122 results about "Artery aneurysm" patented technology

The invention provides a micro-catheter shaping method and system for adjuvant therapy of aneurysm and related equipment, and relates to the technical field of image processing, and the micro-catheter shaping method for adjuvant therapy of aneurysm comprises the steps: obtaining an aneurysm to be treated and an image corresponding to a blood vessel where the aneurysm is located; according to the image, performing overall modeling on the aneurysm and a blood vessel where the aneurysm is located to obtain a corresponding global model, the global model including an aneurysm model and a blood vessel model; according to the global model, first key parameters corresponding to the aneurysm model and second key parameters corresponding to the blood vessel model are obtained, the micro catheter is shaped based on the first key parameters and the second key parameters, physical laws and the shaping form of the head end of the aneurysm can be considered, it can be guaranteed that the head end of the micro catheter is fed into the aneurysm, and the shaping accuracy is improved. And the in-place rate and the stability of the operation are improved.

To provide stent graft systems and methods of placing such stent graft systems for treating aortic aneurysms.SOLUTION: A stent graft system 100 includes a stent graft, an inflatable fill structure 130, and a cuff 140. The inflatable fill structure 130 at least partially surrounds the stent graft. In various arrangements, the inflatable fill structure 130 has a cavity that is bifurcated. A portion of the cavity is configured to receive a branch stent graft for connection to the stent graft. The cuff 140 is fillable and is located outside of the inflatable fill structure 130, and makes it possible to provide a seal with a wall of a blood vessel. The cuff 140 and the inflatable fill structure 130 are separately fillable from each other to different pressures with a fill medium. In various arrangements, the cuff has a tapered shape such that it is wider at one end than at an opposite end when filled with a fill medium.SELECTED DRAWING: Figure 1

The invention relates to the technical field of medical instruments, and provides a drug delivery balloon system for aortic aneurysm, a drug delivery balloon is a hollow balloon, and a blood flow channel for blood to pass through is arranged in the axial extension direction of the drug delivery balloon; the drug delivery balloon comprises a balloon outer surface and a balloon inner surface, wherein the balloon outer surface is provided with micropores for allowing drugs to pass through; the balloon inner surface and the balloon outer surface are correspondingly arranged to form a balloon main body, and a hollow inner cavity of the balloon main body is a blood flow channel; a filling pipeline communicated with the balloon main body is arranged on the peripheral wall of the balloon catheter, and the filling pipeline is used for conveying liquid medicine and / or a contrast agent into the balloon main body so as to fill the balloon main body. By arranging the filling pipeline at the end part of the drug delivery balloon with a hollow structure, the filling work of the balloon main body can be realized. Therefore, when the drug delivery balloon system is used for treating aortic aneurysm, blood vessels are ensured to be unobstructed, blood flow is not blocked, and balloon drug delivery work is completed at the same time.

Devices and methods for treating vascular defects, such as, for example, balloon-type aneurysms, are described herein. In one embodiment, an apparatus includes an insertion portion and an expandable implant. The expandable implant is configured to be deployed in an aneurysm and is coupled to the insertion portion. The expandable implant has a first portion and a second portion coupled to the first portion. The expandable implant is movable between a first configuration in which the first portion and the second portion are substantially linearly aligned and a second configuration in which the second portion at least partially overlaps the first portion.

The utility model relates to the technical field of artery clamps, and provides an aneurysm clamp for neurosurgery, which comprises a clamp main body, the clamp main body comprises a first clamp and a second clamp, lock catch rods are arranged at the same parts of the first clamp and the second clamp, and the first clamp and the second clamp are jointly connected with a spring. According to the aneurysm clamp, due to the arrangement of the buckle and the clamping piece, when a person uses the aneurysm clamp, the clamping piece clamped on the buckle on one side of the first clamp is replaced, the clamping piece is clamped on the buckle on one side of the second clamp, and therefore the aneurysm clamp can be used conveniently. The buckle connecting piece is clamped and fixed according to the buckle groove of the gap between the inclined pieces, and the buckle is extruded through the gap between the connecting piece and the inclined pieces, so that when the first forceps and the second forceps are used for clamping the aneurysm, the first clamping piece and the second clamping piece can be replaced according to the requirement of an operation; therefore, the problems generated in the operation process are solved.

