401 results about "Nanogel" patented technology

Provided are compositions comprising a block copolymer of the following formula: [A]-B-[Q], wherein [A] is a polymer that has an affinity for a substrate; B is a linking group comprising an optionally-substituted, polyvalent linking group having a molecular weight of no more than 1000 g / mole; and [Q] comprises a semi-crosslinked, ungelled polymer derived from copolymerization of an ethylenically unsaturated monomer with a poly-functional ethylenically unsaturated monomer. Such block copolymers are cross-linked via the [Q] segment, but not macroscopically gelled. The [Q] segment is hydrophilic and has a degree of polymerization in the range of about 10 to about 10,000. The [A] segment is located on at least one terminal end of said block copolymer, comprises between about 1 and about 200 repeating units. The block copolymer is associated, via the linear substrate associative segment with a surface comprising at least one hydrophobic site, such as a silicone hydrogel. The polymers may be incorporated into a formulation from which the silicone hydrogel is made or may be contacted with the silicone hydrogel post-formation.

The invention discloses a compound reverse osmosis membrane with interpenetrating network desalting layer and a preparation method of the membrane. The desalting layer consists of a stereoscopic network which is formed by interpenetrating macromolecule nanogel and polyamide. The preparation method comprises the following steps of: pre-adding hydrophilic and / or oleophylic macromolecule nanogel with good dispersion into a solvent of solution A and / or B, preparing a water phase A solution containing m-phenylenediamine and / or p-phenylenediamine, preparing an organic phase B solution containing trimesoyl chloride, enabling the solution A and the solution B to fully contact on a porous support carrier for interface reaction, rinsing by using deionized water, carrying out moisturizing treatment by using glycerol, and drying. The compound reverse osmosis membrane disclosed by the invention has a sodium chloride removal rate of not less than 99% and a flux of not less than 25GFD (Geophysical Fluid Dynamics) under a pressure of 225psi; the microstructure and the charge property of the desalting layer can be regulated and controlled through the macromolecule nanogel so that the reverse osmosis membrane with high anti-pollution capability is prepared; and the compound reverse osmosis membrane can further be used for developing novel low-pollution reverse osmosis membranes.

The present invention relates to reversible hydrogel systems. Particularly, the hydrogel of the present invention is made up of copolymers that can be a hydrogel when in an oxidized state and can be a solution when in a reduced state. A solution of the copolymer can be oxidized to form a hydrogel; and the hydrogel can be reduced to form a solution of the copolymer. Reversible nanogels can also be formed from a dilute solution of the copolymers. The hydrogel is formed with nanoparticles embedded therein to form a nanocomposite whose refractive index and modulus can be controlled by varying the amounts of nanoparticles and the polymer concentration of the hydrogel, respectively

The invention relates to an Al2O3-MA-SiC-C refractory castable material with carbon wrapped by nano Al2O3-SiC film or nano Al2O3-MgO film, and a preparation method thereof. The preparation method of the nano carbon-containing castable material comprises: preparing carbon-containing sol suspension with Al(OH)3-SiC or Al(OH)3-Mg(OH)2 through a high-speed impact mixer, coating the carbon-containing sol suspension on the surface of carbon powder to form a compact carbon wrapping layer with complete coverage and no crack, and carrying in-situ synthesis of nano gel particles of Al2O3 and SiC or Al2O3 and MgO generated during transformation from sol to gel so as to generate a nano-sized matrix with carbon-containing nano secondary spinellite, Al2O3 and SiC as main crystalline phases, thereby completing the preparation of the Al2O3-MA-SiC-C refractory castable material made of nano material. The castable material has particularly excellent resistance against erosion and scouring of molten iron slag, and can satisfy the requirements for use in the iron tapping channel of the modern large-scale blast furnace. Moreover, the invention significantly prolongs the service life, reduces the cost and facilitates the environmental protection.

