Material for desensitizing teeth by sealing dentinal tubules

A technology of dentinal tubules and teeth, applied in dentistry, dental preparations, dental prostheses, etc., can solve the problems of poor tooth surface binding ability, difficult penetration of desensitizers, and short residence time on the tooth surface. Sensitization, broad clinical application prospects, and simple preparation methods

Active Publication Date: 2018-01-12
STOMATOLOGICAL HOSPITAL TIANJIN MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In view of this, the present invention aims to propose a material for sealing the dentin tubules to desensitize the teeth, so as to solve

Method used

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  • Material for desensitizing teeth by sealing dentinal tubules
  • Material for desensitizing teeth by sealing dentinal tubules
  • Material for desensitizing teeth by sealing dentinal tubules

Examples

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Embodiment 1

[0031] (1) Synthesis of carboxymethyl chitosan-lysozyme nanogel

[0032] Under normal temperature and full stirring with a magnetic stirrer, add 100 mg of carboxymethyl chitosan to 30 ml of deionized water. After it is completely dissolved, add lysozyme to 5 ml of deionized water to obtain liquid A, and slowly add liquid A to the In carboxymethyl chitosan solution, carboxymethyl chitosan-lysozyme nanogel was obtained. Obtain A solution;

[0033] (2) Formation of desensitizing materials

[0034] Under room temperature and full stirring with a magnetic stirrer, 13.92 mg of dipotassium hydrogen phosphate was added to carboxymethyl chitosan-lysozyme nanogel, and reacted for 15 minutes to obtain liquid B, and 23.52 mg of calcium chloride dihydrate Add it into 5ml deionized water to prepare liquid C, and slowly add liquid C dropwise to liquid B under normal temperature and sufficient stirring with a magnetic stirrer to obtain stable carboxymethyl chitosan-lysozyme-amorphous calciu...

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Abstract

The invention provides a material for desensitizing teeth by sealing dentinal tubules. The material comprises the following raw materials in parts by weight: 30-60 parts of carboxymethyl chitosan, 5-10 parts of dipotassium phosphate, 10-20 parts of calcium chloride, 24-48 parts of lysozyme and 12-24 parts of water. Through an electrostatic acting force between the carboxymethyl chitosan and the lysozyme, a carboxymethyl chitosan and lysozyme containing nanogel is formed, the nanogel stabilizes calcium ions and hydrogen phosphate ions in a calcium phosphate solution, and the formed desensitizing material is in the form of rigid solid spheres containing nanometer amorphous calcium phosphate particles. Experiments prove that the desensitizing material is simple and convenient in preparation method and can penetrate into the dentinal tubules to achieve rapid desensitization and mineral crystals are formed and are firmly combined with the surfaces of the teeth; the newly formed crystals cancover the dentinal surfaces; the desensitizing material is good in biocompatibility, low in allergenicity, non-toxic, non-irritant, wide in clinical application range and ideal in using effect.

Description

technical field [0001] The invention belongs to the field of biomaterials, in particular to a material for sealing dentin tubules and desensitizing teeth. Background technique [0002] At present, common desensitization preparations mainly use mineral ions such as calcium and phosphate as active ingredients, or use polyelectrolytes as stable ingredients to achieve the purpose of calcium and phosphorus stabilizers, so as to achieve the purpose of depositing on the surface of exposed dentin tubules. The chemical experiment has great guiding significance for clinical desensitization treatment. However, traditional desensitization preparations have certain limitations. For example: poor controllability during the release of calcium and phosphorus; deposits that can only reach the surface of the tubules are difficult to penetrate deep; poor binding ability with the surface of the tooth, it is difficult to resist the erosion of saliva, and the time to stay on the surface of the t...

Claims

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Application Information

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IPC IPC(8): A61K6/00A61K6/02A61K6/033A61K6/838
Inventor 张旭宋金花王浩荣李彦秋
Owner STOMATOLOGICAL HOSPITAL TIANJIN MEDICAL UNIV
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