Embodiments of the present invention provide a device and a method for treating at least one of hypertension, pulmonary arteries, diabetes,
obesity,
heart failure, end-stage renal
disease, digestive
disease, urological
disease, cancers, tumors, pain,
asthma or chronic obstructive
pulmonary disease by delivering an effective amount of a formulation to a tissue. In embodiments of the present invention, the formulation may include at least one of a gas, a vapor, a liquid, a solution, an
emulsion, or a suspensions of one or more ingredients. In embodiments of the present invention, amounts of the formulation and / or energy are effective to injure or damage tissue, nerves, and nerve endings in order to relieve disease symptoms.