110 results about "Emodin" patented technology

The invention relates to an application of a cytochrome P450 reductase 10273 inactivating agent in construction of an aspergillus terreus engineering strain for high yield of emodin or a derivative thereof. The invention further relates to aspergillus terreus engineering bacteria for high yield of emodin or the emodin derivatives and a construction method of the aspergillus terreus engineering bacteria. By knocking out the cytochrome P450 reductase gene 10273, the activation of anthraquinone methyl hydroxylase 4804 is blocked in aspergillus terreus, so that the hydroxylation pathway of the emodin is blocked, the purity of the emodin and the emodin-3-methyl ether in aspergillus terreus cells is improved, the production cost of the emodin and the emodin-3-methyl ether is reduced, and the method is suitable for industrial production. And a foundation is provided for the microbial industrial synthesis of the emodin and the emodin-3-methyl ether.

The invention belongs to the technical field of pressure sore treatment, and discloses an experimental test method for treating stress injury based on danshen emodin, which comprises the following specific steps: step 1, preparing experimental materials, selecting a healthy SD (Sprague Dawley) rat, and preparing a clean and sterile magnet and a shaver; the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 1 part of isoflurane, 1 part of iodophor, 1 part of Vaseline, 1 part of Rhapontigenin and 1 part of resveratrol. The method comprises the following steps: modeling a stress injury model for an SD (Sprague Dawley) rat so as to simulate a stress injury disease, then respectively smearing three medicines, i.e., Danjie emodin, resveratrol and vaseline, tracking the healing condition of a stress injury wound, and finally performing ELISA (Enzyme-Linked Immunosorbent Assay) and Hamp; according to the present invention, the detection analysis is performed through the dyeing E, and the results show that the rheum emodin has good treatment effect on the stress injury, can reduce the expression of the proinflammatory factor, can promote the wound healing, has characteristics of environmental protection and low cost, and provides the new research direction for the treatment of the stress injury.

The invention discloses a novel application of emodin as an endonuclease inhibitor. The emodin inhibits replication and transmission of viruses by inhibiting the activity of NSP15 ribonuclease, and recovers host interferon reaction so as to enhance the antiviral effect. The application has the advantages that the action target of the emodin is defined, the effectiveness of the emodin in the aspect of preventing and treating coronavirus infection is further revealed, and the broad-spectrum antiviral potential of the emodin is embodied through the link of playing the antiviral effect by inhibiting the virus replication link; the researches provide candidate drugs and scientific basis for research and development of novel broad-spectrum anti-coronavirus drugs, and promote clinical application of the anti-virus traditional Chinese medicines.

The invention relates to an apolipoprotein E detection reagent and application thereof, and belongs to the technical field of biomedicine. The invention provides application of a plant derivative in preparation of an APOE epitope exposure agent. The plant derivative is selected from at least one of curcumin, emodin, EF24 and FLLL-32. The invention also provides an APOE epitope exposure agent which comprises a surfactant, salts, a reducing agent and plant derivatives. According to the present invention, the sample and the protein are pre-treated by using the epitope exposure agent containing the plant derivative to improve the sufficiency of the ApoE protein epitope exposure so as to achieve the accurate typing of the ApoE gene based on the immunological detection method and the accurate quantification of the proteins with different genotypes. Genetic typing of ApoE and quantitative detection of proteins with different genotypes are carried out based on an immunological detection method, and the genotype detection result is highly consistent with a fluorescent PCR (Polymerase Chain Reaction) result.

The invention discloses a genetically engineered bacterium, a method for constructing the genetically engineered bacterium and a method for preparing emodin and physcion by using the genetically engineered bacterium. The genetically engineered bacterium carries an exogenous gene; the exogenous gene comprises a gene npgA for coding phosphopantetheinyl transferase and a gene gedC for coding polyketide synthase, further comprises at least one of a gene HyTE and a gene gedB for coding beta-lactamase thioesterase, and further comprises at least one of a decarboxylase gene TpCK and a gene AfDC. According to the invention, a complete synthetic route of the physcion is constructed from the beginning in a heterologous host microorganism for the first time; a novel microbial fermentation mode is used for replacing traditional plant extraction, and novel biological manufacturing of the emodin and the emodin monomethyl ether is developed.

