135 results about "Aortic aneurysm" patented technology

The invention discloses an abdominal aortic aneurysm progress prediction method and system based on cross-modal knowledge distillation. The method comprises the following steps: collecting blood of a target object; the method comprises the following steps: detecting the concentration of blood protein fingerprint markers of blood of a target object, wherein the blood protein fingerprint markers comprise matrix metalloproteinase-12, calcitonin-related polypeptide-alpha, uromodulin, nerve injury induction protein-1, glycosylated hemoglobin A1c and fibroblast growth factor-9; carrying out abdominal aortic aneurysm risk calculation by calling Student-net of cross-modal knowledge distillation based on the blood protein fingerprint marker concentration; wherein the input of the Teaser-net of the cross-modal knowledge distillation comprises a CTA image feature and a pathological section feature, and a category probability vector output by the Student-net is aligned with a category probability vector output by the Teaser-net; and outputting the risk level of the abdominal aortic aneurysm and the probability of occurrence / progress / rupture of the abdominal aortic aneurysm in the preset year. And the development of the aortic aneurysm disease is accurately predicted.

The invention discloses an abdominal aortic aneurysm risk screening method based on HbA1c multiple risk markers, and aims to solve the problems that AAA screening in the prior art depends on a single marker, is lack of nonlinear analysis and is insufficient in application tool, a comprehensive risk prediction model is constructed by integrating HbA1c, proteomics data and non-genetic factors, a nonlinear risk relationship is revealed, and the risk of the abdominal aortic aneurysm is predicted to be the risk of the abdominal aortic aneurysm of the abdominal aortic aneurysm of the abdominal aortic aneurysm. And an application tool is developed, visual display of the morbidity probability and the risk level of n years is provided, a personalized screening strategy is supported, and the accuracy and practicability of AAA early screening are improved.

The invention discloses a screening method of a protein marker combination, which is used for risk prediction of abdominal aortic aneurysm or ruptured abdominal aortic aneurysm, and optimizes the stability of a protein expression profile by constructing an initial protein expression profile; screening differential expression proteins by adopting statistical analysis, and preliminarily locking candidate proteins remarkably associated with a disease endpoint based on survival analysis or a risk regression model; performing cross validation by combining a sparse constraint algorithm and a nonlinear feature selection algorithm, and extracting a robust core marker; the independent contribution degree of each marker is evaluated through the standardized weight, and finally the optimal protein combination for disease prediction or diagnosis is determined. According to the method, six core proteins obtained through multi-algorithm cross screening can be detected in serum, multivariable logistic regression and external verification set performance both show good robustness, and an aorta protein fingerprint feature set which can be popularized and explained is formed.

To provide stent graft systems and methods of placing such stent graft systems for treating aortic aneurysms.SOLUTION: A stent graft system 100 includes a stent graft, an inflatable fill structure 130, and a cuff 140. The inflatable fill structure 130 at least partially surrounds the stent graft. In various arrangements, the inflatable fill structure 130 has a cavity that is bifurcated. A portion of the cavity is configured to receive a branch stent graft for connection to the stent graft. The cuff 140 is fillable and is located outside of the inflatable fill structure 130, and makes it possible to provide a seal with a wall of a blood vessel. The cuff 140 and the inflatable fill structure 130 are separately fillable from each other to different pressures with a fill medium. In various arrangements, the cuff has a tapered shape such that it is wider at one end than at an opposite end when filled with a fill medium.SELECTED DRAWING: Figure 1

Embodiments described herein relate to a shunt for treating an aortic aneurysm. In some embodiments, the shunt may include a central portion, an arterial sealing structure, and a venous sealing. In some embodiments, the venous sealing structure may have a lateral length in its deployed configuration, and the arterial sealing structure having a lateral length in its deployed configuration that is greater than the lateral length of the venous sealing structure. A method of implanting the shunt may include selecting the shunt based on a lateral thickness of a thrombus formed in an aortic aneurysm determined by imaging of the aortic aneurysm. The shunt may be advanced in a delivery configuration through a venous puncture site of a vein to access an arterial puncture site of the artery, and then deployed, thereby enabling blood flow through the central portion of the shunt from the artery to the vein.

