4 results about "Fat body" patented technology

A kind of biotin or avidin labeled fat body and its preparation method, nano-carrier system. Biotin or avidin labeled fat body is prepared using specific amount of Bio-phospholipid or avidin-phospholipid, and the prepared fat body has the advantages of high purity, small particle size, good uniformity and high stability. Based on the biotin-avidin system, a nano-carrier system is constructed, which includes the biotin labeled fat body and the avidin modified target component. The system enables the fat body to carry any interested substance, such as viral recombinant protein, antibody and other protein drugs, nucleic acid drugs or small molecule drugs, etc., so as to be used for the treatment of diseases such as vaccines, cancer, infectious diseases and metabolic diseases.

The application relates to a fusion protein and application thereof in the field of biotechnology. A polypeptide fragment for specifically recognizing a single-molecule phospholipid membrane and a polypeptide fragment for specifically recognizing a tissue or a cell are connected to form a fusion protein which can be specifically combined to a fat body surface in a non-covalent manner, so that precise targeting of the fat body is realized. The fat body targeting peptide segment can be widely used in the fields of precise drug delivery and vaccine preparation, so as to be used for treating diseases such as cancer, infectious diseases and metabolic diseases. Lung tissues and breast cancer cells are taken as target points, and good targeting of the fat body is realized.

A neogambogic acid adiposome formulation, a preparation method therefor, and use thereof. The neogambogic acid adiposome formulation comprises a monomolecular phospholipid membrane, and neogambogic acid and neutral lipid which are wrapped in the monomolecular phospholipid membrane. The adiposome formulation has good bioavailability and safety, thereby improving the anti-tumor effect.

Disclosed is a lyophilization method for an adiposome. In the lyophilization process, a lyophilization protective agent is employed to protect the adiposome. The method utilizes lipid materials that are natural or possess high biocompatibility, thereby ensuring effective emulsification during adiposome preparation and enhancing biological safety. The disclosed method establishes a lyophilization process suitable for adiposome-based delivery platforms, in which the adiposome-based delivery platform is preserved in the form of a lyophilized powder. The lyophilized adiposome-based delivery platform is resistant to structural collapse, and upon reconstitution with water, the pre-lyophilization morphology thereof is restored with minimal variations in particle size and polydispersity index. This method enables direct use in related biomedical applications. The lyophilization process improves the storage stability, transportability, and ease of use of the adiposome-based delivery platform.