200 results about "Nanogel" patented technology

The invention relates to the technical field of concrete materials, and discloses rapidly-reinforced high-performance sprayed concrete for an existing tunnel lining and a preparation method of the rapidly-reinforced high-performance sprayed concrete. The sprayed concrete is prepared from the following raw materials in parts by weight: 300 to 350 parts of low-calcium high belite sulphoaluminate cement, 80 to 100 parts of superfine slag powder, 3 to 8 parts of a trigger type activating agent, 5 to 15 parts of slow-release particles, 2 to 5 parts of nanogel, 800 to 900 parts of fine aggregate, 800 to 900 parts of coarse aggregate, 30 to 50 parts of copper-plated steel fiber, 0.8 to 1.2 parts of polypropylene fiber, 30 to 40 parts of a viscosity-adjusting accelerator, 10 to 20 parts of a water reducing agent and 160 to 180 parts of water. The sprayed concrete is high in compressive strength and good in durability, the double threats of chemical corrosion and chloride ion permeation / steel bar corrosion are cooperatively solved, and the requirement for rapid reinforcement of tunnels and underground engineering is met.

The application provides a tyrosinase-based transdermal delivery system for treating vitiligo, which is a core-shell structure, the core is tyrosinase, and the shell is a polymer shell layer. The application coats a polymer protective layer on the surface of the tyrosinase through in-situ polymerization reaction on the double bond of the tyrosinase, can effectively protect the activity of the tyrosinase and promote the transdermal delivery of the tyrosinase, and can control the targeted delivery of the tyrosinase nanogel to melanocytes in the deep part of the skin and hair follicle by adjusting the polymerization conditions of the polymer shell, so as to promote the in-situ synthesis of melanin. The transdermal delivery system of the application can also load active small molecules with anti-inflammatory function in the center of the tyrosinase, and the small molecules are released after being targeted and delivered to the inflammation area of vitiligo along with the tyrosinase nanogel, so as to relieve inflammation and protect melanocytes from damage.

The invention relates to hyaluronic acid-based nanogel with intestinal targeting and inflammation responsiveness as well as a preparation method and application of the hyaluronic acid-based nanogel, and discloses multifunctional composite nanogel based on hyaluronic acid as well as a preparation method and application of the multifunctional composite nanogel. The preparation method comprises the following steps: loading galangin into bovine serum albumin to prepare BSA-GA nanoparticles with antioxidant and anti-inflammatory activity; 2, synthesizing a multifunctional molecule Se-MHA which is targeted to M2 macrophages and responds to ROS degradation on the basis of hyaluronic acid; 3, BSA-GA nano-particles with the same solution concentration are used as anti-inflammatory functional components to be mixed with Se-MHA to prepare Se-MHA / BG nano-gel, model probiotics are subjected to single-cell modification, probiotic-loaded nano-gel EcN-Se-MHA / BG is prepared, the nano-gel has specific binding and responding capacity on the colitis disease part, colonization of EcN on the colon part is promoted, and the anti-inflammatory effect is achieved. The IBD disease is effectively relieved.

Provided is a superoxide dismutase-based nanoscale transdermal delivery system, which is a capsule composite structure consisting of a small molecule active ingredient, superoxide dismutase, and a polymer coating. The small molecule active ingredient is loaded in the superoxide dismutase, and the surface of the superoxide dismutase is coated with the polymer coating. The superoxide dismutase-based active ingredient transdermal delivery system has a diameter of 20-100 nm, and the polymer coating has a thickness of 7.5-52.5 nm. In the delivery system, the polymer coating protects the superoxide dismutase and the small molecule functional substance having an antioxidant effect, and the capsule composite structure is in the form of nanogel. The nanogel not only promotes the penetration depth of the delivery system, but also mitigates the stimulation of the delivery system to the skin. The delivery system features biofriendly starting materials, simple preparation method, and high yield, and thus can be produced in large scale industrially.

