323 results about "Nanogel" patented technology

The invention provides a nano transdermal delivery system based on superoxide dismutase, the nano transdermal delivery system is of a capsule composite structure of a small molecule active component-superoxide dismutase-polymer shell layer, the small molecule active component is loaded in superoxide dismutase, the surface of the superoxide dismutase is coated by the polymer shell layer, and the superoxide dismutase is loaded in the capsule composite structure. The diameter of the superoxide dismutase-based active ingredient transdermal delivery system is 20-100 nm, and the thickness of the polymer shell layer is 7.5-52.5 nm. In the delivery system, the polymer shell layer provides a protection effect for the superoxide dismutase and the micromolecular functional substances with the anti-oxidation effect, the capsule composite structure is in a nanogel form, and the nanogel not only promotes the penetration depth of the capsule, but also reduces the irritation effect of the capsule on the skin. The raw materials are biologically friendly, the preparation method is simple, the yield is high, and industrial large-scale production can be realized.

The invention relates to the technical field of concrete materials, and discloses rapidly-reinforced high-performance sprayed concrete for an existing tunnel lining and a preparation method of the rapidly-reinforced high-performance sprayed concrete. The sprayed concrete is prepared from the following raw materials in parts by weight: 300 to 350 parts of low-calcium high belite sulphoaluminate cement, 80 to 100 parts of superfine slag powder, 3 to 8 parts of a trigger type activating agent, 5 to 15 parts of slow-release particles, 2 to 5 parts of nanogel, 800 to 900 parts of fine aggregate, 800 to 900 parts of coarse aggregate, 30 to 50 parts of copper-plated steel fiber, 0.8 to 1.2 parts of polypropylene fiber, 30 to 40 parts of a viscosity-adjusting accelerator, 10 to 20 parts of a water reducing agent and 160 to 180 parts of water. The sprayed concrete is high in compressive strength and good in durability, the double threats of chemical corrosion and chloride ion permeation / steel bar corrosion are cooperatively solved, and the requirement for rapid reinforcement of tunnels and underground engineering is met.

The invention relates to mussel mucin-hyaluronic acid nanogel and a preparation method and application thereof and a pharmaceutical composition, and belongs to the field of biomedical materials, the structural formula of the mussel mucin-hyaluronic acid nanogel is # imgabs0 #, Mussel mucin is a mussel mucin molecule, and n is the number of repetitive units. The mussel mucin-hyaluronic acid nanogel can be swelled in a water-based medium to form a three-dimensional space net-shaped structure, pharmaceutical active molecules are better entrapped, lysine and dopa groups in the structure can be tightly combined with the surface or mucous membrane of an organism through electrostatic interaction, hydrogen-bond interaction and oxidative crosslinking, so that the bioavailability of the mussel mucin-hyaluronic acid nanogel is improved, and the bioavailability of the mussel mucin-hyaluronic acid nanogel is improved. The carrier has good biological adhesion, can prolong the residence time of the carrier on an organism or mucous membrane surface, and promotes drug absorption. The mussel mucin-hyaluronic acid nanogel can also be used as a drug storage cavern, so that the slow release effect of drugs is improved, the action time of the drugs is prolonged, and the administration frequency is reduced.

The invention belongs to the field of drug-loaded nanoparticles, and provides a targeted drug-loaded nanoparticle with multiple responsiveness and a preparation method thereof. The targeted drug-loaded nano-particle with multiple responsiveness is prepared from poly (N-isopropylacrylamide-co-acrylic acid-co-N-acryloyloxy succinimide) nanogel with temperature and pH response characteristics, an anti-tumor drug and a folic acid layer capable of specifically targeting a folic acid receptor of a tumor cell, wherein the temperature and pH response characteristics are realized by the poly (N-isopropylacrylamide-co-acrylic acid-co-N-acryloyloxy succinimide) nanogel; the anti-tumor drug is loaded in the polymer network structure of the nanogel to form drug-loaded nanoparticles, the folic acid layer is composed of aminated folic acid molecules, the folic acid layer coats the drug-loaded nanoparticles, and amino groups of the aminated folic acid molecules are grafted on the surfaces of the drug-loaded nanoparticles. According to the invention, the preparation method of the existing chemotherapy nano-drug carrier can be simplified, the controllability of the preparation process is improved, the biocompatibility of the existing chemotherapy nano-drug carrier is improved, and the targeting property of the existing chemotherapy nano-drug carrier is enhanced.

