388 results about "Nanogel" patented technology

The invention relates to an Al2O3-MA-SiC-C refractory castable material with carbon wrapped by nano Al2O3-SiC film or nano Al2O3-MgO film, and a preparation method thereof. The preparation method of the nano carbon-containing castable material comprises: preparing carbon-containing sol suspension with Al(OH)3-SiC or Al(OH)3-Mg(OH)2 through a high-speed impact mixer, coating the carbon-containing sol suspension on the surface of carbon powder to form a compact carbon wrapping layer with complete coverage and no crack, and carrying in-situ synthesis of nano gel particles of Al2O3 and SiC or Al2O3 and MgO generated during transformation from sol to gel so as to generate a nano-sized matrix with carbon-containing nano secondary spinellite, Al2O3 and SiC as main crystalline phases, thereby completing the preparation of the Al2O3-MA-SiC-C refractory castable material made of nano material. The castable material has particularly excellent resistance against erosion and scouring of molten iron slag, and can satisfy the requirements for use in the iron tapping channel of the modern large-scale blast furnace. Moreover, the invention significantly prolongs the service life, reduces the cost and facilitates the environmental protection.

The invention relates to a pH-sensitive reduction responsive nanogel, which comprises a disulfide-bond-crosslinked sodium alginate derivate serving as an active ingredient. A preparation method of the nanogel comprises the following steps of: adding periodate into a sodium alginate aqueous solution according to molar ratio of the glycosyl unit of the sodium alginate aqueous solution to the periodate as 1:(0.01-10), and reacting away from light to obtain dialdehyde sodium alginate; stirring and uniformly mixing a dialdehyde sodium alginate aqueous solution and a 4-aminothiolphenol ethanol solution according to the molar ratio of the aldehyde group of the dialdehyde sodium alginate to the amino group of the 4-aminothiolphenol as 1:(0.01-10) away from light at the temperature of 0-25 DEG C, and then adding sodium borohydride to obtain sulphydryl sodium alginate; and self-assembling the sulphydryl sodium alginate in an aqueous solution and oxidizing the sulphydryl sodium alginate by oxygen in the solution to obtain the nanogel. The nanogel prepared by the invention has stability, pH sensitivity and reduction responsiveness and has a potential application value in the fields of biomedical implants, biological nanotechnology, drug delivery system and the like.

Lipobeads (liposome-encapsulated hydrogels) combine properties of hydrogels and liposomes to create systems that are sensitive to environmental conditions and respond to changes in those conditions in a fast time scale. Lipobeads may be produced by polymerizing anchored or unanchored hydrogels within liposomes or by mixing anchored or unanchored hydrogels with liposomes. Giant lipobeads may be produced by shrinking unanchored nanogels in lipobeads and fusing the resulting lipobead aggregates, long-term aging of anchored or unanchored lipobeads, or mixing anchored or unanchored aggregated nanogels with liposomes. Poly(acrylamide), poly(N-isopropylacrylamide), and poly(N-isopropylacrylamide-co-1-vinylimidazole) lipobeads were produced and characterized.

The present invention relates to a polymer according to Formulas (1) or (2): The present invention further relates to nanogels and nanoparticles made of a polymer according to general Formulas (1) and (2). The nanogels may comprise a biologically active component such as siRNA, miRNA, DNA, an (oligo)peptide or a proteins.

The invention discloses a stable nanometer gel of core-shell structure and application in the macromolecular chemistry and drug agent technical domain, which is characterized by the following: reacting protein and Maillard of polysaccharide to form protein-polysaccharide covalent compound; heating the protein-polysaccharide covalent compound solution under certain pH value; obtaining the product as micromolecular carrier; loading micromolecular drug and nourishing material in the dispersing or gel forming course; obtaining the nanometer particle of drug and nourishing material.

