67 results about "Artery aneurysm" patented technology

The utility model relates to the technical field of artery clamps, and provides an aneurysm clamp for neurosurgery, which comprises a clamp main body, the clamp main body comprises a first clamp and a second clamp, lock catch rods are arranged at the same parts of the first clamp and the second clamp, and the first clamp and the second clamp are jointly connected with a spring. According to the aneurysm clamp, due to the arrangement of the buckle and the clamping piece, when a person uses the aneurysm clamp, the clamping piece clamped on the buckle on one side of the first clamp is replaced, the clamping piece is clamped on the buckle on one side of the second clamp, and therefore the aneurysm clamp can be used conveniently. The buckle connecting piece is clamped and fixed according to the buckle groove of the gap between the inclined pieces, and the buckle is extruded through the gap between the connecting piece and the inclined pieces, so that when the first forceps and the second forceps are used for clamping the aneurysm, the first clamping piece and the second clamping piece can be replaced according to the requirement of an operation; therefore, the problems generated in the operation process are solved.

The application discloses an aneurysm segmentation landing zone positioning and identifying method and system based on an optimal blood flow guiding model, and the method comprises the following steps: collecting image data of a target blood vessel region, and pre-processing the image data to obtain a blood vessel enhanced image; performing binaryzation on the blood vessel enhanced image to obtain a blood vessel cavity binary mask; extracting a tree-shaped blood vessel center line from the blood vessel enhanced image by using a blood vessel center line extraction algorithm; analyzing the tree-shaped blood vessel center line to obtain a multi-modal fusion feature vector; predicting a neck aneurysm probability value of the multi-modal fusion feature vector by using a pre-constructed neck aneurysm detection deep learning model, and screening a candidate neck aneurysm region and a parent artery region; and performing membrane membrane on the candidate neck aneurysm region and the parent artery region by using a blood vessel cavity three-dimensional binary mask, and extracting a device anchoring landing zone. According to the scheme, the neck aneurysm precisely positioned by the membrane membrane is taken as a starting point, and an anchoring landing zone section can be accurately screened out by searching upstream and downstream along the parent artery center line.

This application discloses a method and related products for training a generative model for generating three-dimensional aneurysms. The method includes: extracting at least one perspective of two-dimensional image data from original three-dimensional image data; semi-transparentizing the aneurysm-bearing artery region in the two-dimensional image data and marking the centerline of the aneurysm-bearing artery to obtain preprocessed data; extracting aneurysm-related two-dimensional and three-dimensional features using a pre-trained image encoder and shape encoder based on the preprocessed data and the original three-dimensional image data; and training the generative model using the two-dimensional and three-dimensional features as the input and output, respectively, so that the generative model outputs a three-dimensional aneurysm containing the aneurysm-bearing artery region and surrounding vessels. Using the solution of this application, high-precision three-dimensional aneurysm reconstruction can be achieved without original DICOM data, providing a reliable aneurysm-assisted diagnosis and treatment decision-making solution.

The invention relates to the technical field of medical image processing, in particular to an intracranial aneurysm image segmentation method based on a 3D U-Net optimization model, and the method comprises the following steps: obtaining intracranial aneurysm CTA image data; an aneurysm area is recognized and positioned in the intracranial aneurysm CTA image data through a MedLAM algorithm, and a multi-scale probability graph containing aneurysm position information is obtained; and inputting the multi-scale probability graph into a 3D U-Net network to segment the aneurysm region to obtain a segmentation result of the anatomical structure of the aneurysm. According to the method, firstly, the MedLAM is used for preliminarily identifying and positioning the intracranial aneurysm, then the 3D U-Net is used for precise segmentation, and the pre-positioning step of the MedLAM is introduced before the intracranial aneurysm is segmented, so that the intracranial aneurysm can occupy a significant part in the image, the defect that the long-distance correlation is not enough to be captured in the 3D U-Net can be effectively made up, and the accuracy and the accuracy of the segmentation of the intracranial aneurysm can be improved. The pre-positioning is matched with the 3D U-Net, so that the segmentation precision is remarkably improved, and the overall efficiency can also be improved.

Ina system, device and method for treating an aneurysm of a human or mammal patient an implantable member adapted to hold fluid is provided. The member is adapted to be placed in connection with a blood vessel having the aneurysm and to exercise a pressure on the aneurysm of said blood vessel.

