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74 results about "Capillary network" patented technology

Vascularized gastric cancer organ chip and preparation method thereof

The invention relates to the technical field of tumor biomedical engineering and organ chips, in particular to a vascularized gastric cancer organ chip and a preparation method thereof.The chip is composed of an integrated micro-fluidic main body, an annular micro-column array and an optical sealing film, and a central culture cavity is divided into a tumor area and a blood vessel area by micro-columns; the preparation method comprises the following steps: injecting a fibrous protein solution containing human umbilical vein endothelial cells and cancer-related fibroblasts into a vascular region, and adding thrombin for in-situ gelation to form a pre-vascularized network; the method comprises the following steps: mixing a patient-derived gastric cancer organ with a methacrylic acid esterified gelatin pre-polymerized solution, injecting the mixture into a tumor area, and carrying out photo-crosslinking immobilization; culturing for 7-14 days under the dynamic perfusion condition of a mixed culture medium to obtain a three-dimensional gastric cancer organ model containing a capillary network; the method is expected to be used for rapid, low-cost and high-throughput screening of chemotherapy or anti-angiogenesis drugs and accurate prediction of individual curative effects of patients.
Owner:THE SEVENTH AFFILIATED HOSPITAL SUN YAT SEN UNIV SHENZHEN

Capillary net cage heat exchanger with phase change energy storage function, heat pump unit system and method

The invention discloses a capillary tube net cage heat exchanger with phase change energy storage, a heat pump unit system and a method, solves the problem of limited heat exchange capacity of a heat pump unit in the prior art, and has the beneficial effect of effectively enhancing the heat exchange capacity of the heat pump unit. The capillary tube net cage heat exchanger body is supported by the frame body, the upper side and / or the lower side of the frame body are / is provided with the cover bodies, the cover bodies are internally provided with the cavities, the multiple bag bodies are arranged in the cavities, the core materials are arranged in the bag bodies, and the core materials are made of phase-change materials. And the phase-change material absorbs latent heat to generate state transformation so as to absorb heat energy accumulated at the front end, and / or under the heating working condition, when the temperature of a heat source at the front end of the heat pump unit is reduced to the set temperature, the phase-change material generates state transformation and releases heat, and thermal compensation is carried out on the front end.
Owner:QINGDAO UNIV OF TECH

Simulation of mineralization in rock porous media by statistical sampling of nucleation sites

A representation of a rock capillary network is obtained and initial and boundary conditions of fluid flow and mineral precipitation process simulations for the rock capillary network are set. One or more instances of a geometry evolution simulation are performed, each geometry evolution simulation comprising obtaining fluid flow vectors for the rock capillary network, identifying one or more hotspots of nucleation in the rock capillary network, starting a mineral precipitation analysis and estimating a mineral accumulation over a given time interval for at least the identified hotspots of nucleation, adjusting a pore geometry to an effect of mineral precipitation for the rock capillary network, and iteratively repeating each of the one or more geometry evolution simulations until corresponding stop criteria are met for each geometry evolution simulation. A resulting rock under analysis property is computed from an aggregate of results of the one or more geometry evolution simulations.
Owner:INTERNATIONAL BUSINESS MACHINE CORPORATION

Method and system for evaluating facial skin aging

The invention provides a method and system for evaluating facial skin aging, and the method comprises the steps: obtaining visible light, ultraviolet reflection and near-infrared spectrum images through multispectral imaging, and extracting skin texture, color spots and capillary network parameters through preprocessing; constructing a three-dimensional facial skin model, and measuring skin elasticity parameters in combination with a mechanical sensor; and inputting the parameters into a deep learning aging evaluation model, outputting a comprehensive evaluation report containing the physiological age of the skin, the elasticity grade and the regional aging difference index, and providing personalized aging protection suggestions. According to the method, multi-modal data and a deep learning technology are fused, multi-dimensional quantitative evaluation is realized, the method has the characteristics of high precision, objectivity and individuation, a powerful tool is provided for skin health management, and the method has a wide application prospect.
Owner:暨选健康科技(广州)有限公司

Radiation air conditioner heat and humidity decoupling cooperative control method based on dynamic dew point prediction

