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225 results about "White adipose tissue" patented technology
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White adipose tissue (WAT) or white fat is one of the two types of adipose tissue found in mammals. The other kind is brown adipose tissue. In healthy, non-overweight humans, white adipose tissue composes as much as 20% of the body weight in men and 25% in women. Its cells contain a single large fat droplet, which forces the nucleus to be squeezed into a thin rim at the periphery. They have receptors for insulin, sex hormones, norepinephrine, and glucocorticoids.
Generation of adipose tissue and adipocytes
The invention provides novel methods by which adipose tissue, preadipocytes, and adipocytes can be generated for research purposes, and methods for identifying cell populations that can proliferate and differentiate into adipocytes in vivo. The invention further provides a means for the in vivo derivation of “designer” or “customized” adipose tissue, preadipocytes, and adipocytes. Also provided are methods for identifying agents that affect adipocytes and adipose tissue, as well as the agents themselves. In particular, the present invention allows for creation of tissues and cells that can be used to screen for agents useful for treating human disorders associated with adipose tissue, including obesity, metabolic syndrome, and diabetes.
Owner:LOREM VASCULAR PTE LTD
Ultrasonic treatment and imaging of adipose tissue
A system for the destruction of adipose tissue utilizing high intensity focused ultrasound (HIFU) within a patient's body. The system comprises a controller for data storage and the operation and control of a plurality of elements. One elements is a means for mapping a human body to establish three dimensional coordinate position data for existing adipose tissue. The controller is able to identify the plurality of adipose tissue locations on said human body and establish a protocol for the destruction of the adipose tissue. A HIFU transducer assembly having one or more piezoelectric element(s) is used along with at least one sensor wherein the sensor provides feed back information to the controller for the safe operation of the piezoelectric element(s). The sensor is electronically coupled to the controller, and the controller provides essential treatment command information to one or more piezoelectric element(s) based on positioning information obtained from the three dimensional coordinate position data.
Owner:LIPOSONIX
Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair
Methods and compositions for directing adipose-derived stromal cells cultivated in vitro to differentiate into cells of the chondrocyte lineage are disclosed. The invention further provides a variety of chondroinductive agents which can be used singly or in combination with other nutrient components to induce chondrogenesis in adipose-derived stromal cells either in cultivating monolayers or in a biocompatible lattice or matrix in a three-dimensional configuration. Use of the differentiated chondrocytes for the therapeutic treatment of a number of human conditions and diseases including repair of cartilage in vivo is disclosed.
Owner:COGNATE BIOSERVICES
Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof
InactiveUS6555374B1Enhance and inhibit differentiationIncrease differentiationMicrobiological testing/measurementMammal material medical ingredientsGerm layerSmooth muscle
The invention relates to methods and compositions for the differentiation of stromal cells from adipose tissue into hematopoietic supporting stromal cells and myocytes of both the skeletal and smooth muscle type. The cells produced by the methods are useful in providing a source of fully differentiated and functional cells for research, transplantation and development of tissue engineering products for the treatment of human diseases and traumatic tissue injury repair.
Owner:COGNATE BIOSERVICES
Devices for harvesting and homogenizing adipose tissue containing autologous endothelial cells
InactiveUS6020196AExpand the populationEasy to operateBioreactor/fermenter combinationsElectrotherapyAmbient pressureWhite adipose tissue
Disclosed herein are methods for harvesting adipose tissue so as to preserve an increased population of viable microvascular endothelial cells. Adipose tissue containing microvascular endothelial cells is harvested using a collection apparatus incorporating an elongate cannula having apertures with tissue cutting edges. A sub-ambient pressure is applied to a lumen in the cannula to draw the adipose tissue through the aperture where it is then severed using the cutting edge to disrupt the connective adipose matrix. This harvesting provides a cleaner, more homogeneous sample of adipose tissue, thereby increasing the population of viable microvascular endothelial cells obtained through further processing. Rapid and easy methods for the further homogenization of the harvested adipose tissue are also disclosed.