The present invention provides a traditional Chinese medicine composition for clearing heat, removing blood stasis, stopping bleeding and regulating menstruation, and a preparation method thereof, relating to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition of the present invention comprises the following components: catalpol, aucubin, β-sitosterol, emodin, chrysophanol, sanguisorba officinalis extract, Panax notoginseng saponins, septamine, cuttlefish scaly, rubiacin, typhaneuroside, and p-coumaric acid; the components synergistically work together to significantly reduce plasma prothrombin time and plasma recalcification time, and significantly reduce the whole blood viscosity, plasma viscosity, and hematocrit of rats with blood stasis syndrome. The traditional Chinese medicine composition of the present invention is used in the preparation of drugs for menstrual disorders or menstrual bleeding and metrorrhagia, and has a significant therapeutic effect on irregular menstruation, excessive menstrual bleeding, or metrorrhagia.

The composition for repairing the meniscus comprises a growth differentiation factor and emodin, and is used for improving inflammation and oxidative stress in a microenvironment and promoting a cell chondrogenic differentiation process. Through verification, according to the core-shell co-delivery nano-carrier provided by the invention, two bioactive compounds, namely emodin and a growth differentiation factor, are wrapped by mesoporous silicon dioxide nano-particles, and the two bioactive compounds are used for promoting fibrocartilage differentiation. The double-drug nano delivery system provides continuous release of emodin and GDF, synergistically regulates severe inflammation and oxidation environments, and promotes in-vitro and in-vivo fibrous cartilage regeneration. Benefited from this, according to the invention, a three-dimensionally printed meniscus-shaped PCL framework is combined with the composition by using cartilage-specific matrix hydrogel, a stability-enhanced meniscus replacement model is constructed, a cartilage immune microenvironment is synergistically adjusted, and successful repair of animal (rabbit) full meniscus replacement is realized.

The invention relates to an application of an anthraquinone methyl hydroxylase 4804 inactivating agent in construction of an aspergillus terreus engineering strain for high yield of emodin or a derivative thereof. The invention further relates to aspergillus terreus engineering bacteria for high yield of emodin or the emodin derivatives and a construction method of the aspergillus terreus engineering bacteria. The anthraquinone methyl hydroxylase 4804 gene is knocked out, so that a hydroxylation pathway of the emodin is blocked in aspergillus terreus cells, the yield of the emodin and the emodin-3-methyl ether in the aspergillus terreus cells is increased, the production cost of the emodin and the emodin-3-methyl ether is reduced, and the yield of the emodin and the emodin-3-methyl ether is increased. And a foundation is provided for the microorganism synthesis industrialization of the emodin and the emodin-3-methyl ether.

The invention discloses a quality detection method of a gout clearing mixture for treating hyperuricemia, which adopts a separation analysis technology of ultra-high performance liquid chromatography to detect eight chemical components in the gout clearing mixture. Comprising the following components: 3-O-feruloylquinic acid, 5-O-caffeoylshikimic acid, paeoniflorin, polydatin, neoastilbin, astilbin, berberine hydrochloride and emodin-8-beta-D-glucopyranoside. According to the method, eight chemical components of six active components in the gout clearing mixture are quantitatively analyzed at the same time, and the method has the advantages of being easy and convenient to operate, good in stability and easy to popularize. The invention can provide a comprehensive and reliable quality control basis for the gout clearing mixture, and has important significance for ensuring the clinical curative effect of the gout clearing mixture.

The present application relates to the field of pharmaceutical chemistry, and specifically discloses a emodin mannich base, a preparation method and application thereof. The emodin mannich base has a structure as shown in formula I, the structure is simple, has strong in-vitro antimicrobial activity, especially high inhibitory activity to staphylococcus aureus, bacillus subtilis, micrococcus luteus, escherichia coli, proteus vulgaris, pseudomonas aeruginosa, shigella dysenteriae, salmonella typhimurium and other bacteria, and candida utilis, candida albicans, saccharomyces cerevisiae, monascus and other fungi, and can be used for preparing antibacterial and / or antifungal drugs.

