits, as well as promoting wound healing. The developed Yufu Jiedu ointment has demonstrated excellent initial efficacy in the clinical treatment of capecitabine-induced hand-foot syndrome, receiving unanimous praise from patients and addressing the shortcomings of the existing technology.

The invention belongs to the technical field of medicines for treating rheumatoid arthritis complications, and particularly relates to a traditional Chinese medicine composition for rheumatoid arthritis interstitial pulmonary lesion as well as a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises ginseng, astragalus membranaceus, prepared rehmannia root, schisandra chinensis, radix asteris, white mulberry root-bark, angelica sinensis, eclipta, radix glehniae, salvia miltiorrhiza, turmeric, exocarpium citri rubrum and liquorice. The traditional Chinese medicine composition has the effects of regulating qi and blood and treating both symptoms and root causes, is suitable for the symptoms of lung arthralgia, deficiency of both qi and yin and stasis of veins and collaterals, can obviously relieve the lung function of patients with rheumatoid arthritis interstitial pulmonary disease, reduces the symptom scores of shortness of breath, dry cough and progressive dyspnea, and improves the curative effect. And the progress of RA-ILD can be effectively inhibited by reducing macrophage apoptosis, activating and proliferating myofibroblasts and inhibiting MMT.

The invention discloses a method for identifying target components of QingNing powder. The method comprises the following steps: step 1, ensuring that a finished product contains three medicinal materials including honey white mulberry root-bark, wine-fried red poria cocos and fried semen lepidii from the level of microscopic identification; 2, 1-2 g of the product is taken, an extraction solvent is added, a corresponding extraction method is selected, filtration is performed, filtrate is evaporated to dryness, 1-2 ml of a dissolving agent is added to residues to dissolve the residues to serve as a test solution, reference medicinal materials are taken and prepared into a reference medicinal material solution with the method the same as that in the step 2, and 1-5 microliters of the test solution and 1-5 microliters of the reference medicinal material solution are sucked according to a thin-layer chromatography test; according to the method for identifying the target component of the Qingning powder, identification is carried out through thin-layer chromatography, complex data processing is not needed, existence of one or more characteristic components can be visually and specifically confirmed, interference caused by mixture signal superposition in a spectrum method is avoided, and different components in a complex sample can be clearly distinguished.

The application discloses a traditional Chinese medicine for treating hyperlipidemia and hypertension, which comprises an active ingredient, wherein the active ingredient is composed of the following components in parts by weight: American ginseng 6-14 parts, rhizoma polygonati 5-15 parts, fructus aurantii immaturus 9-15 parts, rhizoma atractylodis 18-60 parts, radix rehmanniae preparata 6-20 parts, prepared rhizome 15-60 parts, semen plantaginis 12-30 parts, earthworm 12-30 parts, hawthorn 15-60 parts, white mulberry root-bark 12-30 parts, and prunella vulgaris 20-80 parts; compared with the prior art, the application takes natural plants, American ginseng and prunella vulgaris, as the core components, and is composed of various traditional Chinese medicines for benefiting qi and invigorating the spleen, dredging bowels and resolving turbidity, so that the traditional Chinese medicine has the effects of invigorating the spleen, benefiting qi, dredging bowels and resolving turbidity; through organic matching of the medicines, three metabolisms are regulated, hyperlipidemia is reduced, the vascular intima is protected, blood lipid deposition in the vascular intima is reduced, the myocardial blood supply is improved, diuresis is achieved, the tension degree of blood vessels is relieved, and the like, so that the utility of improving clinical syndromes is achieved; the safety and effectiveness of the traditional Chinese medicine have been verified through clinical research, and the traditional Chinese medicine has good practical clinical application value.

