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3 results about "White adipose tissue" patented technology
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White adipose tissue (WAT) or white fat is one of the two types of adipose tissue found in mammals. The other kind is brown adipose tissue. In healthy, non-overweight humans, white adipose tissue composes as much as 20% of the body weight in men and 25% in women. Its cells contain a single large fat droplet, which forces the nucleus to be squeezed into a thin rim at the periphery. They have receptors for insulin, sex hormones, norepinephrine, and glucocorticoids.
Use of dickkopf-related protein 3 modulators in the manufacture of metabolic regulation products
This invention discloses the application of a Dickkopf-related protein 3 regulator in the preparation of metabolic regulation products. This invention is the first to propose and verify the novel functions of exogenous Dickkopf-related protein 3 in the regulation of adipose thermogenesis and the regulation of energy metabolism homeostasis in the body. It clarifies that it can promote lipid decomposition in adipocytes, enhance the thermogenic activity of adipocytes, promote the browning of white adipose tissue, and exert its effects through a non-UCP1-dependent pathway that promotes the stability of SERCA2b protein. This provides a new target and technical means for the intervention of lipid metabolism disorders such as obesity, type 2 diabetes, metabolic syndrome, and non-alcoholic fatty liver disease.
Owner:NANJING MATERNITY & CHILD HEALTH CARE HOSPITAL
An aptamer targeting the growth hormone receptor and its uses
PendingCN122081334ASmall molecular weightlow immunogenicityPharmaceutical non-active ingredientsBiological testingAptamerSomatotropic hormone
This invention provides an aptamer targeting the growth hormone receptor and its uses, the nucleotide sequence of which is shown in SEQ ID NO.1 or SEQ ID NO.2. This invention utilizes a modified SELEX technique to perform multiple rounds of screening targeting recombinant GHR protein, obtaining specific nucleic acid aptamers with high affinity for GHR (KD values at the micromolar level). In vivo distribution experiments show that the fluorescently labeled aptamer can efficiently and specifically accumulate in white adipose tissue (including inguinal and gonadal fat) at the in vivo level, exhibiting excellent tissue targeting. The nucleic acid aptamer and its derivatives of this invention can be used to prepare drugs or diagnostic reagents targeting adipose tissue, for example, for the prevention or treatment of metabolic diseases such as obesity, type 2 diabetes, fatty liver, hyperlipidemia, or cardiovascular disease.
Owner:SICHUAN AGRI UNIV
A white fat browning related tsrna molecule and application thereof
This invention discloses a tsRNA molecule associated with the browning of white adipose tissue and its applications. This invention provides a potential therapeutic target for the prevention and / or treatment of obesity and related metabolic diseases.
Owner:BEIJING HOSPITAL