155 results about "Dentinal Tubule" patented technology

A device, method and composition of matter for use in mobilizing a medicament into the dentinal wall of a tooth comprising depositing a charged substance within a cavity of a tooth and subjecting the substance to an electric charge.

An oral care composition includes an effective amount of a basic amino acid in free or salt form; and an effective amount of calcium silicate particles. The calcium silicate particles have an average diameter of less than about 5 microns, such that they can occlude dentinal tubules of the teeth. An oral care method includes applying the composition to an oral cavity of a subject to reduce or inhibit hypersensitivity of the teeth and to achieve other benefits.

A dentin mineralizing agent comprising tetracalcium phosphate particles (A) and an alkali metal salt of phosphoric acid (B), wherein the dentin mineralizing agent contains the tetracalcium phosphate particles (A) in an amount of 1 to 80 parts by weight relative to 100 parts by weight of the whole amount of the dentin mineralizing agent, and the blended amount of the alkali metal salt of phosphoric acid (B) relative to 100 parts by weight of the tetracalcium phosphate particles (A) is 1 to 100 parts by weight. Thus is provided a dentin mineralizing agent by which a dense HAp is formed on a dentin surface and HAp is deposited to a deep portion of a dentinal tubule, so that it can close the dentinal tubule.

A composition for the treatment of sensitive teeth comprising a suitable carrier and a desensitizing amount of: a) at least one tubule blocking agent preferably a combination of two such agents; and b) a nerve desensitizing agent selected from the group consisting of at least one potassium salt at least one strontium salt and mixtures thereof wherein the tubule blocking agent deposits or swells upon the dentinal surface and/or precipitates within the dentinal tubules retaining a higher concentration of the nerve desensitizing agent at the exposed dentinal surface and within the dentinal tubules The compositions may further contain a source of physiologically acceptable fluoride ion such as stannous fluoride Also disclosed are methods of using the subject compositions in the treatment of sensitive teeth.

A dental ultrasonic drug delivery system capable of accurately cleaning the inside of root canals and killing bacteria in dentin tubules is provided. The dental ultrasonic drug delivery system delivers a drug to a target using an ultrasonic delivery device 800. The drug is delivered in a mixed state with nanobubbles. A dental therapeutic probe for applying ultrasound is attached to the ultrasonic delivery device 800. The dental therapeutic probe is selected from: (1) a root canal insertion probe 100 which is configured to be inserted into a root canal and causes ultrasound to propagate in the root canal; (2) a dental caries therapeutic probe which causes ultrasound to propagate in a dental caries portion; (3) a periodontal disease therapeutic probe which applies ultrasound to a periodontal disease portion; and (4) a hyperesthesia therapeutic probe which applies ultrasound to hyperesthesia portion.

A method of and composition for bleaching teeth is provided. The composition includes a methacrylate and a bleaching agent homogeneously mixed together. The method includes sealing the dentinal tubules of the teeth to be bleached to reduce the sensitivity of the teeth to be bleached; and applying a bleaching agent that includes an oxidative agent to a surface of the teeth to be bleached. The composition includes a composition including a methacrylate and a bleaching agent mixed together.

A dentinal tubule sealant comprises poorly-soluble calcium phosphate particles (A), a phosphorus-free calcium compound (B), and water (C), wherein the particles (A) are at least one member selected from the group consisting of dicalcium phosphate anhydrous [CaHPO₄] particles, α-tricalcium phosphate [α-Ca₃(PO₄)₂] particles, β-tricalcium phosphate [β-Ca₃(PO₄)₂] particles, amorphous calcium phosphate [Ca₃(PO₄)₂.nH₂O] particles, calcium pyrophosphate [Ca₂P₂O₇] particles, calcium pyrophosphate dihydrate [Ca₂P₂O₇.2H₂O] particles, octacalcium phosphate pentahydrate [Ca₈H₂(PO₄)₆.5H₂O] particles, and dicalcium phosphate dihydrate [CaHPO₄.2H₂O] particles, and the dentinal tubule sealant contains 30 to 76% by weight of the particles (A), 0.001 to 4% by weight of the compound (B), and 23 to 69% by weight of the water (C). Thus, there is provided a dentinal tubule sealant capable of sealing dentinal tubules of an exposed dentin and also remineralizing the surrounding dentin after the sealing.