The invention discloses a radiation air conditioner heat and humidity decoupling cooperative control method based on dynamic dew point prediction, and the method comprises the steps: building a multi-dimensional environment state sensing system, collecting indoor environment parameters in real time, including indoor temperature and humidity and capillary network water supply temperature, calculating indoor air dew point temperature and moisture content change rate, and forming a dynamic anti-condensation safety margin. And the minimum water supply temperature constraint allowed by the capillary radiation system is generated. Based on the constraint, the system achieves sensible heat and latent heat decoupling of indoor cold loads, sensible heat loads are preferentially borne by the capillary radiation system, wet load disturbance of latent heat loads is eliminated by the fresh air system through feedback compound control, and stable adjustment of indoor temperature and humidity is achieved. And under the working condition of insufficient sensible heat, the system automatically performs self-adaptive redistribution of sensible heat load, and the fresh air system assists in supplementing cold energy, so that comfort and high-energy-efficiency operation are ensured to be maintained within an anti-condensation safety boundary. According to the method, indoor air condensation can be effectively prevented, cooperative operation of the capillary radiation system and the fresh air system is optimized, and accurate heat and humidity control is achieved.
Owner:CHINA CONSTR SECOND ENG BUREAU LTD

Vascular microcirculation chip and system for in-vitro three-dimensional tissue

The invention belongs to the technical field of biochips, and relates to a blood vessel microcirculation chip and system for in-vitro three-dimensional tissue. The blood vessel microcirculation chip of the in-vitro three-dimensional tissue comprises a chip shell component with a culture tank, an in-vitro three-dimensional tissue is arranged in the culture tank, and the in-vitro three-dimensional tissue comprises a matrix, cells in the matrix and a microcirculation vessel network in the matrix; the microcirculation vessel network in the matrix comprises a bionic artery, a bionic vein and a self-development capillary network in the matrix. The in-vitro three-dimensional tissue blood vessel microcirculation chip and system provided by the invention have bionic artery, bionic vein and capillary networks similar to organisms, and simulate the blood vessel microcirculation process of arterial high-pressure exudation mass transfer and oxygen transfer and vein low-pressure reflux metabolism.
Owner:XI AN JIAOTONG UNIV +1

Condensation water preventing device for air conditioner capillary tube

The utility model relates to the technical field of capillary network air conditioners, in particular to a condensation water preventing device for air conditioner capillary tubes, which comprises a drainage plate, a movable plate is movably mounted in the drainage plate, a movable plate is movably connected to one side of the movable plate, cleaning sponges are arranged at the top and the bottom of the movable plate, and a mounting mechanism is arranged on the drainage plate. A connecting mechanism is arranged at the bottom of the drainage plate. The drainage plate and the movable plate are arranged, the drainage plate is installed below the capillary tube, water condensed on the capillary tube can be guided, the condensed water is prevented from permeating into a building, the cleaning sponge on the top of the movable plate abuts against the capillary tube and moves in the drainage plate, and through the operation mode, the cleaning effect is good. Condensate water on the capillary tube can be scraped off by the movable plate, and the condensate water on the capillary tube is prevented from dripping for a long time to affect normal use of the capillary tube network air conditioner.
Owner:LUAN WUHENG ENVIRONMENTAL TECH CO LTD

Relay

The invention relates to the technical field of electrical control, in particular to a relay which comprises a relay assembly and a cooling assembly, the relay assembly comprises a shell, an electromagnetic adjusting piece, two static contacts and a closing element, and a closing bridge of the closing element is made of a shape memory material. The contact state of the movable contact and the static contact is controlled by presenting different shapes at different temperatures; and the cooling assembly is provided with a capillary network, a cooling tank, radiating fins, an exhaust fan and the like which are wound outside the static contact, and is also provided with instantaneous temperature control structures such as an infrared temperature sensor and an atomizing nozzle and the like. The technical effects that the on-off of the circuit can be effectively controlled, meanwhile, key components such as the static contact are efficiently cooled through the cooling assembly, and it is ensured that the relay stably works under the high-load condition are achieved.
Owner:NINGBO ZETTLER ELECTRONICS