The present invention relates to a method of making a ringing nanogel with low levels of emulsifiers. The oil-in-water nanogel is thickened by an oil phase and a silicone component that self-structure to increase the complex viscosity of the composition and form the nanogel. The pre-emulsion, containing the silicone component, the oil phase and a water phase, is subjected to a high shear and high pressure treatment at least two consecutive times. The self-thickening of the gel occurs when the silicone component and the oil phase provide structure to the composition. Alternatively, the silicone component can be added to a pre-emulsion of the oil and water phases after the two phases are subjected to high shear and high pressure treatment. The combination of the silicone component with the treated intermediary emulsion is subjected to a second high shear and high pressure treatment which results in self-structuring of the silicone component and the oil phase. The resulting ringing nanogel has a difference in complex viscosity of at least about 10,000 poise under oscillation stress in the range of about 0 to 5,000 (dyne/cm²), and has an initial complex viscosity greater than about 15,000 poise.

The invention relates to a preparation method of nanoparticles for improving the bioavailability of curcumin, and belongs to the technical field of functional food production process. The problems oflow solubility, poor stability of processing and storage and low bioavailability of curcumin are solved, curcumin and zein are dissolved in ethanol to form an organic phase, then an aqueous solution of casein is subjected to ultrasonic treatment, casein is crosslinked by transglutaminase, chitooligosaccharide is grafted onto casein, the nano gel aqueous phase of cross-linked casein and the casein-chitosan oligosaccharide graft material is formed, finally, the organic phase is mixed with the casein-chitosan oligosaccharide nano gel aqueous phase by a high-pressure homogenization method or a solvent evaporation method, ethanol is removed by a rotary evaporation method, high speed centrifugation is carried out and freeze-drying is carried out, and finally, nanoparticles loaded with curcumin is obtained. The average particle size of the nanoparticles ranges from 140 to 390 nm, and the encapsulation rate of curcumin is about 70%-82%. The nanoparticles have good physical and chemical stability during storage.

The invention provides a nanogel with hydrophilic and hydrophobic reversal, charge reversal and intracellular redox responsiveness on the basis of pH regulation. The nanogel is prepared by cross-linking of thermo-sensitive monomer with controllable radical polymerization, amphoteric ionic monomer and amido-containing pH sensitive monomer through a disulfide-bond-containing cross-linking agent. The invention further provides a nanogel drug carrier system with smart response to tumor microenvironment and its preparation method. On the condition of blood pH 7.4, the nanogel is in a hydrophilic swelling state that is favorable for avoiding being phagocytosed by the reticuloendothelial system (RES) and accordingly, the nanogel has blood long circulation capacity; on the condition of tumor tissue subacidity, the state of the nanogel is reversed into a hydrophobic shrinking state that is favorable for the nanogel to realize effective concentration, depth penetration and be absorbed effectively by tumor cells on the tumor location. Besides, in the intracellular lysosome environment, negative charge of the nanogel is reversed into positive charge, which is favorable for the nanogel to escape from the lysosome; and then the nanogel releases drugs responsively in cytoplasm high-GSH environment, thereby achieving a good tumor inhibition effect.

The invention discloses a cross-linkable amphiphilic natural polysaccharide and application thereof. Specifically, in particular, a double-bond and a hydrophobic chain are employed for dual modification of a natural polysaccharide polymer to obtain cross-linkable amphiphilic natural polysaccharide, and the cross-linkable amphiphilic natural polysaccharide is applied to loading and delivery of protein drugs. The amphiphilic natural polysaccharide provided by the invention can self-assemble into nanogel with protein loading capacity in an aqueous solution, and then an initiator is employed to activate the double-bond modifying natural polysaccharide to generate a free radical, thus triggering mutual crosslinking of the double-bond to form a new covalent bond, and the stable action force of the covalent bond is utilized to obtain the preparation so as to achieve efficient delivery of protein drugs.

The invention discloses a preparation method of hyaluronic acid nanogel. The target product hyaluronic acid nanogel is synthesized from chitosan quaternary ammonium salt and sodium hyaluronate through an ion crosslinking and polymer coacervation two-step technology, the average particle size of the product is 150-230nm, and the Zeta potential of the product is -28.6 ~ -36.7mV. The hyaluronic acid nanogel prepared in the invention can be used for treating oral ulcer, can maintain the effective active concentration of a basic fibroblast growth factor in the oral ulcer position for a long time, and improves the clinic treatment effect.

