125results about How to "Aid in diagnosis" patented technology

The invention comprises systems and methods for evaluating changes in the operational efficiency of an HVAC system over time. The climate control system obtains temperature measurements from at least a first location conditioned by the climate system, and status of said HVAC system. One or more processors receives measurements of outside temperatures from at least one source other than said HVAC system and compares said temperature measurements from said first location with expected temperature measurements. The expected temperature measurements are based at least in part upon past temperature measurements.

The invention comprises systems and methods for evaluating changes in the operational efficiency of an HVAC system over time. The climate control system obtains temperature measurements from at least a first location conditioned by the climate system, and status of said HVAC system. One or more processors receives measurements of outside temperatures from at least one source other than said HVAC system and compares said temperature measurements from said first location with expected temperature measurements. The expected temperature measurements are based at least in part upon past temperature measurements.

The invention comprises a system for calculating a value for the effective thermal mass of a building. The climate control system obtains temperature measurements from at least a first location conditioned by the climate system. One or more processors receive measurements of outside temperatures from at least one source other than the control system and compare the temperature measurements from the first location with expected temperature measurements. The expected temperature measurements are based at least in part upon past temperature measurements obtained by said HVAC control system and said outside temperature measurements. The processors then calculate one or more rates of change in temperature at said first location.

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

Disclosed are compositions and methods for isolating, detecting, amplifying, and quantitating Mycobacterium-specific nucleic acids in a sample. Also disclosed are compositions and diagnostic kits comprising Mycobacterium IS6110-specific oligonucleotide amplification primers and labeled oligonucleotide detection probes that specifically bind to the amplification products obtained therefrom. Also disclosed are compositions and methods for the isolation and characterization of nucleic acids that are specific to one or more tubercular pathogens, including Mycobacterium tuberculosis, in particular, from a wide variety of samples including those of biological, environmental, clinical and / or veterinary origin.

An image guidance system is provided for improving tissue culture extraction where the tissue is extracted under the guidance of first and second knowledge-based systems. The first knowledge-based system provides initial suggested regions of interest for tissue biopsy in an internal organ. These regions of interest are then confirmed as being of interest of being benign by the second knowledge-based system. Information from two different sources may provide a more accurate, intelligent and robust method that helps in selecting biopsy sites accurately, such that suspicious regions are not overlooked and the benign regions are not unnecessarily operated upon. This not only helps in better diagnosis and treatment, but also helps reduce pain to the patient, in addition to reducing wastage of resources and invaluable time.

A method and a system for monitoring and characterizing a person's heart condition for various medically related purposes. The method includes the steps of (a) acquiring a selected person's acoustic heart signature, (b) acquiring, substantially simultaneously, that same person's electrical heart signature, (c) choosing elements of determined interest from these two acquired signatures and selectively processing and inter- and / or cross-relating such elements, and (d) employing the results of the relating step to create a heart-condition fingerprint useful in the characterization of that person's heart condition. From a systemic point of view, that system includes (a) acoustic and electrical data-gathering devices employable to collect acoustic and electrical data from a person, and (b) processing structure operatively connected to these devices, operable to process and inter- and / or cross-relate data gathered by the devices for the purpose of generating a reportable heart-condition fingerprint of a person from whom such data has been collected.

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

Techniques for visualizing and monitoring the quality of service for a computer network. Herein, a method and system monitor network transactions and behaviors for the computing network, which computing network includes one or more client subnets accessing one or more servers, The monitoring may be independent of client site monitors. Statistical data is gathered for relating to at least the network, the server, and the applications for generating a plurality of measurements. The measurements assess at least one quality of service indicator associated with the performance of the computer network. The method and system graphically display the plurality of measurements of the quality of service indicator according to the date and time of gathering the statistical data and further display graphically the degree by which each of the measurements of the quality of service indicator varies from a predetermined threshold quality of service level for the computing network. Also, dynamic quality of service indicators are monitored against average quality of service indicators.

A system and method is disclosed to reduce variation of the clinical decision making process when an image reporting and data system (IRADS) for medical diagnosis is used. Image reporting and data systems provide guidelines for an operator to identify images as belonging to one of a number of categories and specific clinical actions are then recommended based upon such categories. Some clinical actions such as biopsies may be recommended by IRADS even when they are not necessary. The present inventive concept is configured to utilize a Computer-Assisted Diagnosis (CAD) system that is specifically programmed to minimize discrepancies between the recommended clinical actions of an individual or specific group of experts using the standard IRADS process and the optimum clinical actions based on correlation with biopsy proven data. The resulting CAD system reduces the number of unnecessary clinical actions such as biopsies based on the operator's error profile.

A video oculography system for calculation and display of Corrective Secondary Saccades Analysis is disclosed. A method for Objective Diagnostics of at least one of traumatic brain injury, Internuclear Opthalmopligia, Ocular Lateral Pulsion, Progressive Supernuclear Palsy And Glissades comprises the steps of using a VOG system to calculate corrective saccades. The video oculography based system for the subject is configured to collect eye images of the patient in excess of 60 hz and configured to resolve eye movements smaller than at least 3 degrees of motion. The video oculography based system collects eye movement data wherein at least one fixation target is presented to the subject in a defined position configured to yield a voluntary saccadic eye response from at least one eye of the patient. The latency, amplitude, accuracy and velocity of each respective corrective saccade and totals latency and accuracy is calculated.

