139 results about "Analgesic" patented technology

The invention discloses a postoperative block analgesia curative effect evaluation system based on multi-modal data analysis, particularly relates to the technical field of medical information processing, and is used for solving the problem of poor analgesia evaluation standardization. An evaluation path of analgesia deviation quantification, state time sequence judgment and strategy generation is realized by constructing a structured comparison mechanism of an analgesia observation frame and an individualized analgesia baseline trajectory, pain, medication and activity deviations are dynamically calculated by fusing an anesthesia record, an analgesia pump log and clinical monitoring data, and an analgesia result is obtained. Typical states such as insufficient retardation effect are identified in combination with a time sequence inference model, a curative effect level and an early warning mark are automatically output, additional retardation, parameter adjustment and medicine remedy suggestions are generated according to a credibility level, and a state, disposal and result chain is constructed by continuously learning historical case data, so that the treatment efficiency is improved. The adaptive optimization of the baseline trajectory, the state threshold and the adjustment strategy is realized, and the individual matching performance, the response timeliness and the risk control capability of the analgesia strategy are improved.

The application discloses a kind of intelligent service systems of advanced cancer pain pain, including: analgesic device, massage piece, driving source and ice piece, ice piece is located inside the mounting seat side surface, ice piece is used to contact cooling massage ball;Push module is used to daily push the predetermined check quantization table to patient, check quantization table at least includes one or more of the following each item: diet condition, sleep condition, body pain condition, self cognitive ability and mental state;Evaluation module, evaluation module obtains patient state evaluation result according to the data of patient to check quantization table, and according to evaluation result, push management scheme to patient and adjust analgesic device analgesic scheme, the living condition of patient every day is obtained regularly by push module, and the individualized, centralized pain intervention scheme is formed by evaluation module, one aspect realizes the timely evaluation of patient life quality, while quantized mode is convenient for others to view specific change situation, to improve specific condition of patient in a targeted manner.

The invention relates to the technical field of medical technology, in particular to a method for evaluating and adjusting pain in maternal and child anesthesia, which comprises the following steps of: constructing a physiological signal acquisition subsystem, a pretreatment subsystem, a self-adaptive evaluation subsystem and a closed-loop analgesia control subsystem to realize continuous, objective and specific evaluation of pain states of maternal and child patients under anesthesia; and the analgesic medicine is accurately and automatically adjusted. The continuous, objective and specific pain assessment can be realized, the analgesic medicine can be accurately and automatically adjusted, and the safety and comfort of maternal and child anesthesia are improved.

The invention provides a novel analgesic injection composition. The composition comprises tapentadol in an active ingredient quick release form and a quick-acting and long-acting composition of bistapentadol sebacate in an active ingredient slow release form. The invention also relates to a method for preparing the quick-acting and long-acting injection composition and application of the prepared dosage form in preparation of medicines for treating chronic or acute pain, such as preoperative and postoperative administration. The quick-acting and long-acting injection composition provided by the invention has ideal pharmaceutical technology and clinical attributes.

The invention belongs to the technical field of pharmaceutical preparations, and particularly discloses a compound bear gall pain-relieving gel as well as a preparation method and application thereof. The compound bear gall pain-relieving gel comprises the following components in percentage by mass: 15-25% of a traditional Chinese medicine composition, 2.5-3.5% of a matrix, 7-13% of a humectant, 1-10% of a penetration enhancer and a proper amount of a pH regulator. The invention discloses a compound bear gall pain-relieving gel as well as a preparation method and application thereof. The compound bear gall pain-relieving gel has a remarkable treatment effect on inflammatory pain and can quickly relieve pain and relieve swelling, the gel dosage form is convenient to smear and can directly reach a focus, and a safe, efficient and convenient new choice is provided for treatment of the inflammatory pain.

The invention provides an epidural catheter which comprises a first catheter body or a second catheter body, one to five cavities are annularly formed in the end section of the insertion end of the first catheter body at equal intervals around the catheter, and sensors are arranged in the cavities; 1-5 sensors are annularly attached to the outer surface of the end section of the second guide pipe body at equal intervals around the guide pipe, and the outer surface of the second guide pipe body is further coated with a coating. The invention further provides an epidural space catheterization position detection device which comprises an epidural catheter, a connecting tube, a demodulator and an analgesia pump, the demodulator is suitable for converting and displaying signals received by the sensor or conducting early warning, and the demodulator is further suitable for controlling or adjusting drug administration parameters of the analgesia pump according to the received signals; according to the detection device, the position of the epidural catheter in the epidural cavity is judged through an electric signal, epidural administration can be more accurately carried out, and the problems of epidural catheter placement, position monitoring and the like in epidural cavity catheterization are solved.