Breeding cage capable of automatically adjusting temperature

The utility model discloses an automatic temperature regulation breeding cage, relates to poultry breeding technical field, including breeding cage, on the breeding cage is provided with capillary network, collecting water inlet pipe, collecting water outlet pipe, fixed plate, moving plate, drive slide rail, capillary network is tiled in the bottom side of breeding cage, collecting water inlet pipe and collecting water outlet pipe are both communicated with capillary network, and the drive slide rail is fixed on the fixed plate. The water inlet collecting pipe and the water outlet collecting pipe are fixedly mounted outside the breeding cage; a brush is arranged on the bottom surface of the moving plate; the bottom of the brush is attached to the capillary network; water meeting the temperature is conveyed into the capillary network through the water collecting and feeding pipe, heat of the water is dissipated into the breeding cage through the capillary network, poultry in the breeding cage can also make direct contact with the capillary network, the transmission efficiency is higher, loss is reduced, energy is saved, and the cooling and warm keeping effects of breeding become safer, more automatic and more controllable by adjusting the water temperature; meanwhile, cage space is saved, and breeding benefits are improved.
Owner:SHANDONG DAJIA MASCH CO LTD

Capillary network leakage detection device

The utility model discloses a leakage detection device, belongs to the technical field of capillary network detection, and particularly relates to a capillary network leakage detection device which comprises a water pressure system, a filtering system, a rapid sealing connector, a horizontal clamping mechanism, an anti-deformation positioning mechanism and a drainage device. The water pressure system, the filtering system and the drainage device are arranged in the rack; the quick sealing connector, the horizontal clamping mechanism and the anti-deformation positioning mechanism are placed on a panel of the rack; according to the utility model, capillary networks can be positioned one by one, the interiors of the capillary networks can be automatically pressurized, the pressurizing pressure can be automatically set, whether leakage occurs or not is detected by judging the change of the internal pressure, meanwhile, residual water in the capillary networks can be automatically discharged after detection is completed, the personnel investment is reduced, the labor intensity of workers is reduced, and the detection efficiency is improved.
Owner:WUXI ZHIHANG CONTROL TECH CO LTD

Moisture-conducting quick-dry weft knitting fabric and processing technology thereof

The invention provides a moisture-conducting quick-dry weft knitted fabric and a processing technology thereof, and relates to the technical field of knitted fabrics. The moisture-conducting quick-drying weft knitting fabric is composed of three layers of composite weft knitting structures and sequentially comprises an inner layer, a middle layer and an outer layer from inside to outside. The inner layer is made of 150D / 288F high-F-number polyester filament yarns, a compact and fluffy capillary network is formed through plain stitch weaving, and the porosity is larger than 40%; the middle layer is made of double-special-shaped section polyester fibers, the double-special-shaped section is of a cross-shaped and groove-shaped composite structure, the middle layer is woven in a one-interval-one tucking mode to form a three-dimensional moisture guiding channel, the proportion of a moisture guiding area is larger than or equal to 60%, and the porosity of the middle layer is larger than 30% so that an air microcirculation layer can be formed; the outer layer is made of graphene modified polyester fibers, the content of graphene is 3-5%, and the outer layer is woven in a full-needle mode with the density of 30-35 needles / inch. According to the invention, the three-layer composite structure and the nano silica sol are subjected to after-finishing, so that efficient moisture conduction, quick drying and durable durability are realized.
Owner:FUJIAN XINYUANXIN TEXTILE CO LTD

Indoor assembly type inorganic composite capillary network system decorative wallboard

The utility model discloses an indoor assembly type inorganic composite capillary network system decorative wallboard which comprises a first side plate, a first heat exchange tube set, a second heat exchange tube set and a third heat exchange tube set, a second side plate is installed at one end of the first side plate, and single plates capable of being assembled are evenly installed between the first side plate and the second side plate. By installing the first butt-joint insertion pipe, the second butt-joint insertion pipe and the like, the performance of the device is optimized, and after a user assembles the first side plate, the single plate capable of being spliced and the second side plate on the wall face, the single plate capable of being spliced can be spliced through the butt-joint effect of the first butt-joint insertion pipe and the second butt-joint insertion pipe. In cooperation with the sealing effect of silica gel sealing rings which are connected to the first butt joint insertion pipe and the second butt joint insertion pipe in a vulcanization mode, the splicing and communicating effect among the first heat exchange pipe set, the second heat exchange pipe set and the third heat exchange pipe set is achieved, and the heat exchange mechanism enables the device to achieve the heat supply or cold supply function indoors.
Owner:SHANGHAI LEXIANGZHU INTELLIGENT TECH CO LTD

