Application of Plitidepsin in preparation of medicine for treating obesity and improving glucose metabolism

Through Plitidepsin targeting eEF1A2, the technical difficulties of obesity and improvement of sugar metabolism were solved, and weight and fat reduction, as well as glucose tolerance and insulin sensitivity were achieved, without causing liver, kidney or heart side effects.

CN120478341AActive Publication Date: 2025-08-15CAPITAL UNIVERSITY OF MEDICAL SCIENCES +1
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Patent Information

Application Number
CN202510628203.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-05-15
Publication Date
2025-08-15
Estimated Expiration
2045-05-15

AI Technical Summary

Technical Problem

The prior art lacks effective ways to control obesity and improve sugar metabolism, especially the role of Plitidepsin, an inhibitor against eEF1A2, in this regard has not been fully explored.

Method used

Plitidepsin is used as an eEF1A2 inhibitor, and by targeting eEF1A2, it reduces body weight, fat content, especially the white adipose tissue around the groin and epididymis, improving glucose tolerance and insulin sensitivity.

Benefits of technology

Plitidepsin significantly reduced the weight and fat content of db/db mice, enhanced glucose tolerance and insulin sensitivity, and did not cause significant liver and kidney damage or cardiac abnormalities.

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Abstract

The invention relates to the technical field of novel application of targeted drugs, in particular to application of Plitidepsin in preparation of drugs for treating obesity and improving glucose metabolism. It can be known through exploration that plitidepsin can reduce the weight and fat content of a treated object and the content of white adipose tissue around inguinal white fat and epididymis, and meanwhile, the sugar tolerance and insulin sensitivity of the treated object can be improved. Therefore, the plitidepsin can be used for preparing the medicine for treating obesity and improving glucose metabolism.
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