The invention belongs to the technical field of biology, and particularly relates to an immunogenic peptide fragment aiming at a human sphingosine 1-phosphate receptor 2 and application of the immunogenic peptide fragment. The amino acid sequence of the immunogenic peptide fragment is SEQ ID No.1. The immunogenic vector vaccine aiming at the human sphingosine 1-phosphate receptor 2 is prepared by coupling the immunogenic peptide fragment of the human sphingosine 1-phosphate receptor 2 and a vector, and the vector is Q beta-2aa bacteriophage virus-like particle protein. According to the invention, the preferentially designed immunogenic peptide fragment of the human sphingosine 1-phosphate receptor 2 is coupled with the Qbeta-2aa bacteriophage virus-like particle protein carrier to successfully prepare the carrier vaccine. The immunogenic vector vaccine can be used for preparing drugs for preventing and treating abdominal aortic aneurysm.

The invention discloses shRNA (short hairpin Ribonucleic Acid) for targeted knockout of an Eif2ak2 gene and application, and belongs to the technical field of gene engineering. The shRNA comprises a positive-sense strand and an antisense strand which is reversely complementary with the positive-sense strand, and the nucleotide sequence of the positive-sense strand is shown as SEQ ID NO. 5. It is found for the first time that the recombinant adeno-associated virus capable of inhibiting Eif2ak2 gene expression can successfully inhibit the phenotype of the abdominal aortic aneurysm of a mouse, obviously reduce the morbidity of the abdominal aortic aneurysm of the mouse, improve the severity of the abdominal aortic aneurysm of the mouse, reduce the inner diameter of a blood vessel and the ratio of the weight to the body weight of the blood vessel, and promote the contraction function of vascular smooth muscle cells of the mouse; the method can be used for effectively treating the abdominal aortic aneurysm, provides a new thought and strategy for treating the abdominal aortic aneurysm, and has a wide clinical application prospect.

A method for providing information about the possibility of abdominal aortic aneurysm occurrence according to an embodiment of the present invention comprises the steps of: receiving an input of a plurality of pieces of demographic information and personal clinical information; generating an abdominal aortic aneurysm occurrence prediction model by performing training on the basis of the demographic information and the personal clinical information; inputting demographic information and personal clinical information about a subject to the abdominal aortic aneurysm occurrence prediction model; and outputting information about the possibility of abdominal aortic aneurysm occurrence in the subject from the abdominal aortic aneurysm occurrence prediction model.

The invention relates to the technical field of medical health, and discloses a health assessment system and method based on multi-dimensional retinal aortic aneurysm monitoring data, and the method comprises the steps: collecting a retinal image of a patient with retinal aortic aneurysm, and extracting the aortic aneurysm features of the patient with retinal aortic aneurysm, setting an eye dynamic monitoring network of the patient with the greater aneurysm of the retina; performing time synchronization processing on the iconography image, the clinical examination data, the biomarker data and the real-time eye data to obtain multi-modal synchronization data; based on the multi-modal synchronous data, determining a risk evaluation index of the patient with the greater retina aneurysm, and constructing a personalized risk analysis model of the patient with the greater retina aneurysm; creating a risk scoring mechanism for the patient with the greater retinal aneurysm, and setting a health feedback tool for the patient with the greater retinal aneurysm. According to the invention, accurate prediction of the retina great aneurysm can be realized.

