68 results about "Tissue construct" patented technology

The invention discloses a tooth intelligent segmentation and parameterized bionic reconstruction method fusing multi-modal data, and belongs to the field of artificial intelligence and computer-aided biomedical engineering. The method comprises a CBCT intelligent segmentation module, an intraoral scanning intelligent segmentation module, an internal tissue segmentation module, a point cloud generation registration module and a parameterized bionic reconstruction module. The point cloud generation registration module further comprises a point cloud generation sub-module and a point cloud registration sub-module; the parameterized bionic reconstruction module further comprises a dentin reconstruction sub-module, a cancellous bone reconstruction sub-module and a gingival reconstruction sub-module. The invention aims to realize tooth semantic segmentation, point cloud reconstruction and parameterized bionic modeling of an organization structure under cross-modal data fusion, and provides high-precision bionic internal structure information for teeth in combination with an artificial intelligence model and parameterized modeling.

To provide a manufacturing system and method for creating multiple tissue constructs from cells.SOLUTION: A system can include a thaw subsystem (if the cells are provided in a frozen state), an expansion subsystem, a concentration subsystem, and a tissue maturation subsystem. Each of these subsystems is modular and can be reconfigured, and a process can be repeated depending on the specific tissue process being implemented. Multiple tissue types can be combined in multiple bioreactors. The activities of multiple bioreactors can be coordinated and controlled in an automated manner by a supervisor controller. The supervisor controller can receive user input at the start of the process, and can manage the process thereafter, alerting the user if user actions are required.SELECTED DRAWING: None

The invention discloses a composite material performance prediction method based on multi-field coupling multi-scale analysis and a knowledge graph, which integrates microstructure modeling, graph neural network representation learning, cross-scale parameter coupling modeling and robust optimization analysis. The method is suitable for prediction and design of key mechanical properties such as modulus, strength and toughness of a thermosetting / thermoplastic composite material under different working conditions. The method comprises the following steps: firstly, constructing a grain-level tissue knowledge graph based on an electron backscatter diffraction image, secondly, constructing a multi-scale input system comprising a microscopic variable (such as a fiber volume fraction), a mesoscopic variable (such as a layer thickness sequence) and a macroscopic variable (such as a load condition), and finally, performing robust optimization by utilizing a multi-objective evolutionary algorithm to obtain a multi-scale input system. And outputting a material performance prediction result and a knowledge graph associated with the ji structure-process-performance. According to the method, the accuracy and interpretability of performance prediction of the composite material can be remarkably improved, and data-knowledge dual-drive support is provided for design optimization of the high-performance composite material.

The invention provides a fine-grained multi-dimensional configuration permission control method and system, electronic equipment and a storage medium, and aims to solve the problem that permission division cannot meet fine-grained permission control requirements, the method comprises the following steps: on the basis of an RBAC model, adding organization elements, and adding an organization structure hierarchical relationship, the relationship between the organization structure and the content of each part in the model is obtained; a dynamic role allocation and role inheritance mechanism is introduced, the inheritance relation between roles is specified when the roles are defined, so that the child-class roles can inherit the permission set of the parent-class roles, and permission expansion is carried out; performing permission configuration, performing cross organization on the function permission and the data permission, then distributing the function permission and the data permission to corresponding organization roles, ensuring that each organization role has the basic permission, and expanding private permissions for the organization roles according to different business requirements; the organization roles are distributed to the users, so that authority distribution of the users is realized. According to the invention, validity and timeliness of authority management can be ensured.

The invention discloses a tissue engineering integrated trachea regeneration construction method based on a frame structure scaffold and application. A multi-tissue-structure integrated gas pipe is constructed based on a 3D printing bioelastomer frame structure support, and the complex structure and physiological functions of a natural gas pipe are highly simulated. The preparation method comprises the following steps: firstly, by utilizing the characteristic that temperature-sensitive hydrogel Pluronic F-127 becomes semi-solid gel at 37 DEG C and is liquefied at a low temperature of 4 DEG C, and by adopting a strategy that the temperature-sensitive hydrogel is sacrificed after occupying, the patterned distribution of chondrocytes and fibroblasts on a two-dimensional plane is realized; secondly, simulating a three-dimensional tubular trachea structure through a 2D-3D (two-dimensional to three-dimensional) rolling assembly strategy, and realizing the ordered regeneration of C-shaped cartilage ring / O-shaped fiber ring alternate distribution and axial strip-shaped fiber bundle triple structures under the skin of the nude mouse. And finally, successfully extracting the airway mucosa epithelium, separating and amplifying enough airway basal cells in vitro, and loading the airway basal cells to the inner wall of the regenerated trachea by utilizing the photo-crosslinking hydrogel, thereby realizing the function simulation of the airway epithelium and enhancing the physiological functionality.