The invention discloses a duplex dentin hypersensitivity resistant composition and an application of the composition. The active ingredients of the duplex dentin hypersensitivity resistant composition include a potassium salt and titanium containing bioactive glass, wherein the weight percentage of the potassium salt in the composition is 0.3-12%, and the weight percentage of the titanium containing bioactive glass in the composition is 0.5-15%. The duplex dentin hypersensitivity resistant composition disclosed by the invention can be used for preventing and treating (eliminating or relieving) dentin hypersensitivity; on one side, the potassium salt releases potassium ions to rapidly relieve pain (by reducing the excitability of a dental pulp nerve), on the other side, the bioactive glass can be used for supplementing minerals for a tooth structure to form stable carbonated hydroxyapatite so as to deeply close a dentinal tubule (by improving the permeability of the dentinal tubule); treatment effect is greatly improved, and aching feeling and anaphylaxis can be radically eliminated to achieve the purposes of treating both symptoms and root causes; in addition, as the bioactive glass comprises titanium, the phosphorite layer formed on the surface of a tooth is firmer and more wear-resistant, and the tooth can better resist daily stimulation.

Precipitated silica materials are provided for utilization as abrasives or thickeners within dentifrice formulations that simultaneously effectuate tubule blocking within tooth dentin to reduce dentin sensitivity. Such precipitated silica materials have sufficiently small particle sizes and exhibit certain ionic charge levels by, for example, adjusting the zeta potential properties of the precipitated silica materials through treatment with certain metals to permit effective static attraction and eventual accumulation within dentin tubules when applied to teeth from a dentifrice formulation.

The ability to incorporate iodoform, tetracycline and a combination of iodoform/tetracycline into root canal gutta percha points is described. The iodoform, tetracycline and iodoform/tetracycline combination are bound within the gutta percha points. They act as a reservoir of antimicrobial that is capable of diffusing onto the surface of the gutta percha thereby inhibiting the colonization of bacteria on the gutta percha points and within the root canal system. Tetracycline is capable of coalescing within the dentinal tubules to inhibit long term microbial growth. These medicated gutta percha points are site specific, surface acting antimicrobial gutta percha points.A method of the usage and delivery of amorphous form iodoform gutta percha, iodoform/tetracycline gutta percha, or tetracycline gutta percha within a heated compule with a pressure plunger by delivering the thermo-softened heat labile amorphous form via a pressure extrusion system through a cannula into the prepared root canal system.

A composition for reducing dentinal hypersensitivity and remineralizing exposed dentinal surface and open dentinal tubules, comprising a non-aqueous carrier and a desensitizing amount of a desensitizing/remineralizing agent which consists essentially of a water soluble calcium salt and an incompatible ingredient which would otherwise react with the calcium salt. Upon contact with saliva when applied to an oral cavity, the desensitizing/remineralizing is then formed in situ by the reaction between the calcium salt and the incompatible ingredient, thereby remineralizing exposed dentinal surface and open dentinal tubules.

