54 results about "Tissue construct" patented technology

The invention discloses a tooth intelligent segmentation and parameterized bionic reconstruction method fusing multi-modal data, and belongs to the field of artificial intelligence and computer-aided biomedical engineering. The method comprises a CBCT intelligent segmentation module, an intraoral scanning intelligent segmentation module, an internal tissue segmentation module, a point cloud generation registration module and a parameterized bionic reconstruction module. The point cloud generation registration module further comprises a point cloud generation sub-module and a point cloud registration sub-module; the parameterized bionic reconstruction module further comprises a dentin reconstruction sub-module, a cancellous bone reconstruction sub-module and a gingival reconstruction sub-module. The invention aims to realize tooth semantic segmentation, point cloud reconstruction and parameterized bionic modeling of an organization structure under cross-modal data fusion, and provides high-precision bionic internal structure information for teeth in combination with an artificial intelligence model and parameterized modeling.

The invention discloses a composite material performance prediction method based on multi-field coupling multi-scale analysis and a knowledge graph, which integrates microstructure modeling, graph neural network representation learning, cross-scale parameter coupling modeling and robust optimization analysis. The method is suitable for prediction and design of key mechanical properties such as modulus, strength and toughness of a thermosetting / thermoplastic composite material under different working conditions. The method comprises the following steps: firstly, constructing a grain-level tissue knowledge graph based on an electron backscatter diffraction image, secondly, constructing a multi-scale input system comprising a microscopic variable (such as a fiber volume fraction), a mesoscopic variable (such as a layer thickness sequence) and a macroscopic variable (such as a load condition), and finally, performing robust optimization by utilizing a multi-objective evolutionary algorithm to obtain a multi-scale input system. And outputting a material performance prediction result and a knowledge graph associated with the ji structure-process-performance. According to the method, the accuracy and interpretability of performance prediction of the composite material can be remarkably improved, and data-knowledge dual-drive support is provided for design optimization of the high-performance composite material.

The invention provides a fine-grained multi-dimensional configuration permission control method and system, electronic equipment and a storage medium, and aims to solve the problem that permission division cannot meet fine-grained permission control requirements, the method comprises the following steps: on the basis of an RBAC model, adding organization elements, and adding an organization structure hierarchical relationship, the relationship between the organization structure and the content of each part in the model is obtained; a dynamic role allocation and role inheritance mechanism is introduced, the inheritance relation between roles is specified when the roles are defined, so that the child-class roles can inherit the permission set of the parent-class roles, and permission expansion is carried out; performing permission configuration, performing cross organization on the function permission and the data permission, then distributing the function permission and the data permission to corresponding organization roles, ensuring that each organization role has the basic permission, and expanding private permissions for the organization roles according to different business requirements; the organization roles are distributed to the users, so that authority distribution of the users is realized. According to the invention, validity and timeliness of authority management can be ensured.

The invention relates to the technical field of acoustic wave device application and biological tissue engineering, in particular to a method for constructing a multi-component heterogeneous fiber structure under the assistance of acoustic tweezers. According to the method, an acoustic tweezers technology and a microfluidic spinning technology are combined, an electric signal is converted into an acoustic surface wave through the piezoelectric effect of a piezoelectric material, and a beam-shaped acoustic standing wave field is formed in a microchannel of a specific structure; different target cells form a stable fiber configuration under the interaction of microchannel limitation and acoustic radiation force, and spatial precise classification and arrangement of multiple types of cells are realized. The low-temperature-sensitive hydrogel is introduced in the cell injection process, and the fiber scaffold is formed after ultraviolet curing, so that the fiber structure of the cells is still maintained after the sound field is removed. The cells treated by the surface acoustic wave can form a complex three-dimensional bionic tissue structure more easily, and the cell viability is remarkably improved. Various fiber structures can be formed by regulating and controlling sound field parameters, and great potential is shown in the field of in-vitro barrier model construction.

