11 results about "Aortic wall" patented technology

The invention discloses a proximal anastomosis auxiliary device in coronary artery bypass grafting, and relates to the technical field of medical instruments. Comprising a puncture needle, a puncture cannula and an annular compressor. The puncture needle is sleeved with the puncture cannula, and a bulged ball is arranged at the head end of the puncture cannula; the annular compressor is arranged outside the puncture cannula in a sleeving mode and can slide in the axial direction, a compression ring with a notch is arranged at the head end of the annular compressor, and the inner diameter of the compression ring is smaller than the outer diameter of the bulging ball. During puncture, the annular compressor is pressed down after puncture enters the aorta, and the compression ring and the bulging ball cooperate to clamp and close a puncture point to achieve blood-free operation; after the aorta wall in the compression ring is cut off, the bridge vessel is matched with the aorta, and the suture passes through the compression ring together; after suturing is completed, the annular compressor is rotated, the suture retreats from the notch, the suture is tightened and knotted after the whole device is withdrawn, and anastomosis is completed. The aorta forceps clip operation is avoided, the plaque falling risk is eliminated, anastomosis can be completed only through a single hole, operation is easy and convenient, hemostasis is reliable, and cost is low.

The invention provides a biomarker composition and an application thereof. The biomarker composition comprises the following proteins: MMP12, UMOD, HbA1c, FGF9, NINJ1 and PRSS8. According to the biomarker composition provided by the invention, through combination of matrix metalloproteinase 12, uromodulin, glycosylated hemoglobin, FGF9, NINJ1 and serine protease 8, the problem of lack of a specific marker for aortic wall structure damage in the prior art is solved.

This invention relates to the field of finite element stress calculation technology, specifically to an aortic stress calculation system based on finite element analysis. In this invention, multiple sets of aortic displacement vectors and element stress vectors are spliced ​​into a response matrix according to the sequence of nodal degrees of freedom and element numbering. The Gram-Schmidt orthogonalization method is introduced to process the retained vectors, compressing the directional coincident components and linearly correlated components, resulting in stronger stability of the reduced-order basis space and smoother conversion of high-dimensional discrete equations to low-dimensional expressions. The Newton-Raphson algorithm is introduced in the path state update stage, where load step difference, nodal displacement increment, and integral point stress tensor are continuously recorded. The path turning state and load propagation form are adjusted synchronously. Facing high internal pressure, large deformation, and nonlinear response scenarios, peak tracking continuity is stronger, the frequency of solving repeated integral models is reduced, the high-risk area of ​​the aortic wall is more concentrated, and the numerical support for scheme comparison, parameter scanning, and risk pre-assessment is more sufficient.

The present application relates to cardiovascular disease medical equipment technical field, disclose a kind of aortic covered stent, the aortic covered stent includes support stent, closure layer and elastic connecting layer, closure layer is spaced apart and is set to the outer periphery of support stent, closure layer includes first covering, elastic connecting layer is connected between support stent and closure layer, blood flow can flow between support stent and closure layer;With aortic pulsation, closure layer and elastic connecting layer produce elastic deformation, so that first covering is always close to aortic and the blood vessel wall adjacent to closure layer.The aortic covered stent can be better applied to the special form of ascending aortic dissection and the mechanical characteristics of blood flow, higher stability, better closure for ascending aortic wall.

The application discloses a blood pressure calculation method and equipment based on cross-scale fluid-solid coupling and considering nonlinear biomechanical characteristics of an aorta, and the method comprises the following steps: establishing a three-dimensional ideal aorta geometric model; establishing a zero-dimensional heart lumped parameter model to simulate the process that the heart pumps blood to the aorta inlet through periodic contraction and diastole; establishing a zero-dimensional three-element Windkessel model of small arteries to simulate blood flow microcirculation of peripheral small arteries; establishing a blood vessel wall biomechanical model containing residual stress of the aorta wall and active contraction of smooth muscle cells to obtain a pressure-radius relationship of the aorta wall as a fluid wall boundary condition to simulate the change process of the aorta radius in blood circulation; and coupling the three-dimensional ideal geometric model of the aorta, the zero-dimensional heart lumped parameter model and the zero-dimensional three-element Windkessel model to construct a cross-scale fluid-solid coupling system of hemodynamics, and the blood pressure in the aorta is calculated through iterative solution.