The invention discloses traditional Chinese medicine toothpaste with the effects of preventing and relieving tooth sensitivity. The traditional Chinese medicine toothpaste comprises 70%-99.7% of base material components and 0.3%-30% of anti-sensitivity components, wherein the base material components comprise an abrasive, a humectant, a thickener, a foaming agent, a sweetening agent, essence, a preservative and water; the anti-sensitivity components comprise 0.01%-5% of ginger root extract, 0.01%-5% of rhizoma cimicifugae extract, 0.01%-5% of moutan bark extract, 0.01%-5% of mangnolia officinalis extract, 0.1%-8% of strontium salt and 0.1%-10% of hydroxyapatite. According to the traditional Chinese medicine toothpaste, the ginger root extract, the rhizoma cimicifugae extract, the moutan bark extract and the mangnolia officinalis extract are compounded as anti-sensitivity components so as to add into toothpaste; meanwhile, the strontium salt and the hydroxyapatite are added to seal dentinal tubules and relieve sensitivity of teeth on cold, heat, sour and sweet due to nerve stimulation, so that the tooth sensitivity symptom is relieved, and even disappears, and thus, the tooth sensitivity can be prevented and relieved radically, antisepsis and anti-inflammation can be achieved, and oral cavity problems such as redness, swelling and bleeding of the gum can be relieved.

The invention relates to hydroxyapatite toothpaste which comprises micron-order hydroxyapatite, nano-hydroxyapatite and fluoride. The grain size of the micron-order hydroxyapatite ranges from 0.1 micrometer to 10 micrometers, and the grain size of the nano-hydroxyapatite is smaller than 100 nm. The mass concentration of fluorine of fluoride in the hydroxyapatite toothpaste is not larger than 8.0 wt%, the mass content of the nano-hydroxyapatite is not larger than 20 wt%, and the mass ratio of the micron-order hydroxyapatite to the nano-hydroxyapatite is 1:10 to 18:1. When the hydroxyapatite toothpaste is used, demineralized dentine sheets are helped to be subjected to biomineralization, the dentin sheets are restored, the aperture of the dental canaliculi is reduced, and even the dentinal tubule is blocked or a hydroxyapatite layer is deposited on the surface of the dentin. At the same time, fluoride matched with the content of the micron-order hydroxyapatite and the content of the nano-hydroxyapatite is hydrolyzed to generate fluorinions, the mineralization process of the hydroxyapatite in the dentin is promoted, and the restoring function of the hydroxyapatite toothpaste on the dentin is remarkably improved.

The invention provides a material for desensitizing teeth by sealing dentinal tubules. The material comprises the following raw materials in parts by weight: 30-60 parts of carboxymethyl chitosan, 5-10 parts of dipotassium phosphate, 10-20 parts of calcium chloride, 24-48 parts of lysozyme and 12-24 parts of water. Through an electrostatic acting force between the carboxymethyl chitosan and the lysozyme, a carboxymethyl chitosan and lysozyme containing nanogel is formed, the nanogel stabilizes calcium ions and hydrogen phosphate ions in a calcium phosphate solution, and the formed desensitizing material is in the form of rigid solid spheres containing nanometer amorphous calcium phosphate particles. Experiments prove that the desensitizing material is simple and convenient in preparation method and can penetrate into the dentinal tubules to achieve rapid desensitization and mineral crystals are formed and are firmly combined with the surfaces of the teeth; the newly formed crystals cancover the dentinal surfaces; the desensitizing material is good in biocompatibility, low in allergenicity, non-toxic, non-irritant, wide in clinical application range and ideal in using effect.

The invention relate to anhydrous toothpaste containing water-soluble phosphate, micron-sized calcium carbonate and fluoride. The mass percent of water-soluble phosphate is larger than 2.0 wt%, the mass percent of micron-sized calcium carbonate is less than 40 wt%, the mass ratio range of water-soluble phosphate and micron-sized calcium carbonate is 1/10-5, and the mass concentration of fluorine of fluoride in the toothpaste is less than 8.0 wt%. When the anhydrous toothpaste containing water-soluble phosphate and micron-sized calcium carbonate is used, biological mineralization can be helped to be conducted on demineralized enamel and demineralized dentin slices, the enamel surface is repaired, the bore diameters of dental canaliculi on the dentin dental face is reduced, and even dentinal tubules are blocked. At the same time, fluoride is hydrolyzed to generate fluoride ions, the mineralization process of hydroxyapatite in teeth is promoted, and the repairing function of the toothpaste on enamel and dentin is improved.

