The invention discloses a new Chinese medicinal composition for treating osteopyrexia and a preparation method thereof. The Chinese medicinal composition mainly comprises the following raw material medicaments: lycium bark, raw gypsum, anemarrhena asphodeloides bunge, reed rhizome, mongolian snakegourd root, gardenia jasminoides, starwort root, figwortflowerpicrorhizarhizome, raw rehmannia root, tuber fleeceflower root, common lophatherum herb, honeysuckle, mongolian dandelion herb, radix scrophulariae, white paeony root, medlar, oriental waterplantain rhizome, fragrant solomonseal rhizome, dendrobium, Chinese angelica, raw astragalus, mentha haplocalyx, Leonurus heterophyllus, cortex moutan radicis, root of straight ladybell, ophiopogon root, cochinchnese asparagus root and the like. The Chinese medicinal composition of the invention can be prepared into any common oral administration preparation according to the conventional method of Chinese medicinal preparations. The Chinese medicinal composition can improve symptoms such as afternoon fever, dysphoria, uneasy sleeping, restless upset, cold limbs, constant heat in palms, night sweat, spermatorrhea, sexual intercourse in dream or menstrual disorder and the like obviously, and has definite clinical effect, obvious curative effect and quick response. The Chinese medicinal composition has the advantages of low cost, no toxic or side effect and the like.