The invention belongs to the technical field of nano biomedical materials, and particularly relates to a water-soluble sound-sensitive agent nanogel and a preparation method and application thereof, the nanogel has the following structural formula I: # imgabs0 #, R is H or 5, 10, 15, 20-tetra (pentafluorophenyl) porphyrin, at least one R is 5, 10, 15, 20-tetra (pentafluorophenyl) porphyrin, and n is a positive integer. Compared with the prior art, the problems that in the prior art, a sound-sensitive agent is poor in water solubility, low in sound-sensitive efficiency and difficult to apply practically are solved, on one hand, the water solubility of the sound-sensitive agent is improved, the biocompatibility of the sound-sensitive agent is improved, on the other hand, the large-size cavity provides a cavitation nucleus for the sound-sensitive agent, and the sonodynamic efficiency is enhanced.

The application provides a tyrosinase-based transdermal delivery system for treating vitiligo, which is a core-shell structure, the core is tyrosinase, and the shell is a polymer shell layer. The application coats a polymer protective layer on the surface of the tyrosinase through in-situ polymerization reaction on the double bond of the tyrosinase, can effectively protect the activity of the tyrosinase and promote the transdermal delivery of the tyrosinase, and can control the targeted delivery of the tyrosinase nanogel to melanocytes in the deep part of the skin and hair follicle by adjusting the polymerization conditions of the polymer shell, so as to promote the in-situ synthesis of melanin. The transdermal delivery system of the application can also load active small molecules with anti-inflammatory function in the center of the tyrosinase, and the small molecules are released after being targeted and delivered to the inflammation area of vitiligo along with the tyrosinase nanogel, so as to relieve inflammation and protect melanocytes from damage.

The invention relates to hyaluronic acid-based nanogel with intestinal targeting and inflammation responsiveness as well as a preparation method and application of the hyaluronic acid-based nanogel, and discloses multifunctional composite nanogel based on hyaluronic acid as well as a preparation method and application of the multifunctional composite nanogel. The preparation method comprises the following steps: loading galangin into bovine serum albumin to prepare BSA-GA nanoparticles with antioxidant and anti-inflammatory activity; 2, synthesizing a multifunctional molecule Se-MHA which is targeted to M2 macrophages and responds to ROS degradation on the basis of hyaluronic acid; 3, BSA-GA nano-particles with the same solution concentration are used as anti-inflammatory functional components to be mixed with Se-MHA to prepare Se-MHA / BG nano-gel, model probiotics are subjected to single-cell modification, probiotic-loaded nano-gel EcN-Se-MHA / BG is prepared, the nano-gel has specific binding and responding capacity on the colitis disease part, colonization of EcN on the colon part is promoted, and the anti-inflammatory effect is achieved. The IBD disease is effectively relieved.

Provided is a superoxide dismutase-based nanoscale transdermal delivery system, which is a capsule composite structure consisting of a small molecule active ingredient, superoxide dismutase, and a polymer coating. The small molecule active ingredient is loaded in the superoxide dismutase, and the surface of the superoxide dismutase is coated with the polymer coating. The superoxide dismutase-based active ingredient transdermal delivery system has a diameter of 20-100 nm, and the polymer coating has a thickness of 7.5-52.5 nm. In the delivery system, the polymer coating protects the superoxide dismutase and the small molecule functional substance having an antioxidant effect, and the capsule composite structure is in the form of nanogel. The nanogel not only promotes the penetration depth of the delivery system, but also mitigates the stimulation of the delivery system to the skin. The delivery system features biofriendly starting materials, simple preparation method, and high yield, and thus can be produced in large scale industrially.

The invention relates to exosome-coated dendrimer nanogel co-loaded with gold nanoparticles and antibiotics as well as a preparation method and application of the exosome-coated dendrimer nanogel, the dendrimer nanogel is taken as a carrier, the gold nanoparticles and drugs are co-loaded in the carrier, and the surface of the carrier is coated with exosome. The operation condition is simple, purification is easy, the bioavailability of antibiotics can be improved, targeted delivery and responsive release of the medicine at the focus position are achieved, and the good application prospect in pulmonary tuberculosis treatment is achieved.