Embodiments described herein relate to a shunt including a self-adjusting mechanism for treating conditions such as an aortic aneurysm. In some embodiments, the shunt may include a central portion, a distal end, and a proximal end. In some embodiments, the distal end of the shunt may be configured to roll proximally (e.g., into a toroidal structure) when the shunt transitions from a delivery configuration to a deployed configuration. In some embodiments, the distal end of the shunt may be configured to roll and / or unroll after deployment such that a length of the shunt can be adjustable to accommodate changing anatomy. In some embodiments, the proximal end may be configured to expand into a disc-like shape when the shunt transitions from the delivery configuration to the deployed configuration.

A stent graft delivery system includes a handle, a guidewire catheter extending distally from the handle, at least one tube, and at least one wire extending through the at least one tube, wherein each wire of the stent graft delivery system is configured as a loop at the distal end of the tube. The stent graft delivery system can be employed to implant stent grafts in a patient to thereby treat, for example, an aortic aneurysm spanning a region of an aorta that includes at least one arterial branch.

The invention relates to the technical field of medical instruments, and provides a drug delivery balloon system for aortic aneurysm, a drug delivery balloon is a hollow balloon, and a blood flow channel for blood to pass through is arranged in the axial extension direction of the drug delivery balloon; the drug delivery balloon comprises a balloon outer surface and a balloon inner surface, wherein the balloon outer surface is provided with micropores for allowing drugs to pass through; the balloon inner surface and the balloon outer surface are correspondingly arranged to form a balloon main body, and a hollow inner cavity of the balloon main body is a blood flow channel; a filling pipeline communicated with the balloon main body is arranged on the peripheral wall of the balloon catheter, and the filling pipeline is used for conveying liquid medicine and / or a contrast agent into the balloon main body so as to fill the balloon main body. By arranging the filling pipeline at the end part of the drug delivery balloon with a hollow structure, the filling work of the balloon main body can be realized. Therefore, when the drug delivery balloon system is used for treating aortic aneurysm, blood vessels are ensured to be unobstructed, blood flow is not blocked, and balloon drug delivery work is completed at the same time.

Devices, systems, and method for treating abdominal aortic aneurysms are disclosed. An illustrative system can include an occlusion catheter with an elongate catheter shaft. The elongate catheter shaft can have a first expandable member and a second expandable member. The elongate catheter shaft can have a therapeutic fluid infusion port disposed in an isolated area between the first expandable member and the second expandable member, where the occlusion catheter is configured to infuse a therapeutic fluid via the elongate catheter shaft and through the therapeutic fluid infusion port to a position proximate to an abdominal aortic aneurysm in the isolated area. The illustrative system including an elongate light-emitting catheter including a light-emitting element, wherein the light-emitting element is configured to emit light and be disposed at the position.

The application belongs to the technical field of biological medicine, and relates to application of a CXCL14 inhibitor in preparation of a drug for preventing or treating abdominal aortic aneurysm of a patient. The inhibitor effectively eliminates the gender difference of abdominal aortic aneurysm by specifically blocking the combination of CXCL14 and its receptor CXCR4, significantly reduces aortic macrophage infiltration and PDGFRA + macrophage accumulation in the progress of abdominal aortic aneurysm, reduces the degree of collagen degradation and elastic fiber damage, and thus inhibits the pathological progress of abdominal aortic aneurysm. The application provides a new target and drug combination for precise treatment of male abdominal aortic aneurysm, and has clear clinical application value.

The invention discloses an application of methylene blue in preparation of drugs for preventing and treating aortic dissection and aortic aneurysm, which proves that after methylene blue is orally taken in an aortic aneurysm mouse model, expansion of aortic diameter can be inhibited and occurrence rate of aortic dissection and aortic aneurysm can be reduced after methylene blue is given. Abnormal aorta dilatation of mice and disorder and fracture of elastic fibers caused by BAPN water drinking are improved. Therefore, the death rate of the BAPN-induced aortic dissection and aortic aneurysm mice can be reduced and the disease progress of the aortic dissection and aortic aneurysm can be delayed by giving the methylene blue, so that the expansion condition of the aorta of the mice is improved and the survival rate is increased.

