72 results about "Analgesic" patented technology

The invention discloses a postoperative block analgesia curative effect evaluation system based on multi-modal data analysis, particularly relates to the technical field of medical information processing, and is used for solving the problem of poor analgesia evaluation standardization. An evaluation path of analgesia deviation quantification, state time sequence judgment and strategy generation is realized by constructing a structured comparison mechanism of an analgesia observation frame and an individualized analgesia baseline trajectory, pain, medication and activity deviations are dynamically calculated by fusing an anesthesia record, an analgesia pump log and clinical monitoring data, and an analgesia result is obtained. Typical states such as insufficient retardation effect are identified in combination with a time sequence inference model, a curative effect level and an early warning mark are automatically output, additional retardation, parameter adjustment and medicine remedy suggestions are generated according to a credibility level, and a state, disposal and result chain is constructed by continuously learning historical case data, so that the treatment efficiency is improved. The adaptive optimization of the baseline trajectory, the state threshold and the adjustment strategy is realized, and the individual matching performance, the response timeliness and the risk control capability of the analgesia strategy are improved.

The invention relates to the technical field of medical technology, in particular to a method for evaluating and adjusting pain in maternal and child anesthesia, which comprises the following steps of: constructing a physiological signal acquisition subsystem, a pretreatment subsystem, a self-adaptive evaluation subsystem and a closed-loop analgesia control subsystem to realize continuous, objective and specific evaluation of pain states of maternal and child patients under anesthesia; and the analgesic medicine is accurately and automatically adjusted. The continuous, objective and specific pain assessment can be realized, the analgesic medicine can be accurately and automatically adjusted, and the safety and comfort of maternal and child anesthesia are improved.

The invention provides a preparation method and application of graphene pain-relieving health-care paste, and the method comprises the following steps: mixing carrageenan with water to obtain a carrageenan solution, and carrying out ionization degradation on the carrageenan solution to obtain a carrageenan oligosaccharide solution; the preparation method comprises the following steps: stirring graphene oxide and a carrageenan oligosaccharide solution, cleaning to obtain a mixed solution, adding sodium alginate into the mixed solution to prepare a gel precursor, and adding an anhydrous calcium chloride solution and effective components into the gel precursor to obtain the pain-relieving gel, and drying the gel to obtain the health-care paste. The health-care ointment has the effects of promoting blood circulation, activating collaterals and inhibiting inflammation, and is suitable for various chronic pains such as rheumatic arthritis and lumbar muscle degeneration and acute pains such as traumatic injury and muscle strain; the composition is also suitable for auxiliary relieving of postoperative pain, and has safety and long-term effect. Due to the thermal conductivity of the graphene oxide in the health-care cream, local skin blood circulation can be accelerated, the permeation efficiency of the herbal extract is improved, and the medicine effect of the effective components is improved.

This invention belongs to the field of biomedical materials technology, and particularly relates to an analgesic microneedle patch, its preparation method, and its application. The analgesic microneedle patch of this invention uses extracted mesenchymal stem cell exosomes and ginger exosomes as analgesic active substances, and by combining them with microneedle patch technology, it provides a new technical approach for surface anesthesia. The analgesic microneedle patch of this invention combines microneedle technology and photopolymerization 3D printing technology to develop a customizable hydrogel microneedle patch, achieving minimally invasive and precise percutaneous delivery of local anesthetics, providing a new technical approach for surface anesthesia.

The application discloses a kind of acute trauma patient using analgesia pump, it is related to medical instrument technical field, including functional shell, functional shell contains shell, the control cavity of upper side and the liquid cavity of lower side are separated by horizontal partition in shell, the bottom and right side in liquid cavity are separated by L-shaped partition L-shaped medicine pipe passage, the middle part of horizontal portion of L-shaped partition is provided with limit seat, further including medicine bag limit extrusion executing mechanism, medicine liquid supply mechanism, medicine bag extrusion power mechanism, medicine delivery pump air mechanism and medicine delivery volume adaptability control mechanism, medicine bag limit extrusion executing mechanism contains medicine bag side limit plate and opposite displacement control component, two left and right corresponding medicine bag side limit plates are transversely slidably connected in the liquid cavity, the acute trauma patient using analgesia pump can let acute trauma patient select corresponding analgesic liquid infusion speed according to own pain feeling, and medicine pipe used for medicine liquid infusion is conveniently arranged and installed.