The invention discloses a smoke suction knife capable of rapidly replacing a smoke suction cover and a knife head and automatic assembling equipment thereof, the smoke suction knife comprises a pen body, a conductive elastic piece, a circuit board, an electrode knife head and the smoke suction cover, and the automatic assembling equipment comprises a conveying belt, a tail plug inserting area, a circuit board placing area, an upper pen body pressing area, an ultrasonic heat sealing area, an electrode knife head inserting area and a function testing area. Automatic assembly is completed through automatic equipment, the smoke suction cutter with the smoke suction hood and the cutter head capable of being rapidly replaced is completed, the electrode cutter head is inserted into the conductive elastic piece, the conductive elastic piece is tightly attached to the outer side wall of the electrode cutter head, and the cutter head can be detached and replaced while electric connection is guaranteed; and meanwhile, the smoke suction cover is detachably arranged at the front end of the pen body, so that the smoke suction cover can be synchronously replaced after the cutter head is replaced, the generated smoke can be absorbed in the first time, the smoke which is removed in time is prevented from shielding an operation area, reducing the identification degree of a doctor on a tissue structure, increasing the operation risk and improving the manual operation efficiency.

The invention relates to the technical field of acoustic wave device application and biological tissue engineering, in particular to a method for constructing a multi-component heterogeneous fiber structure under the assistance of acoustic tweezers. According to the method, an acoustic tweezers technology and a microfluidic spinning technology are combined, an electric signal is converted into an acoustic surface wave through the piezoelectric effect of a piezoelectric material, and a beam-shaped acoustic standing wave field is formed in a microchannel of a specific structure; different target cells form a stable fiber configuration under the interaction of microchannel limitation and acoustic radiation force, and spatial precise classification and arrangement of multiple types of cells are realized. The low-temperature-sensitive hydrogel is introduced in the cell injection process, and the fiber scaffold is formed after ultraviolet curing, so that the fiber structure of the cells is still maintained after the sound field is removed. The cells treated by the surface acoustic wave can form a complex three-dimensional bionic tissue structure more easily, and the cell viability is remarkably improved. Various fiber structures can be formed by regulating and controlling sound field parameters, and great potential is shown in the field of in-vitro barrier model construction.

The present invention relates to systems, compositions and methods for multicellular bioprinting vascularized tissue constructs comprising a hierarchical vascular network. The methods employ a dual bio-ink strategy involving fibrous microgel matrix bio-inks with adjustable hardness, self-healing rheology, and microporosity to support capillary self-assembly, and sacrificial bio-inks that define a large pourable channel after removal. The system integrates top-down printing and bottom-up cell self-organization within a programmable bio-printing platform. The key aspect of the invention is to engineer the physical topography of the matrix to actively guide vascular morphogenesis beyond conventional permissive stents. The integrated platform enables the manufacture of complex bionic vascular networks with enhanced mass delivery, cellular viability, and in vivo integration potential. The invention represents an important progress in the aspect of extendable production of functional human tissues, and has application in regenerative medicine, disease modeling and drug discovery.

An arc wire feeding additive manufacturing method for a 321 stainless steel tissue gradient material, which relates to the field of additive manufacturing. The purpose of the present invention is to address the problems of complex processes, high costs, low deposition efficiency, easy contamination, and limited forming size existing in the preparation process of existing tissue gradient materials. The present invention proposes to control the recrystallization degree of different deposition positions by matching different ultrasonic impact and arc wire feeding additive manufacturing process parameters, and then achieve the purpose of tissue structure gradient transition, so as to prepare a metal FGM with a tissue structure gradient in this way. The present invention can achieve a relatively continuous gradient transition of the tissue structure and function gradient material of large and complex structures, achieving the effects of improving deposition efficiency, simplifying the process flow, and reducing manufacturing costs.