The invention belongs to the technical field of gene therapy and biological medicine, and particularly provides application of leucine in preparation of a medicine for preventing and / or treating aortic aneurysm. The leucine is independently used or is combined with other medicines for preventing and / or treating aortic aneurysm. The activity of GLUD1 is enhanced through leucine, so that conversion of Glu to alpha-KG is promoted, degradation of Glu is promoted, namely, the Glu level is reduced by enhancing degradation of Glu, and aortic aneurysm is improved. In a Glu metabolic network, Gln can be converted into Glu under the action of glutaminase 1 (GLS1), so that the generation of Glu is inhibited by inhibiting the activity of GLS1, and the effect of preventing and / or treating aortic aneurysm is achieved.

The invention relates to a medical implant (10) for treating a local lesion in a vessel, in particular for treating a bifurcation aneurysm, comprising a radially compressible and expandable support body (11), which has at least one support mesh (12) and one compression mesh (13), each of these formed by interwoven filaments (20, 21), wherein the compression mesh (13) is braided in sections into the support mesh (12) in such a way as to form at least one compressed region (13a) having a first porosity (13b) and at least one support region (12a) having a second porosity (12b), which is free with respect to the compression mesh (13), as a result of which the ratio of the first porosity (13b) to the second porosity (12b) is between 1:1.15 and 1:2, in particular between 1:1.2 and 1:2, in particular between 1:1.4 and 1:2, in particular between 1:1.6 and 1:2, in particular between 1:1.8 and 1:2. The invention further relates to a method for producing a medical implant (10), in which at least two filaments (20) are braided helically about a common longitudinal axis and form a support mesh (12), wherein, during the braiding of the filaments (20) of the support mesh (12), one or more filaments (21) which form a compression mesh (13) are integrally braided into at least one section of the support mesh (12) in such a way as to form at least one compressed region (13a) having a first porosity (13b) and at least one support region (12a) having a second porosity (12b), which is free with respect to the compression mesh (13).

The invention discloses a bifurcated aneurysm stent structure. The structure comprises a far-end anchoring stent; a proximal anchoring stent; the skeleton is arranged to be of a bent structure, the two ends of the skeleton are connected with the far-end anchoring stent and the near-end anchoring stent respectively, and the far-end anchoring stent and the near-end anchoring stent can be matched to limit the skeleton to a to-be-treated position in a blood vessel; the covering film is connected to the skeleton and covers the skeleton in the bending direction of the skeleton, and the skeleton and the covering film are matched to support the position to be treated in the blood vessel. According to the invention, a tumor neck opening can be effectively blocked, the blood flow of a blood vessel can be kept smooth, the thrombosis probability is reduced, the problem of vascular occlusion is avoided, and the occurrence of ischemic events is reduced.

This invention provides an aneurysm embolization auxiliary device, belonging to the field of medical device technology. The device includes a delivery catheter, an operating handle, a balloon, and a filling unit. The delivery catheter delivers a treatment device to the aneurysm location. The operating handle is located at the proximal end of the delivery catheter. The balloon, after inflation, supports the blood vessel. The filling unit fills the aneurysm with an injectable gel for treating the aneurysm from the operating handle location along the delivery catheter. The injectable gel solidifies within the aneurysm. During operation, the delivery catheter delivers the balloon to the aneurysm location. After inflation, the balloon supports and positions the blood vessel. The filling unit fills the aneurysm with the injectable gel, which solidifies upon entering the aneurysm to treat it. This invention primarily addresses technical problems in existing interventional aneurysm treatment methods, such as easy displacement of coils and the increased risk of bleeding due to the need for long-term medication after stent implantation.

The present application provides a hollow structure embolism spring ring assembly and pushing system, comprising a spring ring and a core member, the spring ring is coiled into a lumen along an axis, the core member is arranged in the lumen, the spring ring is a hollow structure made of a metal wire, a filter assembly is arranged on the spring ring to reduce the thrombus in an aneurysm from entering a blood vessel through the filter assembly. The spring ring is a hollow structure, so that the spring ring is lighter in mass, the softness is improved, the hardness is reduced and the compliance is enhanced, the ability of the implanted spring ring to conform to the shape of the aneurysm is improved, the spring ring is beneficial to enter the aneurysm, the risk of the implanted spring ring top breaking the aneurysm is reduced, and the implanted spring ring embolism artery is more dense.