The application discloses an aneurysm segmentation landing zone positioning and identifying method and system based on an optimal blood flow guiding model, and the method comprises the following steps: collecting image data of a target blood vessel region, and pre-processing the image data to obtain a blood vessel enhanced image; performing binaryzation on the blood vessel enhanced image to obtain a blood vessel cavity binary mask; extracting a tree-shaped blood vessel center line from the blood vessel enhanced image by using a blood vessel center line extraction algorithm; analyzing the tree-shaped blood vessel center line to obtain a multi-modal fusion feature vector; predicting a neck aneurysm probability value of the multi-modal fusion feature vector by using a pre-constructed neck aneurysm detection deep learning model, and screening a candidate neck aneurysm region and a parent artery region; and performing membrane membrane on the candidate neck aneurysm region and the parent artery region by using a blood vessel cavity three-dimensional binary mask, and extracting a device anchoring landing zone. According to the scheme, the neck aneurysm precisely positioned by the membrane membrane is taken as a starting point, and an anchoring landing zone section can be accurately screened out by searching upstream and downstream along the parent artery center line.

This application discloses a method and related products for training a generative model for generating three-dimensional aneurysms. The method includes: extracting at least one perspective of two-dimensional image data from original three-dimensional image data; semi-transparentizing the aneurysm-bearing artery region in the two-dimensional image data and marking the centerline of the aneurysm-bearing artery to obtain preprocessed data; extracting aneurysm-related two-dimensional and three-dimensional features using a pre-trained image encoder and shape encoder based on the preprocessed data and the original three-dimensional image data; and training the generative model using the two-dimensional and three-dimensional features as the input and output, respectively, so that the generative model outputs a three-dimensional aneurysm containing the aneurysm-bearing artery region and surrounding vessels. Using the solution of this application, high-precision three-dimensional aneurysm reconstruction can be achieved without original DICOM data, providing a reliable aneurysm-assisted diagnosis and treatment decision-making solution.

Disclosed are flow diverters including a self-expanding tubular member comprising a plurality of expandable cells having interconnected zig-zag rings and diagonal struts. The tubular member has a constrained configuration having a first outer diameter of at least 1.0 mm sized for delivery using a flow diverter delivery system and an expanded configuration having a second outer diameter larger than the first outer diameter. Related devices, delivery systems, and methods of using the devices and delivery systems for treating disease, particularly intracranial and cerebral aneurysms by deploying implantable expandable devices, are provided.

A system and a method for continuously monitoring an abdominal aortic aneurysm are described. The system (100) comprises an internal unit (10), which comprises at least one sensor (S1, S2, S3, S4) for detecting blood pressure and flow data inside the aneurysmal sac and an electronic control unit (11) in electrical communication with the at least one sensor (S1, S2, S3, S4); an external unit (20) in electrical communication with the internal unit (10); and a remote server (30) in electrical communication with the external unit (20). The external unit (20) is configured to read the blood pressure and flow data detected by the at least one sensor (S1, S2, S3, S4) of the internal unit (10) and transmit them to the remote server (30) for their analysis, organization and protection.

The present invention relates to a novel intracranial aneurysm occlusion device and a manufacturing method thereof. The occlusion device includes an occlusion device body, a radiopaque marker, a delivery guide wire, a separation point, a delivery tube, and a separator. The radiopaque markers are respectively fixed to the distal end and the proximal end of the occlusion device body. The occlusion device is woven into a net shape by 24 - 72 strands of nitinol shape memory alloy wire. After the occlusion device is fully expanded, radiopaque markers are provided at both the distal end and the proximal end, and the radiopaque markers respectively bundle and fix the nitinol shape memory alloy wires at the distal end and the proximal end of the occlusion device. The delivery guide wire is located inside the delivery tube. A separation point is provided between the radiopaque marker at the proximal end of the occlusion device and the distal end of the delivery guide wire. The proximal end of the delivery guide wire is connected to the separator. The manufacturing method of the occlusion device is shaped by an occlusion device mold. Without craniotomy, for intracranial aneurysms with a narrow upper part and a wide lower part, giant aneurysms, and bifurcation aneurysms, by implanting the occlusion device body, the occlusion device has a stable structure, can quickly and densely fill the aneurysm cavity after deployment, thereby slowing down the blood flow in the aneurysm cavity, reducing the impact pressure of the blood on the aneurysm cavity, enhancing the repair ability, and achieving the purpose of treating aneurysms.