The invention discloses a traditional Chinese medicine composition for treating type 2 diabetes mellitus endoretention of damp-heat. Comprising the following raw material medicines in parts by weight: 21-30g of coptis chinensis, 18-25g of rhizoma atractylodis, 32-45g of astragalus membranaceus, 11-15g of gynostemma pentaphylla, 11-15g of poria cocos, 14-20g of white mulberry root-bark, 7-10g of fructus amomi, 14-20g of dried rehmannia root, 11-15g of kudzu vine root, 11-15g of smoked plum, 3-5g of cinnamon, 4-6g of dried ginger, 11-15g of herba epimedii, 14-20g of salvia miltiorrhiza, 14-20g of mulberry twig, 14-20g of cortex lycii radicis and 14-20g of folium mori. The traditional Chinese medicine composition disclosed by the invention is researched and developed on the basis of etiology and pathogenesis for diagnosing and treating the damp-heat intrinsic syndrome of the type 2 diabetes mellitus in traditional Chinese medicine, and has an expected effect on treating the damp-heat intrinsic syndrome of the type 2 diabetes mellitus.

The invention relates to the technical field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine composition for treating refractory chronic cough and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 6-12 parts of ephedra, 6-12 parts of semen armeniacae amarae, 6-12 parts of scutellaria baicalensis, 6-12 parts of gardenia jasminoides, 4-8 parts of platycodon grandiflorum, 6-12 parts of radix ophiopogonis, 6-12 parts of thunberg fritillary bulb, 6-12 parts of exocarpium citri rubrum, 6-12 parts of poria cocos, 4-8 parts of white mulberry root-bark, 4-8 parts of rhizoma anemarrhenae, 4-8 parts of semen trichosanthis and 6-12 parts of honey-fried licorice root. The compatibility of the traditional Chinese medicine composition accords with the theory of monarch, minister, assistant and guide in traditional Chinese medicine, the compatibility is ordered, and the whole formula has the effects of dispelling cold, clearing heat, nourishing yin, relieving cough and reducing phlegm. Clinical effects show that after the traditional Chinese medicine composition is used for treating the refractory chronic cough for two weeks, the total effective rate of treatment reaches up to 97.73%, and the treatment effect is remarkable.

The invention is suitable for the technical field of medicines, and provides a traditional Chinese medicine composition for treating kidney qi deficiency type chyluria and a preparation method thereof. Comprising the following components in parts by weight: 5-10 parts of ginseng, 10-15 parts of astragalus membranaceus, 10-15 parts of semen cuscutae, 3-10 parts of mantis egg-case, 15-30 parts of lotus seed pulp, 10-15 parts of poria cocos, 10-60 parts of Chinese yam, 1-3 parts of cornu cervi pantotrichum, 10-15 parts of white mulberry root-bark, 15-30 parts of dragon bone, 5-10 parts of fructus psoraleae, 2-6 parts of schisandra chinensis, 0.3-3 parts of antelope horn, 10-30 parts of tortoise-plastron glue and 1.5-3 parts of human placenta. According to the traditional Chinese medicine composition for treating kidney qi deficiency type chyluria provided by the invention, all the medicines interact and synergistically interact, practice proves that seven days are taken as a treatment course, the effective rate of one treatment course can reach 70% or above, the effective rate of four treatment courses can reach 98% or above, and the traditional Chinese medicine composition has an obvious improvement effect on chyluria, takes effect quickly and has no side effect.

