240 results about "Microvessel" patented technology

The invention relates to the technical field of medical robot systems, and discloses a nerve plexus intelligent positioning anesthesia puncture robot system based on multi-modal fusion, which performs time-space synchronization on ultrasonic image flow and contact force data. The frequency domain analysis module extracts a main peak frequency by using optical flow field frequency domain transformation, and generates a probability mask for marking pulsatile tissues. The viscoelasticity verification module calculates phase lag parameters of visual deformation and contact force, identifies tissue rheological properties and calculates a dynamic damping coefficient. The deformation compensation module calculates a mechanical residual error based on a reference mechanical model, and inversely calculates the mechanical residual error into space deformation displacement of the tissue. The feedback control module combines the probability mask and the deformation displacement to generate a motion instruction. According to the invention, through multi-modal data fusion, precise identification of tiny blood vessels, dynamic identification of tissue attributes and real-time compensation of soft tissue conceding deformation are realized.

The invention relates to ultra-small prussian blue nano-particles (T-USPB-C) carrying tirofian, a preparation method of the nano-particles and application of the nano-particles in preparation of drugs for reducing MVO and MIRI. According to the preparation method, the T-USPB-C is prepared by three steps. The T-USPB-C provided by the invention can carry tirofiban, and has catalase and superoxide dismutase simulated nano-enzyme activity. Moreover, the size of the nano-scale drug is required to reach a nano-scale size, and the drug can be efficiently cleared through kidney excretion, so that the potential long-term toxicity problem is minimized. The ultra-small prussian blue nanoparticle carrying the tirofian has an excellent active oxygen scavenging capability. Microvascular perfusion can be rapidly improved through the antithrombotic effect, then the protection effect is continuously achieved through the anti-oxidation and anti-inflammatory mechanism, and microvascular injury and MIRI are effectively prevented.

The invention belongs to the technical field of biomedical tissue engineering materials, and particularly relates to injectable composite plastic gel and a preparation method thereof. The injectable plastic gel provided by the invention is formed by suspending and compounding the cross-linked sodium hyaluronate gel particles and the biological tissue extracellular matrix particles, the two material particles in the injectable composite plastic gel are uniform in size and controllable in size, other toxic catalysts do not need to be added in the preparation process, and the injectable plastic gel is easy to prepare. The collagen / elastin composite material is rich in collagen and elastin, and shows good biomechanical properties. Meanwhile, the composite plastic gel contains a plurality of bioactive factors, and after the composite plastic gel is injected and filled into a body, the composite plastic gel is slowly degraded and can promote the generation and ingrowth of autologous fat cells and microvessels, so that the balance of degradation and remodeling is achieved. The preparation method of the injectable plastic gel provided by the invention can be widely applied to the fields of plastic surgery, medical beauty and the like.

The invention relates to a retina nerve and blood vessel unit in-vitro three-culture model and a preparation method thereof, and belongs to the technical field of biology. The invention provides an in-vitro three-culture model of a retina nerve and blood vessel unit. The in-vitro three-culture model is obtained by carrying out in-vitro Transwell indirect co-culture on retina microvascular endothelial cells, retina ganglion cells and retina Muller cells. The in-vitro three-culture model of the retina nerve and blood vessel unit is based on a three-cell indirect co-culture method, retina microvascular endothelial cells, retina ganglion cells and retina Muller cells are simultaneously incorporated by utilizing Transwell, and the three cells are in indirect contact. The in-vitro three-culture model of the retina nerve and blood vessel unit can be used for more objectively simulating pathophysiological states of various cells of the retina nerve and blood vessel unit, so that common pathophysiological changes of mutual dependence and interaction of the three cells under in-vitro conditions can be observed.

The invention provides a tissue microvessel analysis method and system for assisting drug design based on artificial intelligence. The method comprises the steps that two channel images of a blood vessel marking channel and a nano probe channel are collected; carrying out preprocessing, registration and feature fusion on the two channel images to obtain a fusion feature tensor for simultaneously coding a blood vessel-nanoparticle space coupling relationship; extracting multi-scale structure information based on the fusion feature tensor to obtain an enhanced feature tensor; constructing double models based on a U-Net + + architecture, and combining the double models with an enhanced feature tensor to obtain a blood vessel mask, a nanoprobe mask and a preprocessed probe intensity graph; and obtaining a permeability index based on the blood vessel mask, the nano probe mask and the preprocessed probe intensity graph, and obtaining a blood vessel typing and drug recommendation design strategy by adopting a clustering and random forest regression algorithm. According to the method, the quantitative analysis precision and efficiency of the vascular permeability are remarkably improved, intelligent linkage of image analysis and a nano-drug design strategy is realized for the first time, and the method has good application potential.