The invention relates to the technical field of medical instruments, in particular to a plugging device for femoral artery pseudoaneurysm and an operation method of the plugging device. The plugging device comprises a sheathing canal assembly, an air bag assembly and a thrombin conveying assembly, and the air bag assembly and the thrombin conveying assembly are arranged in the sheathing canal assembly; the air bag assembly comprises an air bag body and an inflation tube. The inflation tube penetrates through the air bag body and is communicated with the air bag body; the air bag assembly can move in the axial direction of the sheathing canal assembly and is inflated and expanded after the air bag body extends out of the head end of the sheathing canal assembly. The thrombin conveying assembly can eject thrombin through the head end of the sheath tube assembly. Compared with non-invasive compression, through the design of the high-compliance air bag, flexible plugging of the tumor neck and self-adaption to the shape and the size of the tumor neck, the pain feeling of a patient is effectively relieved, the sealing effect is enhanced, and the operation requirements for the thrombin injection speed and the dose precision are reduced. After the air bag body seals the tumor neck, a small amount of thrombin can be injected into the tumor body, and therefore the risk that the thrombin escapes to the femoral artery is avoided.

The invention relates to the technical field of medical image processing, in particular to an intracranial aneurysm image segmentation method based on a 3D U-Net optimization model, and the method comprises the following steps: obtaining intracranial aneurysm CTA image data; an aneurysm area is recognized and positioned in the intracranial aneurysm CTA image data through a MedLAM algorithm, and a multi-scale probability graph containing aneurysm position information is obtained; and inputting the multi-scale probability graph into a 3D U-Net network to segment the aneurysm region to obtain a segmentation result of the anatomical structure of the aneurysm. According to the method, firstly, the MedLAM is used for preliminarily identifying and positioning the intracranial aneurysm, then the 3D U-Net is used for precise segmentation, and the pre-positioning step of the MedLAM is introduced before the intracranial aneurysm is segmented, so that the intracranial aneurysm can occupy a significant part in the image, the defect that the long-distance correlation is not enough to be captured in the 3D U-Net can be effectively made up, and the accuracy and the accuracy of the segmentation of the intracranial aneurysm can be improved. The pre-positioning is matched with the 3D U-Net, so that the segmentation precision is remarkably improved, and the overall efficiency can also be improved.

Ina system, device and method for treating an aneurysm of a human or mammal patient an implantable member adapted to hold fluid is provided. The member is adapted to be placed in connection with a blood vessel having the aneurysm and to exercise a pressure on the aneurysm of said blood vessel.

The invention belongs to the technical field of gene therapy and biological medicine, and particularly provides application of leucine in preparation of a medicine for preventing and / or treating aortic aneurysm. The leucine is independently used or is combined with other medicines for preventing and / or treating aortic aneurysm. The activity of GLUD1 is enhanced through leucine, so that conversion of Glu to alpha-KG is promoted, degradation of Glu is promoted, namely, the Glu level is reduced by enhancing degradation of Glu, and aortic aneurysm is improved. In a Glu metabolic network, Gln can be converted into Glu under the action of glutaminase 1 (GLS1), so that the generation of Glu is inhibited by inhibiting the activity of GLS1, and the effect of preventing and / or treating aortic aneurysm is achieved.

Provided herein is an occlusion device for intrasaccular implantation and / or vascular occlusion comprising: (a) a substantially solid marker having a proximal end, and a distal end; and (b) a low profile resilient mesh body attached to the distal end of the marker, the body having a delivery shape and a deployed shape capable of conforming to aneurysm walls; wherein the body has a diameter greater than a diameter of an aneurysm to be treated. Also provided herein is a kit comprising the occlusion device disclosed herein and a means for delivery thereof. Methods of manufacture and use of the occlusion device disclosed herein are also disclosed.