The present invention includes a method for preparing polymer hydrogel spherical particles on a nanometer scale (nanogels). The method includes encapsulating hydrogel-forming components into liposomes, diluting the large unilamellar liposomes suspension to prevent polymerization outside the liposomes, and polymerizing the encapsulated hydrogel-forming components. The lipid bilayer may be solubilized with detergent. The phospholipid and detergent molecules and their micelles may then be removed by dialysis. The resulting nanogels may then be dried by evaporation in a temperature gradient. Poly(acrylamide), poly(N-isopropylacrylamide), and poly(N-isopropylacrylamide-co-1-vinylimidazole) hydrogel particles with a diameter from 30 to 300 nm were detected and characterized by dynamic light scattering technique. The solvent, temperature, pH, and ionic sensitivities of the nanogels were studied.

The invention relates to a pH-sensitive reduction responsive nanogel, which comprises a disulfide-bond-crosslinked sodium alginate derivate serving as an active ingredient. A preparation method of the nanogel comprises the following steps of: adding periodate into a sodium alginate aqueous solution according to molar ratio of the glycosyl unit of the sodium alginate aqueous solution to the periodate as 1:(0.01-10), and reacting away from light to obtain dialdehyde sodium alginate; stirring and uniformly mixing a dialdehyde sodium alginate aqueous solution and a 4-aminothiolphenol ethanol solution according to the molar ratio of the aldehyde group of the dialdehyde sodium alginate to the amino group of the 4-aminothiolphenol as 1:(0.01-10) away from light at the temperature of 0-25 DEG C, and then adding sodium borohydride to obtain sulphydryl sodium alginate; and self-assembling the sulphydryl sodium alginate in an aqueous solution and oxidizing the sulphydryl sodium alginate by oxygen in the solution to obtain the nanogel. The nanogel prepared by the invention has stability, pH sensitivity and reduction responsiveness and has a potential application value in the fields of biomedical implants, biological nanotechnology, drug delivery system and the like.

Lipobeads (liposome-encapsulated hydrogels) combine properties of hydrogels and liposomes to create systems that are sensitive to environmental conditions and respond to changes in those conditions in a fast time scale. Lipobeads may be produced by polymerizing anchored or unanchored hydrogels within liposomes or by mixing anchored or unanchored hydrogels with liposomes. Giant lipobeads may be produced by shrinking unanchored nanogels in lipobeads and fusing the resulting lipobead aggregates, long-term aging of anchored or unanchored lipobeads, or mixing anchored or unanchored aggregated nanogels with liposomes. Poly(acrylamide), poly(N-isopropylacrylamide), and poly(N-isopropylacrylamide-co-1-vinylimidazole) lipobeads were produced and characterized.

The invention discloses a novel method for preparation of a chitosan nano carrier and functionalization thereof, which relates to the chitosan nano carrier. The invention provides a novel method for preparation of the chitosan nano carrier and functionalization thereof. The chitosan is dissolved in acetic acid solution, meanwhile, pH is adjusted to 4.5-5.5 with NaOH solution, STPP (sodium tripolyphosphate) solution is added to the chitosan solution to obtain nanogels, then, crosslinking glutaraldehyde is provided for the chitosan, centrifugation is conducted after ending of reaction, reduction reaction is conducted with excess sodium borohydride, then centrifugation is conducted again, then, the obtained compound is dispersed in hydrochloric acid solution to remove the unreacted sodium borohydride, then dialysis is conducted, in order to wash STPP to obtain nanoparticles; the folic acid is weighed to be dissolved in the phosphate buffer solution, then the solution is added to chitosan nanoparticles water solution, after adding EDCI to the solution, folic acid modified nanoparticles are obtained through reaction; PEG succinimidyl propionate is weighed to be dissolved in the phosphate buffer solution, then is added to the chitosan nanoparticles water solution, after reaction, PEG modified nanoparticles are obtained.

The present invention is generally directed to novel polymeric mateirals for use in the electrophoretic separation of nucleic acids. In particular, the novel polymer materials are sparsely crosslinked nanogels, dissolved in an aqueous buffer to form solutions with moderate to high viscosity. The present invention further provides methods for generating such novel polymers, and related methods of their use.

The present invention relates to a polymer according to Formulas (1) or (2): The present invention further relates to nanogels and nanoparticles made of a polymer according to general Formulas (1) and (2). The nanogels may comprise a biologically active component such as siRNA, miRNA, DNA, an (oligo)peptide or a proteins.