Described herein are bioprinters comprising: one or more printer heads, wherein a printer head comprises a means for receiving and holding at least one cartridge, and wherein said cartridge comprises contents selected from one or more of: bio-ink and support material; a means for calibrating the position of at least one cartridge; and a means for dispensing the contents of at least one cartridge. Further described herein are methods for fabricating a tissue construct, comprising: a computer module receiving input of a visual representation of a desired tissue construct; a computer module generating a series of commands, wherein the commands are based on the visual representation and are readable by a bioprinter; a computer module providing the series of commands to a bioprinter; and the bioprinter depositing bio-ink and support material according to the commands to form a construct with a defined geometry.

A system with reusable components and methods are disclosed for culturing, forming, perfusing, and maintaining a perfusible-tissue construct. The system uses a production container comprising a floor, a wall extending from the floor, wherein the floor and wall define a production reservoir, a formation section defined in the floor, wherein the formation section comprises at least one well, and a grip extending outwardly from the formation section; wherein the production container is made of a biocompatible material that remains stable when autoclaved.

This invention discloses a self-lubricating hydrogel titanium alloy biomimetic joint bearing interface and its preparation method. The self-lubricating hydrogel titanium alloy biomimetic joint bearing interface is composed of a porous titanium alloy substrate, a functionalized interface layer, a negatively charged hydrogel layer, and a self-lubricating adsorption layer. A laser drilling method is used to create a porous structure on the surface of a Ti6Al4V substrate. A hydrogel precursor solution is coated onto the surface of the Ti6Al4V sample and cured by ultraviolet irradiation to obtain a negatively charged hydrogel titanium alloy composite sample. The negatively charged hydrogel titanium alloy composite sample is subjected to freeze-thaw cycles and then immersed in zwitterionic or cationic solutions for adsorption, resulting in a hydrogel titanium alloy biomimetic joint bearing interface with self-lubricating properties. The hydrogel titanium alloy biomimetic joint bearing interface of this invention significantly improves the lubrication performance of titanium alloy materials used in artificial joints, achieving biomimetic design of natural joints in terms of tissue structure and lubrication function, and is suitable for the repair and replacement of damaged articular cartilage.

A tubular tissue converter (TTT) for a tubular tissue structure. The tubular tissue converter has a plurality of blades and a plurality of retainers on each of the plurality of blades. Each retainer retains the tubular tissue structure on a respective blade. Coupling systems for coupling together tubular tissue structures and tools and methods for attaching and widening tubular tissue structures are also provided.

The invention provides a method for predicting phase structure transformation of an impeller material, which comprises the following steps of: S1, roughly machining a target workpiece, and cutting a test ring on the target workpiece; s2, performing heat treatment on the target workpiece and the test ring; s3, cutting a first sample on the test ring, applying different loading forces to the first sample for stretching, performing X-ray diffraction detection on the first sample when the different loading forces are applied, and forming a corresponding peak curve; according to the method, the first sample is subjected to performance sample stretching and X-ray diffraction detection, the volume percentage of the phase structure of the target workpiece before and after stretching is tested, the austenite volume structure tissue transformation condition of the impeller in the overspeed process is predicted, and the phase structure of the impeller can be stabilized in advance; and phase structure transformation in the overspeed test process is prevented, and the performance stability and reliability of the target workpiece in actual application are greatly improved.

The application discloses a processing method and device of a 3D printing module dissection teaching model of a nasal cavity and nasal sinus, which can be widely applied in the technical field of teaching data processing. After real nasal cavity and nasal sinus image data are acquired, a 3D virtual model including a bone structure virtual model, a soft tissue structure virtual model, a nerve and blood vessel virtual model or a skull base and eye socket virtual model is constructed according to the real nasal cavity and nasal sinus image data, then a printing process of the 3D printing module dissection teaching model is performed according to the 3D virtual model, so as to obtain a 3D printing module dissection teaching model with a proportion of 1:1 with the real nasal cavity and nasal sinus image data, and nasal cavity and nasal sinus dissection teaching is performed according to the 3D printing module dissection teaching model, so that the nasal cavity and nasal sinus structure can be restored by the 3D printing module dissection teaching model, and the 3D printing module dissection teaching effect of the nasal cavity and nasal sinus is effectively improved.