The present invention relates to systems, compositions and methods for multicellular bioprinting vascularized tissue constructs comprising a hierarchical vascular network. The methods employ a dual bio-ink strategy involving fibrous microgel matrix bio-inks with adjustable hardness, self-healing rheology, and microporosity to support capillary self-assembly, and sacrificial bio-inks that define a large pourable channel after removal. The system integrates top-down printing and bottom-up cell self-organization within a programmable bio-printing platform. The key aspect of the invention is to engineer the physical topography of the matrix to actively guide vascular morphogenesis beyond conventional permissive stents. The integrated platform enables the manufacture of complex bionic vascular networks with enhanced mass delivery, cellular viability, and in vivo integration potential. The invention represents an important progress in the aspect of extendable production of functional human tissues, and has application in regenerative medicine, disease modeling and drug discovery.

An arc wire feeding additive manufacturing method for a 321 stainless steel tissue gradient material, which relates to the field of additive manufacturing. The purpose of the present invention is to address the problems of complex processes, high costs, low deposition efficiency, easy contamination, and limited forming size existing in the preparation process of existing tissue gradient materials. The present invention proposes to control the recrystallization degree of different deposition positions by matching different ultrasonic impact and arc wire feeding additive manufacturing process parameters, and then achieve the purpose of tissue structure gradient transition, so as to prepare a metal FGM with a tissue structure gradient in this way. The present invention can achieve a relatively continuous gradient transition of the tissue structure and function gradient material of large and complex structures, achieving the effects of improving deposition efficiency, simplifying the process flow, and reducing manufacturing costs.

Described herein are bioprinters comprising: one or more printer heads, wherein a printer head comprises a means for receiving and holding at least one cartridge, and wherein said cartridge comprises contents selected from one or more of: bio-ink and support material; a means for calibrating the position of at least one cartridge; and a means for dispensing the contents of at least one cartridge. Further described herein are methods for fabricating a tissue construct, comprising: a computer module receiving input of a visual representation of a desired tissue construct; a computer module generating a series of commands, wherein the commands are based on the visual representation and are readable by a bioprinter; a computer module providing the series of commands to a bioprinter; and the bioprinter depositing bio-ink and support material according to the commands to form a construct with a defined geometry.

A system with reusable components and methods are disclosed for culturing, forming, perfusing, and maintaining a perfusible-tissue construct. The system uses a production container comprising a floor, a wall extending from the floor, wherein the floor and wall define a production reservoir, a formation section defined in the floor, wherein the formation section comprises at least one well, and a grip extending outwardly from the formation section; wherein the production container is made of a biocompatible material that remains stable when autoclaved.

This invention discloses a self-lubricating hydrogel titanium alloy biomimetic joint bearing interface and its preparation method. The self-lubricating hydrogel titanium alloy biomimetic joint bearing interface is composed of a porous titanium alloy substrate, a functionalized interface layer, a negatively charged hydrogel layer, and a self-lubricating adsorption layer. A laser drilling method is used to create a porous structure on the surface of a Ti6Al4V substrate. A hydrogel precursor solution is coated onto the surface of the Ti6Al4V sample and cured by ultraviolet irradiation to obtain a negatively charged hydrogel titanium alloy composite sample. The negatively charged hydrogel titanium alloy composite sample is subjected to freeze-thaw cycles and then immersed in zwitterionic or cationic solutions for adsorption, resulting in a hydrogel titanium alloy biomimetic joint bearing interface with self-lubricating properties. The hydrogel titanium alloy biomimetic joint bearing interface of this invention significantly improves the lubrication performance of titanium alloy materials used in artificial joints, achieving biomimetic design of natural joints in terms of tissue structure and lubrication function, and is suitable for the repair and replacement of damaged articular cartilage.

A tubular tissue converter (TTT) for a tubular tissue structure. The tubular tissue converter has a plurality of blades and a plurality of retainers on each of the plurality of blades. Each retainer retains the tubular tissue structure on a respective blade. Coupling systems for coupling together tubular tissue structures and tools and methods for attaching and widening tubular tissue structures are also provided.