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

A method for the automated analysis of digital images, particularly for the purpose of assessing the presence and severity of cancer in breast tissue based on the relative proportions of tubule formations and epithelial cells identified in digital images of histological slides. The method includes the step of generating a property co-occurrence matrix (PCM) from some or all of the pixels in the image, using the properties of local mean and local standard deviation of intensity in neighbourhoods of the selected pixels, and segmenting the image by labelling the selected pixels as belonging to specified classes based upon analysis of the PCM. In this way relatively dark and substantially textured regions representing epithelial cells in the image can be distinguished from lighter and more uniform background regions Other steps include identifying groups of pixels representing duct cells in the image based on intensity, shape and size criteria, dilating those pixels into surrounding groups labelled as epithelial cells by a dimension to correspond to an overall tubule formation, and calculating a metric based on the ratio of the number of duct pixels after such dilation to the total number of duct and epithelial pixels. Other uses for the method could include the analysis of mineral samples containing certain types of crystal formations.

A method for displaying a computer-generated determination of the overall likelihood of malignancy in a mammogram lesion. The method requires providing a digitized image of a mammogram, displaying the digitized image, and selecting a region of interest directly on the displayed digitized image. The digitized image is then processed so that classifier data of the lesion in the user-selected region of interest are generated and displayed. The overall likelihood of malignancy is generated from the classifier data and also displayed. A clinical recommendation for further assessing the lesion is derived from the overall evaluation of malignancy and presented to the user. A system for displaying a determination of the overall likelihood of malignancy in a mammogram lesion and for presenting a clinical recommendation to the user is also provided. A method for integrating the overall likelihood of malignancy with a physician's independent score for the lesion is discussed.

In a method of monitoring an engine starting system in an engine, the engine starting system includes a charging system, a battery, a starter, a flywheel, and a controller. The controller and monitors can monitor components and systems associated with starting of an engine, such as engine or cranking speed, power cylinder unit compression, injection timing, and proper fuel delivery to predict and / or diagnose problems. For example, a charging system voltage is monitored and the charging system voltage is compared with predetermined charging system voltage values. Voltage of the battery is monitored and battery voltage is compared with predetermined battery voltage values. A signal to an operator is provided if one or more of the charging system voltage and the battery voltage are outside of predetermined ranges for the one or more of the charging system voltage and the battery voltage.

Soluble H4 (sH4) levels have been discovered to correlate with the stage or severity of inflammatory disorders including autoimmune disorders. In particular, circulating levels of sH4 can be used as a diagnostic for determining the severity of an inflammatory disorder or the propensity for developing an inflammatory disorder. The severity of an inflammatory disorder can be determined by assaying the levels of sH4 in a subject and comparing the levels of sH4 to reference sH4 concentrations that correlate to specific stages of an inflammatory disorder. The therapeutic efficacy of treatments for inflammatory disorders can also be determined by comparing levels of sH4 before and during treatment. Methods and devices for measuring sH4 are also provided.

A catheter or lead having electrically conductive traces and arbitrarily-shaped external electrical contacts. Each trace may be in electrical connection with one or more external electrical contacts. More specifically, each trace is typically electrically connected to a single contact. The traces and contacts may assist in diagnosis and / or detection of bio-electrical signals emitted by organs, and may transmit such signals to a connector or diagnostic device affixed to the catheter. The external electrical contacts may detect bioelectric energy or may deliver electrical energy to a target site.

A diagnostic listening device for a vehicle uses at least one input device to retrieve audible signals from the vehicle. Diagnostic circuitry is coupled to the at least one input device to allow a user to listen to the audible signals retrieved and to isolate out certain frequencies to aid in the diagnosis of the vehicle.

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

A system and method is disclosed to reduce variation of the clinical decision making process when an image reporting and data system (IRADS) for medical diagnosis is used. Image reporting and data systems provide guidelines for an operator to identify images as belonging to one of a number of categories and specific clinical actions are then recommended based upon such categories. Some clinical actions such as biopsies may be recommended by IRADS even when they are not necessary. The present inventive concept is configured to utilize a Computer-Assisted Diagnosis (CAD) system that is specifically programmed to minimize discrepancies between the recommended clinical actions of an individual or specific group of experts using the standard IRADS process and the optimum clinical actions based on correlation with biopsy proven data. The resulting CAD system reduces the number of unnecessary clinical actions such as biopsies based on the operator's error profile.

An apparatus and methods for diagnosing and treating nerve compression conditions in a patient, such as carpal tunnel syndrome, tarsal tunnel syndrome and other nerve compression conditions. Ultrasound transducer heads having an array of high frequency piezoelectric crystal elements mounted in the transducer head capable of delivering frequencies of 7.5 MHz or greater, and a low frequency piezocomposite element mounted in the transducer head capable of delivering frequencies of 0.25 MHz to 1.5 MHz at an intensity of about 0.25 W / cm2 to 2.0 W / cm2 can be used to diagnose and also treat the conditions. If necessary, the high frequency piezoelectric elements can be used to visualize the region of therapy to more accurately direct the low frequency ultrasound energy.

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

A method for the automated analysis of digital images, particularly for the purpose of assessing the presence and severity of cancer in breast tissue based on the relative proportions of tubule formations and epithelial cells identified in digital images of histological slides. The method includes the step of generating a property co-occurrence matrix (PCM) from some or all of the pixels in the image, using the properties of local mean and local standard deviation of intensity in neighbourhoods of the selected pixels, and segmenting the image by labelling the selected pixels as belonging to specified classes based upon analysis of the PCM. In this way relatively dark and substantially textured regions representing epithelial cells in the image can be distinguished from lighter and more uniform background regions Other steps include identifying groups of pixels representing duct cells in the image based on intensity, shape and size criteria, dilating those pixels into surrounding groups labelled as epithelial cells by a dimension to correspond to an overall tubule formation, and calculating a metric based on the ratio of the number of duct pixels after such dilation to the total number of duct and epithelial pixels. Other uses for the method could include the analysis of mineral samples containing certain types of crystal formations.