The invention provides a wear-resistant and corrosion-resistant multi-principal-element alloy as well as a preparation method and application of the wear-resistant and corrosion-resistant multi-principal-element alloy. The multi-principal element alloy is composed of five elements of Ni, Co, Al, Cr and Fe. Or, the alloy is composed of four elements of Ni, Co, Al and Cr. The multi-principal-element alloy provided by the technical scheme of the invention has a near eutectic cellular tissue structure, the FCC phase movable slip systems of the cellular outer layer are many, the plasticity is good, the BCC / B2 coherent reticular tissue movable slip systems of the cellular inner part are few, and the dislocation motion is hindered by a high-density coherent interface, so that a cellular soft-hard combined structure with soft edge and hard inner part is formed; the volume fraction of the BCC / B2 coherent reticular structure phase can be increased by increasing the content of the chromium element and reducing the content of the iron element, so that the hardness of the alloy is improved; and meanwhile, the potential difference of each phase can be reduced through component regulation and control, and the stability of a passivation film is improved, so that the common galvanic corrosion rate in a traditional multi-phase alloy is reduced, and the corrosion resistance of the alloy is improved.

According to the welding method for improving the fatigue performance of the rectangular non-bearing accessory structure, firstly, control optimization on macroscopic morphology and control optimization on microstructure uniformity are established; fatigue characteristics of a welding structure of a rectangular non-bearing accessory are converted into a fatigue strength mechanism represented by local microcell cyclic plastic strain accumulated damage controlled by base metal yield strength, and then the base metal is set to be high-strength steel, so that the fatigue performance of the welding structure is improved. According to the welding method for improving the fatigue performance of the rectangular non-bearing accessory structure, the fatigue performance of the welding structure can be converted into a fatigue strength mechanism which is controlled by the yield strength of base metal and is represented by cyclic plastic strain accumulation damage of a local microcell, and the usual concept of the existing industry is broken through.

Systems, devices, and methods described relate to a system including an electrosurgical interface electrically coupled to the generator, an energy delivery element electrically coupled to the electrosurgical interface, the energy delivery element configured to receive energy from the generator to form a puncture in tissue of a patient, and a return electrode electrically coupled to the patient and the generator.

The present disclosure pertains to universal and adoptable cell culture substrates designed for applications in biology, medicine, pharmaceutics, and other relevant fields. The disclosure particularly focuses on processes and methodologies for manufacturing such substrates, which prove advantageous for both non-neural (cells exhibiting robust adhesion and weak cell-cell junctions, as well as cells with regular adhesion and cell-cell junctions) and neural cell sheet engineering. These substrates aim to enhance cell adhesion, stimulate cell growth, and enable rapid and uniform harvesting of cell sheets. Additionally, the present invention introduces a scaffold-free method for tissue engineering, facilitating the creation of a 2D / 3D neural tissue construct featuring unidirectional neuron bundles.

The invention discloses an impurity-free and high-wear-resistant modification method for 2Cr13 stainless steel, which specifically comprises the following steps: step 1, pretreatment: cutting and milling a test block workpiece, processing the test block workpiece into a fixed size and shape, and then cleaning the processed workpiece by using an ultrasonic cleaning machine; step 2, preparing a sample, and polishing the test block by using a metallographic polishing machine until the test block is polished; 3, electron beam treatment, wherein electron beams are adopted for conducting continuous scanning treatment on the sample. And 4, tissue and performance testing: observing the microstructure by adopting a scanning electron microscope, measuring the hardness by utilizing a microhardness tester, and detecting the wear resistance by utilizing a friction wear testing machine. According to the method disclosed by the invention, the surface hardness, the wear resistance and the corrosion resistance of the 2Cr13 stainless steel can be remarkably improved, and the method has an extremely good application scene.

Aspects of the present invention relate to a microphysiological device including a first component having a frame having at least one opening passing through the frame forming a first interior region, wherein the first interior region comprises a tissue construct, a second component having a frame having at least a first opening passing through the frame forming a second interior region, a holder having a frame having at least one opening passing through the frame forming a third interior region, and a membrane positioned across the opening including at least one a cellular monolayer layered thereon, wherein the holder is removably positioned within the second interior region of the second component, and the first component and second component are fixedly and removably attached thereby fluidly connecting the first, second, and third interior regions.

Described herein is a method of forming an aligned tissue or tissue construct. The method includes extruding a bioink material through a nozzle onto a support to form a structure of the bioink material, the bioink material comprising anisotropic organ building blocks (aOBBs) comprising extracellular matrix material (ECM) and cellularly aligned cells, wherein the aOBBs align parallel to the direction of the extrude path, and polymerizing the structure of the bioink material, thereby forming the tissue or tissue construct having arbitrarily programmed alignment. Also, described is a tissue or tissue construct produced by the method, as well as bioink material used to produce the same.