The invention relates to a composition containing i) a DPP-4 inhibitor selected from an extract of dandelion (Taraxacum officinale), an extract of white mulberry (Morus alba), an extract of bitter melon (Momordica charantia), a hydrolysate of yeast (Saccharomyces cerevisiae), an extract of garlic (Allium sativum), an extract of grape (Vitis vinifera), an extract of turmeric (Curcuma longa), an extract of horseradish tree (Moringa oleifera) and an extract of fenugreek (Trigonella foenum-graecum); and ii) a GLP-1 analogue selected from a hydrolysate of yeast (Saccharomyces cerevisiae), a white mulberry (Morus alba) extract, a yerba mate (Ilex paraguariensis) extract, an Arabica coffee (Coffea arabica) extract, a purslane (Portulaca oleracea) extract, a bitter melon (Momordica charantia) extract, a lager flower (Lagerstroemia speciosa) extract, an apple (Malus domestica) extract, a cinnamon (Cinnamomum verum) extract and a fenugreek (Trigonella foenum-graecum) extract; and iii) a GLP-1 secretion enhancer selected from inulin, gum arabic, an extract of bitter melon (Momordica charantia), an extract of purslane (Portulaca oleracea), an extract of common barberry (Berberis vulgaris), an extract of Arabica coffee (Coffea arabica), an extract of Siberian angelica (Angelica dahurica), an extract of turmeric (Curcuma longa) and an extract of fenugreek (Trigonella foenum-graecum), where at least one ingredient is selected from each group i)-iii) and a total of at least three different ingredients are selected.

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine for treating pulmonary arterial hypertension, and effectively solves the problems that the western medicine for treating pulmonary arterial hypertension is limited in curative effect of symptomatic treatment and has many side effects, targeted treatment cannot fundamentally prevent the progress of a disease course and is poor in prognosis, and invasive treatment is relatively large in damage to a body, general in prognosis and high in price. According to the technical scheme, concentrated watered pills are prepared from the following raw medicinal materials by weight: 108 to 132g of astragalus membranaceus, 10 to 20g of bighead atractylodes rhizome, 27 to 33g of rhodiola rosea, 10 to 20g of trichosanthes kirilowii maxim, 27 to 33g of allium macrostemon, 10 to 20g of rhizoma pinellinae praeparata, 27 to 33g of salvia miltiorrhiza, 9 to 11g of safflower, 2.7 to 3.3 g of pseudo-ginseng, 27 to 33g of semen lepidii, 27 to 33g of white mulberry root-bark, 27 to 33g of parasitic loranthus, 45 to 55g of crude dragon bone, 45 to 55g of raw oyster shell, 54 to 66g of kudzu vine root, 45 to 55g of poria cocos, 45 to 55g of coix seed, 27 to 33g of earthworm and 9 to 11g of According to the treatment principle of tonifying qi, reducing phlegm, removing blood stasis and inducing diuresis, the traditional Chinese medicine composition can stably, durably and effectively control pulmonary arterial hypertension, improve the right heart function and control disease progression, and the life quality of patients is fundamentally improved.

The invention belongs to the technical field of medicines, relates to an all-trans Diels-Alder adduct extracted from the root bark of white mulberry, and discloses a method for preparing the Diels-Alder adduct and application of the Diels-Alder adduct. The specific preparation process comprises the following steps: performing alcohol extraction on white mulberry root-bark coarse powder, collecting a fraction containing a target compound through macroporous adsorption resin column adsorption chromatography and thin-layer chromatography detection, and performing silica gel column reduced pressure chromatography, polyamide column chromatography, ODS column chromatography and high performance liquid chromatography separation and purification on the fraction containing the target compound to obtain the white mulberry root-bark extract. The all-trans Diels-Alder adduct is obtained after the reaction is completed; according to the present invention, the Ellman method determination results show that the compound has significant inhibition effect on cholinesterase; the method for preparing the all-trans Diels-Alder adduct is clear and controllable in operation, and the obtained compound is few in impurity and high in purity and has the potential of being developed into an anti-Alzheimer disease medicine.

The invention belongs to the technical field of traditional Chinese medicine formulas, and particularly discloses a traditional Chinese medicine preparation for treating rhinitis and nasosinusitis. The traditional Chinese medicine preparation comprises the following traditional Chinese medicine raw material components in parts by mass: 7-12 parts of ligusticum; 6-11 parts of pogostemon cablin; 6-11 parts of white mulberry root-bark; 7-12 parts of magnolia flower; 2-4 parts of asarum; 6-12 parts of fried cocklebur fruit; 6-11 parts of poria cocos; and 6-11 parts of dahurian angelica root. The traditional Chinese medicine preparation for treating rhinitis and nasosinusitis is refined in materials and small in side effect, and has a good curative effect on rhinitis, nasosinusitis and the like.

