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A tubule is: a small tube or fistular structure a minute tube lined with glandular epithelium any hollow cylindrical body structure a minute canal found in various structures or organs of the body a slender elongated anatomical channel
Scalable and highly accurate context-guided segmentation of histological structures, including tubules / glands and lumens, tubule / glandular clusters, and individual nuclei, in full-slide images of tissue samples from a spatial multi-parameter cell / intracellular imaging platform.
To provide a method and system that segment one or more histological structures in a tissue image represented by multi- parameter cellular and intracellular imaging data.SOLUTION: A method of segmenting one or more histological structures in a tissue image represented by multi-parameter cellular and intracellular imaging data includes: receiving coarsest level image data on a tissue image, in which the coarsest level image data corresponds to the coarsest level of a multiscale representation of first data corresponding to the multi-parameter cellular and intracellular imaging data; further dividing the coarsest level image data into a plurality of non-overlapping superpixels; assigning, to each superpixel, a probability belonging to the one or more histological structures using some pre-trained machine learning algorithms to create a probability map; extracting an estimation boundary of the one or more histological structures by applying a contour algorithm to the probability map; and generating an accurate boundary of the one or more histological structures using the estimation boundary.SELECTED DRAWING: Figure 1
Owner:UNIV OF PITTSBURGH OF THE COMMONWEALTH SYST OF HIGHER EDUCATION