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses an anti-inflammatory analgesic indometacin long-acting suppository and a preparation method thereof.The suppository is composed of indometacin sustained-release microspheres and a modified fatty matrix; eudragit RS100 / RL100 is used as a compound framework of the sustained-release microspheres, the sustained-release microspheres are prepared through a spherocrystal granulation process, the modified fatty matrix is prepared from a mixed fatty glyceride compound matrix sustained-release aid, a three-dimensional suspending dispersant and the like through melting, pre-crystallization and high-speed homogenization processes, and the three-dimensional suspending dispersant contains modified nano silicon dioxide, glycerin monostearate and beewax. According to the invention, a microsphere-matrix dual controlled release system is constructed, so that burst release of drugs is eliminated, and long-acting stable release is realized; the microspheres are prevented from settling and agglomerating through a physical locking mechanism, and the storage stability of the preparation is improved by matching with a dual anti-oxidation system; meanwhile, rectal mucosa stimulation is reduced, the preparation process is simple, the quality is controllable, and the composition is suitable for anti-inflammation and analgesia of various diseases and has a wide clinical application prospect.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to stasis-removing and pain-relieving pills and a quality detection method thereof. The stasis-removing and pain-relieving pill is prepared by taking radix paeoniae alba, rhizoma corydalis, radix paeoniae rubra, angelica sinensis, ligusticum wallichii, rhizoma cyperi, rhizoma zingiberis, fennel and astragalus membranaceus as raw materials and taking 10% starch slurry as an adhesive. The quality detection method of the stasis-removing and pain-relieving pill comprises general inspection, microscopic identification and thin-layer chromatography identification. And high performance liquid chromatography content determination. According to the present invention, by researching the preparation process and the quality standard of the stasis removing and pain relieving pill, the new thought and the new method are provided for the development of the traditional Chinese medicine preparation, the excellent choice is hopefully provided for the common gynecologic symptoms such as irregular menstruation, dysmenorrhea, postpartum blood stasis abdominal pain and the like, and the pain caused by the illness is relieved.

The invention belongs to the technical field of drug carriers, and particularly relates to a magnetic nano-drug carrier which is prepared by the following steps: selecting traditional Chinese medicine raw materials and auxiliary raw materials, and selecting corresponding equipment for treating the raw materials; traditional Chinese medicine raw materials are pretreated, effective components are extracted through ultrasonic and reflux combination, and finally an extracting solution is purified and concentrated; preparing through a coprecipitation method; the flexible traditional Chinese medicine dressing is prepared by taking anti-inflammatory, analgesic, blood-activating and blood-stasis-removing active ingredients of 19 traditional Chinese medicines as cores and combining with the local magnetic response enrichment characteristic of the magnetic nano-carrier, the flexible traditional Chinese medicine dressing is attached to a pressurized silica gel pad of a PCI postoperative wrist strap for use, local directional enrichment of the active ingredients of the traditional Chinese medicines in a wound is promoted through the magnetic carrier, and the wound healing effect is improved. The pressurizing silica gel pad has the synergistic effects of resisting inflammation, easing pain, improving microcirculation and dredging collaterals and restoring the pulse, solves clinical pain points such as inflammation edema, obvious pain and unsmooth local blood supply of a wrist puncture wound after the PCI operation, and meets the requirements of flexibility, ventilation and fitting of the pressurizing silica gel pad at the same time.

Provided is a use of an oncolytic virus in the treatment of pain, especially in the treatment of cancer while relieving cancer pain. The drug effect time of the oncolytic virus for relieving cancer pain is obviously longer than that of the existing opioid analgesic, and the dual effects of treating cancer and easing pain are achieved at the same time.

The invention discloses a compound with a local anesthesia function as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The preparation method of the compound comprises the following steps: mixing and heating lidocaine and 2-bromoethanol to obtain a compound 1; the preparation method comprises the following steps: mixing dicarboxylic acid, N-hydroxysuccinimide, 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride and a solvent to obtain a mixed solution; mixing and dissolving a compound 1, alkali and a solvent, and then adding into the mixed solution; and then carrying out spin-drying, separation and purification to obtain the compound with the local anesthesia function. The medicine can be used as a local anesthetic or analgesic for long-acting nerve block or selective nerve block. The medicine can block nerve conduction, has biocompatibility and biodegradability, is expected to overcome the problems of short time efficiency of single-needle injection and the like, and improves the efficacy of the medicine.