Owner:EDWARDS LIFESCIENCES CORP
Method and apparatus for treatment of adipose tissue
ActiveUS8133191B2Ultrasonic/sonic/infrasonic diagnosticsUltrasound therapySubcutaneous adipose tissueSkin surface
The invention provides methods and apparatuses for the treatment of adipose tissue. The methods comprise application of ultrasound energy to a region of adipose tissue, and the apparatuses comprise at least one source of ultrasound energy configured to direct ultrasound energy through a skin surface into the subcutaneous adipose tissue. In one embodiment, a pressure gradient is created in the region generating relative movement between fat cell constituents having different densities. In another embodiment, a protrusion of skin and underlying adipose tissue containing is formed and ultrasound energy is radiated into the adipose tissue in the protrusion. In another embodiment, an RF electric field is generated inside a region of adipose tissue together with the ultrasound energy.
Owner:SYNERON MEDICAL LTD
Methods of using adipose tissue-derived cells in augmenting autologous fat transfer
ActiveUS20050025755A1Rapid and reliableHigh yieldBiocideElectrotherapyBreast augmentationAutologous Fat Transfer
Methods of treating patients for conditions such as breast augmentation, soft tissue defects, and urinary incontinence, are described. The methods include removing adipose tissue from a patient, processing a portion of the adipose tissue to obtain a substantially isolated population of regenerative cells, mixing the regenerative cells with another portion of adipose tissue to form a composition, and administering the composition to the patient from which the adipose tissue was removed.
Owner:LOREM VASCULAR PTE LTD
Adipose tissue-derived stromal cell that expresses characteristics of a neuronal cell
The invention is in the area of pleuripotent stem cells generated from adipose tissue-derived stromal cells and uses thereof. In particular, the invention includes isolated adipose tissue derived stromal cells that have been induced to express at least one phenotypic characteristic of a neuronal, astroglial, hematopoietic progenitor, or hepatic cell. The invention also includes an isolated adipocyte tissue-derived stromal cell that has been dedifferentiated such that there is an absence of adipocyte phenotypic markers.
Owner:VETSTEM BIOPHARMA INC
Systems and methods for treating patients with collagen-rich material extracted from adipose tissue
InactiveUS20030162707A1Cosmetic preparationsConnective tissue peptidesBrown adipose tissueWhite adipose tissue
Compositions, methods, and systems are disclosed for using collagen-rich material, derived from adipose tissue, that is placed directly into a recipient along with such additives necessary to promote, engender, or support a therapeutic, structural, or cosmetic benefit. The compositions may be obtained during the course of a single surgical procedure, and may be administered to the patient immediately after adipose tissue is removed from a patient, such as within hours or days from being withdrawn from the patient.
Owner:LOREM VASCULAR PTE LTD
Methods of using adipose tissue-derived cells in augmenting autologous fat transfer
ActiveUS7651684B2Diminished and non-existent needRapid and reliable deviceBiocideElectrotherapyAutologous Fat TransferBreast augmentation
Methods of treating patients for conditions such as breast augmentation, soft tissue defects, and urinary incontinence, are described. The methods include removing adipose tissue from a patient, processing a portion of the adipose tissue to obtain a substantially isolated population of regenerative cells, mixing the regenerative cells with another portion of adipose tissue to form a composition, and administering the composition to the patient from which the adipose tissue was removed.
Owner:LOREM VASCULAR PTE LTD
Use of adipose tissue-derived stromal stem cells in treating fistula
Provided herein are novel methods and compositions utilizing adipose tissue-derived stromal stem cells for treating fistulae.
Owner:AUTONOMOUS UNIVERSITY OF MADRID +1
Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions
InactiveUS20050008626A1Relieves operatorBiocideGenetic material ingredientsMedicineWhite adipose tissue
Cells present in processed lipoaspirate tissue are used to treat patients, including patients with cardiovascular conditions, diseases or disorders. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of stem cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, cells present in processed lipoaspirate are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic cardiovascular benefit.
