The application relates to a
fusion protein and application thereof in the field of
biotechnology. A polypeptide fragment for specifically recognizing a single-molecule
phospholipid membrane and a polypeptide fragment for specifically recognizing a tissue or a
cell are connected to form a
fusion protein which can be specifically combined to a
fat body surface in a non-covalent manner, so that precise targeting of the
fat body is realized. The
fat body targeting
peptide segment can be widely used in the fields of precise
drug delivery and vaccine preparation, so as to be used for treating diseases such as
cancer, infectious diseases and metabolic diseases.
Lung tissues and
breast cancer cells are taken as target points, and good targeting of the fat body is realized.