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1605 results about "Gastric carcinoma" patented technology

Gastric cancer, also known as stomach cancer or gastric carcinoma, refers to a cancer that arises from the mucosal lining of the stomach. It is the commonest gastric malignancy.

Markers for detection of gastric cancer

Early detection of tumors is a major determinant of survival of patients suffering from tumors, including gastric tumors. Members of the GTM gene family can be over-expressed in gastric tumor tissue and other tumor tissue, and thus can be used as markers for gastric and other types of cancer. GTM proteins can be released from cancer cells, and can reach sufficiently high concentrations in the serum and / or other fluids to permit their detection. Thus, methods and test kits for detection and quantification of GTM can provide a valuable tool for diagnosis of gastric cancer.
Owner:PACIFIC EDGE

Method Of Infrared Thermography For Earlier Diagnosis Of Gastric Colorectal And Cervical Cancer

A device and method to diagnose an internal abnormality in a living subject by sensing a passively occurring electromagnetic radiation signal associated with the abnormality and inside an orifice of the subject. Diagnosis includes detection, imaging or identification of the abnormality. An instrument is used either to bring a sensor into the orifice or to transmit the signal to a sensor located outside of the orifice. An example of the instrument includes a prior art endoscope.
Owner:PASSIVE IMAGING MEDICAL SYST ENG LTD PIMS

Chinese medicinal preparation for treating cancer and preparation method thereof

The invention relates to a Chinese medicinal preparation for treating cancer, and the Chinese medicinal preparation is prepared from 110 raw material drugs, such as yew, barbed skullcap herb, hairyvein agrimony and laggera pterodonta. The preparation can be oral solution, granules, powder, capsules, electuary and tablets. 110 Chinese medicaments are adopted, and monarch, minister, assistant and guide drugs are reasonably compatible and are comprehensively taken to play the effect of treating both principal and secondary aspect of cancers. The raw material drugs adopted in the Chinese medicinal preparation are common Chinese medicaments, and are low in manufacture cost and small in side effect. The medicament has the advantages of capabilities of effectively strengthening the body immunity and attacking pathogen without hurting a body along with quick response, high curative rate, high heal rate, low relapse rate, treatment of both principal and secondary aspect of cancers, safety and reliability, and can be used for treating various types of cancers, especially lung cancer, gastric cancer, liver cancer, esophagus cancer, pancreatic cancer, cervical cancer and breast cancer.
Owner:卢速江

Prognostic and diagnostic method for cancer therapy

The present invention provides novel methods and kits for diagnosing the presence of cancer within a patient, and for determining whether a subject who has cancer is susceptible to different types of treatment regimens. The cancers to be tested include, but are not limited to, prostate, breast, lung, gastric, ovarian, bladder, lymphoma, mesothelioma, medulloblastoma, glioma, and AML. Identification of therapy-resistant patients early in their treatment regimen can lead to a change in therapy in order to achieve a more successful outcome. One embodiment of the present invention is directed to a method for diagnosing cancer or predicting cancer-therapy outcome by detecting the expression levels of multiple markers in the same cell at the same time, and scoring their expression as being above a certain threshold, wherein the markers are from a particular pathway related to cancer, with the score being indicative or a cancer diagnosis or a prognosis for cancer-therapy failure. This method can be used to diagnose cancer or predict cancer-therapy outcomes for a variety of cancers. The markers can come from any pathway involved in the regulation of cancer, including specifically the PcG pathway and the “stemness” pathway. The markers can be mRNA, microRNA, DNA, or protein.
Owner:ORDWAY RES INST