The invention relates to (i) the prevention or treatment of a sleep disturbance, preferably in a patient having neuropathic pain; and / or (ii) the prevention or treatment of neuropathic pain in a patient having a sleep disturbance; and / or (iii) the prevention or treatment of neuropathic pain in a patient having been treated previously and / or being treated concomitantly with an analgesic medication for relief of neuropathic pain, preferably selected from antiepileptics, antidepressants and opioid analgesics, wherein the patient preferably has a sleep disturbance; in either cases by means of one or more high-concentration capsaicin and / or capsaicinoid topical dose units, preferably pharmaceutical patches, comprising capsaicin and / or capsaicinoid at a concentration of at least 2.5 wt.-%, relative to the total weight of dose unit.

The utility model relates to the technical field of medical instruments, in particular to an analgesia pump recycling bin which is characterized in that the top of the recycling bin is rotationally connected with a bin door through a rotating shaft, and a blade lock is fixedly installed in the right side of the surface of the bin door; when the analgesia pump needs to be recycled, the analgesia pump can be placed into the recycling box through the placing opening, so that the analgesia pump can be in contact with the water absorption pad, and when residual liquid in the analgesia pump flows out, the residual liquid can permeate the non-woven fabric to be in contact with the macromolecular water absorption resin; the water absorption pad can absorb residual liquid after being in contact with the residual liquid, the residual liquid can be prevented from permeating out from the bottom and the periphery of the edge of the water absorption pad through the waterproof performance of the TPU waterproof layer, meanwhile, the residual liquid is difficult to extrude out through a physical method after being absorbed by the high-molecular water absorption resin, and the high-molecular water absorption resin can repeatedly absorb the liquid. Therefore, residual liquid flowing out of the analgesia pump can be treated in time while the analgesia pump is recycled, and human health is affected.

The present application provides a kind of whole fruit fruit wine, it is by fruit, 50 degrees of liquor base liquor, yellow sugar, honey proportion mixed soak and is made into.The fruit is unique plant in Wudang Mountain of Hubei, has the effect of generating fluid to quench thirst, clearing spirit and reducing qi, is respected as holy fruit in ancient times, Ming Dynasty emperor Zhu Di also lists fruit as tribute to the court.Fresh fruit contains rich phosphorus, iron, calcium, vitamin C, carotene and other nutrients and seventeen kinds of amino acids necessary for human body, has the effect of helping digestion, resolving phlegm, tonifying kidney, refreshing brain, invigorating blood, strengthening body, tranquilizing pain, reducing pressure and reducing lipid, also has the health care effect of anti-inflammatory analgesic, eliminating fatigue, detoxification, enhancing immunity, etc.The present application not only improves the utilization value of fruit, but also greatly improves the nutritional and health care function of fruit wine, with low cost, improves economic benefit, and creates good social benefit.

1. Name of the product in this design: Analgesic Patch Packaging Box (Jianluotong). 2. Purpose of this design: A packaging box for the outer packaging of analgesic patches. 3. The key design elements of this product are the combination of shape, pattern, and color. 4. The image or photograph that best illustrates the design's key points: an unfolded view. 5. The design for which protection is sought includes color.

The present application provides a kind of Laumei fruit vinegar beverage, is by Laumei fruit, brewing rice vinegar, yellow granulated sugar, honey proportion (weight ratio is 10:40:5:2) mixed after soaking, add appropriate amount of purified water and be made into.The Laumei fruit is the plant that Hubei Wudang mountain is unique, has generating effect of Xitie, clearing spirit and lowering qi, is called as holy fruit in ancient times, Ming Dynasty emperor Zhu Di also lists Laumei as tribute to the court.Fresh Laumei fruit contains rich phosphorus, iron, calcium, vitamin C, carotene and other nutrients and seventeen kinds of amino acids necessary for human body, has the effect of helping digestion, phlegm, kidney, refreshing, invigorating blood, strengthening body, tranquilizing pain, reducing pressure and reducing fat, also has the health care effect of anti-inflammatory analgesic, eliminating fatigue, detoxification, enhancing immunity, etc.The present application not only improves the utilization value of Laumei fruit, but also greatly improves the nutritional and health care function of Laumei fruit vinegar, low cost, improves the economic benefit, and creates good social benefit.

1. The name of the design product: analgesic external packaging box (Dian Dian Ning). 2. The use of the design product: a packaging box, used for the external packaging of analgesics. 3. The design points of the design product: the combination of shape, pattern and color. 4. The picture or photo that best indicates the design points: design 1 unfolded diagram. 5. The design protected contains color. 6. Design 1 is designated as the basic design.