The invention relates to exosome-coated dendrimer nanogel co-loaded with gold nanoparticles and antibiotics as well as a preparation method and application of the exosome-coated dendrimer nanogel, the dendrimer nanogel is taken as a carrier, the gold nanoparticles and drugs are co-loaded in the carrier, and the surface of the carrier is coated with exosome. The operation condition is simple, purification is easy, the bioavailability of antibiotics can be improved, targeted delivery and responsive release of the medicine at the focus position are achieved, and the good application prospect in pulmonary tuberculosis treatment is achieved.

The invention discloses a gelatinized and / or micronized nucleoside drug and a preparation method thereof, and belongs to the technical field of drugs. The preparation method comprises the following steps: mixing lipoic acid, a nucleoside drug and an esterification catalyst, carrying out a grafting reaction in a reaction solvent to obtain a lipoic acid grafted nucleoside drug, dispersing the lipoic acid grafted nucleoside drug in an organic solvent to obtain a dispersion liquid, dropwise adding the dispersion liquid into hot water, and carrying out ring opening polymerization to obtain the lipoic acid grafted nucleoside drug. The nucleoside drug nanogel, nanoparticle or nanofiber is obtained, and the structure and performance improvement based on the drug itself is realized. The gelated and / or micronized nucleoside medicine prepared by the invention has obviously improved scavenging rates of DPPH free radicals and ABTS free radicals, and the method can improve the oxidation resistance of the nucleoside medicine and has the characteristic of improving the stability and functionality of the medicine.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a blood-activating and detoxifying traditional Chinese medicine formula and a nanogel preparation method thereof. The invention provides a traditional Chinese medicine formula for promoting blood circulation and removing toxicity and a nanogel preparation method of the traditional Chinese medicine formula for promoting blood circulation and removing toxicity to solve the problem that in the prior art, a good external application traditional Chinese medicine formula capable of being used for skin with damp-heat toxin accumulation does not exist, and the traditional Chinese medicine formula for promoting blood circulation and removing toxicity and the nanogel preparation method of the traditional Chinese medicine formula for promoting blood circulation and removing toxicity comprise monarch drugs, ministerial drugs, adjuvant drugs and conductant drugs, the ministerial drugs comprise honeysuckle flowers, fructus forsythiae, paris polyphylla, cortex dictamni and fructus kochiae, the adjuvant drugs comprise radix salviae miltiorrhizae, flos carthami, garden balsam stems and centella asiatica, and the conductant drug comprises bletilla striata. The traditional Chinese medicine composition provided by the invention is precise and appropriate in compatibility and distinct in gradation, and can form a synergistic treatment chain of clearing heat, detoxifying, activating blood and promoting tissue regeneration, so that the wound healing speed of the skin surface is accelerated, and the traditional Chinese medicine composition has a relatively good curative effect on damp-heat and toxic stasis type skin diseases.

The invention provides a diesel oil anti-wear agent and a preparation process thereof, and belongs to the technical field of diesel oil additives, and the preparation process comprises the following steps: mixing and stirring diisooctyl maleate and xylene, adding diethylenetriamine and deionized water, carrying out heating reaction, adding toluene, 4-(aminomethyl) pyridine and ethylene oxide, carrying out mixing reaction, filtering, washing, and drying to obtain the diesel oil anti-wear agent. The pyridinium-based polyester hollow capsule is prepared; the preparation method comprises the following steps: mixing xylene, catechol, ethylene phosphonic acid, ammonium persulfate and deionized water, heating, dispersing in cyclohexane, adding polyvinyl alcohol, octadecyl methacrylate and azodiisobutyronitrile, mixing and reacting to obtain catechol phosphonate nano colloidal particles; mixing and stirring the fatty acid ester solution, the oleoyl fluorocarbon copolymer and the pyridinium-based polyester hollow capsule, adding the catechol phosphonate nano colloidal particles, continuously stirring, performing ultrasonic treatment, and degassing to obtain the diesel oil anti-wear agent. The diesel oil antiwear agent can improve the antiwear property and demulsibility of the diesel oil antiwear agent.