Antitumor agent for undifferentiated gastric cancer

ActiveUS20090264464A1High therapeutic effectBiocideOrganic chemistryKinase activityUndifferentiated Gastric Carcinoma
The present invention relates to a therapeutic agent represented by the General formula (I), or a pharmacologically acceptable salt thereof, or a solvate of the compound or the salt thereof:The therapeutic agent comprises a substance having the activity of inhibiting kinase activity of fibroblast growth factor receptor 2 (“FGFR2”). The therapeutic agent can be used for treating undifferentiated gastric cancer, and can also be used to treat organisms comprising a cell overexpressing FGFR2 or a cell expressing mutant FGFR2, or both. The present invention further relates to a pharmaceutical composition comprising an FGFR2 inhibitory and methods of treatment therewith. The present invention also relates to a method for predicting the effect of an FGFR2 inhibitory substance on a patient.
Owner:EISIA R&D MANAGEMENT CO LTD

Treatments of therapy resistant diseases and drug combinations for treating the same

InactiveUS20080312199A1Accurately predict resistanceEasy to carryAntibacterial agentsBiocideCancers diagnosisMesothelioma
The present invention provides novel methods and kits for diagnosing the presence of cancer within a patient, and for determining whether a subject who has cancer is susceptible to different types of treatment regimens. The cancers to be tested include, but are not limited to, prostate, breast, lung, gastric, ovarian, bladder, lymphoma, mesothelioma, medullablastoma, glioma, and AML. Identification of therapy-resistant patients early in their treatment regimen can lead to a change in therapy in order to achieve a more successful outcome. One embodiment of the present invention is directed to a method for diagnosing cancer or predicting cancer-therapy outcome by detecting the expression levels of multiple markers in the same cell at the same time, and scoring their expression as being above a certain threshold, wherein the markers are from a particular pathway related to cancer, with the score being indicative or a cancer diagnosis or a prognosis for cancer-therapy failure. This method can be used to diagnose cancer or predict cancer-therapy outcomes for a variety of cancers. The markers can come from any pathway involved in the regulation of cancer, including specifically the PcG pathway and the “stemness” pathway. The markers can be mRNA, microRNA, DNA, or protein.
Owner:ORDWAY RES INST

Antibodies, including FV molecules, and immunoconjugates having high binding affinity for mesothelin and methods for their use

InactiveUS20050214304A1Sugar derivativesBacteriaAntigenAnti-Mesothelin Antibody
Mesothelin ins a differentiation antigen present on the surface of ovarian cancers, mesotheliomas and several other types of human cancers. Because among normal tissues, mesothelin is only present on mesothelial cells, it represents a good target for antibody mediated delivery of cytotoxic agents. The present invention is directed to anti-mesothelin antibodies, including Fv molecules with particularly high affinity for mesothelin, and immunoconjugates employing them. Also described are diagnostic and therapeutic methods using the antibodies. The anti-mesothelin antibodies are well-suited for the diagnosis and treatment of cancers of the ovary, stomach, squamous cells, mesotheliomas and other malignant cells expressing mesothelin.
Owner:US DEPT OF HEALTH & HUMAN SERVICES

Fusion gene of cep55 gene and ret gene

InactiveUS20150177246A1Efficient detectionEffective treatment of cancerBiocideAntibody mimetics/scaffoldsRet geneTyrosine-kinase inhibitor
In order to identify genes that can serve as indicators for predicting the effectiveness of drug treatments in cancers and provide novel methods for predicting the effectiveness of treatments with drugs targeting said genes, transcriptome sequencing was performed of diffuse-type gastric cancer. As a result, in-frame fusion transcripts between the CEP55 gene and the RET gene were identified. It was also found that said gene fusions induce activation of RET protein, thereby causing canceration of cells. Further, it was demonstrated that the RET protein activation and canceration caused by said gene fusion can be suppressed by using a RET tyrosine kinase inhibitor, and that treatments with a RET tyrosine kinase inhibitor are effective in patients with detection of said gene fusion.
Owner:NAT CANCER CENT +1