Fresh air top air supply and top air return design structure based on residential radiation air conditioning system

The utility model discloses a fresh air top air supply and top air return design structure based on a residential radiation air conditioning system. The fresh air top air supply and top air return design structure comprises a ceiling structure composed of a keel structure layer, a gypsum board, a capillary network, a gypsum mortar layer and a putty emulsion paint layer. The height of the suspended ceiling structure is not greater than 100mm; a capillary main pipe is laid in the keel structure layer between the gypsum board and the floor, and capillary tubes in the capillary network penetrate through the gypsum board to be communicated with the capillary main pipe; fresh air pipelines are laid in the keel structure layer between the gypsum board and the floor slab and comprise an air supply pipeline and an air return pipeline, the air supply pipeline and the air return pipeline are provided with an air supply opening and an air return opening respectively, and holes used for installing the air supply opening and the air return opening are formed in the gypsum board; on the premise of ensuring the indoor clear height of 2.60 m, the floor height of the residence can be designed to be 2.95 m, for a residence building with the limited height of 80 m, one more floor can be built compared with a floor air supply design, the plot ratio of the building is increased, and large economic benefits are brought.
Owner:NANJING YANGTZE RIVER URBAN AGCHITECTURAL DESIGN

Hemodynamics modeling method for microvascular network with multilayer structure

The invention provides a capillary network hemodynamic modeling method with a multilayer structure, and aims to solve the problem that a traditional model is difficult to truly reflect a capillary multilayer structure and blood flow topological characteristics, and combines the hierarchical structure characteristics of a capillary network disclosed by a high-resolution imaging image. And constructing a multi-layer blood vessel network model consisting of a microarteriovenous layer, a connecting layer and a capillary network layer. Wherein the micro artery and vein layer is a tree-shaped blood vessel network formed by micro arteries and micro veins; the capillary network layer is of a regular network blood vessel structure constructed based on a hexagonal grid; and the connecting layer is a connecting blood vessel for connecting the microarteriovenous layer and the capillary network layer. Through standardized numbering rules, node insertion and blood vessel splitting operation, embedding, reconstruction and overall structure integration of blood vessel segments are completed, and therefore a capillary network system which is complete in structure and is in topological communication is constructed. On the basis of structural modeling, a linear equation solving system is established for hemodynamic simulation. The method has the advantages in the aspects of structural definition, simulation precision and expansibility, and has important scientific research and engineering application value.
Owner:ZHEJIANG UNIV OF TECH

Capillary network structure for a radiant air conditioner

The utility model discloses a capillary network structure for radiation air conditioner, including main pipeline, and the capillary pipeline is equipped on main pipeline, its characterized in that still includes: support main part, support main part is vacuum, and the plug -in block is located in support main part, and the main pipeline is inserted and locked, and the support arm is located in the outside of support main part, and the adjusting block is located in the support arm, and it is used for the capillary pipeline to hold up fixed. Capillary network structure for radiation air conditioner, support main part is vacuum, and the plug -in block is inserted and locked to the main pipeline, and the lock catch plate and the clamping block are combined and clamped, and the stable main pipeline fixed structure is formed, compared with bolt, and the ribbon connection reduces the installation step, and improves the installation efficiency, and the first adjusting groove is seted up in the outside of support main part, and the support arm is slid in the groove through connecting shaft and sliding roller, can adjust support arm position according to capillary network actual arrangement demand, realizes the random setting of fixed device, avoids the problem of traditional mode space restriction.
Owner:TIANJIN RUIDE TONGCHUANG ENERGY SAVING TECHCO

Geothermal development system and method with bionic capillary network cooperating with CO2 expansion acting

The invention belongs to the technical field of geothermal energy development and CO2 resource utilization, and provides a geothermal energy development system and method with a bionic capillary network cooperating with CO2 expansion acting, CO2 heating-expansion-fracturing synchronization is achieved through the bionic capillary network structure, and the reservoir transformation and heat energy extraction effect is enhanced; through a well pair type circulation structure, a stable and communicated artificial fracture network is formed between the two horizontal wells, and cross-well flowing and continuous heat removal of CO2 in a reservoir are achieved; high-temperature and high-pressure supercritical CO2 and circulating water are simultaneously conveyed to a ground heat exchange and power generation device after being subjected to underground collaborative heat exchange, geothermal energy and CO2 expansion energy are subjected to combined conversion, generated electric energy is preferentially used for driving a CO2 compression and circulating water system to operate, and a closed circulation mode of heat energy gradient utilization and system energy self-sustaining is constructed. The process significantly reduces the dependence of the system on external energy.
Owner:QINGDAO UNIV OF TECH