The described systems, devices and methods relate to a system that includes an electrosurgical interface electrically coupled to a generator, an energy delivery element electrically coupled to the electrosurgical interface, the energy delivery element configured to receive energy from the generator and form a puncture hole in tissue of a patient, and a return electrode electrically coupled to the patient and the generator.

Described herein are apparatuses, systems, and methods for fabricating tissue constructs, such as by fabricating perfusable tissue constructs by embedding a sacrificial material into a composite matrix yield stress support bath. A composite matrix bath can include a microgel filler and a hydrogel precursor. An extrusion tip can be used for embedded printing of perfusable tissue constructs by disposing sacrificial material into the composite matrix bath while the extrusion tip travels along a predefined course through the composite matrix bath. This sacrificial material can be the printed tissue construct or can be removed to render the matrix bath a perfusable tissue construct. The composite matrix bath can include acellular or cell-laden hydrogels. The sacrificial material can include a salt and a physiological buffer or a non-cytotoxic porogen material. The hydrogel precursor can include at least one of gellan and gelatin. Cross-linking can be carried out chemically, thermally, enzymatically, or physically.

The present invention relates to a novel bioreactor system for preparing an engineered three-dimensional biological tissue construct. The bioreactor system comprises a cultivation chamber that is designed to allow the formation, cultivation and the subsequent testing and / or stimulation of tissue constructs on one or more support elements with a minimum risk of microbial contamination or mechanical damage. The invention furthermore relates to a method for preparing an engineered tissue construct using the novel bioreactor system. The invention also relates to the use of the bioreactor system for preparing engineered biological tissue constructs, preferably tissue constructs which are suitable for being used in clinical tissue replacement and reconstructive therapy, drug development, drug screening, toxicity testing, cosmetic studies, safety testing, developmental studies, disease modeling, or food purposes.

Disclosed are living, three-dimensional tissue constructs for in vitro scientific and medical research, arrays thereof, and methods of making said tissues and arrays.

1. The name of the design product: the head of surgical knives. 2. The use of the design product: overall use: for surgical tools; partial use: for cutting tissue structure and containing surgical tool accessories. 3. The design points of the design product: the shape of the partial design. 4. The picture or photo that best shows the design points: design 1A enlarged view. 5. Design 1 is designated as the basic design. 6. Other circumstances that need to be explained: the design product involves partial design, the green coated part in each figure is the unclaimed part, and the part other than the green coating is the claimed part; design 1A enlarged view is the partial enlarged view of point A in design 1 perspective view 1; design 1B enlarged view is the partial enlarged view of point B in design 1 perspective view 2; design 1C enlarged view is the partial enlarged view of point C in design 1 front view; design 2D enlarged view is the partial enlarged view of point D in design 2 perspective view; design 2E enlarged view is the partial enlarged view of point E in design 2 front view; design 3F enlarged view is the partial enlarged view of point F in design 3 perspective view; design 3G enlarged view is the partial enlarged view of point G in design 3 front view; design 4H enlarged view is the partial enlarged view of point H in design 4 perspective view; design 4I enlarged view is the partial enlarged view of point I in design 4 front view.

The invention discloses a steel microstructure identification method and system based on deep learning driving, and a medium. The method comprises the steps of obtaining a steel microstructure image, performing data enhancement, and performing division to obtain a training set and a verification set; based on the MobileNetV2 pre-training model, using a transfer learning method to construct a SteelIDNet model; using the training set to train the SteelIDNet model, and using the verification set to verify and evaluate the trained SteelIDNet model to obtain a final SteelIDNet model; and deploying the final SteelIDNet model at a mobile terminal to carry out steel microstructure identification. According to the method, the SteelIDNet model is constructed through deep learning and transfer learning technologies, the advantage (CNN) of the convolutional neural network is brought into full play, and the recognition efficiency of the steel microstructure is remarkably improved; the method is not only suitable for PC terminal development, but also convenient to deploy on a mobile terminal, can realize millisecond-level response speed, and is particularly suitable for high-efficiency requirements of the mobile terminal on real-time detection and analysis.

Described are methods for producing tissue constructs, tissue constructs produced by the methods, and their use. The described method of producing a tissue construct comprises providing a granular tissue, depositing one or more filaments on or in the granular tissue, each filament comprising an ink, and gelling or fusing the granular tissue, thereby producing the tissue construct.