The invention encompasses combinations of bioactive glass composition and potassium salts that are useful in conjunction with delivery agent such as, for example, toothpastes, mouthwashes, and oral gels. In certain embodiments, the compositions of the invention form a rapid and continuous reaction with body fluids (e.g., saliva) to promote the immediate and long-tem release of Ca and P ions to produce a stable crystalline layer deposited onto and into the dentin tubules for the immediate and long term reduction of dentin hypersensitivity and tooth surface remineralization.

The invention discloses a dentin surface bionic hydroxyapatite coating preparation method, which relates to a method for preparing a bionic hydroxyapatite coating having a certain shape and a certain structure on the surface of decayed and sensitive dentin by using an electrochemical process. The method comprises the following steps: pretreating a dentin sample; subjecting the dentin sample to deproteinization treatment; and placing the sample in electrolyte gel for electrolysis, wherein the electrolyte gel comprises calcium and phosphorus solution, pig ameloblastin and hydroxymethyl cellulose, the pH value of the electrolyte gel is between 5.5 and 7.4, the treatment temperature is 30 to 55 DEG C, the current density is 0.3 to 2MA/cm<2>, and the treatment time is 30 minutes to 1 hour. When the method is used, the bionic coating of which the thickness is about 2 to 20 mu m is prepared, and the coating has the same mechanical performance as nature enamel and can combine with substrate dentin tightly. The coating has higher hardness and higher wear resistance and can restore dentin caries in early period, fill dentinal tubules and relieve dentine hypersensitivity.

The invention relates to a tooth desensitizer as well as a preparation method and application of the tooth desensitizer. The tooth desensitizer is a powdery composite material, comprises mesoporous silica nano-particles and bioactive glass which is injected into pores of the mesoporous silica nano-particles by fusing. The preparation method of the tooth desensitizer comprises the following steps: (1), providing mesoporous silica nano-particles; (2), providing bioactive glass, wherein the bioactive glass is heated until being fused; (3), immersing the mesoporous silica nano-particles into the fused biological active glass, so that the fused biological active glass is injected into the pores of the mesoporous silica nano-particles; and (4), cooling the mesoporous silica nano-particles which are injected with the bioactive glass to form the powdery tooth desensitizer. The powdery tooth desensitizer disclosed by the invention can be mixed with water to form paste, is coated on a tooth surface with a dentin sensitivity symptom by using a brush, and can deeply seal an exposed dentinal tubule, so that external stimuli in an oral cavity is isolated to achieve effect of treating dentin sensitivity.

The application belongs to the technical field of toothpastes. Specifically, the application relates to a whitening and restoring toothpaste containing bioactive glass, and a preparation method of thetoothpaste. The whitening and restoring toothpaste containing bioactive glass provided by the invention comprises the following components in parts by weight: 1-15 parts of the bioactive glass, 1-10parts of a pyrophosphate, 0.1-5 parts of a polyphosphate, 5-30 parts of a friction agent, 0.1-1.5 parts of a thickener, and 5-15 parts of a dispersant. Compared with traditional fluorides, the bioactive glass material is applied to toothpaste products to restore damaged teeth and dental caries, and the long-term anti-sensitivity effects are achieved by restoring exposed dentin tubules. The whitening and restoring toothpaste of the invention uses a special type of friction agent hydrated silica, the finish of teeth is improved and the teeth are cleaned and whitened while dental stains on the surface of the teeth are effectively cleaned. The whitening and restoring toothpaste of the invention uses the pyrophosphate and the polyphosphate, and thereby can effectively remove exogenous stains ofthe teeth, resist the exogenous pigmentation of the teeth, and whiten the teeth.