The present invention relates to a self-expanding stent (1) for implantation in the abdominal aorta of a human body for the treatment of abdominal aortic aneurysm, the stent (1) comprising an expandable framework (2) formed from a shape memory alloy and having a distal end (4), a proximal end (6), and an interior volume extending along a central axis from the distal end (4) to the proximal end (6), the framework (2) having at least a distal end ring (8) and a proximal end ring (10) with peaks (12) and valleys (13), and optionally at least one ring (14, 15) disposed between the distal end ring (8) and the proximal end ring (10), the framework (2) having a length LF from the distal end (4) to the proximal end (6) of at least 10 mm, the stent having a compressed state having a minimum diameter (Dmin), an expanded state having a nominal diameter (DN), and a relaxed state having a maximum diameter (Dmax). According to the present invention, at least one of the distal ring (8), the proximal ring (10), and the optional rings (14, 15) of the stent (1) exhibits a nominal radial resistance pressure (RRP-N) of 100 mmHg or greater at a nominal diameter (DN). The present invention also relates to a method.

A system and a method for continuously monitoring an abdominal aortic aneurysm are described. The system (100) comprises an internal unit (10), which comprises at least one sensor (S1, S2, S3, S4) for detecting blood pressure and flow data inside the aneurysmal sac and an electronic control unit (11) in electrical communication with the at least one sensor (S1, S2, S3, S4); an external unit (20) in electrical communication with the internal unit (10); and a remote server (30) in electrical communication with the external unit (20). The external unit (20) is configured to read the blood pressure and flow data detected by the at least one sensor (S1, S2, S3, S4) of the internal unit (10) and transmit them to the remote server (30) for their analysis, organization and protection.

The utility model discloses an aorta intracavitary stent with an external expansion balloon, and belongs to the technical field of medical instruments. Comprising a covered stent, at least one degradable balloon is arranged on the outer side of the covered stent in the length direction, and the degradable balloon is filled with hydrogel. According to the aorta intracavitary stent with the external expansion balloon, the degradable balloon is arranged outside the covered stent, the hydrogel is filled in the degradable balloon, and the anchoring capacity of the stent to blood vessels can be improved through the external expansion balloon at the early stage; in the later stage, the balloon releases the internal hydrogel through self-degradation or under the action of external force, expands after being in contact with blood, and allows fibroblasts and the like to enter and grow, so that thrombosis of the aortic aneurysm can be promoted, and a tumor cavity can be stabilized.

1. Name of the product in this design: Packaging box for early risk warning kit for abdominal aortic aneurysm. 2. Purpose of this design: For the outer packaging of an early risk warning kit for abdominal aortic aneurysm. 3. The key design feature of this product is its pattern. 4. The image or photograph that best illustrates the design's key features: the front view.

The invention relates to the technical field of biological medicines, and particularly relates to a method for researching the influence of silencing or inhibiting a UBE2G1 gene on the growth of abdominal aortic aneurysm by constructing a UBE2G1 gene function deletion mouse model. Results show that silence or inhibition of UBE2G1 gene expression can inhibit growth of abdominal aortic aneurysm, alleviate destruction of elastic fibers of arterial tissues, reduce levels of inflammatory factors such as TNF-alpha, IL-1beta and IL-6 in a body and inhibit polarization of macrophage M1. According to the invention, a certain theoretical basis is provided in the aspect of treatment of abdominal aortic aneurysm by means of biotechnology, and the UBE2G1 gene (or protein) can be used as a drug target for treatment of abdominal aortic aneurysm.

To provide simple yet accurate stent graft fenestration, a patient-specific fenestration template is used as a guide for graft fenestration. To generate the fenestration template, a patient's medical imaging data such as CT scan data may be used to generate a 3-D digital model of an aorta lumen of the patient. The aorta lumen may encompass one or more branch vessels, which may be indicated on the 3-D digital model. Based on the 3-D digital model or a segment thereof, the fenestration template may be generated, for example, using 3-D printing technology. The fenestration template may include one or more holes or openings that correspond to the one or more branch vessels. To fenestrate a stent graft, the fenestration template is coupled to the stent graft so that the holes or openings on the fenestration template indicate the fenestration locations.