Multi-flow multi-functional high-efficiency heat exchange tube and radiator

The application discloses a kind of multi-flow path multifunctional high-efficiency heat exchange pipe and radiator, including outer tube, inner tube, first capillary network and second capillary network arranged in inner tube;Outer tube and inner tube form pipe interlayer;Water supply pipe network and return water pipe network are equipped in pipe interlayer;Water supply pipe network is connected with the water inlet end of a plurality of first capillary network and second capillary network respectively;Return water pipe network is connected with the water outlet end of a plurality of first capillary network and second capillary network respectively.The application is arranged in inner tube by sequentially alternating multiple capillary network, so that the whole pipe is filled with heat exchange branch pipe network, increase the contact area of fluid and heat exchange branch pipe network in pipe;And the capillary in adjacent two layers of capillary network is crossed and forms a certain angle, so that the flow state of fluid flow is turbulent in the cross-flow heat exchange process between fluid in pipe and capillary network, to promote the effect of convective heat transfer, improve heat exchange efficiency.
Owner:SMC ASIA GAS SYST CO LTD CHENGDU

A waste heat energy recovery system for converter valves based on heat pipe technology

The present invention discloses a waste heat energy recovery system for a converter valve based on heat pipe technology. The system includes a main circulation loop, a capillary network heat recovery system, a fresh air heat recovery system, and a seawater cooling system; the main circulation loop includes an internal cooling main circulation water pump connected to the outlet of the converter valve bridge arm, a first heat exchange pipeline, a second heat exchange pipeline, and a third heat exchange pipeline that are sequentially connected in series at the outlet end of the internal cooling main circulation water pump, and the other end of the third heat exchange pipeline is connected to the inlet of the converter valve bridge arm; a branch of the first heat exchange pipeline exchanges heat with the fresh air heat recovery system through a water-air type heat pipe heat exchanger; a branch of the second heat exchange pipeline exchanges heat with the capillary network heat recovery system through a water-water type plate heat exchanger. The present invention is used when the outdoor temperature at sea is too low in winter, makes full use of the waste heat of the converter valve, reduces waste, preheats the fresh air system, and heats the office rooms by using capillaries at the same time.
Owner:ELECTRIC POWER RES INST CHINA SOUTHERN POWER GRID CO LTD

Method to prevent and treat diabetic retinopathy by calcium channel blockers, angiotensin converting enzyme inhibitors, and angiotensin receptor blockers

Methods are provided to prevent and to treat diabetic retinopathy by using Calcium channel blockers, Angiotensin-Converting Enzyme (ACE) Inhibitors, or angiotensin receptor blockers (ARB), and more particularly, to a method to prevent and treat diabetic retinopathy by using calcium channel blockers, Angiotensin-Converting Enzyme Inhibitors, or angiotensin receptor blockers that may not need to be taken orally, but may also be administered by ophthalmic preparation directly onto or into the eye where diabetic retinopathy is formed, to increase the capillary network and augment the blood supply to the anatomy of the eye.
Owner:WEINBERG ASSA

Foundation pit backfilling structure and anti-floating and anti-seepage system

The invention discloses a foundation pit backfilling structure and an anti-floating impervious system, and relates to the technical field of building construction.The foundation pit backfilling structure comprises a foundation pit, the foundation pit comprises an impervious area, a structural area and an anti-floating area which are arranged from bottom to top, and the anti-floating area comprises a drainage layer, a water-resisting layer, a capillary network layer and an anti-floating layer which are arranged from bottom to top; the anti-floating layer is filled with aggregate used for forming pores, and the capillary network layer and the drainage layer are used for being communicated with an external water storage structure. The anti-floating and anti-seepage system comprises a drainage system and the foundation pit backfilling structure, the drainage system comprises a water collecting well, a water level sensor, a pressure sensor, water pumping equipment and a remote control terminal, and the water pumping equipment comprises a first drainage pump and a second drainage pump. The aggregate can form a plurality of pores, the density of the anti-floating layer can be reduced, underground water in the lateral direction of the foundation pit can be rapidly discharged into the capillary network layer and then discharged, the influence of buoyancy on the backfill structure is eliminated, and the technical effect of improving the building safety is achieved.
Owner:THE 2ND ENG CO LTD OF CHINA RAILWAY 22ND BUREAU GRP +1