The invention discloses a stable nanometer gel of core-shell structure and application in the macromolecular chemistry and drug agent technical domain, which is characterized by the following: reacting protein and Maillard of polysaccharide to form protein-polysaccharide covalent compound; heating the protein-polysaccharide covalent compound solution under certain pH value; obtaining the product as micromolecular carrier; loading micromolecular drug and nourishing material in the dispersing or gel forming course; obtaining the nanometer particle of drug and nourishing material.

The invention relates to a preparation method of ferric oxide nanoparticle supported sodium alginate nanogel. The preparation method comprises steps as follows: (1), PEI (polyethylenimine) coated Fe3O4 nano-particles (Fe3O4-PEI) are synthesized with a hydrothermal method; (2), an aqueous solution of sodium alginate is firstly activated by EDC (carbodiimide) and has a double emulsion reaction to form a W / O / W polymer emulsion; (3), Fe3O4-PEI in the step (1) is taken as a crosslinking agent and added into the polymer emulsion in the step (2) to have a crosslinking reaction, and the ferric oxide nanoparticle supported sodium alginate nanogel is obtained after an organic solvent and a surface active agent are removed. The method is very simple, and operation and separation are easy; meanwhile, sources of raw materials are extensive; the prepared sodium alginate nanogel has a smaller grain diameter, is uniformly distributed, high in relaxation rate and low in cost, has a remarkable radiography effect, simultaneously has excellent water solubility, gel stability, biocompatibility and blood compatibility, doesn't have a harmful effect on a living body, and has potential application value in the magnetic resonance imaging diagnosis field.

The present invention relates to a method of making a ringing nanogel with low levels of emulsifiers. The oil-in-water nanogel is thickened by an oil phase and a silicone component that self-structure to increase the complex viscosity of the composition and form the nanogel. The pre-emulsion, containing the silicone component, the oil phase and a water phase, is subjected to a high shear and high pressure treatment at least two consecutive times. The self-thickening of the gel occurs when the silicone component and the oil phase provide structure to the composition. Alternatively, the silicone component can be added to a pre-emulsion of the oil and water phases after the two phases are subjected to high shear and high pressure treatment. The combination of the silicone component with the treated intermediary emulsion is subjected to a second high shear and high pressure treatment which results in self-structuring of the silicone component and the oil phase. The resulting ringing nanogel has a difference in complex viscosity of at least about 10,000 poise under oscillation stress in the range of about 0 to 5,000 (dyne / cm2), and has an initial complex viscosity greater than about 15,000 poise.

The invention relates to a preparation method of nanoparticles for improving the bioavailability of curcumin, and belongs to the technical field of functional food production process. The problems oflow solubility, poor stability of processing and storage and low bioavailability of curcumin are solved, curcumin and zein are dissolved in ethanol to form an organic phase, then an aqueous solution of casein is subjected to ultrasonic treatment, casein is crosslinked by transglutaminase, chitooligosaccharide is grafted onto casein, the nano gel aqueous phase of cross-linked casein and the casein-chitosan oligosaccharide graft material is formed, finally, the organic phase is mixed with the casein-chitosan oligosaccharide nano gel aqueous phase by a high-pressure homogenization method or a solvent evaporation method, ethanol is removed by a rotary evaporation method, high speed centrifugation is carried out and freeze-drying is carried out, and finally, nanoparticles loaded with curcumin is obtained. The average particle size of the nanoparticles ranges from 140 to 390 nm, and the encapsulation rate of curcumin is about 70%-82%. The nanoparticles have good physical and chemical stability during storage.

The invention provides a nanogel with hydrophilic and hydrophobic reversal, charge reversal and intracellular redox responsiveness on the basis of pH regulation. The nanogel is prepared by cross-linking of thermo-sensitive monomer with controllable radical polymerization, amphoteric ionic monomer and amido-containing pH sensitive monomer through a disulfide-bond-containing cross-linking agent. The invention further provides a nanogel drug carrier system with smart response to tumor microenvironment and its preparation method. On the condition of blood pH 7.4, the nanogel is in a hydrophilic swelling state that is favorable for avoiding being phagocytosed by the reticuloendothelial system (RES) and accordingly, the nanogel has blood long circulation capacity; on the condition of tumor tissue subacidity, the state of the nanogel is reversed into a hydrophobic shrinking state that is favorable for the nanogel to realize effective concentration, depth penetration and be absorbed effectively by tumor cells on the tumor location. Besides, in the intracellular lysosome environment, negative charge of the nanogel is reversed into positive charge, which is favorable for the nanogel to escape from the lysosome; and then the nanogel releases drugs responsively in cytoplasm high-GSH environment, thereby achieving a good tumor inhibition effect.