The invention belongs to the technical field of experiments and the field of anatomical research, and particularly relates to a self-developing vascular casting agent and a preparation method thereof. The invention discloses a preparation method of a self-developing vascular casting agent. The self-developing vascular casting agent is obtained by uniformly mixing iopromide, natural latex, II-type barium sulfate and pigment, wherein in parts by weight, the iopromide accounts for 30-40%; 25%-30% of natural latex; 40% of type II barium sulfate; and 5%-10% of pigment. The blood vessel casting agent developed by the invention is excellent in formula flowability (smooth perfusion), does not cause blockage, can avoid reverse osmosis of a capillary microenvironment, and realizes arteriovenous differentiated perfusion; and meanwhile, high-contrast development is realized, and complete coverage of capillary vessels is basically realized. The optimized blood vessel casting agent formula is completely cured (at room temperature) within 24 hours, the shrinkage rate is low, and blood vessel deformation is avoided.

This invention discloses a magnetically controlled balloon guidewire for microvascular revascularization and its manufacturing method. The magnetically controlled balloon guidewire for microvascular revascularization includes a magnetically controlled tip, a phase-change balloon, and a guidewire connected in sequence. This magnetically controlled balloon guidewire for microvascular revascularization can precisely navigate and flexibly steer, and the phase-change balloon can accurately navigate to the stenotic lesion site of the microvessel.

Disclosed is a method of treating patients with microvascular angina by using a combination of zibotentan and dapagliflozin.

The invention relates to an imbedding device for a nerve microvascular nerve decompression operation gasket under direct vision. The imbedding device comprises a tube assembly, a guide wire assembly, a decompression gasket and a pushing component, the tube assembly comprises a sheathing canal, a balloon and a gas transmission component, the balloon is arranged on the sheathing canal and close to the front end of the sheathing canal, and the gas transmission component is arranged on the sheathing canal and communicated with the balloon; the guide wire assembly is contained in the sheath tube, the guide wire assembly comprises a guide wire, at least two pull wires and a camera, a snake bone mechanism is arranged on the guide wire, the front end of the guide wire extends out of the front end of the sheath tube, the pull wires are connected to the snake bone mechanism, and the camera is arranged at the front end of the guide wire; the decompression gasket is of a cylindrical hollow structure and is arranged outside the sheath tube in a sleeving mode. The pushing component is arranged outside the sheathing canal in a sleeving mode and used for pushing the pressure reduction gasket towards the front end of the sheathing canal. The implantation device does not need to enter and exit from the opening repeatedly, operation of a doctor is simplified, the surgical operation difficulty is reduced, the surgical time is shortened, and the surgical risk is reduced.

The invention discloses a construction method of a coronary artery microcirculation disturbance cell model, and belongs to the technical field of biological medicine. According to the method, mouse heart microvascular endothelial cells (MCMEC) are taken as objects, tetrachlorohydroquinone (TCHQ) is used for treating for 6 hours at the concentration of 20-40 [mu] M, and CMD typical characteristics such as apoptosis, increase of reactive oxygen species (ROS), reduction of nitric oxide (NO) and release of inflammatory factors (TNF-alpha and IL-1beta) of the cells are induced. The TCHQ is applied to construction of the CMD model for the first time, and the model is stable, good in repeatability and capable of being used for CMD pathogenesis research and drug screening.

This invention discloses a wired dual-modal imaging capsule endoscopy system, belonging to the field of medical device technology. The system includes a capsule module, a transmission and control module, a dual-modal imaging module, and a signal analysis module. The capsule module is used to achieve 360° circumferential scanning imaging of the esophageal mucosa. The transmission and control module ensures stable transmission of optical and electrical signals and precise control of capsule movement. The dual-modal imaging module integrates an optical coherence tomography submodule and a photoacoustic imaging submodule to acquire tissue morphology information and microvascular distribution information, respectively. The signal analysis module processes the dual-modal signals. This invention achieves three-dimensional high-resolution integrated imaging of the esophageal mucosa without the need for exogenous labeling agents, significantly improving the detection accuracy of early esophageal cancer and precancerous lesions.