The application discloses a processing method and device of a 3D printing module dissection teaching model of a nasal cavity and nasal sinus, which can be widely applied in the technical field of teaching data processing. After real nasal cavity and nasal sinus image data are acquired, a 3D virtual model including a bone structure virtual model, a soft tissue structure virtual model, a nerve and blood vessel virtual model or a skull base and eye socket virtual model is constructed according to the real nasal cavity and nasal sinus image data, then a printing process of the 3D printing module dissection teaching model is performed according to the 3D virtual model, so as to obtain a 3D printing module dissection teaching model with a proportion of 1:1 with the real nasal cavity and nasal sinus image data, and nasal cavity and nasal sinus dissection teaching is performed according to the 3D printing module dissection teaching model, so that the nasal cavity and nasal sinus structure can be restored by the 3D printing module dissection teaching model, and the 3D printing module dissection teaching effect of the nasal cavity and nasal sinus is effectively improved.

The invention provides a wear-resistant and corrosion-resistant multi-principal-element alloy as well as a preparation method and application of the wear-resistant and corrosion-resistant multi-principal-element alloy. The multi-principal element alloy is composed of five elements of Ni, Co, Al, Cr and Fe. Or, the alloy is composed of four elements of Ni, Co, Al and Cr. The multi-principal-element alloy provided by the technical scheme of the invention has a near eutectic cellular tissue structure, the FCC phase movable slip systems of the cellular outer layer are many, the plasticity is good, the BCC / B2 coherent reticular tissue movable slip systems of the cellular inner part are few, and the dislocation motion is hindered by a high-density coherent interface, so that a cellular soft-hard combined structure with soft edge and hard inner part is formed; the volume fraction of the BCC / B2 coherent reticular structure phase can be increased by increasing the content of the chromium element and reducing the content of the iron element, so that the hardness of the alloy is improved; and meanwhile, the potential difference of each phase can be reduced through component regulation and control, and the stability of a passivation film is improved, so that the common galvanic corrosion rate in a traditional multi-phase alloy is reduced, and the corrosion resistance of the alloy is improved.

The present disclosure pertains to universal and adoptable cell culture substrates designed for applications in biology, medicine, pharmaceutics, and other relevant fields. The disclosure particularly focuses on processes and methodologies for manufacturing such substrates, which prove advantageous for both non-neural (cells exhibiting robust adhesion and weak cell-cell junctions, as well as cells with regular adhesion and cell-cell junctions) and neural cell sheet engineering. These substrates aim to enhance cell adhesion, stimulate cell growth, and enable rapid and uniform harvesting of cell sheets. Additionally, the present invention introduces a scaffold-free method for tissue engineering, facilitating the creation of a 2D / 3D neural tissue construct featuring unidirectional neuron bundles.

The invention discloses an impurity-free and high-wear-resistant modification method for 2Cr13 stainless steel, which specifically comprises the following steps: step 1, pretreatment: cutting and milling a test block workpiece, processing the test block workpiece into a fixed size and shape, and then cleaning the processed workpiece by using an ultrasonic cleaning machine; step 2, preparing a sample, and polishing the test block by using a metallographic polishing machine until the test block is polished; 3, electron beam treatment, wherein electron beams are adopted for conducting continuous scanning treatment on the sample. And 4, tissue and performance testing: observing the microstructure by adopting a scanning electron microscope, measuring the hardness by utilizing a microhardness tester, and detecting the wear resistance by utilizing a friction wear testing machine. According to the method disclosed by the invention, the surface hardness, the wear resistance and the corrosion resistance of the 2Cr13 stainless steel can be remarkably improved, and the method has an extremely good application scene.

The described systems, devices and methods relate to a system that includes an electrosurgical interface electrically coupled to a generator, an energy delivery element electrically coupled to the electrosurgical interface, the energy delivery element configured to receive energy from the generator and form a puncture hole in tissue of a patient, and a return electrode electrically coupled to the patient and the generator.

The present invention relates to a novel bioreactor system for preparing an engineered three-dimensional biological tissue construct. The bioreactor system comprises a cultivation chamber that is designed to allow the formation, cultivation and the subsequent testing and / or stimulation of tissue constructs on one or more support elements with a minimum risk of microbial contamination or mechanical damage. The invention furthermore relates to a method for preparing an engineered tissue construct using the novel bioreactor system. The invention also relates to the use of the bioreactor system for preparing engineered biological tissue constructs, preferably tissue constructs which are suitable for being used in clinical tissue replacement and reconstructive therapy, drug development, drug screening, toxicity testing, cosmetic studies, safety testing, developmental studies, disease modeling, or food purposes.