The invention discloses a cross-linkable amphiphilic natural polysaccharide and application thereof. Specifically, in particular, a double-bond and a hydrophobic chain are employed for dual modification of a natural polysaccharide polymer to obtain cross-linkable amphiphilic natural polysaccharide, and the cross-linkable amphiphilic natural polysaccharide is applied to loading and delivery of protein drugs. The amphiphilic natural polysaccharide provided by the invention can self-assemble into nanogel with protein loading capacity in an aqueous solution, and then an initiator is employed to activate the double-bond modifying natural polysaccharide to generate a free radical, thus triggering mutual crosslinking of the double-bond to form a new covalent bond, and the stable action force of the covalent bond is utilized to obtain the preparation so as to achieve efficient delivery of protein drugs.

The invention discloses a preparation method of hyaluronic acid nanogel. The target product hyaluronic acid nanogel is synthesized from chitosan quaternary ammonium salt and sodium hyaluronate through an ion crosslinking and polymer coacervation two-step technology, the average particle size of the product is 150-230nm, and the Zeta potential of the product is -28.6 ~ -36.7mV. The hyaluronic acid nanogel prepared in the invention can be used for treating oral ulcer, can maintain the effective active concentration of a basic fibroblast growth factor in the oral ulcer position for a long time, and improves the clinic treatment effect.

The invention discloses a chitosan nanogel immobilized capsule preparation technology used for oral drug delivery and discloses a method for preparing composite chitosan nanogel immobilized multi-layer capsules. The method comprises the step of fixing chitosan-carboxymethyl chitosan composite nanogel which is uniformly dispersed in an aqueous solution to multi-layer sodium alga acid capsules through an ionotropic gelation process. The multi-layer capsules have high pH responsiveness and are stable in structure in a gastric acid environment, and complete nanogel can be rapidly released in a neutral and faintly alkaline intestinal environment. The composite chitosan nanogel can be effectively prevented from being disintegrated in advance in the acid environment, and the oral drug delivery efficiency is improved. The method can be used for medical biological materials and drug carriers and has high research and development and utilization prospect.

The invention relates to an immobilized ionic liquid catalyst and application thereof. The immobilized ionic liquid catalyst has a general structural formula as defined in the specification. In the general structural formula, P is a nanogel resin matrix; n is an integer in a range of 2 to 12; and M<-> is a negative ion selected from a group consisting of a trifluoromethanesulfonate group, a p-toluenesulfonate group, a benzenesulfonate group, a methanesulfonate group, a tetrafluoroborate group and a hexafluorophosphate group. The immobilized ionic liquid catalyst can be applied to industrial olefine acid addition for preparation of corresponding esters.

The present invention relates to an aqueous polyurethane-polyurea dispersion (PD) having polyurethane-polyurea particles, present in the dispersion, having an average particle size of 40 to 2000 nm, and having a gel fraction of at least 50%, the polyurethane-polyurea particles comprising, in each case in reacted form,(Z.1.1) at least one polyurethane prepolymer containing isocyanate groups and comprising anionic groups and / or groups which can be converted into anionic groups, and(Z.1.2) at least one polyamine comprising two primary amino groups and one or two secondary amino groups, and the dispersion (PD) consisting to an extent of at least 90 wt % of the polyurethane-polyurea particles and water.The present invention also relates to basecoat materials comprising the dispersion (PD), and to multicoat paint systems produced using the basecoat materials.

The invention discloses an ultrasonic preparation method of casein-polysaccharide nanogel and application of functional food, and relates to the technical field of functional food microcapsules. The casein-polysaccharide nanogel is prepared from the following raw materials in parts by weight: 2-40 parts of sodium caseinate and 2.5-25 parts of sodium alginate. The sodium alginate is added in the sodium caseinate, the advanced structure of the sodium caseinate is changed, the structure of the sodium caseinate is opened to expose an active group, meanwhile, protein and polysaccharides form small aggregates, and therefore, the various aggregates are promoted to form gel under the hydrophobic interaction so as to lay a foundation for embedding of bioactive components. In a process of embedding beta-carotene by using sodium caseinate-sodium alginate composite gel, the protein and the polysaccharides are promoted to be crosslinked to obtain the aggregates by a frequency sweeping ultrasonic treatment technology or a multi-mode ultrasonic technology through an ultrasonic physical force, the various aggregates are promoted to form gel through the hydrophobic interaction, and a foundation is laid for embedding of the bioactive components.