The invention relates to the technical field of veterinary drugs, and particularly provides a veterinary carprofen injection and a preparation method thereof, the veterinary carprofen injection comprises carprofen, emodin, galuteolin, coumarin, Radix Astragali, wolfberry, Schisandra chinensis, resveratrol and other components. According to the veterinary carprofen injection, emodin and luteoloside are added for compound anti-inflammation, the dosage of carprofen is reduced, the kidney burden is relieved, meanwhile, drug resistance is not likely to be generated, radix astragali, fructus lycii and fructus schizandrae extracts are added for protecting the kidney, regulating immunity and avoiding renal function damage, and finally the effects of compound anti-inflammation and renal function damage avoiding are achieved.

The invention belongs to the technical field of pesticides, and particularly relates to a biopesticide for preventing and treating citrus red mites. The invention relates to a biopesticide. The biopesticide is prepared by compounding emodin and abamectin or osthole. When the emodin and the abamectin or the cnidium lactone are combined and compounded, the emodin and the abamectin or the cnidium lactone show a synergistic interaction effect on the citrus red mites, the prevention and treatment effect on the citrus red mites can be improved, the problems caused by long-term use of the same medicament or the same medicament can be relieved, meanwhile, the generation and development of the drug resistance of the citrus red mites can be delayed, and the prevention and treatment effect on the citrus red mites is improved. And support is provided for comprehensive treatment of drug resistance. Secondly, emodin, abamectin and osthole are biopesticide components, are environmentally friendly and can provide support for developing biopesticides for preventing and treating citrus red mites.

The present invention belongs to the technical field of organic chemical synthesis, and specifically relates to a nitrogen oxide free radical derivative of rhubarb and its synthesis method and application. The present invention takes rhubarb, a lipid-lowering medicinal substance of traditional Chinese medicine, as the research object, selects its 3rd hydroxyl group as the modification site, and based on different length carbon chain substitution, A 3 Based on the reaction mechanisms of coupling, esterification and pharmacophore splicing, six active intermediate nitroxide free radicals were introduced into the structure of emodin. 50 nitroxide free radical derivatives of emodin in three series and 8 other derivatives were designed and synthesized. Several synthetic methods for novel nitroxide free radical derivatives of emodin with mild reaction conditions, environmental friendliness and high yield were established. The novel nitroxide free radical derivatives of emodin provided have low toxicity to normal liver cells, significant anti-proliferative activity against liver cancer cells, and are novel active molecules with better effects than emodin, providing a new idea for the preparation of anti-tumor drugs.

The invention provides a nano-composite for tomato virus disease prevention and control and a whole growth period prevention and control method. The nano-composite comprises an emodin monomethyl ether aqueous solution and a nano-carrier hydrophilic lipophilic diblock polymer HLDP in a mass ratio of 1: (10-20). According to the nanocomposite for tomato virus disease prevention and control, HLDP is added into an emodin methyl ether aqueous solution, and the HLDP and the emodin methyl ether aqueous solution are spontaneously combined through a hydrogen bond and Van der Waals' force, so that the particle size of an emodin methyl ether medicament is remarkably reduced to nanoscale size, and the affinity of the emodin methyl ether medicament to water is increased; the dispersibility in an aqueous solution and the wetting effect of the medicament on leaves are improved; meanwhile, the nano-composite has certain improvement on prevention and treatment effects on tomato spotted wilf virus, and the prevention effect is improved by about 11% compared with that of a single emodin monomethyl ether commodity medicament; compared with daily management measures of a base, the whole-growth-period field control effect of field seed dressing, root dipping and foliage spraying is adopted, and the morbidity of virus diseases is smaller than 10%; the tomato yield increase is promoted.

The invention relates to the technical field of pharmaceutical analysis, in particular to an HPLC (High Performance Liquid Chromatography) fingerprint spectrum construction method and application of a twelve-ingredient numbness pain liniment. The construction method comprises the following steps: preparing a test solution; preparing a reference substance solution; and HPLC determination. The HPLC fingerprint spectrum construction method of the twelve-ingredient numbness pain liniment is provided for the first time, and the method has the advantages of being high in precision, good in reproducibility, high in stability and good in durability. Meanwhile, the method disclosed by the invention can be used for detecting the contents of three components including polydatin, stilbene glucoside and emodin in the twelve-ingredient numbness pain liniment at one time. Technical support is provided for comprehensively improving the product quality standard of the twelve-ingredient arthralgia pain liniment and optimizing the preparation process, identifying true and false and carrying out follow-up material basic research of the twelve-ingredient arthralgia pain liniment.