Disclosed are living, three-dimensional tissue constructs for in vitro scientific and medical research, arrays thereof, and methods of making said tissues and arrays.

1. The name of the design product: the head of surgical knives. 2. The use of the design product: overall use: for surgical tools; partial use: for cutting tissue structure and containing surgical tool accessories. 3. The design points of the design product: the shape of the partial design. 4. The picture or photo that best shows the design points: design 1A enlarged view. 5. Design 1 is designated as the basic design. 6. Other circumstances that need to be explained: the design product involves partial design, the green coated part in each figure is the unclaimed part, and the part other than the green coating is the claimed part; design 1A enlarged view is the partial enlarged view of point A in design 1 perspective view 1; design 1B enlarged view is the partial enlarged view of point B in design 1 perspective view 2; design 1C enlarged view is the partial enlarged view of point C in design 1 front view; design 2D enlarged view is the partial enlarged view of point D in design 2 perspective view; design 2E enlarged view is the partial enlarged view of point E in design 2 front view; design 3F enlarged view is the partial enlarged view of point F in design 3 perspective view; design 3G enlarged view is the partial enlarged view of point G in design 3 front view; design 4H enlarged view is the partial enlarged view of point H in design 4 perspective view; design 4I enlarged view is the partial enlarged view of point I in design 4 front view.

The invention discloses a steel microstructure identification method and system based on deep learning driving, and a medium. The method comprises the steps of obtaining a steel microstructure image, performing data enhancement, and performing division to obtain a training set and a verification set; based on the MobileNetV2 pre-training model, using a transfer learning method to construct a SteelIDNet model; using the training set to train the SteelIDNet model, and using the verification set to verify and evaluate the trained SteelIDNet model to obtain a final SteelIDNet model; and deploying the final SteelIDNet model at a mobile terminal to carry out steel microstructure identification. According to the method, the SteelIDNet model is constructed through deep learning and transfer learning technologies, the advantage (CNN) of the convolutional neural network is brought into full play, and the recognition efficiency of the steel microstructure is remarkably improved; the method is not only suitable for PC terminal development, but also convenient to deploy on a mobile terminal, can realize millisecond-level response speed, and is particularly suitable for high-efficiency requirements of the mobile terminal on real-time detection and analysis.

The invention relates to the technical field of novel metal materials, in particular to a novel light high-strength single-phase refractory high-entropy alloy based on machine learning design and a design and preparation method thereof, the alloy is composed of five elements of Cr, Mo, Ti, V and W, and the composition ranges (at.%) of the alloy are as follows: 5-25% of Cr, 5-15% of Mo, 25-35% of Ti, 20-35% of V and 5-20% of W. The invention further provides a design method of the single-phase refractory high-entropy alloy, according to the method, the yield strength of the single-phase refractory high-entropy alloy is predicted through a machine learning regression model, and the valence electron concentration and density are calculated through a mixing rule. And drawing a performance map based on the prediction data, and screening out a target component from the performance map for microstructure and mechanical property characterization. The as-cast structure of the high-entropy alloy provided by the invention is a single-phase BCC structure, and the high-entropy alloy has low density, high yield strength and good compression plasticity at room temperature.

The invention relates to the technical field of high-strength titanium alloys, in particular to a high-strength and high-toughness titanium alloy with a toughened double-tissue structure and a preparation method of the high-strength and high-toughness titanium alloy. The high-strength and high-toughness titanium alloy with the strengthened and toughened double tissue structures comprises two tissue structures, namely a widmanstatten tissue and a basket tissue. The Ti55531 titanium alloy with both the widmanstatten structure and the basket-shaped structure is obtained by adding the extrusion treatment on the forge piece, eliminating the primary equiaxed alpha phase and refining the grains and then accurately controlling the cooling speed from the beta annealing temperature to the alpha aging temperature, and high strength and high toughness are achieved.