Owner:LOREM VASCULAR PTE LTD
Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease
InactiveUS20110206646A1Ease and low morbidityAvoid contaminationBiocideMetabolism disorderProgenitorLymphatic vessel
Aspects of the invention provides methods for preparing and using adipose-tissue-derived stem and progenitor cells, adipose-tissue-derived lymphatic endothelial cells, and cells capable of differentiating into lymphatic endothelial cells to treat disorders of the lymphatic system and to modulate expansion, repair, and / or regeneration of the lymphatic system. The invention further provides using adipose-tissue-derived lymphatic endothelial cells and cells capable of differentiating into lymphatic endothelial cells for delivery of therapeutic agents to tumor cells as a means for treating malignant disease, and assays to screen for drugs that modulate lymphatic system expansion, repair or regeneration.
Owner:LOREM VASCULAR PTE LTD
Methods for the upregulation of glut4 via modulation of PPAR delta in adipose tissue and for the treatment of disease
The present invention is directed to novel compositions and their application as pharmaceuticals for the treatment of disease. Methods of upregulation of GLUT4 via activation of peroxisome proliferator activated receptor delta activity in the adipose tissue of a human or animal subject are also provided, for the treatment of conditions such as diabetes, obesity, insulin resistance, metabolic syndrome, and others in which a reduction in insulin resistance, an increase in glucose utilization, a reduction in visceral fat, a reduction in triglyceride (TG) levels, or an increase in levels of high-density lipoprotein (HDL), is beneficial.
Owner:KALYPSYS INC
Tissue transfer systems
ActiveUS8632498B2Precision injectionEasy to controlMedical devicesFlow monitorsGuidance systemTransfer system
Devices and methods for tissue transfer are described where a cannula may be inserted into the breast of a subject at one of several points of entry. Insertion of the cannula into the breast may be accomplished by using a guidance system to distinguish between tissue types. Once desirably positioned, the cannula may be withdrawn from the breast while automatically (or manually) injecting the fat in multiple deposits of adipose tissue or fat such that the deposited fat remains within the tract formed by the withdrawn cannula. Multiple tracts of the deposited fat may be injected within the breast until the breast has been desirably remodeled and / or augmented.
Owner:LIFECELL
Method for separating and extracting stem cells from placenta, umbilical cord or adipose tissue
ActiveCN101693884AEasy accessSpecification acquisitionSkeletal/connective tissue cellsArtificially induced pluripotent cellsFicollDisease
The invention relates to a method for separating and extracting stem cells from a placenta, umbilical cord or adipose tissue, which comprises the following process steps: firstly mixing the placenta, umbilical cord or adipose tissue and a cell maintenance fluid according to the proportion by weight of 2.5-4:1, putting the mixture into a tissue crushing barrel, adding collagenase after crushing, uniformly mixing, hatching at the temperature of 37 DEG C, filtering, adding a precipitator, sucking a supernatant fluid after settling, centrifuging, removing the supernatant fluid, adding concentrated cells into a liquid of diatrizoate sodium-ficoll 400#, then centrifuging, collecting 10-15 ml of intermediate cell layer, washing with the cell maintenance fluid, counting the collected cells, and providing the cells for clinical use when the cell survival ratio is more than or equal to 95 percent. The invention not only realizes the separation and the extraction of all stem cells from the placenta, umbilical cord or adipose tissue, but also realizes industrialized production, and enables doctors to conveniently, safely and canonically obtain the adult stem cells in clinic and use the adult stem cells for treating the diseases of patients as using medicaments, thereby solving the bottleneck problem of difficult obtainment of adult stem cells in clinic and popularizing a cell treatment technology.
Owner:NINGXIA ZHONGLIANDA BIOPHYSICS
Compositions and methods for implantation of adipose tissue and adipose tissue products
ActiveUS20110183001A1Non toxicPharmaceutical delivery mechanismMammal material medical ingredientsWhite adipose tissueBiological organism
The invention provides compositions and methods for the preparation of biocompatible biomaterials from adipose tissue. Biocompatible biomaterials are cellular or acellular biomaterials. The invention further provides methods of use of the biocompatible biomaterials.