The invention belongs to the technical field of pest control, and particularly relates to a method for efficiently controlling guava leaf rollers. The invention relates to an insecticidal composition. The insecticidal composition is prepared by binary compounding of an effective component I and an effective component II, the effective component I is pyridalyl, and the effective component II is emodin; the mass ratio of the effective component I to the effective component II is (1-100): (100-1). According to the prevention and control method, the insecticidal composition is selected for foliage spraying, meanwhile, the guava fruits are subjected to bagging treatment, and therefore the angutortria can be effectively prevented and controlled. When the effective components in the insecticidal composition are compounded, the insecticidal composition has a synergistic effect on psidium guajava leaf roller, and compared with a single effective component, the insecticidal composition can improve the prevention and control effect on the psidium guajava leaf roller, reduce the use dosage of pesticides and reduce the influence on the environment; in addition, generation and development of pesticide resistance can be delayed, the service life of the pesticide is prolonged, and comprehensive prevention and control of agricultural pests are facilitated.

The application discloses a composite photocatalytic bacteriostatic agent and a preparation method thereof, and belongs to the technical field of aquatic diseases. The emodin (Em) is loaded on sodium alginate (SA) to prepare the composite photocatalytic bacteriostatic agent Em / SA. Compared with the emodin alone, the composite photocatalytic bacteriostatic agent Em / SA can further improve the inactivation effect on Aeromonas hydrophila cells. The survival rate of the Aeromonas hydrophila with a bacterial concentration of 10 7 cfu / mL is reduced from 99.33% when the emodin is used alone to less than 21.65%. The preparation method of the photocatalytic bacteriostatic agent Em / SA is simple and green, the composite photocatalytic bacteriostatic agent Em / SA only contains the natural product emodin and sodium alginate, the reaction is carried out under light, no secondary pollution is caused to the environment, and the photoinactivation of the Aeromonas hydrophila can be efficiently realized under white light illumination for 30 min.

This invention provides a fingerprint spectrum of Yishen Wufa Oral Liquid, its construction method, and its application, as well as a multi-index component detection method for Yishen Wufa Oral Liquid, relating to the field of pharmaceutical analysis and structural technology. The fingerprint spectrum of Yishen Wufa Oral Liquid constructed by this invention includes 20 characteristic peaks, including ferulic acid, 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside, astragaloside A, psoralen, isopsoralen, and emodin. The chromatographic peaks are abundant and attributed to the effective components of psoralen (roasted with black sesame seeds), angelica, poria cocos, wolfberry, fleeceflower root (processed with black bean wine), achyranthes bidentata, and astragalus complanatus. This provides a more comprehensive reflection of the overall chemical composition and quality of Yishen Wufa Oral Liquid, facilitating more effective guidance for feed addition and strict standardization of production operations. It also helps improve the safety and efficacy of Yishen Wufa Oral Liquid in clinical use, possessing high application value.

The present application belongs to the technical field of traditional Chinese medicine component detection method, and particularly relates to a content determination method of trans-emodin di-anthrones in Radix Polygoni Multiflori, wherein Radix Polygoni Multiflori powder is taken, a mixture of water and cellulase is added in a mass ratio of 100:1-2, ultrasonic treatment is performed, then anhydrous ethanol is added, ultrasonic treatment is performed, components including trans-emodin di-anthrones are extracted, filtration is performed, the filtrate is evaporated to dryness, an acid solution containing sulfur elements is added for dissolution, a water bath is performed at 55-65 DEG C, it is placed at room temperature, ethyl acetate is added for extraction, so as to remove impurity components remaining in the acid solution layer, improve the purity of trans-emodin di-anthrones, facilitate liquid chromatography separation, methanol is added for dissolution, and a test sample solution is obtained; liquid chromatography is used to detect the content of trans-emodin di-anthrones in the test sample solution. The method has strong specificity, good reproducibility, stability and precision, and can effectively and accurately detect the content of trans-emodin di-anthrones in Radix Polygoni Multiflori.