The present invention relates to an integrated device for assisting in the formation of the aneurysm neck of an intracranial aneurysm and a method for using the same. The device includes a tip, a stent, a delivery tube, a traction wire, a connecting member, a locking sleeve, and a support wire. The tip, the stent, and the delivery tube are connected in sequence from the distal end to the proximal end. The traction wire passes through the tip, the stent, and the delivery tube and exits from the delivery tube. The support wire is connected to the delivery tube through the connecting member. The locking sleeve is sleeved outside the traction wire and the support wire and is used to control the locking or loosening of the traction wire and the support wire. An electrolytic detachment area is provided between the distal end wire winding section of the stent and the traction wire, and a hydrolytic detachment area is provided between the proximal end wire winding section of the stent and the delivery tube. The device provided by the present invention can pass through a microcatheter with a smaller diameter; before the coil is implanted, the aneurysm orifice can be fully expanded, which can not only assist the coil filling to avoid insufficient coil filling, but also play a role in guiding blood flow.

The invention provides a method for detecting pressure in an intracranial aneurysm cavity, and belongs to the technical field of pressure detection in an aneurysm cavity. The detection method comprises the following steps: S1, planning an implantation path, positioning an aneurysm focus position under the guidance of image equipment before an operation, and planning the implantation path of a pressure monitoring system; s2, a pressure monitoring system is implanted, a guide catheter is intervened through femoral artery puncture, and the pressure monitoring system is sent to a target blood vessel section; s3, data are collected, and pressure values in the aneurysm cavity and the aneurysm neck opening are collected before the operation, during the operation and after the operation respectively; s4, data analysis: analyzing the collected data so as to respectively determine changes of pressure values in the aneurysm cavity and the aneurysm neck opening before, during and after an operation; the method is mainly used for solving the technical problems that in the prior art, real-time monitoring means for the pressure of an aneurysm cavity is lacked, and the force change in the aneurysm cavity cannot be accurately measured.

The invention relates to a medical implant (10) for treating a local lesion in a vessel, in particular for treating a bifurcation aneurysm, comprising a radially compressible and expandable support body (11), which has at least one support mesh (12) and one compression mesh (13), each of these formed by interwoven filaments (20, 21), wherein the compression mesh (13) is braided in sections into the support mesh (12) in such a way as to form at least one compressed region (13a) having a first porosity (13b) and at least one support region (12a) having a second porosity (12b), which is free with respect to the compression mesh (13), as a result of which the ratio of the first porosity (13b) to the second porosity (12b) is between 1:1.15 and 1:2, in particular between 1:1.2 and 1:2, in particular between 1:1.4 and 1:2, in particular between 1:1.6 and 1:2, in particular between 1:1.8 and 1:2. The invention further relates to a method for producing a medical implant (10), in which at least two filaments (20) are braided helically about a common longitudinal axis and form a support mesh (12), wherein, during the braiding of the filaments (20) of the support mesh (12), one or more filaments (21) which form a compression mesh (13) are integrally braided into at least one section of the support mesh (12) in such a way as to form at least one compressed region (13a) having a first porosity (13b) and at least one support region (12a) having a second porosity (12b), which is free with respect to the compression mesh (13).

The invention discloses a bifurcated aneurysm stent structure. The structure comprises a far-end anchoring stent; a proximal anchoring stent; the skeleton is arranged to be of a bent structure, the two ends of the skeleton are connected with the far-end anchoring stent and the near-end anchoring stent respectively, and the far-end anchoring stent and the near-end anchoring stent can be matched to limit the skeleton to a to-be-treated position in a blood vessel; the covering film is connected to the skeleton and covers the skeleton in the bending direction of the skeleton, and the skeleton and the covering film are matched to support the position to be treated in the blood vessel. According to the invention, a tumor neck opening can be effectively blocked, the blood flow of a blood vessel can be kept smooth, the thrombosis probability is reduced, the problem of vascular occlusion is avoided, and the occurrence of ischemic events is reduced.

The invention provides an aneurysm embolism auxiliary device, and belongs to the technical field of medical instruments. The device comprises a conveying catheter, an operating handle, a balloon and a filling unit, wherein the conveying catheter is used for conveying a treatment instrument to an aneurysm position; the operating handle is arranged at the near end of the conveying catheter; the balloon is arranged at the far end of the conveying catheter and is used for supporting a blood vessel after being filled; the filling unit is used for filling injection gel for treating the aneurysm into the aneurysm along the conveying catheter from the position of the operating handle, and the injection gel is used for being solidified in the aneurysm; during working, the conveying catheter conveys the balloon to the aneurysm position, the balloon supports a blood vessel for positioning after being filled, the filling unit fills injection gel into the aneurysm, and the injection gel is solidified and formed after entering the aneurysm so as to treat the aneurysm; the technical problems that in an existing aneurysm interventional therapy mode, a spring ring is prone to displacement, and bleeding risk is increased due to long-term medicine taking after stent implantation are mainly solved.