The invention discloses a shoulder operation rapid rehabilitation regulation and control system combined with an analgesia path, and the system firstly collects signals in real time through a multi-mode physiological sensing network, constructs a shoulder dynamic function spectrogram reflecting pain and functional states, and recognizes a functional abnormality core region; then, a targeted drug infusion system is controlled, and a personalized analgesia path matched with the physiological response of the object is generated in combination with a multi-physics field coupling model and a model prediction control algorithm; thirdly, calculating the comprehensive rehabilitation confidence coefficient for quantifying the rehabilitation potential by analyzing the space-time correlation between the functional spectrogram and the analgesia path; and finally, based on the comprehensive rehabilitation confidence, generating a safe, effective and object-tolerant personalized rehabilitation training instruction set by using a multi-target rehabilitation optimization model, and driving rehabilitation equipment to execute. The method has the following advantages and effects: precise space-time matching and dynamic coordination of analgesia and rehabilitation training are realized, so that the rehabilitation efficiency and quality are remarkably improved on the premise of ensuring safety.

1. Name of the product in this design: Packaging Box (Tianqi Analgesic Gel Patch). 2. Purpose of this design: For packaging Tianqi analgesic gel patches. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The invention provides a preparation method and application of graphene pain-relieving health-care paste, and the method comprises the following steps: mixing carrageenan with water to obtain a carrageenan solution, and carrying out ionization degradation on the carrageenan solution to obtain a carrageenan oligosaccharide solution; the preparation method comprises the following steps: stirring graphene oxide and a carrageenan oligosaccharide solution, cleaning to obtain a mixed solution, adding sodium alginate into the mixed solution to prepare a gel precursor, and adding an anhydrous calcium chloride solution and effective components into the gel precursor to obtain the pain-relieving gel, and drying the gel to obtain the health-care paste. The health-care ointment has the effects of promoting blood circulation, activating collaterals and inhibiting inflammation, and is suitable for various chronic pains such as rheumatic arthritis and lumbar muscle degeneration and acute pains such as traumatic injury and muscle strain; the composition is also suitable for auxiliary relieving of postoperative pain, and has safety and long-term effect. Due to the thermal conductivity of the graphene oxide in the health-care cream, local skin blood circulation can be accelerated, the permeation efficiency of the herbal extract is improved, and the medicine effect of the effective components is improved.

This invention belongs to the field of biomedical materials technology, and particularly relates to an analgesic microneedle patch, its preparation method, and its application. The analgesic microneedle patch of this invention uses extracted mesenchymal stem cell exosomes and ginger exosomes as analgesic active substances, and by combining them with microneedle patch technology, it provides a new technical approach for surface anesthesia. The analgesic microneedle patch of this invention combines microneedle technology and photopolymerization 3D printing technology to develop a customizable hydrogel microneedle patch, achieving minimally invasive and precise percutaneous delivery of local anesthetics, providing a new technical approach for surface anesthesia.

At least one therapy (e.g., one or more of photobiomodulation (PBM), pharmaceutical nerve block, electrical nerve block, temperature-based nerve block, etc.) can be delivered to a target nerve by a surgical tool through a surgical opening (e.g., during surgery) to manage post-operative pain. The at least one therapy can reduce or eliminate the need for analgesics to reduce post-operative pain. The at least one therapy can include at least one dose of light for PBM to selectively silence conduction in small fibers within the target nerve that are known to cause post-operative pain for a time (e.g., extending after the surgery). Doses of the at least one therapy can be determined and provided by a controller in communication with the surgical tool.

The topical composition is for application to a portion of skin at a locus of postsurgical pain and comprises: an amount of anti-inflammatory analgesic; an amount of muscle relaxant; an amount of neuropathic analgesic; an amount of anesthetic; and a carrier having skin penetration enhancement qualities.

The application discloses a kind of acute trauma patient using analgesia pump, it is related to medical instrument technical field, including functional shell, functional shell contains shell, the control cavity of upper side and the liquid cavity of lower side are separated by horizontal partition in shell, the bottom and right side in liquid cavity are separated by L-shaped partition L-shaped medicine pipe passage, the middle part of horizontal portion of L-shaped partition is provided with limit seat, further including medicine bag limit extrusion executing mechanism, medicine liquid supply mechanism, medicine bag extrusion power mechanism, medicine delivery pump air mechanism and medicine delivery volume adaptability control mechanism, medicine bag limit extrusion executing mechanism contains medicine bag side limit plate and opposite displacement control component, two left and right corresponding medicine bag side limit plates are transversely slidably connected in the liquid cavity, the acute trauma patient using analgesia pump can let acute trauma patient select corresponding analgesic liquid infusion speed according to own pain feeling, and medicine pipe used for medicine liquid infusion is conveniently arranged and installed.