According to the screening method of the natural antibiotic-free medicine for preventing and treating methicillin-resistant staphylococcus aureus, the provided screening method can screen out the optimal medicine composition and proportion, and the screened medicine serves as an alternative scheme of antibiotic treatment; and a medicine screening and research and development foundation is laid for treating infection of methicillin-resistant staphylococcus aureus. The method for rapidly screening the natural drug monomer composition aiming at the methicillin-resistant staphylococcus aureus is provided by comprehensively applying a minimum inhibitory concentration experiment and an orthogonal method, and the method is low in cost, less in time consumption and simple to operate. The method provided by the invention verifies that the three natural drug monomers of baicalin, emodin and caffeic acid have a synergistic effect, and meanwhile, when the three drug monomers of baicalin, emodin and caffeic acid are screened according to the method provided by the invention and are combined according to the mass ratio of 2: 1: 4, the antibacterial effect on methicillin-resistant staphylococcus aureus is the best.

The invention discloses a preparation method of natural product co-assembled nanoparticles, and hesperidin and emodin are subjected to a co-assembly process to form carrier-free nanoparticles, so that the natural product co-assembled nanoparticles are obtained. The invention further provides the natural product co-assembled nanoparticles prepared by the preparation method and application of the natural product co-assembled nanoparticles. According to the natural product co-assembled nanoparticles provided by the invention, emodin which is rapidly released in an early stage can rapidly kill methicillin-resistant staphylococcus aureus (MRSA) on the surface of a wound, and a local antibacterial barrier is established; the hesperidin continuously released in the later stage plays an anti-inflammatory role by regulating and controlling the expression of inflammatory factors, and promotes the proliferation of fibroblasts and the secretion of angiogenesis-related growth factors (such as VEGF) at the same time. The'space-time synergistic release strategy 'provides a multifunctional platform integrating antibiosis, anti-inflammation and tissue repair for chronic wound treatment, and is suitable for accelerating healing of chronic wounds such as infection, diabetes and burn.

The invention discloses a method for establishing a heat-clearing and eyesight-improving tea fingerprint spectrum by using a high performance liquid chromatography method and an application of the heat-clearing and eyesight-improving tea fingerprint spectrum. By utilizing the method disclosed by the invention, 17 fingerprint peaks can be confirmed, and the three components including fried semen cassiae, chrysanthemum and stevia rebaudiana in the heat-clearing and eyesight-improving tea all have corresponding attribution peaks. According to the present invention, the characteristic peaks of the six chemical components such as chlorogenic acid, rebaudioside A, stevioside, aurantio-obtusin, emodin and chrysophanol are identified through the comparison of the reference substance and the combination of the ultraviolet absorption spectrum characteristics, the rebaudioside A and the stevioside are the characteristic peaks of stevia rebaudiana, and the chrysanthemum and the stevia rebaudiana can be separated by the two characteristic peaks; according to the fingerprint spectrum detection method disclosed by the invention, the fingerprint spectrum with good separation degree and comprehensive chromatographic peaks can be obtained, the overall quality of the heat-clearing and eyesight-improving tea can be evaluated more objectively and comprehensively, and a foundation is laid for quality control of the heat-clearing and eyesight-improving tea.

The invention relates to the field of biological agriculture, and particularly discloses an emodin monomethyl ether suspending agent and a preparation method of the emodin monomethyl ether suspending agent. The suspending agent is prepared from the following raw materials in parts by weight: 2.8 to 3.2 parts of a physcion composite material, 1 to 1.5 parts of a dispersing agent, 0.5 to 1 part of a stabilizing agent, 1 to 2 parts of a wetting agent, 0.5 to 1 part of a defoaming agent, 350 to 400 parts of water, 0.5 to 1 part of high-fat pectin particles and 0.2 to 0.5 part of a nano whisker mixture, the preparation method comprises the following steps: S1, weighing the physcion composite material, the dispersing agent, the high-fat pectin particles and the water, and uniformly mixing and stirring to obtain a primary mixture; s2, adding a stabilizer, a wetting agent, a defoaming agent and a nano-whisker mixture into the primary mixture, and continuously mixing and uniformly stirring to obtain a suspending agent; meanwhile, the composition has the advantages of good stability and high active ingredient activity, thereby ensuring healthy growth of crops and improving the quality of agricultural products.

