The application discloses a kind of biological bionic water-permeable membrane and its preparation method, to solve the problems of poor
skin adhesion, insufficient one-way
moisture permeability and unstable
active ingredient delivery of existing dressings and films. By constructing a
layered structure of wet
adhesive biomimetic layer (L1), lipid compatible layer (L2) and outer one-way
permeation layer (L3), and using lipid-
ion double-continuous nanocapsule carrier and the polarity reversal strategy of "positive shell-
chitosan first and negative shell-
hyaluronic acid later", the film has the functions of airtight adhesion to the
skin surface in wet state, one-way
permeation from inside to outside and
controlled release. The method of the application comprises: preparing L1, cross-linking working solution B, lipid phase C, active water phase D and outer layer dispersion E; shaping L1, applying B to pre-set
osmotic pressure gradient, constructing and completing nanocapsule polarity reversal, vacuum
permeation injection of L2 containing
nanocapsules within a controlled time window, spraying and curing L3, and grading
drying and sterilization. The bionic water-permeable membrane can be used for
skin repair,
wound care and
sensitive skin protection, and has the significant benefits of airtight adhesion, one-way
perspiration,
moisture permeability and stable delivery of active ingredients.