Anti-cldn6 antibody

The present invention relates to an antibody binding to Claudin6 (CLDN6) expressed on a cell membrane. The antibody of the present invention recognizes human CLDN6 present in a native form on cell membrane surface and exhibits cytotoxicity through ADCC and / or CDC activities against cancer cell lines highly expressing human CLDN6. Moreover, the antibody of the present invention has cell growth inhibitory effect through conjugation with toxin on cancer cell lines highly expressing human CLDN6. The human CLDN6 is overexpressed in tumor tissues (lung adenocarcinoma, gastric cancer, and ovarian cancer), although its expression is not observed in normal tissues. Thus, the anti-CLDN6 antibody is expected to highly accumulate in tumors highly expressing human CLDN6 and can serve as a very effective antitumor agent.
Owner:CHUGAI PHARMA CO LTD +1

Novel phthalazinone derivatives and uses thereof

The present invention provides novel phthalazinone compounds and isomer thereof, pharmaceutically acceptable salts, solvates, chemically protected forms, and prodrugs; which can be used as PARP inhibitor and pharmaceutical compositions containing the novel phthalazinone compounds; wherein A, R1 and X are defined as shown. The medicine is used for the treatment of: vascular diseases, neurotoxicity, or diseases improved through the inhibition of PARP activity; or used as adjuvants for the treatment of cancers, or used for enhancing the therapeutic effect of radiation or chemotherapeutic agents on tumor cells, wherein the cancers includes breast cancer, ovarian cancer, colon cancer, melanoma, lung cancer, gastrointestinal stromal tumor, brain cancer, cervical cancer, pancreatic cancer, prostate cancer, gastric cancer, chronic myeloid leukocytes hypercytosis, liver canser, lymphoma, peritoneal cancer, soft tissue sarcoma, neuroendocrine tumors, advanced solid tumors, and glioblastoma.
Owner:NANJING SANHOME PHARMACEUTICAL CO LTD

Detection and tracking of interventional tools

InactiveCN101809618AImage enhancementImage analysisVoxel volumeFluorescence
The present invention relates to minimally invasive X-ray guided interventions, in particular to an image processing and rendering system and a method for improving visibility and supporting automatic detection and tracking of interventional tools that are used in electrophysiological procedures. According to the invention, this is accomplished by calculating differences between 2D projected image data of a preoperatively acquired 3D voxel volume showing a specific anatomical region of interest or a pathological abnormality (e.g. an intracranial arterial stenosis, an aneurysm of a cerebral, pulmonary or coronary artery branch, a gastric carcinoma or sarcoma, etc.) in a tissue of a patient's body and intraoperatively recorded 2D fluoroscopic images showing the aforementioned objects in the interior of said patient's body, wherein said 3D voxel volume has been generated in the scope of a computed tomography, magnet resonance imaging or 3D rotational angiography based image acquisition procedure and said 2D fluoroscopic images have been co-registered with the 2D projected image data. After registration of the projected 3D data with each of said X-ray images, comparison of the 2D projected image data with the 2D fluoroscopic images - based on the resulting difference images - allows removing common patterns and thus enhancing the visibility of interventional instruments which are inserted into a pathological tissue region, a blood vessel segment or any other region of interest in the interior of the patient's body. Automatic image processing methods to detect and track those instruments are also made easier and more robust by this invention. Once the 2D-3D registration is completed for a given view, all the changes in the system geometry of an X-ray system used for generating said fluoroscopic images can be applied to a registration matrix. Hence, use of said method as claimed is not limited to the same X-ray view during the whole procedure.
Owner:KONINK PHILIPS ELECTRONICS NV

Quercetin-3-O-acyl ester and preparation method thereof

The invention relates to quercetin-3-O-acyl ester and a preparation method thereof and belongs to the technical field of pharmaceutical chemistry. The preparation method comprises the following steps: taking cheap rutin as a starting raw material and preparing a quercetin-3-O-acyl ester compound through benzylation, hydrolysis under the acidic conditions, esterification, catalytic hydrogenolysis and other reactions. The method has the characteristics of good selectivity, mild reaction condition, high yield, low cost, simplicity and convenience in operation, easiness in industrial production and the like. In addition, the inhibitory effect of the obtained quercetin-3-O-acyl ester on human esophageal squamous carcinoma cells EC9706, human prostatic cancer cells PC-3 and human gastric cancer cells MGC-803 is remarkably superior to that of quercetin; and the quercetin-3-O-acyl ester can be used in the field of foods and medicines and is possible to develop into a new candidate drug for treating tumor.
Owner:ZHENGZHOU UNIV