A preparation method for a micro-vehicle formed by enveloping siRNA-loaded polypeptide dendrimer nanogel with a cell membrane of engineered MSCs, and the use of same. The method comprises: using lentivirus-mediated gene transfection technology for constructing MSCs that highly express CXCR4 and PSGL-1; using cytokinin B for stimulating a cell to generate vesicles, and then performing centrifugation to collect the vesicles; by means of the electrostatic attraction between polypeptide dendrimer nanoparticles and siRNAs, attaching the siRNAs of IL-6 and HIF-1α into the polypeptide dendrimer nanoparticles; and by means of using a membrane extruder, enveloping the siRNA-loaded polypeptide dendrimer nanogel with the cell membrane. The prepared micro-vehicle exhibits a good property of aggregating at inflammatory blood vessel sites and a targeting function for joint cavities with rheumatoid arthritis. In addition, the loaded siRNAs can inhibit the expressions of IL-6 and HIF-1α in the joint cavities and inhibit the cell migration and angiogenesis. The micro-vehicle targeting inflammation sites has the advantages of excellent biocompatibility, ideal siRNA loading ratio, good inflammation targeting function, etc.

The invention provides a nanogel for rapid permeation of articular cartilage and responsive release of a growth factor, which is prepared by polymerizing a peptide fragment which can be cut by a substance (mainly enzyme) which can be specifically expressed on the surface of osteoarthritis cells or secreted into a matrix with the growth factor, an acrylamide monomer and a cationic micromolecule monomer. Unreacted monomer molecules are filtered out through an ultrafiltration tube or other filtering systems, so that the nanogel which can rapidly permeate into the deep part of articular cartilage and can be recognized and cut by enzyme highly expressed on the surface of osteoarthritis cells or secreted enzyme to release growth factors is prepared, and the effect of the growth factors can be more effectively exerted; the nanogel has strong cartilage infiltration capacity, can completely infiltrate cartilage with the thickness of 1mm within less than 3 days, can be cut by MT1-MMP protein specifically expressed on the surfaces of osteoarthritis cells, releases growth factors, is specifically combined with growth factor receptors on the surfaces of cartilage cells, and activates downstream signal channels, so that the proliferation of the cartilage cells is promoted, and the cartilage cell proliferation rate is increased. The cartilage matrix secretion is promoted, so that the cartilage matrix thickening effect is realized, and the osteoarthritis is prevented and treated.

The invention provides RU.521-EVs anti-radiation nanogel as well as a preparation method and application of the RU.521-EVs anti-radiation nanogel. The RU.521-EVs anti-radiation nanogel is a nanogel obtained by loading microalgae-derived extracellular vesicles and a small molecule compound RU.521 on chitosan nanoparticles formed by cross-linking chitosan, and the extracellular vesicles and the small molecule compound RU.521 are derived from microalgae. The RU.521-EVs anti-radiation nanogel has higher adhesion and permeability in the lung and effectively releases RU.521 and EVs, the RU.521 and EVs can synergistically play anti-inflammatory and anti-oxidation roles, local anti-oxidation and anti-inflammatory defense reactions of the lung are effectively started, the excellent anti-radiation effect is shown, and the RU.521-EVs anti-radiation nanogel can be used for preventing and treating radiation-induced lung injury.