The invention discloses an application of valerian triester in preparation of products for preventing and treating aortic dissection, which can reduce the occurrence rate of aortic events, relieve the reduction of survival rate caused by aortic dissection, inhibit aortic dilatation caused by aortic dissection, reduce the number of elastic fiber fractures caused by aortic dissection and improve the survival rate of aortic dissection. The hematoma and the false cavity between aortic walls caused by the aortic dissection are improved, and the structural damage of the aortic walls caused by the aortic dissection is improved. According to the technical scheme provided by the invention, a brand new compound option is provided for the drug treatment of the aortic dissection.

The three-legged aortic valve forceps comprise three supporting arms and an outer ring, the supporting arms are elastic and can be folded inwards, measuring rings are connected to the outer sides of the supporting arms in a sleeving mode, grabbing parts are arranged at the lower ends of the supporting arms, the upper ends of the supporting arms are fixedly connected, the lower sides of the supporting arms are separated and unfolded outwards, and the outer ring is arranged on the outer ring. The valve leaflet clamping device has the advantages that the valve leaflet can be rapidly and safely clamped and fixed, and the inner diameter of a prosthesis for replacing the aorta wall can be measured in an auxiliary mode.

An auxiliary device for proximal aortic anastomosis in coronary artery bypass grafting (CABG) includes a puncture needle, a puncture cannula, a cutting cannula, and a ring compressor. The puncture cannula is fitted over the puncture needle, with a bulging ball at its tip and an annular groove at its tail end. The ring compressor is fitted over the puncture cannula and can slide axially; its tip has a notched compression ring with an inner diameter smaller than the outer diameter of the bulging ball. During puncture, after the aorta is penetrated, the ring compressor is pressed down, and the compression ring and bulging ball work together to clamp the puncture site, achieving a bloodless procedure. The cutting cannula is then pressed down, and the aortic wall within the compression ring is removed. The graft vessel is then anastomosed to the aorta, with the suture passing through the compression ring. After suturing, the ring compressor is rotated, and the suture exits through the notch. The entire device is then withdrawn, and the suture is tightened and knotted to complete the anastomosis. This invention avoids aortic clamping, eliminates the risk of plaque dislodgement, requires only a single port for anastomosis, and is simple to operate with reliable hemostasis.

This invention discloses the application of targeting the PDGFD gene in the treatment of hypertension. This invention demonstrates in a mouse model of angiotensin II-induced hypertension that systemic knockout... Pdgfd It can significantly lower blood pressure, reduce aortic wall thickening, and decrease the vessel wall-to-lumen ratio. In vitro vascular ring experiments confirmed that knocking out PDGFD can enhance vascular elasticity. In summary, PDGFD is a key new target for regulating blood pressure, and its inhibitors or gene interventions can be used to prepare antihypertensive drugs, providing new strategies for precision treatment of hypertension.

The invention discloses an application of a targeted PDGFD gene in hypertension treatment. In an angiotensin II induced hypertension mouse model, it is proved that whole-body knockout of Pdgfd can significantly reduce blood pressure, relieve aorta vascular wall thickening and reduce the vascular wall-cavity ratio. An in-vitro vascular ring experiment proves that the blood vessel elasticity can be enhanced by knocking out the PDGFD. In conclusion, the PDGFD is a key new target for regulating and controlling blood pressure, and an inhibitor or a gene intervention means of the PDGFD can be used for preparing antihypertensive drugs, so that a new strategy is provided for precise treatment of hypertension.

The invention discloses a biomarker for predicting the onset risk of aortic dissection, a kit and application. The invention provides application of a reagent for detecting the SERPINE1 level of peripheral blood in preparation of products for aortic dissection attack risk prediction, early screening, diagnosis or curative effect monitoring. The marker and the related detection kit can be used for predicting the occurrence risk of the aortic dissection, and are not limited to diagnosis of the occurred dissection; the method is suitable for screening and dynamic follow-up visit of high-risk groups; the operation is simple and convenient, and a detection sample can be obtained through peripheral blood; the aortic wall pathological remodeling and fibrinolytic / matrix stability change can be reflected. Clinical sample verification shows that the method for predicting the onset risk of the aortic dissection through the SERPINE1 level of the peripheral blood has relatively high sensitivity and specificity, and relatively high clinical application value and application prospect are shown.