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Artificial endovascular stent and preparation method thereof

A technology of artificial blood vessels and inner stents, which is applied in the field of medical devices to achieve the effects of increasing flexibility, no heat generation, and strong flexibility

Inactive Publication Date: 2005-01-26
ZHONGSHAN HOSPITAL FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, the intravascular stents used in the existing domestic research institutes are nickel-titanium alloy self-expanding stents, and the materials of artificial blood vessels include polyester, silk, polyester-silk blended weaving and silica gel, and the integration methods are all hand-sewn. Materials and preparation methods make the developed artificial vascular stents have some defects in flexibility, caliber size and biocompatibility

Method used

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  • Artificial endovascular stent and preparation method thereof
  • Artificial endovascular stent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 1. Preparation of Nitinol Stents

[0031] According to conventional methods, sponge nickel (Ni) and titanium (Ti) are pressed into electrodes, smelted in a consumable furnace, and the smelted consumable ingot is induction remelted to obtain a nickel-titanium alloy ingot, wherein the Ni content is 51.8%, The Ti content is 47.5%. The nickel-titanium alloy ingot was hot-rolled, hot-swaged and cold-drawn to produce a nickel-titanium alloy wire with a diameter of 0.4 mm.

[0032] Use the above-mentioned nickel-titanium alloy monofilament to weave a rough diamond-shaped mesh stent according to the sinusoidal method, and then go through the procedures of setting, welding, heat treatment (three times in total, 400-500 ° C, blued), pickling, cleaning, drying and inspection Made into a finished product. The nickel-titanium alloy stent has a length of 6 cm and a diameter of 11 mm, braided in a rhombus shape, with 7 rhombus peaks on each circumference, and each rhombus has a leng...

Embodiment 2

[0038] 1. Fabrication of Nitinol stents

[0039] According to conventional methods, sponge nickel (Ni) and titanium (Ti) are pressed into electrodes, smelted in a consumable furnace, and the smelted consumable ingot is induction remelted to obtain a nickel-titanium alloy ingot, wherein the Ni content is 52.8%. , Ti content is 46.5%. The nickel-titanium alloy ingot is hot-rolled, hot-swaged and cold-drawn to produce a nickel-titanium alloy wire with a diameter of 0.35 mm.

[0040] Use the above 0.35mm nickel-titanium alloy wire monofilament to weave into a rhomboid mesh stent with a certain diameter and length according to the sinusoidal method. Washing, cleaning, drying and inspection processes make finished products. The obtained nickel-titanium alloy stent has a length of 4 cm and a diameter of 8 mm, and is braided in a rhombus shape. There are 6 rhombus peaks on each circumference, and the length of each rhombus is 1 cm.

[0041] 2. Fabrication of expanded polytetrafluoroe...

Embodiment 3

[0046] 1. Fabrication of Nitinol stents

[0047] According to conventional methods, sponge nickel (Ni) and titanium (Ti) are pressed into electrodes, smelted in a consumable furnace, and the smelted consumable ingot is induction remelted to obtain a nickel-titanium alloy ingot, wherein the Ni content is 55.8%, The Ti content is 43.5%. The nickel-titanium alloy ingot is hot-rolled, hot-swaged and cold-drawn to produce a nickel-titanium alloy wire with a diameter of 0.45 mm.

[0048] Use the above-mentioned nickel-titanium alloy monofilament to weave into a rough mesh stent with a certain diameter and length in the form of a rhombus according to the sinusoidal curve method, and then go through setting, welding, heat treatment (three times in total, 400-500 ° C, blued), pickling, cleaning , drying and inspection processes to make finished products. The obtained nickel-titanium alloy stent has a length of 10 cm and a diameter of 15 mm, and is braided in a rhombus shape, with 8 r...

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Abstract

The invention belongs to the medical appliance field, particularly relates to an artificial endovascular stent and method for preparing thereof. The invention adopts tunica vasculosa made from varicosity Teflon and nickel-titanium alloy stent, and makes domestically produced artificial endovascular stents for the intracavity therapy of aneurism. The invention improves the performance of existing artificial endovascular stents, presents a small caliber, fits the windings of arteries, and improves the flexibility and biocompatibility. The stent is nontoxic, nonirritating for tissues, non-pyretogenic, non-sensitizing, non-teratogenic, and does not induce thrombosis in arteriae, thus reduces the direct damages to aorta walls.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to an artificial intravascular stent and a preparation method thereof. Background technique: [0002] Aneurysm refers to the gradual expansion and thinning of the arterial wall under the impact of blood flow, including descending aortic aneurysm, abdominal aortic aneurysm, aortic dissection aneurysm and peripheral aneurysm, etc. If not treated in time, aneurysms, especially aortic aneurysms, The tumor will progressively increase and eventually rupture and die, which is extremely harmful to the health of the population. With the increase of the proportion of my country's elderly population, the incidence of hypertension, hyperlipidemia and atherosclerosis is gradually increasing, resulting in an increasing incidence of aneurysms. [0003] The traditional treatment of aneurysm is aneurysm resection and artificial blood vessel transplantation. However, due to the large surgi...

Claims

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Application Information

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IPC IPC(8): A61F2/90A61L27/00A61M29/00
Inventor 符伟国史振宇叶明王玉琦郭大乔王震
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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