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses an anti-inflammatory analgesic indometacin long-acting suppository and a preparation method thereof.The suppository is composed of indometacin sustained-release microspheres and a modified fatty matrix; eudragit RS100 / RL100 is used as a compound framework of the sustained-release microspheres, the sustained-release microspheres are prepared through a spherocrystal granulation process, the modified fatty matrix is prepared from a mixed fatty glyceride compound matrix sustained-release aid, a three-dimensional suspending dispersant and the like through melting, pre-crystallization and high-speed homogenization processes, and the three-dimensional suspending dispersant contains modified nano silicon dioxide, glycerin monostearate and beewax. According to the invention, a microsphere-matrix dual controlled release system is constructed, so that burst release of drugs is eliminated, and long-acting stable release is realized; the microspheres are prevented from settling and agglomerating through a physical locking mechanism, and the storage stability of the preparation is improved by matching with a dual anti-oxidation system; meanwhile, rectal mucosa stimulation is reduced, the preparation process is simple, the quality is controllable, and the composition is suitable for anti-inflammation and analgesia of various diseases and has a wide clinical application prospect.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to stasis-removing and pain-relieving pills and a quality detection method thereof. The stasis-removing and pain-relieving pill is prepared by taking radix paeoniae alba, rhizoma corydalis, radix paeoniae rubra, angelica sinensis, ligusticum wallichii, rhizoma cyperi, rhizoma zingiberis, fennel and astragalus membranaceus as raw materials and taking 10% starch slurry as an adhesive. The quality detection method of the stasis-removing and pain-relieving pill comprises general inspection, microscopic identification and thin-layer chromatography identification. And high performance liquid chromatography content determination. According to the present invention, by researching the preparation process and the quality standard of the stasis removing and pain relieving pill, the new thought and the new method are provided for the development of the traditional Chinese medicine preparation, the excellent choice is hopefully provided for the common gynecologic symptoms such as irregular menstruation, dysmenorrhea, postpartum blood stasis abdominal pain and the like, and the pain caused by the illness is relieved.

The invention belongs to the technical field of drug carriers, and particularly relates to a magnetic nano-drug carrier which is prepared by the following steps: selecting traditional Chinese medicine raw materials and auxiliary raw materials, and selecting corresponding equipment for treating the raw materials; traditional Chinese medicine raw materials are pretreated, effective components are extracted through ultrasonic and reflux combination, and finally an extracting solution is purified and concentrated; preparing through a coprecipitation method; the flexible traditional Chinese medicine dressing is prepared by taking anti-inflammatory, analgesic, blood-activating and blood-stasis-removing active ingredients of 19 traditional Chinese medicines as cores and combining with the local magnetic response enrichment characteristic of the magnetic nano-carrier, the flexible traditional Chinese medicine dressing is attached to a pressurized silica gel pad of a PCI postoperative wrist strap for use, local directional enrichment of the active ingredients of the traditional Chinese medicines in a wound is promoted through the magnetic carrier, and the wound healing effect is improved. The pressurizing silica gel pad has the synergistic effects of resisting inflammation, easing pain, improving microcirculation and dredging collaterals and restoring the pulse, solves clinical pain points such as inflammation edema, obvious pain and unsmooth local blood supply of a wrist puncture wound after the PCI operation, and meets the requirements of flexibility, ventilation and fitting of the pressurizing silica gel pad at the same time.

Provided is a use of an oncolytic virus in the treatment of pain, especially in the treatment of cancer while relieving cancer pain. The drug effect time of the oncolytic virus for relieving cancer pain is obviously longer than that of the existing opioid analgesic, and the dual effects of treating cancer and easing pain are achieved at the same time.

The present application relates to a kind of two-edged needle medicinal materials and its preparation fast identification method, the preparation is containing two-edged needle Chinese medicine preparation such as Huatou Fengtongbao tablet, Huatou Fengtongbao capsule, two-edged needle analgesic tablet, the method includes the respective preparation of each test solution of the sample, then each test solution is spotted on the same silica gel G thin layer plate, using the uplink development method, with volume ratio 12:1:4:0.1 of petroleum ether-cyclohexane-ethyl acetate-glacial acetic acid as developing agent, development, take out, natural cool dry, under the inspection of ultraviolet light, in the chromatogram of test sample, in the corresponding position with the chromatogram of control drug material, same color fluorescent spot is shown.The present application can be used for the fast identification of two-edged needle medicinal materials and related preparation, and compared with the existing identification technology of two-edged needle and its preparation, no toxic organic solvent is used, with the advantages of simple, fast, environmental protection, green, result exclusive, accurate, controllable operation method.