The invention provides a hinokitiol-dihydromyricetin composite nano condensation body and a preparation method and application thereof, and the composite nano condensation body comprises the following components in 100 mL of a suspension: 0.3 to 0.5 g of hinokitiol, 0.5 to 0.8 g of dihydromyricetin, 1.0 to 1.5 g of chitosan, 0.5 to 0.8 g of sodium alginate, 2.0 to 3.0 mL of polyethylene glycol, 0.3 to 0.5 mL of Tween, 1.0 to 1.5 mL of glycerol, and the balance of a citric acid-sodium citrate buffer solution. The invention provides a hinokitiol-dihydromyricetin composite nano-coacervate which can synchronously solve the problems of synergistic bacteriostasis, membrane rupture and antibiosis, anti-inflammatory repair, application defects of active ingredients and the like of common animal skin antibacterial drugs. The preparation method of the composite nano coacervate is simple, large-scale production is easy, complex equipment is not needed, it can be ensured that active ingredients of a finished product are evenly distributed, the composite nano coacervate can penetrate through the skin cuticle and can also penetrate through a bacterial biofilm, and the synergistic effect is fully achieved.

The invention relates to an amino acid derivative carrier as well as a preparation method and application thereof, and belongs to the technical field of biology, and the preparation method of the amino acid derivative carrier comprises the following steps: providing a cationic amino acid monomer and a neutral-polyanion block polymer template; a cationic amino acid monomer, a neutral-polyanion block polymer template, a cross-linking agent and a photoinitiator are mixed and react under the irradiation of ultraviolet light to obtain an amino acid derivative carrier, and the amino acid derivative carrier is cationic nanogel. The amino acid derivative carrier prepared by the preparation method disclosed by the invention can be used as a nucleic acid drug delivery carrier, and has the advantages of strong nucleic acid loading capacity, high transfection efficiency, safety and the like.

The application belongs to the technical field of dental antibacterial materials, and discloses a kind of nanometer composite antibacterial coating for dental material and preparation method thereof.Method: monomer modified arginine, monomer N-isopropyl acrylamide, monomer methyl hexyl acrylate, initiator azobisdimethylamino propanamide hydrochloride, dispersing agent cetyltrimethylammonium bromide and crosslinking agent N,N-methylene bis(acrylamide) are dissolved in water, and the reaction is carried out under protective atmosphere, dialysis, to obtain nanogel dispersion;The nanogel dispersion is mixed with the nanometer zinc oxide dispersion to obtain a nanogel composite zinc oxide antibacterial coating, and a coating is formed after coating.The nanometer composite antibacterial coating for dental material has excellent retention capacity and antibacterial performance.

The invention provides an allosteric nanogel adjuvant as well as a preparation method and application thereof, and belongs to the technical field of vaccines. The allosteric nanogel adjuvant comprises a self-assembly motif, a responsive site and an immunomodulatory peptide fragment, and the self-assembly motif is composed of 2-5 amino acids; the allosteric nanogel adjuvant has a structure as shown in a formula I, and is named as NTP5 for short; the allosteric nanogel adjuvant is self-assembled into nanoparticles, the nanoparticles are allosteric into a nanofiber structure through responsive broken bonds, nanogel is further formed, and the key problems of a traditional vaccine in the aspects of antigen delivery and immune activation are effectively solved. The nanogel adjuvant can efficiently load various antigens to form a stable nano vaccine, activate an immune microenvironment and provide more means and thoughts for vaccine development.