The invention discloses a gelatinized and / or micronized nucleoside drug and a preparation method thereof, and belongs to the technical field of drugs. The preparation method comprises the following steps: mixing lipoic acid, a nucleoside drug and an esterification catalyst, carrying out a grafting reaction in a reaction solvent to obtain a lipoic acid grafted nucleoside drug, dispersing the lipoic acid grafted nucleoside drug in an organic solvent to obtain a dispersion liquid, dropwise adding the dispersion liquid into hot water, and carrying out ring opening polymerization to obtain the lipoic acid grafted nucleoside drug. The nucleoside drug nanogel, nanoparticle or nanofiber is obtained, and the structure and performance improvement based on the drug itself is realized. The gelated and / or micronized nucleoside medicine prepared by the invention has obviously improved scavenging rates of DPPH free radicals and ABTS free radicals, and the method can improve the oxidation resistance of the nucleoside medicine and has the characteristic of improving the stability and functionality of the medicine.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a blood-activating and detoxifying traditional Chinese medicine formula and a nanogel preparation method thereof. The invention provides a traditional Chinese medicine formula for promoting blood circulation and removing toxicity and a nanogel preparation method of the traditional Chinese medicine formula for promoting blood circulation and removing toxicity to solve the problem that in the prior art, a good external application traditional Chinese medicine formula capable of being used for skin with damp-heat toxin accumulation does not exist, and the traditional Chinese medicine formula for promoting blood circulation and removing toxicity and the nanogel preparation method of the traditional Chinese medicine formula for promoting blood circulation and removing toxicity comprise monarch drugs, ministerial drugs, adjuvant drugs and conductant drugs, the ministerial drugs comprise honeysuckle flowers, fructus forsythiae, paris polyphylla, cortex dictamni and fructus kochiae, the adjuvant drugs comprise radix salviae miltiorrhizae, flos carthami, garden balsam stems and centella asiatica, and the conductant drug comprises bletilla striata. The traditional Chinese medicine composition provided by the invention is precise and appropriate in compatibility and distinct in gradation, and can form a synergistic treatment chain of clearing heat, detoxifying, activating blood and promoting tissue regeneration, so that the wound healing speed of the skin surface is accelerated, and the traditional Chinese medicine composition has a relatively good curative effect on damp-heat and toxic stasis type skin diseases.

The invention relates to an exosome-coated responsive drug-loaded dendrimer nanogel system as well as a preparation method and application thereof. The preparation method comprises the following steps: grafting a drug on the surface of a phenylboronic acid modified third-generation PAMAM (Polyamidoamine) dendrimer through a boric acid ester bond; then, synthesizing active oxygen sensitive drug-loaded nanogel by using a cross-linking agent containing a double-selenium bond through a reversed-phase microemulsion method, and wrapping the surface of the drug-loaded nanogel with exosome through a physical effect. The drug-loaded nanogel system prepared by the invention can effectively improve the bioavailability of small-molecule drugs, realizes targeted delivery and responsive release of the drugs at focus parts, shows an excellent synergistic treatment effect in an acute lung injury model, and has a good application prospect.

The invention relates to a multi-targeting nanogel drug and application thereof in relieving neuroinflammation and promoting spinal cord injury repair, the multi-targeting nanogel drug comprises quercetin-loaded liposome, the quercetin-loaded liposome comprises TAT peptide and CAQK peptide, the quercetin-loaded liposome is incorporated into double-network gel, and the double-network gel is used as a drug carrier. The dual-network gel is jointly formed by a dopamine grafted hyaluronic acid polymer and methacrylated gelatin. The multi-targeting nanogel drug can improve the dissolving property of quercetin, reduce toxic and side effects, promote targeting of an injured part, and contribute to passing through a blood spinal cord barrier, so that the integrity of the blood spinal cord barrier is protected, the spinal cord microenvironment is optimized, formation of glial scars is reduced, axon regeneration is promoted, and the recovery of a motor function is enhanced.

The invention discloses compound enzyme nanogel as well as a preparation method and application thereof. The compound enzyme nanogel is prepared from the following components in parts by weight: 12 to 1310 parts of compound protease; 5-210 parts of a monomer polymer material; 12 to 120 parts of an adhesive; and 12-120 parts of a cross-linking agent. The compound enzyme nanogel disclosed by the invention improves the loading capacity of protein, and is high in stability and good in safety; in addition, due to the stability of the nanogel structure, the protease has a relatively long half-life period, an enzyme cascade effect can be continuously and effectively carried out, and meanwhile, the administration concentration and the administration frequency are reduced.