The invention discloses an ultrasonic preparation method of casein-polysaccharide nanogel and application of functional food, and relates to the technical field of functional food microcapsules. The casein-polysaccharide nanogel is prepared from the following raw materials in parts by weight: 2-40 parts of sodium caseinate and 2.5-25 parts of sodium alginate. The sodium alginate is added in the sodium caseinate, the advanced structure of the sodium caseinate is changed, the structure of the sodium caseinate is opened to expose an active group, meanwhile, protein and polysaccharides form small aggregates, and therefore, the various aggregates are promoted to form gel under the hydrophobic interaction so as to lay a foundation for embedding of bioactive components. In a process of embedding beta-carotene by using sodium caseinate-sodium alginate composite gel, the protein and the polysaccharides are promoted to be crosslinked to obtain the aggregates by a frequency sweeping ultrasonic treatment technology or a multi-mode ultrasonic technology through an ultrasonic physical force, the various aggregates are promoted to form gel through the hydrophobic interaction, and a foundation is laid for embedding of the bioactive components.

The invention provides a material for desensitizing teeth by sealing dentinal tubules. The material comprises the following raw materials in parts by weight: 30-60 parts of carboxymethyl chitosan, 5-10 parts of dipotassium phosphate, 10-20 parts of calcium chloride, 24-48 parts of lysozyme and 12-24 parts of water. Through an electrostatic acting force between the carboxymethyl chitosan and the lysozyme, a carboxymethyl chitosan and lysozyme containing nanogel is formed, the nanogel stabilizes calcium ions and hydrogen phosphate ions in a calcium phosphate solution, and the formed desensitizing material is in the form of rigid solid spheres containing nanometer amorphous calcium phosphate particles. Experiments prove that the desensitizing material is simple and convenient in preparation method and can penetrate into the dentinal tubules to achieve rapid desensitization and mineral crystals are formed and are firmly combined with the surfaces of the teeth; the newly formed crystals cancover the dentinal surfaces; the desensitizing material is good in biocompatibility, low in allergenicity, non-toxic, non-irritant, wide in clinical application range and ideal in using effect.

The present invention relates to preparation and use of water dispersible nanogels and solvent dispersible reactive nanogels as additives to enhance polymer properties or as precursors to polymeric networks.

The invention relates to an ATP responding type drug-releasing nano gel and a preparation method thereof, and belongs to the technical field of medicine. The nano gel is composed of carboxymethyl chitosan, DNA 1 with carboxyl modified terminals, DNA 2 with carboxyl modified terminals, and an ATP aptamer. Amino groups of carboxymethyl chitosan react with carboxyl groups of terminals of single chain DNA 1 and DNA2 to form stable amide bonds; because the ATP aptamer can carry out complementary base pairing with single chain DNA 1 and DNA2, the ATP aptamer can be used as a gel crosslinking agent, which can realize the crosslinking of nano gel; through physical embedding, doxorubicin hydrochloride is embedded in the GC segment of nucleic acid, the drug encapsulation is realized; and a novel ATP responding type drug-releasing nano gel drug delivering system is prepared. The system can respond to the high concentration ATP in tumor cell and competitively combines with the gel crosslinking agent (ATP aptamer); thus the complementarily paired nucleic acid chains are broken, the gel skeleton is broken, and drugs are released. The provided nano gel can improve the safety and targeting property of a tumor drug delivery system to a certain degree.

Disclosed is a composition for forming an injectable hydrogel. The composition includes 1% by weight or less of a graphene-based material and 5% by weight or more of a triblock copolymer. The triblock copolymer may be a copolymer represented by Formula 1:

wherein n is an integer from 8 to 540, m is an integer from 16 to 70, and R is H or a vinylcarbonyl group (CH₂═CHCO—). When R in Formula 1 is a vinylcarbonyl group, the triblock copolymer may be crosslinked through the vinylcarbonyl group to form a nanogel. The composition can be prepared by a simple mixing process. In addition, the composition is substantially free from in vitro and in vivo stability problems encountered with conventional hydrogel compositions. Furthermore, the composition has high biocompatibility as well as excellent mechanical properties such as high storage modulus.