This invention provides an aneurysm embolization auxiliary device, belonging to the field of medical device technology. The device includes a delivery catheter, an operating handle, a balloon, and a filling unit. The delivery catheter delivers a treatment device to the aneurysm location. The operating handle is located at the proximal end of the delivery catheter. The balloon, after inflation, supports the blood vessel. The filling unit fills the aneurysm with an injectable gel for treating the aneurysm from the operating handle location along the delivery catheter. The injectable gel solidifies within the aneurysm. During operation, the delivery catheter delivers the balloon to the aneurysm location. After inflation, the balloon supports and positions the blood vessel. The filling unit fills the aneurysm with the injectable gel, which solidifies upon entering the aneurysm to treat it. This invention primarily addresses technical problems in existing interventional aneurysm treatment methods, such as easy displacement of coils and the increased risk of bleeding due to the need for long-term medication after stent implantation.

The present application provides a hollow structure embolism spring ring assembly and pushing system, comprising a spring ring and a core member, the spring ring is coiled into a lumen along an axis, the core member is arranged in the lumen, the spring ring is a hollow structure made of a metal wire, a filter assembly is arranged on the spring ring to reduce the thrombus in an aneurysm from entering a blood vessel through the filter assembly. The spring ring is a hollow structure, so that the spring ring is lighter in mass, the softness is improved, the hardness is reduced and the compliance is enhanced, the ability of the implanted spring ring to conform to the shape of the aneurysm is improved, the spring ring is beneficial to enter the aneurysm, the risk of the implanted spring ring top breaking the aneurysm is reduced, and the implanted spring ring embolism artery is more dense.

The invention relates to the technical field of artery blood sampling, and discloses an intelligent sensing artery blood sampling auxiliary device which comprises a test pad, a plurality of sensing modules arranged in the test pad in a linear array mode and iodophor marking modules arranged in the sensing modules. The sensing module comprises a mounting hole formed in the test pad and a pressure sensor arranged in the mounting hole; the iodophor marking module comprises an unfolding assembly arranged on one side of the mounting hole, an iodophor bottle arranged in the unfolding assembly and two liquid outlet assemblies symmetrically arranged in the unfolding assembly, and the iodophor bottle is made of a plastic soft material. Artery datamation positioning is achieved through a linear array pressure sensor and an intelligent analyzer, traditional subjective judgment of hand feeling and vision is replaced, repeated puncture on patients with thin blood vessels, deep positions and edema is reduced, complications such as vascular injury and pseudoaneurysm are reduced, the bleeding risk of patients with hepatopathy with poor blood coagulation and chemotherapy can be reduced, and the treatment effect is improved. And the positioning accuracy of weak-beat and obese people is remarkably improved.

This invention discloses a preoperative risk prediction method for cerebral aneurysms based on multimodal deep learning. To address the problems of time-consuming computational fluid dynamics simulations and difficulty in quickly obtaining individualized hemodynamic indicators, this invention reconstructs vascular geometry and a tree diagram by aligning computed tomography angiography, magnetic resonance angiography, and blood pressure and heart rate time series. It employs a graph network that satisfies Kirchhoff conservation and connects differentiable Wendt-Kessel impedance learning boundary conditions. Combining physical constraints of cardiac phase conditional neural operators, Helmholtz projection, and signed distance function boundary embedding, it approximates the flow field, calculates and closes the loop to correct wall shear stress, oscillatory shear exponent, and pressure gradient. Then, it fuses the risk features of the imaging branch, clinical branch, and text branch through expert product to output lesion-level and patient-level risks and confidence levels. This achieves the technical effect of rapidly estimating hemodynamics and performing interpretable preoperative risk assessment under physically consistent constraints.