Aptamer capable of being in specific binding to TS/MDEP protein in gastric cancer cells

The invention discloses a targeted artificial TS / MDEP protein nucleic acid aptamer and a sequence thereof. A new combinatorial chemistry technology SELEX (Systematic Evolution of Ligands by Exponential Enrichment) is applied, the TS / MDEP protein serves as a target protein, and a DNA aptamer capable of being in specific binding to the TS / MDEP protein is screened from a single-chain RNA random library. The aptamer can form a special stem-loop structure in a random sequence area and can be in specific and high-affinity binding to the TS / MDEP protein or targeted binding to gastric cancer cells. The RNA aptamer provides a specific and efficient marker molecule for the gastric cancer diagnosis and treatment field, as well as a new choice for developing gastric cancer diagnosis reagents and gastric cancer treatment medicines.
Owner:刘红卫

Gastric cancer detecting method, reagent and gastric cancer detecting kit

The invention provides a gastric cancer detecting method, a reagent and a gastric cancer detecting kit. The kit comprises a reagent R1 and a reagent R2 or R3; in vitro, the serum of a tested body is mixed with the reagent R1, and the reagent R2 or R3 is added after several minutes; latex particles included in the reagent R2 or R3 are coated with PG antibodies and can be combined with the PG antigen in a sample to form an insoluble complex; based on a latex-enhanced immunoturbidimetry principle, the absorbancy tested by a biochemical analyzer is compared with that of a calibration product, so that the content level of PG is calculated; compared with the content level of the serum PG of healthy people, the content level of PG shows that a health condition of the stomach of the tested human body is initially judged. By comparing a test result obtained by using the kit with that obtained by using an imported kit A, the kit has the advantages that the extremely-high correlation is achieved, and the correlation coefficient is more than or equal to 0.9750. The kit provided by the invention can be used for detecting the gastric cancer, and has stable and reliable detection results; moreover, the use cost can be reduced.
Owner:PUREBIO LAB NINGBO

Enzyme linked immunosorbent assay kit for combined diagnosis of gastrosis or evaluation of gastric cancer risks

The invention discloses an enzyme linked immunosorbent assay kit for combined diagnosis of the gastrosis or evaluation of gastric cancer risks and a preparation method thereof. The kit comprises a micropore plate coated with an antibody against a pepsin antigen I or an antibody against a pepsin antigen II, an enzyme labeled antibody, a color-developing agent, a stop solution and a concentrated cleaning solution, wherein the pepsin antigen I or the pepsin antigen II is a natural protein obtained from extraction of human gastric mucosa tissue. The kit disclosed by the invention adopts a mouse immunized with pepsinogen I and pepsinogen II which are separated from human gastric mucosa to prepare immunogen of a monoclonal antibody, the used standard sample also adopts the pepsin antigen I or the pepsin antigen II separated from the human gastric mucosa, thereby the defects caused by adopting different structures of animal pepsinogen and human pepsinogen are filled. The kit can be used for accurately diagnosing the gastrosis or early gastric cancer and has the advantages of high sensitivity, strong specificity, good accuracy and the like.
Owner:BEIJING MOKOBIO LIFE SCI CO LTD

Chinese medicine composite for treating chronic atrophic gastritis and preparation method thereof