A multispectral photonic imaging system and associated methods are disclosed for classifying wound tissue and generating customized therapeutic wound dressings. The system employs wavelength-specific optical sources and integrated image sensors to capture multispectral reflectance data from a wound, enabling computational classification of distinct tissue types such as granulation, slough, and necrosis. A three-dimensional (3D) digital model of the wound is constructed using spatial data from depth sensors. The classified 3D wound model facilitates automated design of patient-specific dressings, featuring heterogeneous regions tailored with therapeutic compounds like antimicrobial agents, analgesics, collagen scaffolds, and hydrogel matrices precisely aligned to corresponding tissue classifications. Additional imaging modalities, including thermal and ultrasound sensors, can be integrated to enhance classification accuracy and inform targeted therapeutic placement, providing a comprehensive and personalized approach to wound management for medical and veterinary applications.

This invention discloses quaternized chitin, hemostatic sponges, and their preparation methods. First, a quaternization reagent is added to an alkaline urea-chitin aqueous solution at low temperature for homogeneous reaction, preparing temperature- or pH-sensitive quaternized modified chitin. Then, the aqueous solution is freeze-coagulated, regenerated, and purified to produce a sponge material for hemostasis, exhibiting high wet strength. The method of this invention is simple, environmentally friendly, and green, using no chemical cross-linking agents. The material is biodegradable and absorbable in vivo, exhibiting good biocompatibility and biodegradability. This type of hemostatic sponge material absorbs water quickly, possesses good mechanical properties and shape memory properties, provides excellent hemostatic effect, and promotes wound healing. It is particularly suitable for arterial hemostasis and hemostasis of deep and narrow wounds, non-compression wounds, and penetrating wounds. It can also be used as a carrier for sustained-release of local anesthetic analgesics and / or anti-inflammatory and antibacterial drugs.

The present disclosure provides methods and compositions for reducing the addictive liability of opioid analgesics in a subject, for example, by co-administering to the subject the opioid and a serotonin receptor type 2 (5HT2) agonist or a serotonin (5HT) releasing agent. The disclosed methods include methods for preventing opioid abuse, methods for reducing the rewarding effect of an opioid, methods for reducing the addictive liability of an opioid, methods for eliminating or substantially reducing the tendency for a subject to develop physical dependence, tolerance, and / or withdrawal symptoms with respect to an opioid, and methods for eliminating or substantially reducing the tendency for a subject to use opioids in ways not prescribed, take opioids more often or in larger amounts than prescribed, and / or use opioids recreationally. The methods can be performed on a subject, such as a patient (e.g., a human patient).

Provided are a pharmaceutical composition of an analgesic compound and a preparation method therefor. The pharmaceutical composition can be prepared into a liquid injection or a lyophilized powder. The pharmaceutical composition has a controllable particle size and a narrow distribution range, features good stability, and can be used for intravenous injection and achieves a rapid onset of action, thereby effectively replacing the use of opioid analgesics and reducing addiction. In addition, the composition does not contain excipients having a sustained-release function, thereby providing higher safety.

The present application relates to a kind of traditional Chinese medicine composition for treating post-fracture soreness, fatigue, it is made from the following weight parts of raw medicinal materials: flying cinnabar 250-350 parts, top blood 250-350 parts, natural copper 250-350 parts, upper sandalwood 130-170 parts, water fly realgar 130-170 parts, big mei piece 40-80 parts.The present application also provides the use of the above-mentioned drug.Its advantages are that: the traditional Chinese medicine composition of the present application meets the compatibility of monarch, minister, and assistant, with natural copper dispersing blood stasis, stopping pain, and continuing tendon and bone as monarch drug;Bone fracture supplement treating injury, pain relief, kidney and bone strengthening;Realgar dry dampness, dispel wind, kill insects, detoxification;Big mei piece detumescence analgesic, together as minister drug;Sandalwood qi-warming analgesic, cinnabar heat-clearing and detoxifying as assistant drug.

A class of competitive and reversible GlyT2 inhibitors is provided that demonstrate a differentiated pharmacological profile from earlier inhibitors, such as ORG25543. ORG25543 and genetic GlyT2 knockout paradigms can elicit neuromotor or excitatory adverse effects. To overcome these challenges, SAR- and SKR-driven hit-to-lead campaigns were used to design improved, competitive and reversible GlyT2 inhibitors with improved drug-like characteristics and demonstrates a differentiated pharmacological profile. These improved GlyT2 inhibitors include indole, indoline, or indazole cores substituted with a variety of groups to modify the reversible binding activity thereof. The compounds described herein are shown to possess properties useful for safe, efficacious, and orally bioavailable non-opioid analgesics for the treatment of neuropathic pain.

The application discloses an indolone compound and a pharmaceutical composition and application thereof, and has a molecular structure as follows: the indolone compound has double activities of analgesia and antioxidation, can be used as an analgesic with an antioxidation function, and has application potential in inflammatory pain care.

