86results about How to "Easy to operate and separate" patented technology

A process for preparing the non-chiral non-peptide antithrombase depressants BIBR-953, BIBR-1048, etc from 3-nitro-4-chlorophenyl formic acid is disclosed. Said depressant contains 1,2,5-trisubstituted benzimdazole as central skeleton or a F atom.

The invention relates to a method for synthesizing glabridin. The method comprises the following steps: using acetophenone protected by phenol hydroxy as a raw material, carrying out a Willgerodt-Kindler reaction to obtain aryl phenylacetic acid, and carrying out a Friedel-Crafts reaction to obtain an isoflavones compound; causing the isoflavones compound to carry out Pd / C catalytic hydrogenation to obtain a isoflavanone compound; and causing the isoflavanone compound to carrying out a crclizationreaction, a conyl reduction reaction and a removing phenolic hydroxyl group protection group reaction to obtain the glabridin. The operation and the serparation of the steps of the method are simple, the yield is higher, the used reagents are common reagents, are cheap and are easily obtained, the path is shorter, and the tptal yield is not lower than 20 percent.

The invention relates to a preparation method of HPEI (hyperbranched polyethyleneimine)-encapsulated ferroferric oxide magnetic nano particles, comprising the steps of: adding Fe source to ultrapure water, then adding NH3.H2O, stirring in air, adding HPEI, and reacting at 134-140 DEG C for 3h, wherein the mass ratio of Fe source to HPEI is 1-5 :1; cooling, and carrying out washing and magnetic separation on precipitate to obtain HPEI-encapsulated ferroferric oxide nano particles Fe3O4 / HPEI; and then carrying out different surface modification on the Fe3O4 / HPEI nano particles, such as polyethylene glycolation (PEGlation), acetylation and carboxylation, so as to increase biocompatibility of the nano particles to be used for MRI (magnetic resonance imaging) diagnosis. The process is simple, the reaction conditions are mild and operation and separation are easy; and the prepared iron oxide magnetic nano particles have excellent biocompatibility and T2 relaxation effect, and have potential application value in the field of MRI imaging diagnosis.

A process for preparing dichroine and (2R, 3S)-1-benzyloxy-2-allyl-3-alkoxy piperidine as the intermediate of RU-19110 includes such steps as the reaction of imide on protecting agent to obtain compound E, reacting on allyl magnesium to obtain compound F, reacting on lewis acid and silane to obtain compound G, reacting on cerium ammonium nitrate to obtain compound H, reacting on litium aluminium hybrid to obtain protected (2R, 3S)-9, and reacting on meta-chloroperoxy benzoic acid to obtain compound J.

The invention relates to a preparation method of APTS (aminopropyltriethoxysilane)-modified iron oxide magnetic nanoparticles. The preparation method comprises the following steps of: (1) mixing an Fe source with ultrapure water, then adding NH3.H2O, stirring in air, then adding 3-aminopropyltriethoxysilane, reacting at the temperature of 134-140 DEG C for 3-5 hours, wherein the volume ratio of 3-aminopropyltriethoxysilane to ultrapure water is 1:3; naturally cooling to room temperature after reaction, and washing and separating precipitate to obtain Fe3O4 / APTS; and (2) carrying out acetylation and carboxylation on Fe3O4 / APTS. The preparation method has the characteristics of simple process, mild reaction conditions and easiness in operation and separation; and the prepared iron oxide magnetic nanoparticles can be dispersed in a water-based solution for a long time without agglomeration phenomenon and can be potentially applied to MRI (magnetic resonance imaging) diagnosis.

The invention relates to a method for preparing an RGD peptide targeted ultra-small ferriferrous oxide MRI positive nanoprobe. The method comprises the steps of: conducting a one-step solvothermal synthesis method to obtain surface sodium citrate stabilized ultra-small Fe3O4 nanoparticles, then modifying NH2-PEG-RGD to the nanoparticle surface to obtain the RGD targeted ultra-small ferriferrous oxide MRI positive molecular probe. The PEG-RGD modified ultra-small ferriferrous oxide nanoprobe has long cycle time in mice, and realizes targeting T1-weighted enhancement MRI on the surface of cancer cells with alphavbeta3 integrin high expression (U87MG cells, human brain glioma cells) and subcutaneously transplanted tumor on animal level and cellular level. The Fe3O4 nanoparticles prepared by the invention can be in stably dispersed in an aqueous solution for a long time, and do not agglomerate. The preparation method provided by the invention has the advantages of simpleness, low cost and potential in industrialization and commercialization.