The invention discloses a preparation method of pH responsive cation nanogel. The preparation method comprises the following steps: lauryl sodium sulfate and polyethylene glycol dimethyl acrylic ester are sufficiently dissolved in water to prepare a water-phase solution, ethylene glycol dimethacrylate and cationic monomer methylacrylic acid-(N, N-diethyl amine) ethyl ester or 2-(diisopropyl amino) ethyl methacrylate are uniformly mixed to obtain a mixture, and then the mixture is added into the water-phase solution to prepare microemulsion, and a water solution with an initiator is added in the microemulsion to react for 20-24 h to obtain the pH responsive cation nanogel dispersion liquid. The nanogel prepared has good pH responsiveness and dispersion stability, can be placed stably for more than 3 months, and the number-average grain size of the nanogel is smaller than 100 nm.

The invention belongs to the field of crop fertilizer and particularly relates to compound fertilizer synergist modified by oxidized graphene and a preparation method of the compound fertilizer synergist. The compound fertilizer synergist is prepared from, by weight, 70-80 parts of forestry and agricultural residues, 10-20 parts of a modifying agent, 0.5-1 part of a catalyst, 1-5 parts of stabilizer, 5-10 parts of cyclodextrin and 0.3-0.5 part of the oxidized graphene. The preparation method includes the steps that plasma illumination is utilized to conduct bombardment on the surfaces of forestry and agricultural residues, hydroxide radicals, carbanyl groups, carboxyl and other functional groups containing oxygen are introduced into the surfaces of the forestry and agricultural residues, then polymerization with water-soluble polymer modifier occurs under the action of high-field-intensity ultrasound waves, stable nanometer gel particles of three-dimensional network structures are formed, after modification with the oxidized graphene and cyclodextrin is completed, high adsorption, complexing power and a water-retaining property are achieved, nutrient elements in soil can be subjected to complexing, losing of fertilizer nutrients is reduced, the water retention and fertilizer retention performance of soil is improved, and the utilization rate of compound fertilizer can be remarkably raised. The compound fertilizer synergist has the advantages of being environmentally friendly, free of pollution, capable of raising the utilization rate of fertilizer and improving soil environment and the like.

The invention provides a material for desensitizing teeth by sealing dentinal tubules. The material comprises the following raw materials in parts by weight: 30-60 parts of carboxymethyl chitosan, 5-10 parts of dipotassium phosphate, 10-20 parts of calcium chloride, 24-48 parts of lysozyme and 12-24 parts of water. Through an electrostatic acting force between the carboxymethyl chitosan and the lysozyme, a carboxymethyl chitosan and lysozyme containing nanogel is formed, the nanogel stabilizes calcium ions and hydrogen phosphate ions in a calcium phosphate solution, and the formed desensitizing material is in the form of rigid solid spheres containing nanometer amorphous calcium phosphate particles. Experiments prove that the desensitizing material is simple and convenient in preparation method and can penetrate into the dentinal tubules to achieve rapid desensitization and mineral crystals are formed and are firmly combined with the surfaces of the teeth; the newly formed crystals cancover the dentinal surfaces; the desensitizing material is good in biocompatibility, low in allergenicity, non-toxic, non-irritant, wide in clinical application range and ideal in using effect.

The present invention relates to preparation and use of water dispersible nanogels and solvent dispersible reactive nanogels as additives to enhance polymer properties or as precursors to polymeric networks.

A film-forming composition comprises a solvent and unimolecular nanoparticles of a self-crosslinkable nanogel star polymer. The nanogel star polymer comprises i) a crosslinked polymer core (nanogel core) and ii) 6 or more independent polymer arms covalently linked to the core by respective first end groups. A plurality of the arms comprise reactive groups for effecting crosslinking of the nanoparticles. An essentially solvent-free film layer comprising the nanoparticles self-crosslinks, optionally assisted by subjecting the film layer to a thermal treatment and / or a photochemical treatment. A surface treated article comprising the crosslinked film layer can effectively inhibit growth of and / or kill Gram-negative microbes, Gram-positive microbes, fungi, and / or yeasts.