The invention relates to a high-sensitivity glucose colorimetric detector and a preparation method thereof, belongs to the field of new material preparation, and particularly belongs to the field of sensing and detection new material preparation. The glucose colorimetric detector is composed of a base material and a structural color nano-film coated on the base material, wherein the structural color nano-film is formed by orderly and alternately stacking a plurality of organic nano-gel layers and inorganic nano-oxide layers. A large number of mass transfer channels are provided for glucose through the water absorption swelling effect of the strong hydrophilic nanogel, the response speed is increased, a large number of anions are grafted in the nanogel in a modification mode, the electrostatic repulsion effect in the gel is improved, and colorimetric detection of glucose is achieved. The glucose colorimetric detector disclosed by the invention has the advantages of high sensitivity and high detection speed, is good in reversibility and reproducibility, and has very strong application potential and practical popularization value in the aspects of self-monitoring and management of diabetes mellitus.

The invention belongs to the technical field of nanogel preparations, and particularly relates to application of nanogel to preparation of anti-tumor drugs or preparation of the anti-tumor drugs. Experiments find that nanogel with proper hardness can promote expression of M1 related proteins CD86 and iNOS, and up-regulate expression of CD86 mRNA and iNOS mRNA, so that M2 type tumor related macrophages are reversely polarized into M1 type tumor related macrophages. Further research finds that after the nanogel is used for carrying out reverse polarization treatment on M2 type tumor-related macrophages, tumor cell proliferation can be inhibited, tumor cell apoptosis can be induced, and tumor cell phagocytosis can be realized. In addition, the nanogel with proper hardness is directly delivered into the tumor in an intratumor injection manner, so that the growth of the tumor can be effectively inhibited.

The invention relates to the technical field of preparation of products for water treatment, in particular to a preparation method and application of an efficient PDA photo-thermal evaporation modified film, provides a method for co-depositing a PDA photo-thermal material in nanogel for the first time, and greatly improves the load density of the PDA in unit volume, so that the efficient PDA photo-thermal evaporation modified film is prepared. When the photo-thermal evaporation film prepared by the method is actually used, the polydopamine photo-thermal evaporation modified film is obliquely placed at an angle of 45 degrees with the horizontal plane, the photo-thermal conversion efficiency under the condition of one solar illuminance (1kW. M <-2 >) is 91.01-114.10%, the photo-thermal evaporation capacity is 1.34-1.68 kg.m <-2 >. H <-1 >, and the problem that in the prior art, most of the photo-thermal evaporation films take PDA as an additive, and the photo-thermal evaporation efficiency is low is solved. The invention solves the technical problems that the existing PDA photo-thermal evaporation film is poor in evaporation performance due to the fact that the existing PDA photo-thermal evaporation film is used for bonding high-absorbance high-molecular or inorganic materials, and the photo-thermal evaporation performance of the existing PDA photo-thermal evaporation film is rarely deeply studied, so that the development of the PDA in the photo-thermal evaporation field is limited.

The invention provides a diesel oil anti-wear agent and a preparation process thereof, and belongs to the technical field of diesel oil additives, and the preparation process comprises the following steps: mixing and stirring diisooctyl maleate and xylene, adding diethylenetriamine and deionized water, carrying out heating reaction, adding toluene, 4-(aminomethyl) pyridine and ethylene oxide, carrying out mixing reaction, filtering, washing, and drying to obtain the diesel oil anti-wear agent. The pyridinium-based polyester hollow capsule is prepared; the preparation method comprises the following steps: mixing xylene, catechol, ethylene phosphonic acid, ammonium persulfate and deionized water, heating, dispersing in cyclohexane, adding polyvinyl alcohol, octadecyl methacrylate and azodiisobutyronitrile, mixing and reacting to obtain catechol phosphonate nano colloidal particles; mixing and stirring the fatty acid ester solution, the oleoyl fluorocarbon copolymer and the pyridinium-based polyester hollow capsule, adding the catechol phosphonate nano colloidal particles, continuously stirring, performing ultrasonic treatment, and degassing to obtain the diesel oil anti-wear agent. The diesel oil antiwear agent can improve the antiwear property and demulsibility of the diesel oil antiwear agent.