The invention relates to an oral care composition containing hydroxyapatite, a polycarboxylic compound, soluble calcium and an orally acceptable carrier, an aqueous mixed liquid containing hydroxyapatite, the polycarboxylic compound and soluble calcium, and a use of the aqueous mixed liquid in alleviation and prevention of tooth sensitivity. Hydroxyapatite in the oral care composition can plug openings of dentinal tubules, and also can deeply enter dozens-of-micrometers deep positions in the dentinal tubules. The oral care composition is prepared through mixing the aqueous mixed liquid with the orally acceptable carrier. The aqueous mixed liquid is prepared through mixing the polycarboxylic compound hydroxyapatite and soluble calcium in an aqueous solution.

The invention belongs to the technical field of silicon dioxide, and particularly relates to a preparation method and application of silicon dioxide for toothpaste for relieving tooth sensitivity. Sodium sulfate is adopted as an electrolyte, sodium silicate and sulfuric acid react to generate seed crystals, then the seed crystals further react to generate silicon dioxide crystal grains, glycerin is added to enable the surfaces of the silicon dioxide crystal grains to have a large number of hydroxyl groups, cooling tap water is added to reduce the polymerization degree of silicon dioxide, and finally filter pressing, drying, crushing and grinding are conducted. The particle size of silicon dioxide for the toothpaste for relieving tooth sensitivity is close to the diameter of dentinal tubules, silicon dioxide can enter the dentinal tubules and deposit, silicon-oxygen bonds are formed by silicon dioxide and dentinal tubules, the effect of sealing the dentinal tubules is achieved, and theproblem of tooth sensitivity is solved fundamentally; when the anti-allergy toothpaste is applied to toothpaste, the problem of tooth sensitivity can be relieved while the effect of an abrasive is achieved, other components for relieving tooth sensitivity do not need to be added, and therefore the production cost of the anti-allergy toothpaste is reduced.

The invention provides a composite material for treating dentine hypersensitivity and a preparation method thereof. The method comprises the following steps: (1) mixing mesoporous silica nanometer particles, calcium salt and water to obtain a mixture, drying and then calcining the mixture to obtain calcium-carried mesoporous silica nanometer particle microspheres; (2) mixing the mesoporous silica nanometer particles and a phosphoric acid aqueous solution to obtain a mixture, drying and then calcining the mixture to obtain phosphor-carried mesoporous silica nanometer particle microspheres; and (3) mixing calcium-carried mesoporous silica nanometer particle microspheres, phosphor-carried mesoporous silica nanometer particle microspheres and the water to obtain the composite material for treating dentine hypersensitivity. The composite material provided by the invention is toothpaste-like, can be uniformly smeared on tooth surface with dentine hypersensitivity symptoms by using medical small brush head, and can relatively deeply seal exposed dentinal tubules, so as to isolate external stimulation to the oral and achieve the effect of treatment of dentine hypersensitivity.

The invention discloses a desensitizer for treating dentin hypersensitivity and a preparation method thereof. The desensitizer is prepared from two parts: solid powder and dispersion liquid. Before use, the solid powder and the dispersion liquid are separately packaged, when in use, the solid powder and the dispersion liquid are mixed, and after the solid powder and the dispersion liquid are mixed uniformly, paste is formed and coated on an exposed dentin surface; the solid powder is made of micro-nano bioactive glass beads of a Si-Ca-P ternary system; the dispersion is sodium alginate-phosphate buffer solution. The preparation process of the desensitizer comprises preparation of the micro-nano bioactive glass beads of the Si-Ca-P ternary system and preparation of the sodium alginate-phosphate buffer solution. The desensitizer disclosed by the invention can effectively block and seal up a dentin tubule, induces to form a reparative dentin layer, is high in response speed, does not influence tooth attraction, and can be used as a desensitization material for dentin hypersensitivity; meanwhile, the preparation method disclosed by the invention is simple in process, does not require complex equipment, and is mild in preparation condition and easy to popularize.