The invention discloses an exosome slow-release oral soluble film based on enzyme triggering and a preparation method thereof. The oral soluble film comprises a film forming substrate, a plasticizer, a disintegrating agent, mucous membrane adhesion type enzyme-sensitive nanogel and a stable protection component. Wherein the mucous membrane adhesion type enzyme-sensitive nanogel has a three-layer functional structure: an enzyme-sensitive cross-linking core is formed by maleimide starch through gradient cross-linking, and alpha-1, 4 glucosidic bonds on a starch chain can be hydrolyzed by saliva alpha-amylase; the phospholipid-exosome composite layer is located on the surface of the core, and efficient embedding of the exosome is achieved through a pre-fusion-cold locking process; the mucous membrane adhesion layer is made of thiolated mucous membrane adhesion materials and can form disulfide bonds with oral mucosa. Self-regulation slow release insensitive to saliva alpha-amylase concentration fluctuation is realized through a gradient cross-linked structure, the problems of exosome activity loss, uncontrollable release and weak adhesion are effectively solved, and the exosome is suitable for treatment of oral mucosa diseases.

The application discloses a preparation method of a nanogel preparation for preventing and treating tobacco diseases, and specifically comprises the following steps: (1) preparing bacillus licheniformis bacterial liquid; (2) preparing nanometer selenium precipitate; (3) preparing purified nanometer selenium particles; (4) preparing streptomycin-nanometer selenium solid; (5) preparing nanometer titanium dioxide photo-semiconductor sol; and (6) mixing low-melting agarose powder, the streptomycin-nanometer selenium solid and the nanometer titanium dioxide photo-semiconductor sol, centrifuging, washing, and drying to obtain the nanogel preparation. The nanogel preparation has significant bacteriostatic efficacy, can effectively prevent and treat tobacco diseases (especially tobacco bacterial wilt and tobacco wild fire disease), has a promoting effect on tobacco growth, is simple to make, has strong adhesion, and does not pollute the soil environment.

This invention relates to the field of agricultural pest control, and particularly to a compound nanogel sustained-release agent, its preparation method, and its application. This invention provides a compound nanogel sustained-release agent comprising bromonitol, a synergist, a carrier material, and a cross-linking agent, wherein the synergist includes one or more of kasugamycin, amino oligosaccharides, thiazolium zinc, and copper hydroxide. This invention prepares a nanogel sustained-release agent by compounding bromonitol and the synergist, which has significant preventive effects against plant bacterial diseases such as bacterial wilt, bacterial angular leaf spot, canker, and soft rot. Furthermore, the compound nanogel sustained-release agent of this invention has small particle size, stable physicochemical properties under cold and heat, good dispersibility in water, no particle agglomeration, no particle size increase, a decomposition rate of less than 5%, a long-lasting effect, good safety, is not prone to inducing drug resistance, requires a small dosage, and simultaneously increases yield and efficiency.

The invention provides a preparation method and application of response type nanogel with adjustable flexibility, and the preparation method comprises the following steps: preparing a monomer solution which comprises N-isopropyl methacrylamide, methacrylic acid, a cross-linking agent and a surfactant; adding an initiator into the monomer solution, and carrying out polymerization reaction under the water bath condition of 75-90 DEG C to generate an initial product; and purifying, washing and drying the initial product to obtain the nanogel, and applying the nanogel to drug delivery and gene therapy drugs. According to the technical scheme, the temperature and pH dual-sensitive characteristic is achieved, meanwhile, tumor microenvironment stimulation such as intracellular GSH concentration rising can be responded, efficient release of plasmids is achieved, meanwhile, good structure regulation and control performance, biocompatibility and low toxicity are achieved, the transfection efficiency equivalent to PEI in various cell models is shown, and the application prospect is wide. Great clinical application potential is realized.

The invention relates to hydroxylated polyamide-amine dendrimer integrated drug-loaded nanogel as well as a preparation method and application thereof. The drug-loaded nanogel comprises third-generation polyamide-amine dendrimer integrated nanogel modified by double bonds and high-density hydroxyl groups, MnO2 nanoparticles and quercetin, wherein the nanogel is loaded with MnO2 nanoparticles in situ, and quercetin is physically wrapped in the nanogel. The drug-loaded nanogel disclosed by the invention can enhance a blood-brain barrier penetrating effect, regulate microglial cells and neurons in a double-target manner and remodel a brain inflammation microenvironment, so that neuroinflammation and dyskinesia of a Parkinson's disease model mouse are relieved, and the curative effect of the Parkinson's disease is improved. The compound has good development prospect and application value in treatment of Parkinson's disease or other neurodegenerative diseases.