The invention provides a lung-kidney interaction simulation system based on an organ chip, and the system comprises a lung chip module which is used for simulating a qi-blood barrier structure of a lung, and the lung chip module is inoculated with human alveolar epithelial cells and human lung microvascular endothelial cells; the kidney chip module is used for simulating a capillary lumen of a kidney tubule and a kidney tubule lumen structure, and human kidney tubule epithelial cells and human umbilical vein endothelial cells are inoculated on the kidney chip module; the connecting channel is used for communicating the lung chip module with the kidney chip module and allowing the culture medium to flow between the lung chip module and the kidney chip module; and wherein a klebsiella pneumoniae liquid for causing lung injury is applied to the upper layer of the lung chip module. The invention provides a novel simulation system for the research of lung-kidney interaction, and solves the limitation of animal experiments.

A pro-inflammatory and vasoconstrictor and endothelin-1 (ET-1) are pathogenic molecules related to a series of cardiovascular diseases. Unlike ET-1 signaling for vasoconstriction of the main artery, we have proven herein that coronary microvessels exhibit a unique signaling mechanism for constriction (independent of PKC, CPI-17, and intracellular calcium storage). The pathophysiological level of ET-1 acts preferentially on the microvessels to exert persistent vasoconstriction by activating Rho kinase upon binding to ETAR of the ET-1 receptor. The ETAR antagonist BQ123 only blocks but cannot reverse vasoconstriction against ET-1. In contrast, ROCK inhibitors (e.g., H-1152) are effective to reverse arteriolar systole against ET-1. Thus, ROCK inhibition is a potent and specific choice for the treatment of coronary ischemic disease (abnormal vasoconstriction) associated with microvascular dysfunction due to excessive production of ET-1. The ROCK inhibitors may also be used to treat microvascular diseases associated with diabetic retinopathy as well as microvascular dysfunction caused by cancer therapy or immunosuppressive drugs. Since H-1152 can also reduce the basal tension of microvessels, a ROCK inhibitor is also a good diagnostic agent when used during angiography or by a non-invasive method.

The present disclosure proposes a method and apparatus for imaging at a microscopic scale a region of an organ of a human or animal, allowing the use of a 2D subsampled ultrasound probe while providing 3D ULM images with high resolution usually obtained only with a full 2D array matrix, by sorting the detected microbubbles and keeping only the microbubbles corresponding to the spots belonging to the main lobe of the Point Spread Function (PSF) of the microbubble and removing the phantom microbubbles corresponding to the spots belonging to the side lobes. It is also possible to provide a 3D non-invasive imaging of the microvascular flow of the region of an organ, such as a brain in-vivo, with high resolution and high sensitivity.

The invention relates to hypoxia response therapeutic VEGFA (vascular endothelial growth factor A) mRNA (messenger Ribonucleic Acid) and application thereof. The mRNA comprises a 5'end cap, a 5 'UTR (Untranslated Region) containing a Kozak sequence, VEGFA ORF (Open Region Fragment), a 3' UTR containing an RNA (Ribonucleic Acid) binding protein HuR binding site, a RhoBAST fluorescent aptamer at the tail end of the 3 'UTR and a PolyA tail. According to the design, through a HuR hypoxia-dependent nuclear plasma transport mechanism, the stability of mRNA in hypoxic cells is improved by 2.5 times, the protein expression quantity is improved by 2 times, and proliferation of endothelial cells is remarkably promoted. Further disclosed is a VEGFA mRNA delivery system based on engineered extracellular vesicles (EVs): EVs surface modified kidney targeting peptide LTH. The system is efficiently accumulated in ischemic kidneys, VEGFA expression is remarkably enhanced, and abnormal vascular hyperplasia of external renal organs is avoided. Animal experiments prove that the survival rate of a renal ischemia-reperfusion injury model can be increased to 100% by intravenous injection of drug-loaded EVs, and the capillary density is remarkably increased 7 days after treatment. The invention is suitable for treating ischemic diseases, organ ischemia reperfusion injury or chronic wounds and the like, and has the advantages of accurate targeting, hypoxia response, high stability and safety.

