6 results about "Tubule" patented technology

To provide a biomimetic system that mimics the human proximal tubule, which is a high-performance in vitro model that can reproduce the physiological functions of the human proximal tubule in vitro and can be used as an evaluation tool in drug discovery.SOLUTION: The present invention provides a proximal tubule biomimetic system comprising a microfluidic device and LTL-positive cells derived from pluripotent stem cells contained within the microfluidic device. The microfluidic device has (A) a device body, (B) a first chamber provided in the device body, (C) a second chamber provided in the device body, and (D) a porous membrane positioned between the first chamber and the second chamber, separating the first chamber from the second chamber. The LTL-positive cells are contained within the first chamber and adhere to a first surface of the porous membrane facing the first chamber. The first surface of the porous membrane is coated with an extracellular matrix.SELECTED DRAWING: None

The invention belongs to the technical field of medicine, and discloses a vascularized bone micro-tissue and a preparation method thereof, the vascularized bone micro-tissue comprises umbilical cord mesenchymal stem cell spheres and bone marrow mesenchymal stem cells, and the bone marrow mesenchymal stem cells cover the umbilical cord mesenchymal stem cell spheres to form a core-shell structure. Compared with an anoxic environment, the inside of the micro-tissue sphere of the vascularization bone micro-tissue disclosed by the invention promotes formation of tubules, improves an internal inflammation micro-environment, increases extracellular matrix secretion, provides a good basis for bone mesenchymal stem cells (BMSCs) osteogenic differentiation, constructs a cell growth micro-environment, and accelerates bone regeneration in a stent.

The invention relates to a composition with a dental tubule plugging effect and application thereof. The composition comprises hydroxyapatite, arginine and calcium potassium phosphosilicate. The invention creatively finds that the composition is lack of any one of hydroxyapatite, arginine or calcium potassium phosphosilicate, the plugging rate of the dental tubules is obviously reduced, and the hydroxyapatite, arginine and calcium potassium phosphosilicate on the surface have a remarkable synergistic effect in the aspect of the plugging effect of the dental tubules. The composition can well block dental tubules, and has certain enamel repairing and anti-allergy effects.

The present invention belongs to the technical field of medicine. Disclosed in the present invention is a new pharmaceutical use of hepcidin, specifically the use of hepcidin in the preparation of a drug for blocking ferroptosis of a collecting tubule in acute kidney injuries and protecting kidney function. It has been demonstrated in the present invention that both renal endogenous and exogenous hepcidin can alleviate tubular injury and improve renal function in ischemia-reperfusion-induced acute kidney injury by inhibiting ferroptosis in intercalated cells of the collecting tubule. Disclosed in the present invention is a drug for alleviating ferroptosis of a collecting tubule and protecting kidney function in ischemic-reperfusion-induced acute kidney injury. The drug is an intraperitoneal injection prepared by dissolving hepcidin at a therapeutic concentration in PBS.

A cytological collection tool comprising a handle attached at its distal end to a base that includes a head from which broom-like tubules protrude and are arranged to form an elongated central portion and from which an arrangement of brush-like fibers protrude from the central portion.

To provide a method and system that segment one or more histological structures in a tissue image represented by multi- parameter cellular and intracellular imaging data.SOLUTION: A method of segmenting one or more histological structures in a tissue image represented by multi-parameter cellular and intracellular imaging data includes: receiving coarsest level image data on a tissue image, in which the coarsest level image data corresponds to the coarsest level of a multiscale representation of first data corresponding to the multi-parameter cellular and intracellular imaging data; further dividing the coarsest level image data into a plurality of non-overlapping superpixels; assigning, to each superpixel, a probability belonging to the one or more histological structures using some pre-trained machine learning algorithms to create a probability map; extracting an estimation boundary of the one or more histological structures by applying a contour algorithm to the probability map; and generating an accurate boundary of the one or more histological structures using the estimation boundary.SELECTED DRAWING: Figure 1