Owner:THE JOHN HOPKINS UNIV SCHOOL OF MEDICINE
Reduction of adipose tissue
ActiveUS20160310444A1Reducing subcutaneous adipose tissueMetabolism disorderPharmaceutical delivery mechanismBrown adipose tissueWhite adipose tissue
Owner:10XBIO LLC
Adipose tissue derived stromal cells for the treatment of neurological disorders
Owner:VETSTEM BIOPHARMA INC
Method of using abscisic acid to treat diseases and disorders
Owner:VIRGINIA TECH INTPROP INC
Multipotent stem cells derived from human adipose tissue and cellular therapeutic agents comprising the same
ActiveUS7807461B2High proliferation ratePositive immunological responsesNervous disorderSkeletal disorderSerum free mediaBrown adipose tissue
Owner:RNL BIO
Compositions and methods of use of targeting peptides against placenta and adipose tissues
The present invention concerns compositions comprising and methods of identification and use of targeting peptides for placenta or adipose tissue. In certain embodiments, the targeting peptides comprise part or all of SEQ ID NO:5-11, SEQ ID NO:13-22 OR SEQ ID NO:144. The peptides may be attached to various therapeutic agents for targeted delivery. Adipose-targeting peptides may be used in methods for weight control, inducing weight loss and treating lipodystrophy syndrome. Adipose-targeting may also be accomplished using other binding moieties selectively targeted to adipose receptors, such as a prohibitin receptor protein complex. Placenta-targeting peptides may be used to interfere with pregnancy, induce labor and / or for targeted delivery of therapeutic agents to placenta and / or fetus. In other embodiments, receptors identified by binding to placenta-targeting peptides may be used to screen compounds for potential teratogenicity. An exemplary placental receptor is FcRn / β2M, and compounds that bind to FcRn / β2M are potential teratogens.
Owner:BOARD OF RGT THE UNIV OF TEXAS SYST
Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions
InactiveUS20090269315A1Relieves operatorBiocideArtificial cell constructsMedicineWhite adipose tissue
Cells present in processed lipoaspirate tissue are used to treat patients, including patients with cardiovascular conditions, diseases or disorders. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of stem cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, cells present in processed lipoaspirate are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic cardiovascular benefit.
Owner:LOREM VASCULAR PTE LTD
Tissue transfer systems
ActiveUS20130131635A1Easy to controlPrecision injectionDiagnosticsPharmaceutical delivery mechanismGuidance systemTransfer system
Devices and methods for tissue transfer are described where a cannula may be inserted into the breast of a subject at one of several points of entry. Insertion of the cannula into the breast may be accomplished by using a guidance system to distinguish between tissue types. Once desirably positioned, the cannula may be withdrawn from the breast while automatically (or manually) injecting the fat in multiple deposits of adipose tissue or fat such that the deposited fat remains within the tract formed by the withdrawn cannula. Multiple tracts of the deposited fat may be injected within the breast until the breast has been desirably remodeled and / or augmented.
Owner:LIFECELL
System and method for image-based quantification of white and brown adipose tissue at the whole-body, organ and body-region levels
InactiveUS20180165808A1Increases default detection rateHigh level of detectionImage enhancementImage analysisWhole bodyMedicine
A system and method for automatically detecting and quantifying adiposity distribution is presented herein. The system detects, segments and quantifies white and brown fat adipose tissues at the whole-body, body region, and organ levels.
Owner:UNIV OF CENT FLORIDA RES FOUND INC
Method for separating human adipose-derived stem cells from human adipose tissues
ActiveCN104357387AHigh purityReduced differentiation inductionSkeletal/connective tissue cellsParenchymaBrown adipose tissue
The invention relates to the field of cell engineering and particularly relates to a method for separating human adipose-derived stem cells from human adipose tissues. According to the method, by adding a small amount of low-molecular-weight heparin calcium into normal saline, a mixed solution is obtained and used as a cleaning fluid to clean the human adipose tissues, residual impurities such as red blood cells in the human adipose tissues can be well removed and thus human adipose-derived stem cells with relatively higher purity can be separated, the content of the parenchyma cell is significantly reduced, the differentiation induction of the human adipose-derived stem cells is facilitated, the consumption amounts of collagenase I, trypsase and a serum-free culture medium can be reduced and the cost of the process is also decreased. In addition, by centrifuging and digesting the human adipose tissues for 1 hour at a speed of 150r / min, the human adipose-derived stem cells with significantly better activity can be obtained.