The invention discloses a compound with a local anesthesia function as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The preparation method of the compound comprises the following steps: mixing and heating lidocaine and 2-bromoethanol to obtain a compound 1; the preparation method comprises the following steps: mixing dicarboxylic acid, N-hydroxysuccinimide, 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride and a solvent to obtain a mixed solution; mixing and dissolving a compound 1, alkali and a solvent, and then adding into the mixed solution; and then carrying out spin-drying, separation and purification to obtain the compound with the local anesthesia function. The medicine can be used as a local anesthetic or analgesic for long-acting nerve block or selective nerve block. The medicine can block nerve conduction, has biocompatibility and biodegradability, is expected to overcome the problems of short time efficiency of single-needle injection and the like, and improves the efficacy of the medicine.

The invention relates to the technical field of medicines, and particularly discloses a phenoxyethanol amine compound and application of the phenoxyethanol amine compound as a CaV2.2 inhibitor. The phenoxyethanol amine compound has a structure as shown in a formula (I), and the compound or a tautomer, a stereoisomer, a hydrate, a solvate, a pharmaceutically acceptable salt or a prodrug thereof, and a pharmaceutical composition containing the compound can be used as an N-type calcium channel (CaV2.2) inhibitor, and can also effectively relieve and / or eliminate pain. The phenoxyethanol amine compound provided by the invention has a good application prospect in the field of analgesic drugs.

The invention belongs to the technical field of medicine, and discloses application of SHLP2 in preparation of medicine for relieving and treating acute and chronic inflammatory pain, and the amino acid sequence of SHLP2 polypeptide is MGVKFFTLSTRFFPSVQRAVPLWTNS. After the SHLP2 polypeptide is treated in an intrathecal (5 [mu] g / 10 [mu] g / 20 [mu] g) injection mode, the SHLP2 polypeptide shows a good treatment effect in an acute inflammation pain model induced by formalin and capsaicin and a chronic inflammation pain model induced by carrageenan and a complete Freund's adjuvant. The SHLP2 is utilized to target a mitochondrial genome, the effect of relieving acute and chronic inflammatory pain is achieved in a central sheath injection mode, and a target different from a traditional analgesic drug can be searched for treatment of the acute and chronic inflammatory pain.

The invention relates to (i) the prevention or treatment of a sleep disturbance, preferably in a patient having neuropathic pain; and / or (ii) the prevention or treatment of neuropathic pain in a patient having a sleep disturbance; and / or (iii) the prevention or treatment of neuropathic pain in a patient having been treated previously and / or being treated concomitantly with an analgesic medication for relief of neuropathic pain, preferably selected from antiepileptics, antidepressants and opioid analgesics, wherein the patient preferably has a sleep disturbance; in either cases by means of one or more high-concentration capsaicin and / or capsaicinoid topical dose units, preferably pharmaceutical patches, comprising capsaicin and / or capsaicinoid at a concentration of at least 2.5 wt.-%, relative to the total weight of dose unit.

The utility model relates to the technical field of medical instruments, in particular to an analgesia pump recycling bin which is characterized in that the top of the recycling bin is rotationally connected with a bin door through a rotating shaft, and a blade lock is fixedly installed in the right side of the surface of the bin door; when the analgesia pump needs to be recycled, the analgesia pump can be placed into the recycling box through the placing opening, so that the analgesia pump can be in contact with the water absorption pad, and when residual liquid in the analgesia pump flows out, the residual liquid can permeate the non-woven fabric to be in contact with the macromolecular water absorption resin; the water absorption pad can absorb residual liquid after being in contact with the residual liquid, the residual liquid can be prevented from permeating out from the bottom and the periphery of the edge of the water absorption pad through the waterproof performance of the TPU waterproof layer, meanwhile, the residual liquid is difficult to extrude out through a physical method after being absorbed by the high-molecular water absorption resin, and the high-molecular water absorption resin can repeatedly absorb the liquid. Therefore, residual liquid flowing out of the analgesia pump can be treated in time while the analgesia pump is recycled, and human health is affected.