The invention relates to the technical field of artery blood sampling, and discloses an intelligent sensing artery blood sampling auxiliary device which comprises a test pad, a plurality of sensing modules arranged in the test pad in a linear array mode and iodophor marking modules arranged in the sensing modules. The sensing module comprises a mounting hole formed in the test pad and a pressure sensor arranged in the mounting hole; the iodophor marking module comprises an unfolding assembly arranged on one side of the mounting hole, an iodophor bottle arranged in the unfolding assembly and two liquid outlet assemblies symmetrically arranged in the unfolding assembly, and the iodophor bottle is made of a plastic soft material. Artery datamation positioning is achieved through a linear array pressure sensor and an intelligent analyzer, traditional subjective judgment of hand feeling and vision is replaced, repeated puncture on patients with thin blood vessels, deep positions and edema is reduced, complications such as vascular injury and pseudoaneurysm are reduced, the bleeding risk of patients with hepatopathy with poor blood coagulation and chemotherapy can be reduced, and the treatment effect is improved. And the positioning accuracy of weak-beat and obese people is remarkably improved.

This invention discloses a preoperative risk prediction method for cerebral aneurysms based on multimodal deep learning. To address the problems of time-consuming computational fluid dynamics simulations and difficulty in quickly obtaining individualized hemodynamic indicators, this invention reconstructs vascular geometry and a tree diagram by aligning computed tomography angiography, magnetic resonance angiography, and blood pressure and heart rate time series. It employs a graph network that satisfies Kirchhoff conservation and connects differentiable Wendt-Kessel impedance learning boundary conditions. Combining physical constraints of cardiac phase conditional neural operators, Helmholtz projection, and signed distance function boundary embedding, it approximates the flow field, calculates and closes the loop to correct wall shear stress, oscillatory shear exponent, and pressure gradient. Then, it fuses the risk features of the imaging branch, clinical branch, and text branch through expert product to output lesion-level and patient-level risks and confidence levels. This achieves the technical effect of rapidly estimating hemodynamics and performing interpretable preoperative risk assessment under physically consistent constraints.

This disclosure relates to methods of treating or preventing aneurysms or other vascular diseases of conditions related thereto comprising administering an effective amount of a hydroimidazopyridopyrimidinone derivative or salt thereof to a subject in need thereof. In certain embodiments, the derivative comprises a 2,4,6,7,8,9-hexahydro imidazo[1,2-a]pyrido[3,4-e]pyrimidin-5 (1H)-one core structure comprising substituents. In certain embodiments, the compound is 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexa-hydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one (ONC201 / TIC10), derivative, or salt thereof.

The invention belongs to the technical field of biological information processing, and particularly relates to a method and system for constructing a risk prediction model from Kawasaki disease to huge coronary artery tumor. The invention provides a Kawasaki disease MGCAA risk prediction model construction method and system, and the method comprises the steps: building a prediction model based on six conventional clinical variables through employing a random forest (RF ranger) algorithm; an SHAP explanation mechanism is introduced, so that the contribution of each variable to a prediction result can be visually displayed in global and individual levels, and the transparency and clinical interpretability of the model are improved; through external verification and intercept-only recalibration, the reliability and the applicability of the model in different groups of people can be ensured; according to the method, an online webpage tool (Shiny App) is deployed, and a doctor can input clinical data of a patient in real time and immediately obtain individualized risk prediction and explanation, so that clinical early recognition of an MGCAA high-risk child patient is realized, and formulation of an individualized treatment scheme and early intervention measures is assisted.

The present invention provides an aneurysm neck embolization member with flexibility in the neck region, and a method for manufacturing the aneurysm neck embolization member. [Solution] The device has a main body (collectively referred to as a body 52, neck 53, head 54, etc.) made of a tubular mesh material knitted by weft knitting to be flexible, and the main body includes a neck 53 that can fit into the neck of the aneurysm from the inside, and a body 52 knitted continuously with the neck 53 and inserted into the inside of the aneurysm, with the neck 53 interposed between one end in the axial direction and the other end of the neck 53, and the other end of the neck facing the neck N of the aneurysm from the side of the parent artery located outside the aneurysm and locked to the neck N of the aneurysm.

This application discloses a method, device, and storage medium for determining vascular adhesion. The method includes: obtaining an aneurysm segmentation mask and a vascular reconstruction model based on grayscale images of cerebral vessels containing aneurysms; extracting the skeleton of the vascular reconstruction model to construct a vascular skeleton topology graph containing nodes and edges; marking the edges in the vascular skeleton topology graph based on the aneurysm mask and setting the edge weights according to the distance between the nodes and the aneurysm to obtain an optimized vascular skeleton topology graph; performing loop detection based on the optimized vascular skeleton topology graph to obtain abnormal loops; calculating the gradient of the grayscale image of the cerebral vessels to obtain a gradient magnitude map, and verifying the adhesion of the edges contained in the abnormal loops based on the gradient magnitude map to determine the adhered edges and obtain the adhesion result. The solution of this application can combine topological features and image features to construct a multi-evidence fusion discrimination logic, improving the accuracy of adhesion determination.