The preparation method of the agar nanogel interface modification spray is prepared from the following raw materials by weight: agarose 35-70 parts, Tween 80 40-50 parts, dimethyl silicone oil 60-150 parts, and tetrahydrofuran 50-120 parts. The preparation method comprises the following steps: S1: placing agarose into heated deionized water to obtain an agarose aqueous solution, adding Tween 80 and dimethyl silicone oil to obtain a coarse emulsion; S2: ultrasonic dissolving the coarse emulsion to obtain a fine emulsion, cooling and centrifuging, taking the lower liquid, adding tetrahydrofuran to obtain an agar nanogel mixture; S3: rotary evaporation and drying the mixture to obtain agar nanogel; and S4: adding the gel into ethanol or water to obtain the agar nanogel interface modification spray. The agar nanogel spray formed based on the molecular self-assembly strategy has a hexagonal phase columnar structure, the spray can form a modified layer with excellent light-heat conversion efficiency and water transport performance on the water surface, and can significantly enhance the evaporation efficiency.

The application discloses hyperbranched nanocluster solidified isocyanate adhesive as well as a preparation method and application thereof, belongs to the field of adhesives, and specifically comprises the following components in parts by weight: 68-72 parts of polymethylene polyphenyl polyisocyanate, 28-32 parts of hyperbranched amino oligomeric siloxane nanoclusters, 3-6 parts of double-reactive hydrophobic nanogel, 1-3 parts of coupling accelerator, and 0.1-1 parts of catalyst. The application is characterized in that the hyperbranched amino oligomeric siloxane nanoclusters, the double-reactive hydrophobic nanogel and the isocyanate adhesive are synergistically compounded to form a composite adhesive layer structure with high crosslinking density and good interfacial bonding force, the water resistance and the moisture and heat stability of the adhesive layer are improved, and the obtained water-resistant shaving board has high strength, low water absorption and excellent water-resistant bonding performance.

This invention discloses an enzyme- and pH-responsive nucleic acid loading and delivery material and its preparation method. The material can be used for efficient loading and delivery of nucleic acid molecules. The preparation method uses amphiphilic zwitterionic monomers to improve the reverse emulsion polymerization system, enhancing polymerization at the two-phase interface and avoiding the extrusion effect of polymerization in the aqueous core on nucleic acid molecules, thereby improving the loading efficiency of nucleic acid molecules. Further preparation of cross-linking agents MP-CL and CB-CL, which can cleave in response to matrix metalloproteinase II or cathepsin B, endows the nanogel with the ability to respond to charge reversal in the tumor matrix and to release nucleic acid molecules from tumor cells. The acid-sensitive blocks on the amphiphilic monomers give the nanogel lysosomal escape capability. The delivery material can efficiently deliver nucleic acid molecules into cells and exhibits excellent stability and biosafety.

The invention provides novel antibody-nanogel conjugates with encapsulated protein degraders and related methods for controlled and targeted delivery of degrader molecules as therapeutic agents.

The invention discloses nanogel for activating metronidazole to co-treat non-anaerobic bacteria infection through starvation therapy. The nanogel takes composite nano hydrogel which is formed by compounding sodium alginate SA, a natural polyphenol compound and high-valence metal ions and has a three-dimensional network structure as a main carrier; glucose oxidase GOx and anaerobic bacteria antibiotics required by starvation therapy are loaded in composite nanogel, meanwhile, natural polyphenol and high-valence metal ions in the composite nanogel can be self-assembled to form a metal-polyphenol network structure MPNs, and the nanogel loaded with GOx and MNZ is packaged to prepare the composite nanogel. A new cocktail therapy is constructed, a new thought is provided for research and development of antibacterial treatment drugs, and great scientific research significance and clinical application value are achieved for collaborative treatment of tolerant bacteria.