The present application provides a kind of whole fruit fruit wine, it is by fruit, 50 degrees of liquor base liquor, yellow sugar, honey proportion mixed soak and is made into.The fruit is unique plant in Wudang Mountain of Hubei, has the effect of generating fluid to quench thirst, clearing spirit and reducing qi, is respected as holy fruit in ancient times, Ming Dynasty emperor Zhu Di also lists fruit as tribute to the court.Fresh fruit contains rich phosphorus, iron, calcium, vitamin C, carotene and other nutrients and seventeen kinds of amino acids necessary for human body, has the effect of helping digestion, resolving phlegm, tonifying kidney, refreshing brain, invigorating blood, strengthening body, tranquilizing pain, reducing pressure and reducing lipid, also has the health care effect of anti-inflammatory analgesic, eliminating fatigue, detoxification, enhancing immunity, etc.The present application not only improves the utilization value of fruit, but also greatly improves the nutritional and health care function of fruit wine, with low cost, improves economic benefit, and creates good social benefit.

1. Name of the product in this design: Analgesic Patch Packaging Box (Jianluotong). 2. Purpose of this design: A packaging box for the outer packaging of analgesic patches. 3. The key design elements of this product are the combination of shape, pattern, and color. 4. The image or photograph that best illustrates the design's key points: an unfolded view. 5. The design for which protection is sought includes color.

The present application provides a kind of Laumei fruit vinegar beverage, is by Laumei fruit, brewing rice vinegar, yellow granulated sugar, honey proportion (weight ratio is 10:40:5:2) mixed after soaking, add appropriate amount of purified water and be made into.The Laumei fruit is the plant that Hubei Wudang mountain is unique, has generating effect of Xitie, clearing spirit and lowering qi, is called as holy fruit in ancient times, Ming Dynasty emperor Zhu Di also lists Laumei as tribute to the court.Fresh Laumei fruit contains rich phosphorus, iron, calcium, vitamin C, carotene and other nutrients and seventeen kinds of amino acids necessary for human body, has the effect of helping digestion, phlegm, kidney, refreshing, invigorating blood, strengthening body, tranquilizing pain, reducing pressure and reducing fat, also has the health care effect of anti-inflammatory analgesic, eliminating fatigue, detoxification, enhancing immunity, etc.The present application not only improves the utilization value of Laumei fruit, but also greatly improves the nutritional and health care function of Laumei fruit vinegar, low cost, improves the economic benefit, and creates good social benefit.

1. The name of the design product: analgesic external packaging box (Dian Dian Ning). 2. The use of the design product: a packaging box, used for the external packaging of analgesics. 3. The design points of the design product: the combination of shape, pattern and color. 4. The picture or photo that best indicates the design points: design 1 unfolded diagram. 5. The design protected contains color. 6. Design 1 is designated as the basic design.

A multispectral photonic imaging system and associated methods are disclosed for classifying wound tissue and generating customized therapeutic wound dressings. The system employs wavelength-specific optical sources and integrated image sensors to capture multispectral reflectance data from a wound, enabling computational classification of distinct tissue types such as granulation, slough, and necrosis. A three-dimensional (3D) digital model of the wound is constructed using spatial data from depth sensors. The classified 3D wound model facilitates automated design of patient-specific dressings, featuring heterogeneous regions tailored with therapeutic compounds like antimicrobial agents, analgesics, collagen scaffolds, and hydrogel matrices precisely aligned to corresponding tissue classifications. Additional imaging modalities, including thermal and ultrasound sensors, can be integrated to enhance classification accuracy and inform targeted therapeutic placement, providing a comprehensive and personalized approach to wound management for medical and veterinary applications.

The invention discloses a preparation method of an analgesic hydrogel dressing based on fritillaria alkaloid, and belongs to the technical field of biomedical dressing preparation, and the preparation method comprises the following steps: dispersing fritillaria alkaloid in a hydrogel matrix material, and carrying out physical crosslinking or chemical crosslinking to obtain the analgesic hydrogel dressing based on fritillaria alkaloid. The core of the invention lies in that fritillaria alkaloid with natural analgesic activity is combined with the traditional polymer hydrogel, and sustained release of fritillaria alkaloid on the wound surface is realized by virtue of the slow release characteristic of the hydrogel, so that the pain experience of a patient in the wound healing process is effectively relieved. Meanwhile, the hydrogel matrix has good moisture retention, biocompatibility and healing promotion characteristics, and an ideal microenvironment can be provided for tissue repair. The pain feeling in the wound repairing period is remarkably reduced, the wound healing process is accelerated, the overall comfort level and life quality of a patient are improved, and wide clinical application prospects are achieved.