Capillary network suspended ceiling structure

The utility model relates to the technical field of capillary networks, and discloses a capillary network suspended ceiling structure which comprises a top plate assembly and a fixed bottom plate, the fixed bottom plate is arranged at the bottom of the top plate assembly, and the top plate assembly comprises an upper plate body, a supporting installation pipe, an installation frame, a moving groove, a positioning block and a fixed installation plate. The supporting mounting pipe is fixedly connected to the bottom of the upper plate body, the mounting frame is mounted in the middle of the interior of the upper plate body, the moving groove is formed in the bottom of the mounting frame, the positioning block is arranged in the mounting frame, and the fixed mounting plate is fixedly mounted on one side of the supporting mounting pipe. According to the capillary network suspended ceiling structure, through the arrangement of the mounting frame, the capillary network can be mounted in the mounting frame in a pipe penetrating mode, the capillary network can be mounted at will according to the size and position of the upper plate body, use is convenient, operation is easy, then the positioning blocks are used for fixing, the mounting difficulty is reduced, and the mounting efficiency is improved.
Owner:JIANGSU SHIJIAN CONSTR ENG CO LTD

Renal tubule 3D printing chip with peripheral capillary and application

The invention relates to the technical field of biology, in particular to a renal tubule 3D printing chip with peripheral capillary vessels and application. The invention provides a renal tubule chip for constructing a renal tubule model with peripheral capillary vessels. The invention also discloses a method for constructing a renal tubule model with peripheral capillary vessels by using the renal tubule chip. The renal tubule model with the peripheral capillary vessels constructed by the method has a renal tubule structure and the peripheral capillary vessel network of the renal tubule, the peripheral capillary vessel network of the renal tubule can be highly simulated from two aspects of an anatomical structure and a physiological process, and a more bionic renal tubule chip model is provided; an animal model and a traditional two-dimensional culture mode can be replaced, and a more accurate platform is provided for in-vitro simulated drug kidney toxicity evaluation, renal function mechanism research, kidney disease engineering modeling and kidney disease treatment drug effectiveness test.
Owner:UNIV OF SCI & TECH OF CHINA

Dynamic teaching aid for simulating urine and hematuria forming process

ActiveCN223986376UEducational modelsCapillary networkRenal vein
The utility model discloses a dynamic teaching aid for simulating urine and hematuria forming processes. The dynamic teaching aid comprises a teaching aid bracket, a renal artery model, a globular arteriole model, a glomerulus model, a globular arteriole model, a capillary network model, a renal vein model, a renal capsule model and a bladder model, the renal artery model, the renal vein model, the renal capsule model and the bladder model are sequentially arranged on the teaching aid support; the glomerulus model is mounted in the kidney capsule model; a kidney tubule model is arranged at the bottom of the kidney capsule model, the tail end of the kidney tubule model is communicated with the bladder model, and decoloration cotton is distributed in the kidney capsule model; the capillary network is wound on the renal tubule model of the renal capsule model; one end of the ball-entering arteriole model is communicated with the renal artery model, and the other end is communicated with the glomerular model; one end of the bulbous arteriole model is communicated with the glomerulus model, and the other end is communicated with the capillary network model; and the tail end of the capillary network model is communicated with the renal vein model. The teaching aid has the advantages of being simple in structure, convenient to operate and capable of improving teaching quality.
Owner:YINCHUAN NO 9 MIDDLE SCHOOL

Method for intelligent monitoring and hydraulic balance implementation of capillary network system