A robotic surgical method for repair of an infrarenal aortic aneurysm with an aneurysm sac in an aorta of a patient includes introducing at least one arm and a camera of a robotic surgical system into designated ports of the patient. Then, a graft is attached to a proximal wall of the aorta. The aneurysm sac is decompressed by inflating an intravascular balloon and initiating flow in an arteriovenous circuit. Anterior posterior walls of the aneurysm sac are stapled and the robotic incisions are closed. A method for inserting a conduit includes deploying an intimal umbrella, partially expanding an expandable graft, deploying an adventitial umbrella, and fully inflating the expandable stent.

The invention discloses a bifurcated aneurysm stent which is of a self-expanding structure, at least one window is formed in the wall of the stent, and the window can be automatically opened after the stent is released from a micro catheter by means of the hyperelasticity of nickel-titanium alloy, so that the neck of the bifurcated aneurysm is covered. By means of the design, the embolism effect is guaranteed, meanwhile, the influence of the stent on lateral artery blood flow is remarkably weakened, and the risk that a traditional stent shields branch arteries is avoided. The intravascular metal content and the thrombus occurrence rate are effectively reduced, the wide-neck aneurysm treatment problem is solved, and the beneficial effects of being easy and convenient to operate, high in safety and capable of accelerating healing are achieved.

The utility model discloses an aneurysm embolism device which comprises a micro catheter, a micro guide wire and a spring ring, the micro guide wire is inserted into a catheter cavity of the micro catheter in a penetrating mode, and the micro guide wire conveys and guides the micro catheter so as to guide the micro catheter to be inserted into an aneurysm. The spring ring is pushed into the aneurysm from a tube cavity of the micro catheter, the embolism device further comprises a flow velocity sensor used for measuring the flow velocity of blood flow in the aneurysm, and the flow velocity sensor is arranged on the micro catheter or the micro guide wire and located at the end, close to the aneurysm, of the micro catheter or the micro guide wire. According to the aneurysm embolization device, in the process of embolizing the spring ring, the blood flow speed in the aneurysm can be monitored through the flow speed sensor, so that a doctor is assisted in judging whether the spring ring needs to be continuously embolized or not and evaluating the placing effect of the spring ring, it is guaranteed that the aneurysm is effectively treated, meanwhile, excessive treatment can be reduced, and the operation accuracy is improved.

There are provided methods, systems and non-transitory storage mediums for classifying aneurysms in a blood vessel of a given patient. Medically acquired images representing a blood vessel over a portion of the cardiac cycle are received. The images are segmented to obtain segmented anatomical structures of the wall and the lumen of the blood vessel. The volumetric changes of the outer wall and the lumen are calculated over the portion of the cardiac cycle. The volumetric changes of the thrombus are calculated based on the volumetric changes of the outer wall and the lumen. The aneurysm is classified as one four types based at least on the volumetric changes of the lumen and the thrombus. This classification may be used to assess the severity of the aneurysm.

The embodiment of the invention discloses a cerebral aneurysm stent deployment prediction method, which comprises the following steps: acquiring a blood vessel image containing cerebral aneurysm, and extracting a plurality of blood vessel structures related to the aneurysm from the blood vessel image; through a structure encoder, each blood vessel structure is encoded into a structure latent variable; taking the structure latent variable of each blood vessel structure as a node, establishing an edge according to the anatomical connection relationship of each blood vessel structure, generating a structure interaction diagram, and performing information aggregation on the structure interaction diagram by using a graph neural network to obtain a global latent variable for representing a global topological relationship; extracting the geometric features of the aneurysm neck of the aneurysm, and fusing the geometric features of the aneurysm neck with the global latent variables; and processing the fused features by using a prediction decoder, and predicting a position point sequence of an aneurysm stent deployment path. According to the embodiment, the prediction stability and accuracy are improved.

The application provides application of a SIRT6 activator as an active ingredient in preparation of a medicament for treating and preventing a blood vessel aging related disease. Application of the SIRT6 activator in a blood vessel smooth muscle cell can significantly inhibit aging of the blood vessel smooth muscle cell and increase of an aging related inflammatory factor. In a mouse thoracic aortic aneurysm model constructed by a CaCl2 incubation method, application of the SIRT6 activator can obviously inhibit an aneurysm phenotype.