This disclosure relates to methods of treating or preventing aneurysms or other vascular diseases of conditions related thereto comprising administering an effective amount of a hydroimidazopyridopyrimidinone derivative or salt thereof to a subject in need thereof. In certain embodiments, the derivative comprises a 2,4,6,7,8,9-hexahydro imidazo[1,2-a]pyrido[3,4-e]pyrimidin-5 (1H)-one core structure comprising substituents. In certain embodiments, the compound is 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexa-hydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one (ONC201 / TIC10), derivative, or salt thereof.

The invention belongs to the technical field of biological information processing, and particularly relates to a method and system for constructing a risk prediction model from Kawasaki disease to huge coronary artery tumor. The invention provides a Kawasaki disease MGCAA risk prediction model construction method and system, and the method comprises the steps: building a prediction model based on six conventional clinical variables through employing a random forest (RF ranger) algorithm; an SHAP explanation mechanism is introduced, so that the contribution of each variable to a prediction result can be visually displayed in global and individual levels, and the transparency and clinical interpretability of the model are improved; through external verification and intercept-only recalibration, the reliability and the applicability of the model in different groups of people can be ensured; according to the method, an online webpage tool (Shiny App) is deployed, and a doctor can input clinical data of a patient in real time and immediately obtain individualized risk prediction and explanation, so that clinical early recognition of an MGCAA high-risk child patient is realized, and formulation of an individualized treatment scheme and early intervention measures is assisted.

The present invention provides an aneurysm neck embolization member with flexibility in the neck region, and a method for manufacturing the aneurysm neck embolization member. [Solution] The device has a main body (collectively referred to as a body 52, neck 53, head 54, etc.) made of a tubular mesh material knitted by weft knitting to be flexible, and the main body includes a neck 53 that can fit into the neck of the aneurysm from the inside, and a body 52 knitted continuously with the neck 53 and inserted into the inside of the aneurysm, with the neck 53 interposed between one end in the axial direction and the other end of the neck 53, and the other end of the neck facing the neck N of the aneurysm from the side of the parent artery located outside the aneurysm and locked to the neck N of the aneurysm.

The present invention relates to the use of LAT1 inhibitors in the preparation of drugs for treating atherosclerosis, belonging to the field of pharmaceutical technology. To solve the clinical problem that there is still a relatively high residual risk in advanced atherosclerosis under the current treatment strategies, the present invention provides the use of LAT1 inhibitors in the preparation of drugs for treating atherosclerosis. The present invention has confirmed that LAT1 inhibitors delay the progression of atherosclerosis by inhibiting the entry of leucine into macrophages, reducing plaque area and necrotic core; at the same time, LAT1 inhibitors can also enhance the mitochondrial function of macrophages, increase fatty acid oxidation, reduce lipid deposition in atherosclerotic plaques, increase the stability of atherosclerotic plaques, delay the development of atherosclerosis induced by a high-fat diet, and can be applied to patients in whom the use of other types of anti-atherosclerotic drugs is limited due to diseases such as combined gastrointestinal bleeding, aortic aneurysm or tumor.

The invention belongs to the technical field of biological medicines, and particularly provides application of prasugrel or pharmaceutically acceptable salts thereof in preparation of medicines for preventing and / or treating aortic aneurysm. The prasugrel or the pharmaceutically acceptable salt thereof is independently used or is combined with other medicines for preventing and / or treating aortic aneurysm. The activity of GLUD1 is enhanced through leucine, so that conversion of Glu to alpha-KG is promoted, degradation of Glu is promoted, namely, the Glu level is reduced by enhancing degradation of Glu, and aortic aneurysm is improved. In a Glu metabolic network, Gln can be converted into Glu under the action of glutaminase 1 (GLS1), so that the generation of Glu is inhibited by inhibiting the activity of GLS1, and the effect of preventing and / or treating aortic aneurysm is achieved.

A device for treating an aneurysm of a human or mammal patient, wherein the aneurysm may self-expand. The device comprising an implantable member adapted to be placed in around an outside of a blood vessel having the aneurysm to enable the implantable member to exercise a pressure on the outside of the blood vessel having the aneurysm. The device further comprising a measuring device or sensor for measuring or sensing an expansion of the aneurysm and a monitoring system adapted to monitor the expansion of the aneurysm based on a signal received from the measuring device or sensor.