The invention discloses a resveratrol delivery system based on lactoferrin-polyglutamic acid composite nanogel and a preparation method thereof.The preparation method comprises the steps that a lactoferrin aqueous solution and a gamma-sodium polyglutamate aqueous solution are mixed to form a composite system, resveratrol is embedded with the composite system, and the resveratrol delivery system is obtained. And finally, adding calcium chloride into the resveratrol-loaded lactoferrin / polyglutamic acid mixed system, so that the calcium chloride and calcium ions are subjected to ionic crosslinking to form stable nanogel, and freeze-drying the nanogel to obtain the high-resveratrol nanogel powder. According to the invention, lactoferrin and polyglutamic acid are selected to be compounded to construct a resveratrol-loaded lactoferrin / polyglutamic acid nanogel system, a composite structure is formed by utilizing electrostatic interaction between protein and peptide polyacid, and then the composite structure is crosslinked with Ca < 2 + > to form a stable core-shell type three-dimensional nanogel structure. The water solubility, the drug loading capacity and the biological accessibility of the resveratrol are obviously improved.

The invention relates to the technical field of process optimization, and discloses a preparation process optimization method and system of compound lidocaine nanogel. The method comprises the following steps: carrying out difference determination on carrier binding affinity of a lidocaine main drug and an auxiliary drug in compound lidocaine to obtain a drug feeding sequence table; carrying out surface potential pre-adjustment on the nano-carrier according to the drug feeding sequence table to obtain a drug-carrying pretreatment carrier; step-by-step drug loading is carried out according to the drug feeding sequence table based on the drug loading pretreatment carrier, and saturation data in the drug loading process is obtained; the saturation data are synchronously input into a drug loading process regulation and control system for pH and temperature optimization, and multi-component balanced drug loading particles are obtained; layered gel cross-linking is performed according to the multi-component balanced drug-loading particles to obtain nanogel, drug-loading stability and release consistency verification is performed on the nanogel, cross-linking optimization process parameters are generated, and the adaptability and the drug-loading efficiency of the drug-loading process are improved.

The invention discloses enrofloxacin composite nanogel for promoting intestinal absorption and a preparation method of the enrofloxacin composite nanogel. The enrofloxacin composite nanogel comprises 0.1-3% of sodium alginate; 0.1 to 1% of carboxymethyl chitosan; 0.05 to 0.5 percent of mint exosome; and 0.05 to 1 percent of enrofloxacin. According to the composite nanogel disclosed by the invention, the mint exosome and the enrofloxacin are prevented from being damaged by gastric juice through a shell structure of sodium alginate, so that the stability of the mint exosome and the enrofloxacin in the gastric juice is improved; after the enrofloxacin composite nanogel reaches the intestinal tract, the sodium alginate is used as a shell and is subjected to pH responsive swelling hydrolysis, and the wrapped carboxymethyl chitosan-enrofloxacin nanoparticles and the mint exosome are released; the released mint exosome opens close connection of intestinal cells, enrofloxacin is slowly released from carboxymethyl chitosan-enrofloxacin nanoparticles to achieve a slow release effect, and the mint exosome and the enrofloxacin are synergistically targeted to promote absorption of enrofloxacin in intestinal tracts, so that the drug concentration of enrofloxacin in plasma is enhanced.

The present invention discloses a nano-thermosensitive assembled gel for nasal administration, a preparation method thereof and its use, namely, mitochondrion-targeted puerarin nanoparticles, a thermosensitive gel, a preparation method thereof and its use. The nano-thermosensitive assembled gel for nasal administration of the present invention uses chitosan modified with SS-31 peptide having mitochondrion-targeting and transmembrane properties as a carrier material, and uses a thioketal cross-linking agent sensitive to reactive oxygen species (ROS) to cross-link the modified chitosan to prepare nanoparticles loaded with puerarin. Through a poloxamer thermosensitive gel system, a thermosensitive nanogel drug reservoir encapsulating the nanoparticles is constructed, and its application in the preparation of drugs for treating nervous system diseases realizes the targeting of the drug to the mitochondria of cerebral ischemic stroke injury, responsive cleavage in an environment rich in ROS, release of the drug, increase of the drug concentration in the mitochondria, and improvement of the brain bioavailability of puerarin, providing a more suitable and effective new dosage form for the treatment of stroke.