The invention discloses a preparation method of egg white protein nanogel. The preparation method comprises the following steps: firstly, adding an ethanol solution with the volume fraction of 0.1-11.5% into egg white liquid, and diluting until the protein concentration is 1-2%; the egg white protein ethanol solution is subjected to microwave and ultrasonic combined treatment, the treatment time is set to be 3-7 min, ultrasonic is in an intermittent mode, the ultrasonic power is 200-800 W, and the microwave heating temperature is 65-75 DEG C. And finally, removing ethanol in the solution subjected to microwave ultrasonic treatment to obtain the egg white protein nanogel particles. The method is different from an existing'bottom-to-top 'preparation method and comprises the following steps: firstly, carrying out mild denaturation on protein by adopting low-concentration ethanol, changing a protein structure and an intermolecular acting force to expose a hydrophobic structure and expand the structure, and then moderately gathering and crushing the protein into microgel by utilizing an ultrasonic cavitation effect and a microwave heat effect; the nanogel has smaller particle size, higher system stability and interface stability, and the preparation method is simple and low in cost.

The invention relates to the technical field of traditional Chinese medicine extracts and application, and discloses a preparation method of a fresh perfoliote knotweed herb extract and application of the fresh perfoliote knotweed herb extract in preparation of gel for treating herpes zoster. The perfoliote knotweed herb extract is prepared from 5 to 10 percent of perfoliote knotweed herb extract F1 component, 10 to 25 percent of perfoliote knotweed herb extract F2 component, 2 to 10 percent of berberine, 0.1 to 2 percent of herba menthae volatile oil, 0.1 to 2 percent of herba schizonepetae volatile oil, 5 to 10 percent of low-molecular hyaluronic acid, 5 percent of carbomer (940), 2 to 5 percent of poloxamer 407, 2 to 5 percent of Tween (80), 5 to 10 percent of glycerol, 1 to 5 percent of triethanolamine, 2 percent of phenoxyethanol and the balance of pure water. The preparation process of the nanogel has the characteristics of uniform and controllable particle size and excellent skin permeability, the nanogel can accurately target a focus part, the bioavailability of the medicine is remarkably improved, and the stability of a gel system is good; and the preparation process of the active component of the fresh perfoliote knotweed herb for treating the herpes zoster can efficiently retain the active components in the medicinal materials, is high in extraction rate and simple and convenient in process operation, and has a good market prospect.

Among hospital–acquired infections, Pseudomonas aeruginosa-associated urinary tract infections (UTIs) are mainly caused by indwelling urethral catheters (catheter-associated UTIs or CAUTIs) and are difficult to treat, resulting in high rates of morbidity among hospitalized patients. While antibiotics can successfully treat bacteria in the bladder lumen, they are inefficient at crossing stratified urothelium plasma membranes to kill persistent intracellular bacterial communities (IBCs). Herein, UTI IBCs are targeted by locally delivering the antibiotic gentamicin and / or the steroid hormone estradiol via polymeric nanogels conjugated with a cell-penetrating peptide Cys-Gly-Lys-Arg-Lys (CGKRK - SEQ ID NO:1). This approach delivered more intracellular gentamicin compared to drug delivered in solution in vitro and more estradiol compared to conventional methods. In an acute UTI murine model, the nanogel cell-penetrating peptide drug delivery system facilitated the transport of gentamicin into the urothelium and resulted in > 90% clearance of a uropathogenic P. aeruginosa clinical strain in vivo.