The invention discloses a Chinese medicine composite for treating chronic atrophic gastritis and a preparation method thereof. The Chinese medicine composite mainly comprises the following active pharmaceutical ingredients: jobstears seed, rhizoma dioscoreae, pericarpium citri reticulatae, fructus aurantii immaturus, radix aristolochiae, ligusticum chuanxiong, Lignum aquilariae resinatum, rhizoma corydalis, stir-fried frankincense, stir-fried myrrh, pericarpium citri reticulatae viride, radix scrophulariae, rhizoma cyperi, styrax, radix trichosanthis, radix rehmanniae preparata, peach seed, safflower, medicated leaven, fructus setariae germinatus, dandelion, honeysuckle flower, rhizoma coptidis, radix et rhizoma rhei, radish seed, rhizoma curcumae longae, grassleaf sweetflag rhizome, cortex magnoliae officinalis and tuckahoe, and the like. The Chinese medicine composite can be prepared to be any common oral preparation according to the conventional Chinese medicine preparation method. The Chinese medicine composite can obviously improve abdominal distention that is manifest due to more food intake, tastelessness and insipidity, vague pain and complaint in the gastric cavity, lassitude, athrepsy, anorexia, anaemia and the like and the complications including gastric bleeding, gastrelcosis, anaemia and gastric cancer, and the like, which has definite clinical effect, obvious curative effect and fast desired effect.
Owner:TAIYI HEPU BEIJING RES INST OF TCM

Traditional Chinese medicine composition for treating gastric cancer

The invention discloses a traditional Chinese medicine composition for treating gastric cancer, and relates to the technical field of traditional Chinese medicines, to solve the problem that no effective medicine is available for treating the gastric cancer. The traditional Chinese medicine composition is the traditional Chinese medicine preparation comprising burdock, fig, gallnut, gallnut, daemonorops draco, manis pentadactyla, astragalus mongholicus, angelica sinensis and liquorice. The traditional Chinese medicine composition disclosed by the invention has high anti-cancer activity for solid tumor such as gastric cancer, and has few side effects, is capable of improving the immunocompetence of a patient, and is suitable for the clinical patient with the gastric cancer.
Owner:南通好又鲜水产食品有限公司

Methods for enhancing immune response

This disclosure demonstrates a novel therapy immunological approach using polyamine-based therapy (PBT) for relieving tumor-induced suppression of the patient's immune system. The demonstration of the pharmacological release from the naturally occurring polyamine-mediated immune suppression offers profound impact on the immunotherapy of cancer together with a variety of diseases caused by the disease-causing vector's ability to evade an immune reaction. This therapeutic approach is equally applicable to disease states whereby immune system suppression by polyamines has been demonstrated including; bacterial infections, parasitic infections including malaria and typanosomiasis, viral infections, peptic ulcers and gastric cancer due to H. Pylori infection together with prevention of pregnancy. With a small molecule drug, used in combination with DFMO, the pharmacological manipulation of polyamine levels for therapeutic benefit in various disease states is possible.
Owner:AMINEX THERAPEUTICS

Detection and application of new molecular marker hsa-circ-0001017 of gastric cancer

The invention relates to a cyclic RNA molecular marker for diagnosis of gastric cancer, the cyclic RNA molecular marker is characterized in that the cyclic RNA is hsa-circ-0001017, the invention also provides a method for detection of the cyclic RNA molecular marker in plasma, and the method comprises the following steps: (1) collecting blood, and extracting total RNA in the plasma; (2) performing reverse transcription of the total RNA into cDNA; (3) performing droplet digital PCR detection of a cDNA solution of the step (2) by use of specific amplification back-to-back primers and amplification upstream and downstream primers of housekeeping gene GAPDH, after the completion of the reaction, detecting fluorescence signal values of all droplets, setting a threshold, and determining whether the droplets include the cyclic RNA or the housekeeping gene GAPDH, wherein the droplets higher than the threshold are positive droplets, and the droplets below the threshold are negative droplets; and (4) counting the number of the positive droplets, and calculating the copy number of the hsa-circ-0001017 and the housekeeping gene GAPDH in the plasma for quantitative detection of the hsa-circ-0001017 and the housekeeping gene GAPDH in the plasma. Compared with the prior art, the advantages are that the hsa-circ-0001017 can be specifically expressed in plasma in patients with gastric cancer, and can be used as a new molecular marker for diagnosis of the gastric cancer.
Owner:NINGBO UNIV