The application discloses an intelligent monitoring and hydraulic balance implementation method of a capillary tube network system, and belongs to the field of intelligent regulation and control of building heating, ventilation and air conditioning. The method solves the problems of low efficiency of traditional manual debugging and inability to maintain hydraulic balance for a long time. The scheme is as follows: first, intelligent monitoring nodes are arranged at key node positions to collect data, the data are uploaded to a central control system through an edge computing gateway, a built-in hydraulic network calculation model is used to solve system states and output hydraulic imbalance degrees, when the hydraulic imbalance degrees exceed the limit, the system is inversely calculated and encrypted target opening degree instructions are issued to each loop digital twin driven electric balance valve, a closed loop regulation is performed by an embedded controller of the valve, and finally, after installation is completed, a full-automatic initialization debugging is performed, initial opening degree compensation values of the digital twin driven electric balance valves are calculated and written into valve embedded controllers, and presetting is completed. The application is used for realizing automatic construction and continuous and accurate regulation and control of hydraulic balance of the capillary tube network.
Owner:SINOHYDRO BUREAU 6 CO LTD

Use of recombinant fibrinogen-like domain of angiopoietin-like 4 to treat adverse post-ischemic cardiac remodeling in patients who have undergone myocardial infarction

Ischemic heart disease is a leading cause of death and reduced quality of life worldwide. Although revascularization strategies significantly reduce mortality after acute myocardial infarction (MI), many patients with MI develop chronic heart failure over time. We previously reported that human recombinant ANGPTL4 counteracts ischemia-induced vascular endothelial growth factor signaling and disruption of endothelial cell-cell adhesion, thereby inhibiting vascular permeability. We were able to demonstrate that ANGPTL4 administration before MI resulted in protection of the coronary capillary network, no-reflow syndrome, and reduced infarct size in mice. We also demonstrated that the therapeutic effects observed with ANGPTL4 under ischemic conditions were caused by the FLD fragment, not the CCD fragment (WO 2016 / 110498). To further examine the therapeutic potential of the FLD fragment of ANGPTL4 at the onset of reperfusion, we herein used a porcine model, a clinically relevant model of acute myocardial infarction that can be easily and safely translated into patient treatment. We demonstrated that local (antegrade) delivery of the FLD ANGPTL4 to infarcted porcine hearts can efficiently target the lesion site in a clinically relevant manner. A single administration of the FLD of ANGPTL4 improved cardiac function, infarct size, fibrosis, and adverse remodeling parameters 28 days after MI. Short-term MI experiments, coupled with complementary mouse studies, demonstrated myocardial protection. Thus, a single administration of the FLD of ANGPTL4 can reduce ischemia-reperfusion injury and protect against adverse postischemic cardiac remodeling and subsequent ischemic heart failure.
Owner:INST NAT DE LA SANTE & DE LA RECHERCHE MEDICALE (INSERM) +5

Intelligent hydrogel with active shrinkage function as well as preparation method and application of intelligent hydrogel

The invention belongs to the technical field of 3D printing materials, and particularly discloses intelligent hydrogel with an active shrinkage function and a preparation method and application thereof.The preparation method comprises the following steps that S1, 3-acrylamidophenylboronic acid is added into deionized water, and a 3-acrylamidophenylboronic acid solution is obtained; s2, tannic acid is added into the 3-acrylamido phenylboronic acid solution, and a tannic acid 3-acrylamido phenylboronic acid solution is obtained; s3, phenyl-2, 4, 6-trimethylbenzoyl lithium phosphinate and guar gum are sequentially added into the tannic acid 3-acrylamide phenylboronic acid solution, and the intelligent hydrogel with the active shrinkage function is obtained. According to the intelligent hydrogel with the active contraction function as well as the preparation method and the application, the problems of insufficient forming precision and structural resolution in an existing extrusion type 3D printing technology are solved, and a new technical path is provided for in-vitro bionic construction of fine tissues such as capillary networks and nerve microcatheters.
Owner:NINGBO UNIV

Acites concentrating, filtering and reinfusion system

The invention discloses an ascites concentrating, filtering and reinfusion system which comprises an ascites drainage pipeline, a filter, a plasma component separator and an abdominal cavity reinfusion pipeline, the ascites drainage pipeline is communicated with an inlet of the filter and used for conveying ascites to be treated, and a liquid outlet of the filter is communicated with an inlet of the plasma component separator through a first liquid infusion pipeline; the plasma component separator is used for separating and removing harmful components in the concentrated ascites, a bypass side opening of the plasma component separator is communicated with the abdominal cavity back-transfusion pipeline so as to back-transfusion the treated ascites into the abdominal cavity, the multi-intervention treatment principle is achieved, multi-path individualized switching combination is achieved, the removal efficiency of the harmful substances in the ascites is remarkably improved, and the treatment cost is reduced. Meanwhile, macromolecular beneficial or nutrient substances such as albumin are reserved and purified; and then the abdominal omentum majus capillary network is used for slow absorption, so that the risk and high cost caused by venous transfusion after treatment are avoided, the hemodynamics is stable, and the whole treatment system is safer.
Owner:BEIJING YOUAN HOSPITAL CAPITAL MEDICAL UNIV +1

