10 results about "Tubule" patented technology

To provide a biomimetic system that mimics the human proximal tubule, which is a high-performance in vitro model that can reproduce the physiological functions of the human proximal tubule in vitro and can be used as an evaluation tool in drug discovery.SOLUTION: The present invention provides a proximal tubule biomimetic system comprising a microfluidic device and LTL-positive cells derived from pluripotent stem cells contained within the microfluidic device. The microfluidic device has (A) a device body, (B) a first chamber provided in the device body, (C) a second chamber provided in the device body, and (D) a porous membrane positioned between the first chamber and the second chamber, separating the first chamber from the second chamber. The LTL-positive cells are contained within the first chamber and adhere to a first surface of the porous membrane facing the first chamber. The first surface of the porous membrane is coated with an extracellular matrix.SELECTED DRAWING: None

Described herein are perfusable 3D tubule-on-chip models comprising at least one tubule consisting of one patent lumen circumscribed by organoid-derived cells, and a multifluidic platform comprising at least one individually addressable chip. The models may further include an unseeded tubule, where the seeded tubule and the unseeded tubule are co-localized on the chip, and wherein the tubule and the unseeded tubule are embedded within a gelatin-fibrin extracellular matrix (ECM). Also, described here are methods of producing the described perfusable 3D tubule-on-chip models, and uses of the same.

The invention discloses a three-dimensional microcosmic bone fossa-tubule system mass transfer chip and an experimental device, and particularly relates to the field of organoids, microfluidics and bone tissue engineering devices. The mass transfer chip comprises an upper cover plate, a plurality of middle plates and a lower cover plate, the upper cover plate is connected with the adjacent middle plates in a bonding mode, the adjacent middle plates are connected in a bonding mode, the middle plates are connected with the lower cover plate in a bonding mode, and the centers of the upper cover plate, the multiple middle plates and the lower cover plate are jointly provided with Harvard pipes in a penetrating mode. A plurality of bone pits which are annularly distributed at intervals are etched in each middle plate, a bone tubule is communicated between every two adjacent bone pits, the bone pits are communicated with the Harvard tube through the bone tubules, and the Harvard tube, the bone pits and the bone tubules are all made of quartz glass. By the adoption of the technical scheme, the problem of existing bone mass transfer experiment research is solved, and the transportation process of a bone fossa-tubule system can be checked.

The utility model discloses a tracheal catheter connector, which belongs to the technical field of medical equipment and comprises a main body, and a guide wire insertion device is mounted on the main body. The guide wire inserting device comprises a sealing assembly and a self-locking assembly, and the sealing assembly and the self-locking assembly are both connected with the body. By means of the mode, the guide wire inserting device can be connected with a breathing machine while tracheal intubation is carried out, and emergency rescue of a patient is achieved; through the sealing assembly and the self-locking assembly, gas leakage can be prevented when the guide wire is taken out; through the fixing assembly, the guide balloon and the tubule on the tracheal catheter can be fixed, and accidents are prevented.

The invention belongs to the technical field of medicine, and discloses a vascularized bone micro-tissue and a preparation method thereof, the vascularized bone micro-tissue comprises umbilical cord mesenchymal stem cell spheres and bone marrow mesenchymal stem cells, and the bone marrow mesenchymal stem cells cover the umbilical cord mesenchymal stem cell spheres to form a core-shell structure. Compared with an anoxic environment, the inside of the micro-tissue sphere of the vascularization bone micro-tissue disclosed by the invention promotes formation of tubules, improves an internal inflammation micro-environment, increases extracellular matrix secretion, provides a good basis for bone mesenchymal stem cells (BMSCs) osteogenic differentiation, constructs a cell growth micro-environment, and accelerates bone regeneration in a stent.

The invention relates to a composition with a dental tubule plugging effect and application thereof. The composition comprises hydroxyapatite, arginine and calcium potassium phosphosilicate. The invention creatively finds that the composition is lack of any one of hydroxyapatite, arginine or calcium potassium phosphosilicate, the plugging rate of the dental tubules is obviously reduced, and the hydroxyapatite, arginine and calcium potassium phosphosilicate on the surface have a remarkable synergistic effect in the aspect of the plugging effect of the dental tubules. The composition can well block dental tubules, and has certain enamel repairing and anti-allergy effects.

The present invention belongs to the technical field of medicine. Disclosed in the present invention is a new pharmaceutical use of hepcidin, specifically the use of hepcidin in the preparation of a drug for blocking ferroptosis of a collecting tubule in acute kidney injuries and protecting kidney function. It has been demonstrated in the present invention that both renal endogenous and exogenous hepcidin can alleviate tubular injury and improve renal function in ischemia-reperfusion-induced acute kidney injury by inhibiting ferroptosis in intercalated cells of the collecting tubule. Disclosed in the present invention is a drug for alleviating ferroptosis of a collecting tubule and protecting kidney function in ischemic-reperfusion-induced acute kidney injury. The drug is an intraperitoneal injection prepared by dissolving hepcidin at a therapeutic concentration in PBS.

A cytological collection tool comprising a handle attached at its distal end to a base that includes a head from which broom-like tubules protrude and are arranged to form an elongated central portion and from which an arrangement of brush-like fibers protrude from the central portion.

The present invention patent discloses a three-dimensional microscopic bone lacuna-tubule system mass transfer chip and experimental device, specifically relating to the fields of organoids, microfluidics, and bone tissue engineering devices. The mass transfer chip includes an upper cover plate, multiple intermediate plates, and a lower cover plate. The upper cover plate is connected to adjacent intermediate plates, adjacent intermediate plates, and the intermediate plate to the lower cover plate by bonding. The centers of the upper cover plate, multiple intermediate plates, and lower cover plate are all pierced with Haversian tubes. Each intermediate plate is etched with multiple bone lacunas spaced in an annular pattern. Bone canaliculi connect two adjacent bone lacunas. The bone canaliculi connect the bone lacunas to the Haversian tubes. The Haversian tubes, bone lacunas, and bone canaliculi are all made of quartz glass. The technical solution of the present invention solves the problems of existing bone mass transfer experimental research and can examine the transport process of the bone lacuna-tubule system.

To provide a method and system that segment one or more histological structures in a tissue image represented by multi- parameter cellular and intracellular imaging data.SOLUTION: A method of segmenting one or more histological structures in a tissue image represented by multi-parameter cellular and intracellular imaging data includes: receiving coarsest level image data on a tissue image, in which the coarsest level image data corresponds to the coarsest level of a multiscale representation of first data corresponding to the multi-parameter cellular and intracellular imaging data; further dividing the coarsest level image data into a plurality of non-overlapping superpixels; assigning, to each superpixel, a probability belonging to the one or more histological structures using some pre-trained machine learning algorithms to create a probability map; extracting an estimation boundary of the one or more histological structures by applying a contour algorithm to the probability map; and generating an accurate boundary of the one or more histological structures using the estimation boundary.SELECTED DRAWING: Figure 1