Antibodies, pharmaceutical compositions and methods

Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to stage-specific embryonic antigen 4 (SSEA-4) are disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as breast cancer, lung cancer, esophageal cancer, rectal cancer, biliary cancer, liver cancer, buccal cancer, gastric cancer, colon cancer, nasopharyngeal cancer, kidney cancer, prostate cancer, ovarian cancer, cervical cancer, endometrial cancer, pancreatic cancer, testicular cancer, bladder cancer, head and neck cancer, oral cancer, neuroendocrine cancer, adrenal cancer, thyroid cancer, bone cancer, skin cancer, basal cell carcinoma, squamous cell carcinoma, melanoma, and / or brain tumor.
Owner:OBI PHARMA INC

Detection and tracking of interventional tools

The present invention relates to minimally invasive X-ray guided interventions, in particular to an image processing and rendering system and a method for improving visibility and supporting automatic detection and tracking of interventional tools that are used in electrophysiological procedures. According to the invention, this is accomplished by calculating differences between 2D projected image data of a preoperatively acquired 3D voxel volume showing a specific anatomical region of interest or a pathological abnormality (e.g. an intracranial arterial stenosis, an aneurysm of a cerebral, pulmonary or coronary artery branch, a gastric carcinoma or sarcoma, etc.) in a tissue of a patient's body and intraoperatively recorded 2D fluoroscopic images showing the aforementioned objects in the interior of said patient's body, wherein said 3D voxel volume has been generated in the scope of a computed tomography, magnet resonance imaging or 3D rotational angiography based image acquisition procedure and said 2D fluoroscopic images have been co-registered with the 2D projected image data. After registration of the projected 3D data with each of said X-ray images, comparison of the 2D projected image data with the 2D fluoroscopic images—based on the resulting difference images—allows removing common patterns and thus enhancing the visibility of interventional instruments which are inserted into a pathological tissue region, a blood vessel segment or any other region of interest in the interior of the patient's body. Automatic image processing methods to detect and track those instruments are also made easier and more robust by this invention. Once the 2D-3D registration is completed for a given view, all the changes in the system geometry of an X-ray system used for generating said fluoroscopic images can be applied to a registration matrix. Hence, use of said method as claimed is not limited to the same X-ray view during the whole procedure.
Owner:KONINKLIJKE PHILIPS ELECTRONICS NV

Drug selection for cancer therapy by profiling signal transduction proteins in ascites or pleural efflux samples

The present invention provides methods for selecting a suitable anticancer therapy and for identifying and predicting response for the treatment of a gastric cancer by determining the expression level and / or activation level of one or more analytes in a cell such as a cancer cell from an ascites sample. The present invention also provides methods for selecting a suitable anticancer therapy and for identifying and predicting response for the treatment of a lung cancer such as a non-small cell lung cancer by determining the expression level and / or activation level of one or more analytes in a cell such as a cancer cell from a pleural efflux sample.
Owner:NESTEC SA

Chinese medicinal composition for treating malignant tumor and preparation method thereof

The invention discloses a Chinese medicinal composition for treating malignant tumor, belonging to the field of Chinese medicines. The Chinese medicinal composition is a medicament preparation formed from herba oldenlandiae, astragalus root, tuckahoe, prepared pinellia tuber, herba scutellariae barbatae, teloon, scorpion, scolopendra and the like by adopting advanced processes including extraction with water, extraction with ethanol, enzymolysis of trypsinase and the like according to a certain compatible requirement, and the medicament preparation is preferably prepared into capsules and tablets. The Chinese medicinal composition has a certain function for relieving symptoms for lung cancer, liver cancer, gastric cancer, intestinal cancer, breast cancer, encephaloma, lymph cancer and other malignant tumors, reducing tumor bodies, inhibiting the growth of the tumors and the like; and according to the Chinese medicinal composition, the human immune capability can be improved, the lives of patients suffered from tumors can be prolonged and the adverse reactions of leukocytopenia, dizzy, weakness and fatigue, skinniness, poor appetite, nausea and vomiting and the like due to radiotherapy chemotherapy for cancers can be effectively relieved.
Owner:ANHUI BIOLOGICAL PEPTIDE IND RES INST