The invention relates to an ATP responding type drug-releasing nano gel and a preparation method thereof, and belongs to the technical field of medicine. The nano gel is composed of carboxymethyl chitosan, DNA 1 with carboxyl modified terminals, DNA 2 with carboxyl modified terminals, and an ATP aptamer. Amino groups of carboxymethyl chitosan react with carboxyl groups of terminals of single chain DNA 1 and DNA2 to form stable amide bonds; because the ATP aptamer can carry out complementary base pairing with single chain DNA 1 and DNA2, the ATP aptamer can be used as a gel crosslinking agent, which can realize the crosslinking of nano gel; through physical embedding, doxorubicin hydrochloride is embedded in the GC segment of nucleic acid, the drug encapsulation is realized; and a novel ATP responding type drug-releasing nano gel drug delivering system is prepared. The system can respond to the high concentration ATP in tumor cell and competitively combines with the gel crosslinking agent (ATP aptamer); thus the complementarily paired nucleic acid chains are broken, the gel skeleton is broken, and drugs are released. The provided nano gel can improve the safety and targeting property of a tumor drug delivery system to a certain degree.

The invention belongs to the field of a pharmaceutical preparation and discloses a method and a device for rapidly preparing a vesica (including liposome) with inner and outer water phase gradient difference in a large scale, and an application thereof. According to the device and the method disclosed by the invention, a membrane separation mechanism, and an ion exchanging and adsorption mechanism are ingeniously combined; and when the property, the ion gradient type and the preparation scale of the vesica with the needed gradient are different, a membrane separation device and an ion exchanging device, which have the different performances, are combined. With the adoption of a membrane separation method, cations, anions, zwitter ions and / or charge macromolecular substances in a vesica mixed suspension hydrated medium are distributed into a dialysis medium; and an ion exchanging method is used for selectively exchanging or cleaning the cations, the anions, the zwitter ions and / or the charge macromolecular substances in the dialysis medium, so that the vesica can establish the greater inner and outer water phase gradient difference in shorter time. The method and the device can be applied to preparing liposome gel, magnetic liposome, and nano grain / nano gel.

The invention belongs to the field of pharmaceutical preparations and discloses vesicles with inner and outer aqueous-phase gradient difference. The vesicles are prepared by treating blank vesicles by adopting an ion exchange method or combining the ion exchange method and a dialysis method or an ultrafiltration method. The invention also provides a preparation method and application of the vesicles; and the preparation method comprises the following steps of: preparing the blank vesicles; treating the prepared blank vesicles by using an ion exchanger; and performing elution treatment so as to prepare the vesicles with inner and outer aqueous-phase gradient difference. The prepared vesicles can be mixed with medicinal solution to realize active medicament carrying so as to prepare the pharmaceutical preparations. The prepared preparations also can be subjected to ion exchange treatment or freeze-drying treatment. The provided vesicles have higher inner and outer aqueous-phase gradient difference, can realize ion gradient medicament carrying of the vesicles and achieve higher encapsulation rate; meanwhile, the preparation method is simple and is low in cost, and the vesicles can be better applied to preparing liposome gel, magnetic liposome and nanoparticles / nanogel.

Provided herein are methods of inhibiting proliferation of one or more tumor cells comprising contacting the one or more tumor cells with a composition comprising one or more epigenetic drugs that inhibit one or more epigenetic mechanisms of the tumor cells, wherein the one or more epigenetic drugs are encapsulated in a nanogel. The invention is also directed to methods of treating a tumor, metastasis of a tumor or a combination thereof in an individual in need thereof. The invention is also directed to a method of sequentially delivering one or more epigenetic drugs that alter one or more epigenetic mechanisms of a tumor cell and one or more chemotherapeutic drugs to an individual that has a tumor. Compositions which comprise one or more epigenetic drugs that alter one or more epigenetic mechanisms of a tumor cell, wherein the one or more epigenetic drugs are encapsulated in a nanogel.