The invention belongs to the technical field of gene therapy and biological medicine, and particularly provides application of leucine in preparation of a medicine for preventing and / or treating aortic aneurysm. The leucine is independently used or is combined with other medicines for preventing and / or treating aortic aneurysm. The activity of GLUD1 is enhanced through leucine, so that conversion of Glu to alpha-KG is promoted, degradation of Glu is promoted, namely, the Glu level is reduced by enhancing degradation of Glu, and aortic aneurysm is improved. In a Glu metabolic network, Gln can be converted into Glu under the action of glutaminase 1 (GLS1), so that the generation of Glu is inhibited by inhibiting the activity of GLS1, and the effect of preventing and / or treating aortic aneurysm is achieved.

To provide simple yet accurate stent graft fenestration, a patient-specific fenestration template is used as a guide for graft fenestration. To generate the fenestration template, a patient's medical imaging data such as CT scan data may be used to generate a 3-D digital model of an aorta lumen of the patient. The aorta lumen may encompass one or more branch vessels, which may be indicated on the 3-D digital model. Based on the 3-D digital model or a segment thereof, the fenestration template may be generated, for example, using 3-D printing technology. The fenestration template may include one or more holes or openings that correspond to the one or more branch vessels. To fenestrate a stent graft, the fenestration template is coupled to the stent graft so that the holes or openings on the fenestration template indicate the fenestration locations.

The invention related to medical devices, and in particular to arterial reconstruction devices. The aortic reconstruction device of the present invention is able to conveniently, smoothly, and effectively treat aortic aneurysm or dissection and reconstruct adjacent branch arteries without affecting the vascular perfusion thereof throughout the procedure. The present reconstruction device comprises: a stent graft, and an expansion component, said expansion component may be placed in the stent graft and expands to a size no smaller than the inner diameter of said stent graft.

The invention provides a biomarker combination for evaluating the progress of abdominal aortic aneurysm based on an adventitia and application of the biomarker combination, and the biomarker combination comprises at least two biomarkers selected from the following three independent groups, the at least two markers are from the same group or different groups: a myofibroblast transformation marker group: alpha-smooth muscle actin, monocyte chemotactic protein 1 and a tissue metalloproteinase inhibitor 1; the lipid metabolism related biomarker group comprises a lipid metabolism related protein CD36, carnitine palmitoyl transferase 1 and a fatty acid binding protein 4; and an inflammatory factor related biomarker group: IL-6, MCP-1 and TIMP1. According to the biological marker combination for evaluating the progress of the abdominal aortic aneurysm based on the adventitia, multi-channel biological markers are systematically integrated, an innovative tool is provided for accurate diagnosis, drug screening and curative effect monitoring of AAA, and meanwhile, an important foundation is laid for developing a collaborative treatment strategy based on adventitia fibroblast regulation.

The application discloses a method for separating and culturing primary vascular smooth muscle cells from human abdominal aortic wall, and relates to the technical field of human cell culture. The method comprises the following steps: obtaining a collagenase A solution; adding the collagenase A solution to a treated human abdominal aortic aneurysm wall tissue sample and then cutting the sample; transferring the cut human abdominal aortic aneurysm wall tissue sample to a 37-degree cell culture box for culture; centrifuging a cell suspension obtained after termination of digestion; discarding supernatant, resuspending cell precipitate, and repeating centrifugation for three times; resuspending the cell precipitate again, uniformly transferring the cell precipitate to a T25 culture bottle after blowing, and placing the cell precipitate in a 37-degree cell culture box for culture; when a wave peak and wave trough state appears, the cell precipitate is digested and subcultured by using 0.25% trypsin, and then the cell precipitate is transferred to a new T25 culture bottle; and the cell precipitate is subcultured normally to the P3 generation and then stored in liquid nitrogen, so that the cell damage is prevented and the activity and proliferation capacity of the cell are maintained.