The invention discloses a mulberry-derived stilbene multi-site glycosyltransferase, a gene, a preparation method and application, and belongs to the technical field of gene engineering and enzyme engineering. The stilbene multi-site glycosyltransferase is identified from white mulberry, and the amino acid sequence of the stilbene multi-site glycosyltransferase is shown as SEQ ID NO. 1. The in-vitro enzymatic reaction of the recombinant protein shows that the stilbene multi-site glycosyl transferase MaUGT74BK13 can catalyze the glycosylation reaction of a plurality of hydroxyl sites on stilbene, morusin and flavonoid substrates, and the structure prediction and substrate docking show that the MaUGT74BK13 also has good binding and catalyzing capabilities on phenol compounds with resorcinol structures.

The present application relates to the field of cosmetic technology, and discloses a white muscardine polypeptide composite whitening and repairing composition, a preparation method and application thereof. The composition takes fermented white muscardine oligopeptide as a core functional ingredient, and is compounded with ethyl vitamin C and 4D hyaluronic acid. The composition realizes whole-pathway whitening through a wind-phlegm-stasis three-dimensional blocking mechanism, and has barrier repairing and anti-inflammatory soothing effects. The present application also discloses a preparation process of the composition. The white muscardine is subjected to biological fermentation and fractional purification to obtain low molecular active peptides with a molecular weight of 0.3-3 kDa. The double-bin compounding technology is used to ensure the activity of the ingredients. The prepared cosmetic is mild and non-irritating, and is suitable for sensitive skin, people with post-inflammatory hyperpigmentation, and post-medical beauty, and can realize the effects of brightening skin color, improving dullness, and lightening color spots, and has the advantages of traditional Chinese medicine beauty theory and modern biological technology.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to an external traditional Chinese medicine composition for atopic dermatitis and chronic rash, a traditional Chinese medicine preparation based on the composition and a preparation method and application thereof. The external traditional Chinese medicine composition for atopic dermatitis and chronic rash is prepared from the following raw materials in parts by weight: 3 to 15 parts of rhizoma atractylodis, 3 to 15 parts of radix sanguisorbae, 3 to 15 parts of rhizoma coptidis, 3 to 15 parts of gallnut, 3 to 15 parts of fructus cnidii, 3 to 15 parts of frankincense, 3 to 15 parts of myrrh and 3 to 8 parts of borneol. The external traditional Chinese medicine composition for treating chronic rash of atopic dermatitis conforms to the pathogenesis of chronic disease course of atopic dermatitis, repeated attack, difficulty in removing damp evil due to root deficiency and blood stasis due to long illness, has the effects of consolidating root, clearing damp, dispersing blood stasis and healing sore, and is used for treating chronic rash.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to application of a traditional Chinese medicine composition in preparation of a medicine for treating hepatic fibrosis. The traditional Chinese medicine composition is prepared from the following components: rheum officinale, astragalus membranaceus, white mulberry root-bark, radix sophorae flavescentis, codonopsis pilosula, bighead atractylodes rhizome, poria cocos, radix polygoni multiflori preparata, radix paeoniae alba, salvia miltiorrhiza, ligusticum wallichii, chrysanthemum, ginger processed pinellia, plantain herb, radix bupleuri and liquorice. According to the application of the traditional Chinese medicine composition in preparation of the medicine for treating and / or preventing hepatic fibrosis, experimental results show that the traditional Chinese medicine composition can reduce the concentration of AST, ALT and AKP in serum and the content of HYP in liver tissue; the content of hyaluronic acid and laminin in liver tissues and the content of III-type procollagen and IV-type collagen in serum are reduced; and the contents of tumor necrosis factor-alpha and interleukin 6 in the liver are reduced. The traditional Chinese medicine composition is simple in formula, wide in ingredient source, simple in preparation method and good in hepatic fibrosis treatment effect.