Owner:深圳市赛欧细胞技术有限公司
Adipose tissue source exosome gel, preparation method and application
ActiveCN106676065AAvoid time consumingAvoid potential malignant cancer and other disadvantagesArtificial cell constructsSkeletal/connective tissue cellsNude mouseExosome
The invention belongs to the technical field of tissue engineering and particularly relates to adipose tissue source exosome gel, a preparation method and application. The adipose tissue source exosome gel is characterized by comprising an adipose tissue exosome and a solvent in a mass-volume ratio of (1-3):1, wherein an aquogel is served as the solvent. The preparation method comprises the following steps: treating an adipose tissue, acquiring an adipose tissue extract, acquiring the adipose tissue source exosome and preparing the adipose tissue source exosome gel. The adipose tissue source exosome gel is mainly used for promoting the fat regeneration. The invention particularly relates to the exosome extracted from the adipose tissue. When the exosome is applied to the nude mouse body, a new mature adipose tissue can be generated. The defects of insufficient seed cell resource, potential malignant transformation and tumor formation of the traditional tissue engineering can be overcome; the exosome has the advantage of easiness in storage and transportation; a new thought is supplied for acquiring the fat for the tissue engineering.
Owner:成都世联康健生物科技有限公司
Human-derived adipose tissue-derived stem cell factor, preparation method and application thereof
ActiveCN106701672AIncrease productionEfficient removalCosmetic preparationsToilet preparationsSkin InjuryBrown adipose tissue
The invention discloses a human-derived adipose tissue-derived stem cell factor, a preparation method and application thereof, and particularly discloses a method for culturing a human-derived adipose tissue-derived stem cell factor. The method comprises the following steps: culturing human adipose tissue-derived stem cells in a high-coenzyme serum-free culture medium until the cell confluence is 75-85 percent, and collecting supernatant. The invention further discloses a method for preparing human-derived adipose tissue-derived stem cell factor concentrated solution, the concentrated solution prepared by the method, further application of the concentrated solution, a cell factor concentrate prepared by the method, cosmetics and medicines prepared from the cell factor concentrate. The concentrated solution prepared by the method has high content of adipose tissue-derived stem cell factors and stable quality, and a product prepared by combining the concentrated solution with other materials in a specific ratio has a good effect of repairing skin injury; and the method is simple and feasible, is suitable for large-scale production, and has excellent market prospect.
Owner:中科领康(广州)医疗有限公司
Cryopreservation liquid and cryopreservation method for adipose tissue-derived mesenchymal stem cells ( ADSC)
ActiveCN103070161AImprove recovery rateDoes not affect growth characteristicsDead animal preservationVitamin CBrown adipose tissue
The invention relates to a cryopreservation liquid and a cryopreservation method for adipose tissue-derived mesenchymal stem cells ( ADSC). The cryopreservation liquid is composed of the following materials: 3 to 10 mg / ml of vitamine C, 2 to 8 mg / ml of vitamin E, 2 to 8 mg / ml of lipoic acid, 5 to 20 volume percent of human autoserum, and DMEM-LG culture medium in balancing amount. The cryopreservation liquid for ADSC does not contain animal serum and DMSO, and is composed of human autoserum, lipoic acid, vitamin E, vitamin C and other main materials. A cell cryopreserved with the cryopreservation liquid has the advantages of high palinesthesia rate, no impact on cell growth characteristic, and maintanience of stem cell pluripotency after palinesthesia.
Owner:冯文峰
Nuclear receptor binding agents
InactiveUS20100267767A1Increased energy expenditureReduce morbidityBiocideNervous disorderAdipogenesisInsulin resistance
The present invention relates to methods for prevention and / or treatment of metabolic disorders, post-menopausal obesity and conditions associated with high fat diet consumption including, obesity, body weight gain, fat mass formation, bone mineral content reduction, white adipose tissue weight gain, increased cholesterol levels, increased leptin levels, insulin resistance, type II diabetes, increased blood glucose levels, inflammatory diseases, cardiovascular diseases, fatty liver condition (accumulation of fat in the liver), decreased uncoupling protein-1 (UCP-1) levels and increased lipogenesis.
Owner:GTX INCORPORATED
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