Artificial intelligence diagnosis method for gastric cancer under narrow-band imaging amplification gastroscope

PendingCN112435246AAuxiliary differential diagnosisImage enhancementImage analysisPattern recognitionImage segmentation
The invention relates to the technical field of medical technology assistance, in particular to an artificial intelligence diagnosis method for gastric cancer under a narrow-band imaging amplificationgastroscope, which comprises the following steps: S1, constructing a mini-UNet neural network model; S2, constructing a UNet + + image segmentation neural network model, and obtaining an area ratio Rabnormal of an image feature difference region; S3, adopting a generative adversarial network (GAN) technology to obtain a microvascular morphological diagram and a microstructure morphological diagram of the feature abnormal region; S4, identifying the microvessel form dissimilarity degree and the microstructure form dissimilarity degree in the microvessel form diagram and the microstructure formdiagram by the neural network model ResNet50; and S5, carrying out identification and judgment by using the random forest model obtained by training to obtain final judgment of cancer or non-cancer,and identifying the canceration position range of the image, which is judged to be cancer, as the identified image feature difference region Pabnormal. The sensitivity and specificity of the kit to cancer and non-cancer recognition reach about 93.4% and 90.7% respectively, a clinician can be effectively assisted in discriminating and diagnosing cancer and non-cancer, and a canceration position range is given.
Owner:WUHAN ENDOANGEL MEDICAL TECH CO LTD

Tissue chip used for tumour early stage diagnosis and preparation device

Three kinds of tissues including cancer tissue, precancerosis and corresponding normal tissue are sliced up, dyed, marked, and positioned. Receptor holes are prepared by leading designed lattice array mould paper to paste on surface of wax block of receptor. Wax block with tissue core bar is prepared by using perforating needle and puncture needle for tissue. Common cancer such as lung cancer, nasopharyngeal carcinoma, oesophagus cancer etc. and having integrated clinical data and pathology features are selected. Through in situ hybridization, testing mRNA of relevant gene and expression of protein on tissue chip, consistent result between the invented product and traditional test is validated. In the product, cellular morphology is clear and even, and there is no fallen off tissue point. The invention is applicable to filter cancers, early diagnosis and forecasting prognosis.
Owner:中南大学湘雅医学院肿瘤研究所

Nitroxides for use in treating or preventing neoplastic disease

Pharmaceutical compositions are provided that are useful in treating or preventing neoplastic disease, such as cancer. The compositions comprise a pharmaceutically acceptable carrier, and an effective therapeutic or prophylactic amount of a nitroxide antioxidant that alters the expression of one or more genes related to the cancer. Methods are also provided for the use of the pharmaceutical compositions in the treatment or prevention of cancer. In a preferred embodiment, the nitroxide antioxidant is Tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl), and the cancer is esophageal cancer, hepatocellular carcinoma, colon cancer, prostate cancer, lung cancer, gastric carcinoma, renal cell carcinoma, bone cancer, breast cancer, cervical cancer, brain cancer, or a cancer associated with the tumor suppressor gene p53.
Owner:MATRIX BIOMED INC

Gastric cancer detection marker and detecting method thereof, kit and biochip

The invention relates to a gastric cancer detection marker, and a detecting method thereof, a related kit and a biochip. The gastric cancer detection marker comprises 21 specific micro RNAs stable in human serum / plasma. The marker which is broad in detection spectrum, high in sensitivity, low in detection cost, easy to be got and stored can be used for diagnosing and differentially diagnosing the gastric cancer, predicating occurrence and reoccurrence of diseases and conditions, evaluating therapeutic efficiency and efficacy and screening active pharmaceutical ingredients and the like. The method can be widely applied to cancer survey and related work, improves low specificity and low sensitivity caused by individual difference which is difficult for a single marker to overcome, and remarkably improves the clinical detection rate of the gastric cancer. Therefore, the method is an effective means to diagnose early breast cancer.
Owner:JIANGSU MICROMEDMARK BIOTECH
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