18 results about "Localized fat" patented technology

The present invention relates to a molecular association of a bile acid or a bile salt and a composition containing the same, and more specifically, to a skin-permeable formulation of deoxycholic acid, a lipolytic pharmacological agent, which has been developed as an external preparation rather than a conventional injection, and which dramatically improves patient compliance.

To provide a composition useful for reducing localized fat in a subject having localized fat deposits, without pain, edema, or side effects.SOLUTION: A composition for localized fat reduction with reduced pain and side effects, comprising: (i) phosphatidylcholine; and (ii) at least one selected from a group consisting of glycocholic acid (GCA), taurocholic acid (TCA), and salts thereof, wherein (i) and (ii) have a molar ratio of (ii) / (i) of 0.7 to 3.0, and wherein the composition is administered to an affected area of a subject at intervals of less than 4 weeks at a concentration of 25 to 50 mg / ml. The composition according to the present invention provides a safe and stable formulation, is highly effective in reducing fat cells without various side effects, and can maximize its effects by being administered to the affected area at shorter intervals.SELECTED DRAWING: Figure 3

The invention discloses application of sodium humate in preparation of medicines for treating obesity, and relates to the technical field of biological medicines. The research finds that the sodium humate has the effect of treating obesity, and the treatment effect on obesity can be effectively improved by further combining the sodium humate with near-infrared photothermal treatment. Through detection, the sodium humate has excellent photothermal conversion performance and good photothermal stability, and the characteristic lays a key foundation for treating obesity by combining the sodium humate with near-infrared photothermal. Experiments prove that the sodium humate can efficiently realize photothermal conversion in a fat area, and a precise action mode is provided for local fat intervention. Animal experiments prove that the sodium humate and the sodium humate combined photothermal therapy can effectively relieve the obesity degree. Meanwhile, the combined treatment can improve adipose tissue distribution, realizes fat phenotype remodeling, and especially can promote white fat browning.

The invention provides a preparation method and application of isodon amethystoides polysaccharide. The invention provides an extraction and separation process of isodon amethystoides polysaccharide, high-content polysaccharide is obtained, and the polysaccharide has the functions of reducing blood fat, reducing body fat, local fat or fat-body ratio, preventing, treating, improving or relieving liver injury and the like.

A composition for local adipose tissue enlargement and application is disclosed, which relates to the technical field of beauty and body care products, comprising 4-10 parts of Anemarrhena asphodeloides Bunge extract, 1-3 parts of vitamin B12, 1-2 parts of geranium essential oil and 1-3 parts of ceramide. Pure plant extract components are selected in the composition, supplemented with vitamin B and ceramide. The effective components can be absorbed by the skin of the breast and the buttocks by external application, rubbing and massage, so as to promote the accumulation of adipose cells, achieve the effect of breast augmentation and buttock augmentation, avoid side effects caused by surgery and injection, and ensure safety and no irritation. Meanwhile, due to the presence of the ceramide, the composition can also maintain the function and the morphology of fibroblasts, maintain or improve the differentiation ability, promote tissue regeneration, and facilitate wound healing.

The invention discloses garcinia cambogia fat-reducing and shaping health-care cream. Targeted delivery of active components (HCA, escin and the like) is realized through a nano-liposome drug-loading technology. In-vitro experiments prove that the fat decomposition rate (67.5%, Plt, 0.01) of the product can be remarkably increased, the transdermal absorption amount reaches 38.9 micrograms / cm < 3 >, and the stability of the paste is excellent (the retention rate of effective components is greater than 90% after 3-month acceleration at 40 DEG C). The composition is suitable for external application to improve local fat accumulation.

A method for treating or reducing localized fat, and a pharmaceutical composition for use in treating or reducing localized fat. The method comprises injecting the pharmaceutical composition into the localized fat of a subject in need, wherein the pharmaceutical composition comprises deoxycholic acid and a viscous agent, and wherein deoxycholic acid is present in the pharmaceutical composition in an amount of 1% to 5% w / v.

A method for treating or reducing localized fat, and a pharmaceutical composition for use in treating or reducing localized fat. The method comprises injecting the pharmaceutical composition into the localized fat of a subject in need, wherein the pharmaceutical composition comprises deoxycholic acid and a viscous agent, and wherein deoxycholic acid is present in the pharmaceutical composition in an amount of 1% to 5% w / v.

The present invention is drawn towards a composition comprising Artepillin C, naringenin, a carotenoid, and a pharmaceutically acceptable carrier, wherein the carotenoid is selected from the group consisting of beta-carotene, lycopene, or lutein, and methods of using the composition for local fat reduction and / or treating a subject afflicted with a metabolic disorder.