The use of AKR1C3 enzyme-activated DNA alkylating agent prodrug compounds containing aziridine structures, as well as their salts, esters, solvates, and isotopic isomers, in combination with anti-allergy drugs / nonsteroidal analgesics for the treatment of cancer and tumor patients; and the use of AKR1C3 enzyme-activated DNA alkylating agent prodrug compounds containing aziridine structures, as well as their salts, esters, solvates, and isotopic isomers, in combination with anti-allergy drugs / nonsteroidal analgesics in the preparation of drugs for the treatment of cancer and tumors.

The invention discloses a medicine for relieving pain. The medicine contains a compound which is used for acupoint administration and is used for targeted excitation of Piezo1 protein. The invention further discloses application of the Piezo agonist in preparation of the medicine for relieving pain. The invention relates to application of a Piezo agonist in relieving neuropathic pain after peripheral nerve injury, and provides a novel non-central analgesic treatment choice for neuropathic pain through a targeted peripheral mechanism. Micro-injection only needs to be carried out at the acupuncture point, systemic side effects of a traditional analgesic medicine are effectively avoided, the central safety is high, the addiction risk is avoided, compared with 20-30 minutes of needle retaining time generally needed by traditional acupuncture treatment of a single acupuncture point, the time consumed by acupuncture point injection is remarkably shortened, and the clinical efficiency requirement is better met.

The invention relates to an analgesia pump drug delivery control method and device based on multi-dimensional pain indexes, and the method comprises the steps: obtaining multi-dimensional pain data, including physiological data and behavior data, of a target patient, building a pain calculation model containing the multi-dimensional pain indexes, importing the multi-dimensional pain data into the pain calculation model, and calculating the pain of the target patient according to the pain calculation model. Obtaining a pain value corresponding to the target patient, collecting a pain feedback value of the target patient in real time, and controlling the administration process of the analgesia pump in combination with the pain value. Through the core logic of multi-dimensional data acquisition, accurate model evaluation and real-time feedback regulation, the limitation of administration control of a traditional analgesia pump is broken through from the four dimensions of evaluation accuracy, administration individuation, administration safety and management efficiency, and finally the clinical goals of accurate analgesia, safe administration and efficient management are achieved. The method has important value for improving the pain diagnosis and treatment quality, guaranteeing the safety of patients and optimizing the clinical working process.

The present invention provides a painless lymph-targeted drug delivery patch comprising: a patch part having one side attached to a skin surface and having multiple through-holes through which a drug passes; multiple microneedle parts arranged along a pattern configured on one side of the patch part to inject the drug while being inserted into the skin; a drug chamber provided on the other side of the patch part to supply the drug to the microneedle parts through the through-holes; and an adsorption part provided on the other side of the patch part to selectively form negative pressure on the other side surface of the patch part or the skin surface.

This invention provides a hydrophilic, lubricated, and analgesic rubber urinary catheter and its preparation method, relating to the field of medical device technology. The catheter surface is sequentially coated with an adhesion layer, a pH-temperature responsive analgesic layer, and a hydrophilic layer. The pH-temperature responsive analgesic layer is a Janus fiber felt, with a pH-sensitive polymer and an analgesic drug on one side and a temperature-sensitive polymer and an analgesic drug on the other side. The analgesic layer of the catheter provided by this invention employs a Janus fiber structure and simultaneously loads both a pH-sensitive polymer and a temperature-sensitive polymer. This structure can accurately sense pathological changes in the urethral microenvironment and actively and synergistically regulate the release behavior of the analgesic drug accordingly, effectively relieving catheter-related bladder irritation syndrome (CRBD).

A wound dressing including a porous biosynthetic polymer film comprising a poly(lactide-co-caprolactone) (“PLC”) copolymer or other suitable polymer matrix, and a local analgesic loaded therein, to provide pain relief over an extended period of time (e.g., for 5-7 days), e.g., for healing of a partial thickness dermal injury. The PLC copolymer may have a particular lactide / caprolactone molar ratio (e.g., from 2:1 to 9:1) to ensure slow, sustained release of the bupivacaine or other analgesic. The dressing may provide a water vapor transmission rate from 1000 g / m2·day to 3000 g / m2·day to facilitate fast healing and regrowth of new epithelial tissue beneath the dressing. The dressing is configured to remain positioned over the dermal injury, providing wound protection for about 14 days, after which is simply debrides away, falls off, or is easily and painlessly removed, once new epithelial tissue regrows.