A saline-alkali soil improvement device

The application provides a saline-alkali soil improvement device, and belongs to the technical field of land protection. The device comprises a capillary network, the lower part of the capillary network is provided with an underground adsorption section, and the upper part of the capillary network is provided with an aboveground conveying section. The device also comprises a ground support located on one side of the capillary network, at least two support rods are arranged at intervals in the upper part of the ground support, a flexible salt collection plate is laid above the support rods, a water absorption belt is placed above the flexible salt collection plate, one end of the water absorption belt extends into the aboveground conveying section of the capillary network, a salt collection box is arranged below the end of the flexible salt collection plate, the flexible salt collection plate is also provided with a knocking and tilting composite driving mechanism and a curling driving mechanism, the knocking and tilting composite driving mechanism can knock the flexible salt collection plate and drive the flexible salt collection plate to tilt to one side of the salt collection box, and the curling driving mechanism can drive the flexible salt collection plate to roll up or spread out. The application has the beneficial effect of realizing efficient and automatic collection of crystalline salt, avoiding the re-infiltration of crystalline salt, and ensuring stable and reliable improvement effect.
Owner:SHOUGUANG LAND RESERVE CENT

Micro-needle patch based on hierarchical targeting mechanism as well as preparation method and application of micro-needle patch

The invention relates to the technical field of androgen-derived alopecia, and discloses a micro-needle patch based on a hierarchical targeting mechanism as well as a preparation method and application of the micro-needle patch. The finasteride is arranged on the needle tip section of the microneedle, the quercetin is arranged on the needle root section, different cells are targeted through the finasteride and the quercetin in a graded mode, and the microneedle patch with a graded targeting mechanism is formed. After the micro needle pierces into the skin, the water-soluble polymer at the needle tip section is dissolved, finasteride targeted hair papilla cells are released, and then in the process that finasteride acts, the quercetin slowly released at the needle root section gradually acts on endothelial cells in a targeted mode, the proliferation and migration activity of the endothelial cells is promoted, and the effect of the finasteride on the skin is achieved. Endothelial cells are enhanced to form a highly branched capillary network to act on hair papilla cells, the metabolic demand of the hair papilla cells is maintained, and finally the effect of enhancing the finasteride targeting effect is achieved. Therefore, the microneedle patch with the hierarchical targeting mechanism has an excellent AGA curative effect.
Owner:HANGZHOU THIRD PEOPLES HOSPITAL (HANGZHOU HUIMIN HOSPITAL HANGZHOU THIRD AFFILIATED HOSPITAL OF ZHEJIANG UNIV OF TRADITIONAL CHINESE MEDICINE)

Capillary grid pavement structure

The utility model discloses a capillary network grid paving structure, including a plurality of interconnect connecting piece, each in connecting piece includes fixed block, be provided with the clamping seat on the fixed block, and the connecting piece on clamping seat one side is provided with the fixed hole of penetration, is seted up the connecting hole and the connecting groove on the side surface of connecting piece, is provided with the limit block in connecting hole, and the opening of connecting hole is provided with the limit ring, and the other opposite side surface is fixed with the connecting rod and the connecting block, and the free end of connecting rod is from the inside of limit ring and is linked with the limit block in the connecting hole, and the position of connecting groove and connecting block is opposite and mutually matches. The distance of connecting piece can be changed through the plug -in of connecting rod and connecting hole, can adjust the interval between adjacent capillary, can make the multi -angle rotation between two connecting pieces through the limit ring and spherical limit block, and the more wide scope of application, can make all connecting piece fixed connection together through the connecting block and connecting groove, and the whole structure is simple and convenient operation.
Owner:TIANJIN RUIDE TONGCHUANG ENERGY SAVING TECHCO