The invention provides a hinokitiol-dihydromyricetin composite nano condensation body and a preparation method and application thereof, and the composite nano condensation body comprises the following components in 100 mL of a suspension: 0.3 to 0.5 g of hinokitiol, 0.5 to 0.8 g of dihydromyricetin, 1.0 to 1.5 g of chitosan, 0.5 to 0.8 g of sodium alginate, 2.0 to 3.0 mL of polyethylene glycol, 0.3 to 0.5 mL of Tween, 1.0 to 1.5 mL of glycerol, and the balance of a citric acid-sodium citrate buffer solution. The invention provides a hinokitiol-dihydromyricetin composite nano-coacervate which can synchronously solve the problems of synergistic bacteriostasis, membrane rupture and antibiosis, anti-inflammatory repair, application defects of active ingredients and the like of common animal skin antibacterial drugs. The preparation method of the composite nano coacervate is simple, large-scale production is easy, complex equipment is not needed, it can be ensured that active ingredients of a finished product are evenly distributed, the composite nano coacervate can penetrate through the skin cuticle and can also penetrate through a bacterial biofilm, and the synergistic effect is fully achieved.

The invention relates to an amino acid derivative carrier as well as a preparation method and application thereof, and belongs to the technical field of biology, and the preparation method of the amino acid derivative carrier comprises the following steps: providing a cationic amino acid monomer and a neutral-polyanion block polymer template; a cationic amino acid monomer, a neutral-polyanion block polymer template, a cross-linking agent and a photoinitiator are mixed and react under the irradiation of ultraviolet light to obtain an amino acid derivative carrier, and the amino acid derivative carrier is cationic nanogel. The amino acid derivative carrier prepared by the preparation method disclosed by the invention can be used as a nucleic acid drug delivery carrier, and has the advantages of strong nucleic acid loading capacity, high transfection efficiency, safety and the like.

The application belongs to the technical field of dental antibacterial materials, and discloses a kind of nanometer composite antibacterial coating for dental material and preparation method thereof.Method: monomer modified arginine, monomer N-isopropyl acrylamide, monomer methyl hexyl acrylate, initiator azobisdimethylamino propanamide hydrochloride, dispersing agent cetyltrimethylammonium bromide and crosslinking agent N,N-methylene bis(acrylamide) are dissolved in water, and the reaction is carried out under protective atmosphere, dialysis, to obtain nanogel dispersion;The nanogel dispersion is mixed with the nanometer zinc oxide dispersion to obtain a nanogel composite zinc oxide antibacterial coating, and a coating is formed after coating.The nanometer composite antibacterial coating for dental material has excellent retention capacity and antibacterial performance.

The invention provides an allosteric nanogel adjuvant as well as a preparation method and application thereof, and belongs to the technical field of vaccines. The allosteric nanogel adjuvant comprises a self-assembly motif, a responsive site and an immunomodulatory peptide fragment, and the self-assembly motif is composed of 2-5 amino acids; the allosteric nanogel adjuvant has a structure as shown in a formula I, and is named as NTP5 for short; the allosteric nanogel adjuvant is self-assembled into nanoparticles, the nanoparticles are allosteric into a nanofiber structure through responsive broken bonds, nanogel is further formed, and the key problems of a traditional vaccine in the aspects of antigen delivery and immune activation are effectively solved. The nanogel adjuvant can efficiently load various antigens to form a stable nano vaccine, activate an immune microenvironment and provide more means and thoughts for vaccine development.

The invention discloses a composition for antibacterial nanogel, the antibacterial nanogel prepared from the composition and application of the antibacterial nanogel. The composition for the antibacterial nanogel is prepared from carboxymethyl chitosan, a copper manganese oxide nanomaterial, sodium alginate and water. Wherein the mass ratio of the carboxymethyl chitosan to the copper manganese oxide nano material to the sodium alginate is (1-5): (0.05-0.2): (1-5). According to the antibacterial nanogel, carboxymethyl chitosan and a copper manganese oxide nano material with high bacterial cell membrane adhesion capacity are adopted as antibacterial agents, natural gel sodium alginate is combined, no medicine component is added, and the problems of any toxic and side effects, generation of drug-resistant bacteria and the like do not exist.