The invention provides a drug-loaded gelatin nanogel, a bionic nanogel, a preparation method of the drug-loaded gelatin nanogel, a preparation method of the bionic nanogel, a combined drug and application of the bionic nanogel, and belongs to the technical field of biological medicine. According to the invention, all-transretinoic acid, pirfenidone and gelatin react to form drug-loaded gelatin nanogel, and the drug-loaded gelatin nanogel can synergistically inhibit the activation of pancreatic stellate cells and block a fibrosis-promoting signal channel, so that the reversion of a pancreatic cancer fibrosis microenvironment is realized; meanwhile, the activated pancreatic stellate cell membrane is coated with the drug-loaded gelatin nanogel to construct the bionic nanogel, so that the bionic nanogel has active targeting property, and the delivery efficiency and the treatment effect of the drug are remarkably improved; and the drug-loaded gelatin nanogel, the bionic nanogel and the chemotherapeutic drug are combined for treating pancreatic cancer, so that a remarkable anti-tumor effect is achieved, and the combined treatment of the bionic nanogel and gemcitabine has a synergistic anti-tumor effect. The gel provided by the invention realizes effective regulation and control of a pancreatic cancer dense fibrosis microenvironment, and provides a feasible new strategy for treatment of pancreatic cancer.

The invention discloses chloroindole hydrazide-loaded nanogel and a preparation method and application thereof, and relates to the technical field of pesticides, the chloroindole hydrazide-loaded nanogel is successfully prepared, CHI can be stably loaded, slow release is realized, and the chloroindole hydrazide-loaded nanogel has excellent leaf adhesiveness, can resist rain wash and avoid loss of pesticide effect, and can be used as a pesticide for preventing and treating diseases. The application pain point of CHI and the defects of a traditional nano-carrier are overcome; the nano-scale characteristic assists plant cell endocytosis and uptake, breaks through the transport limitation of cell membranes, and gives full play to the high induced resistance activity of CHI. High-speed centrifugal purification is not needed in the preparation process, the process is simplified, the yield is increased, large-scale production is adapted, and meanwhile energy consumption and cost are reduced. Compared with a traditional nano-carrier, the nano-gel does not need expensive precursors or complex modification, is good in dispersity and free of the agglomeration problem, preparation is low in energy consumption and pollution, the comprehensive performance is more suitable for practical application of pesticide carriers, and a solution with practicability and economical efficiency is provided for efficient prevention and treatment of plant virus diseases.

This invention provides a formulation and preparation method for an exosome-based skin medication. Taking the preparation of a 100g finished formulation as an example, it consists of active ingredients, a nanogel carrier, a composite stabilizer, a moisturizer, a pH adjuster, a preservative, and deionized water. By constructing a nanogel sustained-release system adapted to exosomes and a composite protection mechanism, the exosomes are stably and slowly released and efficiently absorbed on the skin surface within 7 days. This solves the problems of rapid release, low utilization rate, poor stability, and frequent reapplication required for exosome-based skin medications, thereby improving the skin care and treatment effects of exosomes.

Disclosed are nanoparticles and nanogel drug compositions and the use thereof for treating age-related macular degeneration.

The invention provides a preparation process of high-purity humic acid, an intelligent integrated production system and application of the high-purity humic acid. Compared with the prior art, the process comprises the following steps: crushing weathered coal / lignite to be more than or equal to 80 meshes; a pH2-3 acid solution prepared from formic acid / acetic acid / citric acid (1: 2: 3) and the powder are stirred for acidolysis; carrying out directional analysis and solid-liquid separation on the mixed solution by using potassium formate-ammonia water compound weak base with the pH value of 8-10; and washing the filter residue with organic acid at pH 2-3, 3-4 and 4-5 sections, and drying at 100-175 DEG C to obtain the high-purity humic acid. The system comprises a self-cleaning filtering module and a flow, temperature and pressure difference online monitoring and control unit, and continuous and stable separation is achieved through target discharge amount control; and a storage monitoring module is arranged to perform real-time control and alarm on the pH value of each stage of acid liquor. The obtained high-purity humic acid and chitosan quaternary ammonium salt are compounded according to the ratio of 3: 1 to prepare nanogel with the drug loading capacity of 15%-20%, and the nanogel is used for preparing drugs for treating psoriasis through transdermal drug delivery.