The invention discloses preparation and application of a double-enzyme-driven stage response type external preparation, which comprises the following steps: preparing drug-loaded hyaluronic acid (HA) microspheres, namely constructing emodin (EMD)-loaded hyaluronic acid microspheres (EMD-HA microspheres) for a responsive traditional Chinese medicine external preparation; preparation of hyaluronidase (HAase) gelatin microspheres; preparing a medicine-containing ointment substrate; and carrying out magnetic stirring or mechanical homogeneous stirring on the obtained EMD-HA microspheres, HAase gelatin microspheres and an ointment matrix for 30 minutes at room temperature on the basis of a dosage ratio, so that the microspheres are fully and uniformly dispersed in the ointment matrix, thereby obtaining the dual-enzyme driven stimulus-responsive external preparation. According to the preparation disclosed by the invention, 'targeted response 'treatment aiming at different stages of rosacea is realized; the convenience and compliance of treatment are improved, and meanwhile, individualized precise treatment for rosacea is realized.

The present application relates to a kind of methyltransferase that can catalyze anthraquinone compound methylation, amino acid sequence is as shown in SEQ ID NO:2, also provide the application of this methyltransferase in the production of emodin-3-methyl ether and other methylated anthraquinone compounds.The present application digs a new methyltransferase, which can methylate anthraquinone compound, and can convert emodin into emodin-3-methyl ether.The present application constructs the engineering bacteria that can produce emodin-3-methyl ether using the coding gene of the enzyme, widens the methyltransferase library that can be used for emodin methylation, provides new way for emodin-3-methyl ether cell factory construction.

The invention provides an acne-eliminating traditional Chinese medicine composition as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The acne-eliminating traditional Chinese medicine composition is prepared from 2-4 parts of radix scutellariae, 1-10 parts of fructus gardeniae and 1-9 parts of radix et rhizoma rhei through the steps that the raw materials are soaked in an ethanol solution and subjected to reflux extraction to obtain an extract, and the extract is concentrated and dried to obtain the acne-eliminating traditional Chinese medicine composition. The radix scutellariae and fructus gardeniae acne eliminating cream can be further developed. The acne-eliminating traditional Chinese medicine composition and the radix scutellariae and fructus gardeniae acne-eliminating cream have high contents of baicalin, geniposide and emodin, can inhibit the activity of propionibacterium acnes and play a bacteriostatic effect, also have a remarkable anti-inflammatory effect and can relieve inflammatory response induced by the propionibacterium acnes.

This invention belongs to the field of pesticide technology, specifically relating to a pesticide composition containing benzimidazole. The pesticide composition's active ingredient is a compound of benzimidazole and fluazinam or emodin methyl ether. This invention, through indoor bioactivity tests, found that the compound of benzimidazole with fluazinam or emodin methyl ether, within a certain mass ratio range, has a synergistic effect against various plant fungal diseases such as Rhizoctonia solani, Curvularia crescentis, and Sclerotium sclerotiorum, helping to improve control efficacy. This is of great significance for the research and development of pesticides for controlling diseases such as cucumber damping-off, corn curvularia leaf spot, and peanut white mold.

The invention belongs to the technical field of medicine, and particularly relates to application of emodin in medicine for treating acute kidney injury, the medicine for treating acute kidney injury is a preparation for inhibiting kidney iron sagging, and inhibition of kidney iron sagging specifically refers to activation of SIRT3, reduction of PINK1 acetylation level, up-regulation of glutathione peroxidase GPX4 and SLC7A11 expression level and reduction of transferrin TF expression level. The ROS level of lipid active oxygen is inhibited, so that the effect of treating the acute kidney injury caused by iron poisoning is achieved.

The invention belongs to the technical field of biological medicines, and particularly relates to a veterinary medicine composition for treating pet renal failure and a liposome and application thereof. The veterinary drug composition comprises curcumin, emodin and astragalus polysaccharide, and the mass ratio of the curcumin to the emodin to the astragalus polysaccharide is (0.5-2): (1-2): (1-2). The veterinary drug composition provided by the invention can achieve the purpose of synergistically treating renal failure in the aspects of resisting inflammation, inhibiting renal fibrosis, improving glomerular filtration function and the like, and provides a new solution for effectively treating the renal failure of pets. The traditional Chinese medicine composition has a good recovery effect on kidney tissues of the renal failure pets, can effectively reduce urea nitrogen and creatinine levels of blood of the renal failure pets and relieve renal failure symptoms, and has a good treatment effect.