The invention provides an abdominal aortic aneurysm early prediction model construction method, system and device and a medium. According to the method, a balanced research queue is constructed through fusion of multi-modal data (ultrasonic images, biochemical indexes and lipidomics) and tendency score matching, so that the accuracy of early risk identification of the abdominal aortic aneurysm and the model robustness are remarkably improved; furthermore, on the basis of a risk migration strategy, the discrimination capability of the complex deep learning model is migrated to a simplified logistic regression model which only needs a simplest lipid feature set and basic demographic information, so that high prediction performance is maintained, model lightweight, parameter immobilization and clinical interpretability are realized, the detection cost and the operation complexity are greatly reduced, and the detection efficiency is improved. A high-precision risk prediction technology can be conveniently deployed in a basic medical scene, and finally an abdominal aortic aneurysm early screening solution with high precision, high interpretability and wide applicability is formed.

The utility model discloses a covered stent capable of being used for treating aortic aneurysm diseases, which relates to the technical field of medical instruments and comprises a self-expanding stent, a clamping piece is fixedly connected to the waist line position of an expanding portion of the self-expanding stent, and the clamping piece is made of super-elastic memory alloy. A mode of combining radial force anchoring and structure anchoring is adopted, a part of an anchoring piece is changed into a clamping piece from a traditional barb, the stent moves downwards after arriving at a designed position, the anchoring piece is unfolded and fixed on small blood vessels on two sides, meanwhile, the upper end of the clamping piece is self-expanded and unfolded, double anchoring is carried out, displacement of the stent is avoided, and the stability of the stent is improved. A self-expanding stent is adopted for supporting and an elastic clamping piece and a native blood vessel are clamped for fixing, additional damage is avoided, meanwhile, double-layer polyurethane films are adopted for covering, the anti-leakage capacity is improved while the flexibility is guaranteed, the blood vessel can be prevented from being damaged, and stable support is provided.

The application belongs to the technical field of molecular diagnosis, and particularly relates to a group of extracellular vesicle proteins as biomarkers for diagnosing abdominal aortic aneurysm and application. The application early diagnoses abdominal aortic aneurysm through determination of circulating extracellular vesicle protein markers, and provides an effective tool for diagnosis of abdominal aortic aneurysm. The extracellular vesicle protein marker is any one or two or more molecular marker combinations of interleukin-4 (IL-4), interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1), nerve growth factor (Neurturin) and tumor suppressor M (Oncostatin-M). The application uses proteins in extracellular vesicles as specific markers for early diagnosis of abdominal aortic aneurysm, which is a less applied field in current early diagnosis of AAA. The specific proteins in EVs may be directly related to the pathological process of AAA, and are different from conventional serum markers, and have higher specificity and sensitivity.

The invention relates to an abdominal aortic aneurysm filling system and treatment system, the filling system comprises a filling assembly, the filling assembly comprises at least two filling blocks, each filling block adopts shape memory polymer foam, and each filling block has a compressed loading state and an implantation state of expanding at a preset position; the interventional catheter is used for containing the filling assembly to implement interventional delivery, and the filling blocks are sequentially arranged in the extending direction of the interventional catheter in the loading state; the connecting shaft is arranged in the interventional catheter in a sliding mode, the far-end portion of the connecting shaft sequentially penetrates through and is connected with the filling blocks so as to carry the filling blocks to be released from the far-end side of the interventional catheter into the abdominal aortic aneurysm, and the far-end portion of the connecting shaft is configured to be spirally wound around a space axis in a pre-shaping mode. The surgical operation process is simplified, the filling blocks are arranged relatively orderly after being released and expanded, the space filling rate is high, and the surgical treatment effect is further improved.