The invention relates to an organization structure division method and device, computer equipment, a computer readable storage medium and a computer program product. The method comprises the following steps: performing organization structure division according to density image data of spatial transcriptome data to obtain first hierarchical information; performing tissue structure division based on a cell grouping result of the spatial transcriptome data to obtain second hierarchical information; and integrating the first hierarchical information and the second hierarchical information to obtain integrated hierarchical information, and performing superposition judgment on the integrated hierarchical information to perform hierarchical fine adjustment on hierarchical information with inconsistent hierarchical division in the integrated hierarchical information to obtain target hierarchical information. By adopting the method, personal errors can be reduced, and the accuracy of organization structure division can be effectively improved.

The present invention relates to three-dimensional (3D) tissue constructs and methods of using such 3D tissue constructs to screen for neurotoxic agents. In particular, provided herein are methods of producing and using complex, highly uniform human tissue models comprising physiologically relevant human cells, where the tissue models have the degree of sample uniformity and reproducibility required for use in quantitative high-throughput screening applications.

The present invention provides apparatus and methods for production of tissue structures and organs. In some examples, a cleanspace facility may be equipped with modelling hardware and software, nanotechnology and microelectronic apparatus, and additive manufacturing equipment to print cells and support matrix to allow cells to grow into tissue structures and organs. Various methods relating to using and producing the tissue engineering system are discussed.

Methods for generating a vascularized tissue engineering construct that involves using the immersed microfluidic spinning to create a network of calcium alginate fibers. These fibers are covered by a layer of the cell-laden hydrogel, another layer of fibers is spun upon the layer of hydrogel, and another layer of hydrogel is deposited over that layer of calcium alginate fibers. DMEM / EDTA / DSC solution is used to dissolve the calcium alginate fibers that would then leave a channel of several hundred microns in diameter inside the cell-laden hydrogel. This microfluidic network can be used to flow the nutrients to the cells and waste products away from the cells inside the hydrogel construct, assisting in the creation of the vascularized tissue construct.

The invention relates to an electric anastomat pressure self-adaptive adjusting method based on multi-source perception. The method comprises the following steps that 1, multi-dimensional data are obtained in real time; 2, based on sensor data, four stages of prepressing, main pressing, sewing and releasing are automatically recognized through a state machine driving mechanism, and an independent pressure curve and an adjustment strategy are adopted in each stage; 3, combining a pre-stored organ multilayer structure mechanical model, matching the real-time thickness map with the organization structure model through a genetic algorithm and a particle swarm optimization algorithm, and generating an optimal pressure distribution matrix; 4, driving corresponding actuators to generate different micro-displacements according to the pressure distribution matrix so as to realize differential pressure application of each area of the jaw; and step 5, integrating a low-power-consumption Bluetooth 5.2 / Wi-Fi 6E module to perform wireless communication, and designing a touch display screen to display a pressure distribution map, a tissue thickness profile and a stage state in real time.

The invention provides a navigation grinding method and a surgical robot system for craniomaxillofacial abnormal proliferation bone fibers, and the method comprises the steps: S1, obtaining craniomaxillofacial bone tissue image data and intraoral scanning data of a target human body, and constructing a three-dimensional digital craniomaxillofacial model; s2, based on abnormal pathological features of abnormal proliferation bone fibers in the craniomaxillofacial bone tissue image data, identifying and obtaining a bone fiber abnormal proliferation disease lesion area, and generating a lesion area three-dimensional model; s3, human body key tissue structures existing in the craniomaxillofacial region are obtained through segmentation, the minimum distance between abnormally proliferated bone fibers in the bone fiber abnormal proliferation disease lesion region and any human body key tissue structure is calculated, and a distance field graph is generated; s4, based on the lesion area three-dimensional model and the distance field map, a navigation grinding path of the surgical robot is established, and therefore the functions of medical image data recognition and analysis, navigation grinding path automatic generation, robot-assisted surgery and the like based on the artificial intelligence technology are achieved.

Described herein are in vitro quantitative methods directed to 3D extracellular matrix (ECM) organization and mechanics. The methods do not require application of an external force, anchorage, or a scaffolding material in order to culture ECM tissue constructs, and the methods enable quantitative measurements without crosstalk noise from variables attributable to external forces, anchorage, and scaffolding material.

Compositions and methods for bioprinting a transplantable vascularized tissue construct that allows for direct surgical anastomosis to a host, to achieve immediate blood perfusion with host vasculature for long-term cell survival and function.