This application provides a method and apparatus for determining blood flow velocity in a blood vessel, comprising: acquiring an initial contrast image and a target contrast image after injecting a contrast agent; comparing the initial contrast image and the target contrast image to determine the length of the blood vessel through which the contrast agent flows; determining the uniformity of the contrast agent in the main vessel region and / or the visualization of microvessels in the background region of the target contrast image based on the contrast agent concentration in the target contrast image; correcting the blood vessel length based on the uniformity of the contrast agent and / or the visualization of microvessels to obtain a corrected blood vessel length; and determining the blood flow velocity based on the corrected blood vessel length. This reduces calculation errors caused by the imaging angle of the contrast image, the shape of the blood vessel, or blood vessel bifurcation, thereby improving the accuracy of blood flow velocity assessment.

This invention belongs to the fields of tissue engineering and biotechnology, specifically relating to a silicone microvascular phantom model, its fabrication method, and its applications. The fabrication method includes the following steps: etching convex textures onto a metal template, and dripping hot melt adhesive at the endpoints of the convex textures; placing a smooth panel into a metal container, laying the metal template flat on the smooth panel with the convex texture facing upwards; dissolving silicone and pouring it into the container, removing air bubbles, and after the silicone solidifies, separating the silicone from the metal template to obtain a first silicone block; pouring the silicone into the metal container, removing air bubbles, and solidifying to obtain a second silicone block; placing the first silicone block on the surface of the second silicone block and solidifying to obtain a silicone composite; inserting a needle connected to a conduit into the cavity of the vascular texture of the silicone composite to reinforce the interface, thus obtaining the final product. The microvascular phantom model prepared by this method has a diameter of less than 100 micrometers and can be preserved for a long time and reused repeatedly.

The invention provides a personalized ear mold 3D printing technology and an application system thereof. The personalized ear mold 3D printing technology comprises the following printing steps: S1, synchronously acquiring multi-modal data: synchronously finishing by using an intelligent ear canal scanner: (1) physiological data: detecting a high-precision ear canal 3D model and a soft tissue elasticity modulus; according to the 3D ear mold printing technology, a non-European acoustic waveguide structure is optimized through multi-modal data fusion and a quantum annealing algorithm, millimeter-level anatomical matching and dynamic acoustic impedance tuning of the ear canal are achieved, and the acoustic impedance spectrum and the personalized frequency response preference of the ear canal of a user are obtained. According to the invention, femtosecond laser coloring is combined to construct a nano grating color developing layer and StyleGAN3 to generate microvascular bionic textures, so that the traditional single adaptive dimension is broken through, the ear mold has the lifelong evolution ability of acoustic self-adaption, aesthetic self-matching and physiological self-optimization, and a static hearing aid device is upgraded to an intelligent biological function extension body.

The invention relates to the technical field of medical artificial intelligence, in particular to a uric acid level prediction method based on multi-source data fusion, and the method comprises the steps: carrying out the synchronous signal collection of a finger tip of a target user through a near-infrared hyperspectral collection device and a flexible microfluidic impedance sensor; obtaining a subcutaneous microvascular hyperspectral image sequence and an epidermal sweat electrochemical impedance spectrum; and performing Euler video amplification processing on the subcutaneous microvascular hyperspectral image sequence to obtain a blood flow micro-dynamic enhancement sequence. According to the method, a calculation and compensation mechanism for physiological response time lag is introduced, nonlinear time sequence alignment is carried out by further utilizing a dynamic time warping algorithm and taking the time lag as a constraint window when the global time lag is obtained, and compared with a traditional simple timestamp alignment method, it is guaranteed that actually-related physiologically features can be accurately matched, and the accuracy of time sequence alignment is improved. High-quality and synchronous input data is provided for subsequent feature fusion, and the logic leakproofness and accuracy of the whole prediction method are improved.

The application discloses a composition for lightening dark circles under eyes containing camellia chrysantha extract and a preparation method and application thereof, and relates to the technical field of cosmetics.The composition comprises component A, component B and component C;the component A comprises andrographis paniculata extract and camellia chrysantha extract;the component B comprises ubiquinone and safflower extract;and the component C is menthol lactate.The andrographis paniculata extract, the camellia chrysantha extract, the ubiquinone, the safflower extract and the menthol lactate are combined to have a synergistic effect; the composition formed by the specific combination of the components can promote blood microcirculation, inhibit microvascular generation, increase epidermal thickness, relieve cell hypoxia and eye fatigue, reduce blood vessel type dark circles, relieve redness and strengthen skin, and is mild and non-irritating to skin, and is suitable for people with sensitive skin.