An implant for vascular treatment may include a wire having three or more sections, with adjacent sections having different stiffnesses and / or other properties to facilitate treating an aneurysm with a single instance of the wire. As compared to treating aneurysms using multiple coils, the wire having three or more sections may reduce the time required for treatment of the aneurysm.

The application discloses a method, device and storage medium for segmenting an aneurysm. The method comprises the following steps: generating a blood vessel graph structure according to a blood vessel segmentation mask, wherein the blood vessel graph structure at least comprises leaf nodes containing radius attributes; determining an initial path node inside the aneurysm according to a positioning point; screening a target path from the initial path node to the leaf node, and sorting the target path according to an average radius to form a path pair; restoring a path through the aneurysm based on the path pair to obtain a restored path; and segmenting the aneurysm based on the restored path to obtain an aneurysm segmentation result. The scheme can guarantee stable segmentation of a large aneurysm, stably obtain the peripheral blood vessel condition of the aneurysm, and improve the accuracy and reliability of aneurysm segmentation.

In a system, device and method for treating an aneurysm of a human or mammal patient an implantable member adapted to hold fluid is provided. The member is adapted to be placed in connection with a blood vessel having the aneurysm and to exercise a pressure on the aneurysm of said blood vessel.

The invention relates to application of an Arteridin gene as a biomarker in preparation of a product for auxiliary diagnosis of abdominal aortic aneurysm, clinical specimens and animal experiments find that the expression of Arteridin in occurrence of abdominal aortic aneurysm is remarkably increased, which indicates that Arteridin can be used as the biomarker for auxiliary diagnosis of abdominal aortic aneurysm; the invention also relates to a product for down-regulating the expression of Arterin and an application of the product in preparation of drugs for treating abdominal aortic aneurysm, the product comprises siRNA and shRNA of a targeted Arterin gene and AAV for coding the sequence of the shRNA, and after specific knockdown of Arterin by smooth muscle cells is realized, in an Elatase-induced abdominal aortic mouse model, the expression of Arterin is reduced, and the expression of Arterin is reduced. The diameter of the aneurysm is reduced, the occurrence rate is reduced, the elastin destruction degree is reduced, the expression quantity of vascular remodeling genes MMP2 and MMP9 is reduced, and the difference is obvious compared with that of a control group; the result shows that Arteridin is expected to become a target spot for treating abdominal aortic aneurysm.

A robotic surgical method for repairing a subrenal aortic aneurysm having an aneurysm sac in an aorta of a patient includes introducing at least one arm of a robotic surgical system and a camera into a specified portal of the patient. A graft is then attached to the proximal wall of the aorta. The aneurysm balloon is decompressed by inflating the intravascular balloon and inducing flow in the arteriovenous circuit. The anterior and posterior walls of the aneurysm sac are stapled and the robotic incision is closed. A method for inserting a tube includes deploying an intimal umbrella, partially expanding an expandable graft, deploying an outer membrane umbrella, and fully inflating the expandable stent.

The present invention relates to the use of recombinant proteins in the preparation of drugs for inhibiting aneurysms, and belongs to the field of biopharmaceuticals. The present invention discloses the use of recombinant AGGF1 protein in the preparation of drugs for inhibiting aneurysms. The recombinant AGGF1 protein can inhibit the TGF-β1 signaling pathway and vascular remodeling through its receptor integrin α7. Therefore, the recombinant AGGF1 protein inhibits aneurysms by inhibiting the synthesis of TGF-β1 and its signaling pathway, and the recombinant protein achieves aneurysm inhibition by improving vascular structure and function.

An apparatus for treating an aneurysm in a blood vessel includes a wire to be advanced within a tube and an occlusion element disposed on the wire. The occlusion element includes a cover and an inner anchoring member. The occlusion element is configured to fit within the tube and slide out of an opening at distal end of the tube in response to movement of the wire. The cover is configured to expand to an expanded configuration when advanced into the aneurysm, wherein the cover comprises a diameter that is greater than the diameter of a neck portion of the aneurysm and is configured such that a first portion of the cover contacts an interior surface of the aneurysm and a second portion covers the neck portion of the aneurysm. The inner anchoring member extends from the cover portion and is configured to contact the interior surface of the aneurysm.

1. The name of the design product: covered stent (180 degree opening). 2. The use of the design product: for treating aortic aneurysm, dissection or vascular rupture and other lesions, repairing the diseased blood vessels. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo that best shows the design points: perspective view.