The present invention relates to a composition containing ascorbic acid or a physiologically acceptable salt thereof and a physiologically acceptable ferrous salt as active ingredients for the preparation of a medicament, medical device or hygiene product, useful for reducing the number of adipocytes in a localized fat accumulation site by controlled lipolysis without producing apoptotic effects.

Compositions, and methods of treating a subject using the compositions, for treating obesity, reducing body weight, treating chronic inflammation associated with obesity, reducing focal adiposity, and improving metabolism. The compositions include a complex comprising cationic PAMAM generation 3 (P-G3) and human serum albumin (HSA). The complex may be a cfRNA or cfDNA scavenger.

A method for non-surgically reducing localized adipose tissue in a patient is provided. The method comprises topically administering to a site at or proximate adipose tissue, with massage at the site of administration, a composition comprising: at least one biologically compatible pharmacologically active detergent selected from the group consisting of a lipophilic detergent, a hydrophilic detergent, an ionic detergent, a non-ionic detergent, a zwitterionic detergent, a glyceride and a bile acid or salt thereof in a concentration ranging from about 0.5% to about 30% by wt of the composition and at least one phospholipid. In one embodiment, a novel composition comprising deoxycholic acid or a salt thereof at a concentration ranging from about 0.5% to about 30% by wt, and phosphatidylcholine at a concentration ranging from about 0.1% to about 2% by wt, in a cream base is also provided.

The present disclosure provides a preparation method of Wangzaozi polysaccharide and its application. The present disclosure provides an extraction and separation process of Wangzaozi polysaccharide, and high-content polysaccharide is obtained. The polysaccharide has the functions of lowering blood lipids, reducing body fat, local fat or fat body ratio, preventing, treating, improving or alleviating liver damage, etc.

Cosmetic composition comprising a conjugated compound consisting of a hexyl secondary alcohol, a polyether organic polymer and, optionally, a C2-C22 hydrocarbon chain, saturated or unsaturated, cis or trans, linear or branched, with at least two carboxyl groups and its use for removing subcutaneous fat deposits.

Provided herein are compositions containing, e.g., particles comprising a curcuminoid and cinnamaldehyde or a derivative thereof. For example, provided herein are compositions comprising a liposome comprising curcumin and cinnamaldehyde or a derivative thereof. Such compositions can be useful for, for example, inducing cell death of adipocytes in a subject and / or reducing subcutaneous fat in a subject.

The invention relates to an engineered exosome for local fat reduction and a preparation method thereof, and belongs to the field of biotechnology and medical beauty. Three fusion proteins, namely an Apelin-first scaffold protein, an NRG4-second scaffold protein and an FLRG-third scaffold protein, are simultaneously displayed on a membrane of the engineered exosome. The preparation method comprises the following steps: constructing a nucleic acid sequence for coding the three fusion proteins, cloning the nucleic acid sequence to an expression vector, introducing the expression vector into a mammal host cell, culturing, and separating and purifying from a cell supernatant to obtain the target exosome. The exosome can be further mixed with locally medicinal or cosmetically acceptable auxiliary materials to prepare local fat-reducing compositions such as gel, cream or essence. Three active proteins with complementary functions are synergistically delivered through a single exosome, glucose and lipid metabolism can be regulated and controlled in a multi-channel mode, muscles are maintained, the composition can act on subcutaneous adipose tissue after being smeared, and the fat reducing effect is achieved.

The present invention relates to a gas-generating micelle for reducing localized fat. In the present invention, by forming a micelle using a material having high biocompatibility and also introducing a cell-targeting ligand (peptide) onto the surface of the micelle, delivery to surrounding cells and tissues other than adipocytes can be minimized, and delivery into adipocytes can be maximized. The gas-generating micelle for reducing localized fat according to the present invention can be produced as an injectable preparation, and can be applied to local lipolysis supplements or diet beauty products that break down localized fat.

The application discloses application of sodium humate in preparation of a medicine for treating obesity, and relates to the technical field of biological medicine. The application finds that the sodium humate has the effect of treating obesity, and further combined with near-infrared photothermal treatment can effectively improve the treatment effect on obesity. It is detected that the sodium humate has excellent photothermal conversion performance and good photothermal stability, and this characteristic lays a key foundation for the sodium humate in combination with the near-infrared photothermal treatment of obesity. Experiments prove that the sodium humate can realize efficient photothermal conversion in the fat area, and provides a precise action mode for local fat intervention. Animal experiments prove that the sodium humate and the sodium humate combined with photothermal treatment can effectively reduce the degree of obesity. Meanwhile, the combined treatment can improve the distribution of adipose tissue, realize remodeling of the adipose phenotype, and especially can promote the browning of white adipose tissue.