Methods, medical systems, and devices for delivering platelet rich plasma, stem cells, exosomes or other extracellular vesicles, growth factors, neuregulins, hormones, extracellular matrix tissue or microvascular tissue fragments allograft, autograft, or xenograft, anti-inflammatories, steroids, and / or other whole, sectioned, particulated, micronized, or otherwise manipulated substances naturally occurring or synthetic that produce, promote, or enhance angiogenesis, reduce inflammation, reduce oxidative stress, promote healing, and / or otherwise reverse neuropathies or improve function of underlying tissues.

The disclosed technology relates to a catheter configured to reduce microvascular obstruction (MVO) in myocardial tissue at risk due to an acute myocardial infarction (AMI). The catheter comprises a catheter shaft that is configured to be inserted into a heart of a patient. A channel is arranged in the heart and is configured to deliver blood from a first location in the heart to a second location in the heart. A pressure sensor is configured to monitor pressure at the second location to ensure controlled delivery of blood from the first location to the second location. The catheter device is operable to reduce the amount of tissue actually comprising MVO by approximately 20% compared to untreated regions.

The invention provides a construction method and application of a sepsis model based on a lung and kidney organ chip. The method comprises the following steps: S1, carrying out ultraviolet sterilization on an organ chip device; s2, modifying a transwell plug-in unit; s3, inoculating human lung microvascular endothelial cells and human umbilical vein endothelial cells; S4, inoculating human alveolar epithelial cells and human renal tubular epithelial cells; s5, transwell inserts are arranged in two holes in the middle of the organ chip device respectively, a mixed culture medium is added into liquid adding holes in the two sides of the organ chip device, and the lung chip and the kidney chip are communicated through a lower channel of the organ chip device; s6, dynamically culturing the lung and kidney organ chip; and S7, sucking up the culture medium in the constructed lung and kidney organ chip, adding the LPS-containing mixed culture medium into a lower channel, and respectively adding the LPS-containing mixed culture medium into the human alveolar epithelial cell side and the human renal tubular epithelial cell side of the lung and kidney organ chip and the transwell plug-in hole for culturing for 2 days. According to the invention, the lung and kidney organ chip is applied to the sepsis model for the first time, and the constructed sepsis model is more suitable for basic research and drug development of sepsis.

This invention discloses an AI model-based system for predicting microvascular invasion in liver cancer. In this invention, the focus on key information in multimodal data is enhanced through attention weight calculation within the model construction submodule, strengthening the capture of subtle features related to microvascular invasion in liver cancer. By focusing attention on key time frames of abnormal blood flow in ultrasound contrast-enhanced videos and lesion areas closely associated with microvascular invasion in CT images, the system avoids being distracted by a large amount of irrelevant normal tissue data. This reduces ineffective learning of non-critical information, improving the specificity of predictions. Through loss calculation and optimization updates, the efficiency and stability of model training are improved, enhancing its adaptability to real-world clinical data. The optimized update formula can quickly adjust the model's internal parameters, allowing the model to converge stably to a reliable predictive state without spending excessive time on trial and error, reducing prediction fluctuations caused by data differences.

The invention provides a capillary network hemodynamic modeling method with a multilayer structure, and aims to solve the problem that a traditional model is difficult to truly reflect a capillary multilayer structure and blood flow topological characteristics, and combines the hierarchical structure characteristics of a capillary network disclosed by a high-resolution imaging image. And constructing a multi-layer blood vessel network model consisting of a microarteriovenous layer, a connecting layer and a capillary network layer. Wherein the micro artery and vein layer is a tree-shaped blood vessel network formed by micro arteries and micro veins; the capillary network layer is of a regular network blood vessel structure constructed based on a hexagonal grid; and the connecting layer is a connecting blood vessel for connecting the microarteriovenous layer and the capillary network layer. Through standardized numbering rules, node insertion and blood vessel splitting operation, embedding, reconstruction and overall structure integration of blood vessel segments are completed, and therefore a capillary network system which is complete in structure and is in topological communication is constructed. On the basis of structural modeling, a linear equation solving system is established for hemodynamic simulation. The method has the advantages in the aspects of structural definition, simulation precision and expansibility, and has important scientific research and engineering application value.

The invention provides an artificial intelligence diagnosis and treatment system based on a magnified endoscope, and belongs to the technical field of computer vision and medical image processing. A movable lens group is arranged at the front end of the soft magnification endoscope and is used for realizing optical zoom magnification; the AI multifunctional endoscope image processor is connected with the soft amplification endoscope and is used for controlling the movable lens group to zoom and receiving image data acquired by the high-pixel sensor; through fusion of an optical amplification technology with high magnification of 100-150 times and a multi-mode artificial intelligence algorithm, cellular level observation and intelligent analysis of mucous membrane surface microvessels and microstructures are achieved, the system can accurately recognize minimal lesions and flat lesions with the diameter smaller than 5 mm, and the defects that a traditional endoscope depends on naked eye judgment of a doctor, diagnosis omission is likely to happen, and the diagnosis accuracy is high are effectively overcome. The subjective limitation that the missed diagnosis rate reaches up to 30%-40% is overcome, the diagnosis process is standardized and quantified, and the missed diagnosis and misdiagnosis risks of early cancers are reduced.

This application discloses a method and system for microvascular anastomosis modeling and effect prediction in assisted spermatic cord anastomosis, relating to the field of data processing technology. The method includes: extracting the pampiniform plexus topology and varicose vein segments from a three-dimensional vascular tree model of the spermatic veins constructed based on spermatic cord vessel images; determining candidate diversion inlet locations based on the spatial adjacency relationship between the obstructed reflux nodes identified by the varicose vein segments and the pampiniform plexus topology; spatially registering the contour of the inferior epigastric vein segmented from the superficial vein images of the inguinal region with the candidate diversion inlet locations to generate a diversion anastomosis path planning map; constructing the geometric configuration of the end-to-side anastomosis and performing hemodynamic simulation to generate a wall shear stress distribution field, assess the thrombosis tendency of the end-to-side anastomosis, and generate a postoperative patency rate prediction value. This application can predict the risk of thrombosis preoperatively through hemodynamic simulation, providing a reliable basis for surgical planning and effectively improving the success rate of the surgery.

The invention discloses a preparation method of a coronary artery microcirculation disturbance animal model, and belongs to the technical field of biological medicine. According to the method, the stable mouse CMD model can be established by injecting 20-40 [mu] g / mL Calcimycin into the cardiac apex for the first time. Calcimycin is a calcium ion (Ca < 2 + >) carrier commonly used in a laboratory and can transport calcium ions outside cells into the cells, so that the concentration of the calcium ions in the cells is increased. Particularly, when 40 [mu] g / mL of Calcimycin is injected, the pathological severity of the Calcimycin is further aggravated, myocardial fiber arrangement is disordered, boundary is unclear, a large number of myocardial cells are necrotic and dissolved, cavitation is formed, vascular wall degeneration swelling is caused, inflammatory cell infiltration is caused, and thrombus is formed in microvessels.

The invention relates to the technical field of diabetic hypoglycemia, and discloses a diabetic hypoglycemia response induced vascular injury biomarker which is a combination of high-sensitivity C reactive protein, 8-isoprostaglandin F2alpha, von willebrand factor, free fatty acid and D-dimer. The invention further discloses application of the diabetic hypoglycemic response induced vascular injury biomarker in preparation of a reagent for early auxiliary diagnosis of diabetic hypoglycemic response induced vascular injury. According to the invention, a combination of high-sensitivity C-reactive protein, 8-isoprostaglandin F2alpha, von willebrand factor, free fatty acid and D-dimer is used as a vascular injury biomarker induced by diabetes mellitus hypoglycemia response; acute vascular dysfunction, cardiovascular system injury, microvascular complications and atherosclerosis can be effectively diagnosed, diabetic vasculopathy can be found at an early stage, disease progression can be predicted, and clinical treatment can be guided; the sensitivity and the specificity are high.

The application relates to the technical field of medical imaging, in particular to a photoacoustic magnetic multi-modal imaging system and method for prostate cancer identification, which comprises the following steps: the photoacoustic imaging unit is used for photoacoustic imaging of microvessels in a prostate part; the ultrasonic elastic imaging unit is used for ultrasonic elastic imaging of the prostate part; the magnetic resonance imaging unit is used for magnetic resonance imaging of the prostate part; the multi-modal image fusion unit is used for information fusion of photoacoustic imaging, ultrasonic elastic imaging and magnetic resonance imaging of the prostate part, so as to obtain a multi-modal fusion image of the prostate part. The application adopts high-quality imaging equipment for the prostate part, guarantees high-quality acquisition of the multi-modal images in the imaging stage, and after the high-quality image acquisition is completed, a bidirectional supervision registration network is used to realize registration and fusion of photoacoustic, ultrasonic elastic images and high-resolution magnetic resonance images, so that high-quality images are provided for image identification of prostate cancer.