The invention relates to a preparation method of ferric oxide nanoparticle supported sodium alginate nanogel. The preparation method comprises steps as follows: (1), PEI (polyethylenimine) coated Fe3O4 nano-particles (Fe3O4-PEI) are synthesized with a hydrothermal method; (2), an aqueous solution of sodium alginate is firstly activated by EDC (carbodiimide) and has a double emulsion reaction to form a W / O / W polymer emulsion; (3), Fe3O4-PEI in the step (1) is taken as a crosslinking agent and added into the polymer emulsion in the step (2) to have a crosslinking reaction, and the ferric oxide nanoparticle supported sodium alginate nanogel is obtained after an organic solvent and a surface active agent are removed. The method is very simple, and operation and separation are easy; meanwhile, sources of raw materials are extensive; the prepared sodium alginate nanogel has a smaller grain diameter, is uniformly distributed, high in relaxation rate and low in cost, has a remarkable radiography effect, simultaneously has excellent water solubility, gel stability, biocompatibility and blood compatibility, doesn't have a harmful effect on a living body, and has potential application value in the magnetic resonance imaging diagnosis field.

The invention relates to a preparation method of a targeted MRI (magnetic resonance imaging) contrast medium based on folic acid modified iron oxide nanoparticles. The method comprises the following steps of: connecting FA to NH2-PEG-COOH to form COOH-PEG-FA; synthesizing PEI coated Fe3O4 nanoparticles (Fe3O4-PEI) by a hydrothermal method; performing surface modification on the Fe3O4-PEI nanoparticles by use of fluorescein isothiocyanate (FI); connecting COOH-PEG-FA to the surface of the Fe3O4 nanoparticles; and finally performing acetylation modification of the residual PEI aminos on the surface of the Fe3O4 nanoparticles to improve the biocompatibility for MRI diagnosis. The preparation method provided by the invention has simple technology and mild reaction conditions, and is easy to operate; and the prepared Fe3O4 magnetic nanoparticles have good colloidal stability, biocompatibility and tumor targeting performance as well as potential application value in the field of in-vivo tumor targeted diagnosis.

The invention provides a fall webworm sex pheromone synthesizing method, which relates to an epoxypropane coumpound. The method takes (Z)-2-acetylene tetradecanol synthesized by cheap and easy obtained 2-propargyl alcohol as raw materials, to synthesize fall webworm sex pheromone 3 [(9S, 10R) -9,10 - epoxy - (3Z, 6Z) -3,6-heneidecadienol] and 4 [(9S, 10R) -9,10 - epoxy - (3Z, 6Z) -1,3 ,6-heneidecatrienol] with high efficiency, high enantioselectivity and high yield. Step 6, 25% of the total yield is synthesized into (9S, 10R) -3; 6-step, 21% of the total yield is synthesized into (9S, 10R)-4; and the antipode excess e. e is more than 99%. The separation of the various steps of the invention is simple; the used reagent are all common reagents, cheap and easy to get; the invention has high yield and a shorter route, and is suitable for requirement o f the industrial production.

The invention relates to a preparation method of RGD-modified subminiature superparamagnetic iron oxide nanoparticles. The preparation method comprises the following steps of preparing PEI-coated subminiature superparamagnetic iron oxide nanoparticles by a mild reduction method, modifying surfaces of USPIO / PEI.NH2 nanoparticles by fluorescein isothiocyanate (FI) and a RGD compound (COOH-PEG-RGD) subjected to pegylation, and carrying out acetylation treatment on the surfaces of the nanoparticles. The preparation method has simple processes and mild reaction conditions and can be operated easily. The RGD-modified subminiature superparamagnetic iron oxide nanoparticles have small sizes, a high relaxation rate, good colloid stability and biocompatibility, and high alpha<v>beta<3> integrin high-expression tumor cell targeting, and have a latent application value in the field of in-vivo tumor targeting MR imaging diagnosis.

The invention relates to a preparation method of folic acid modified multifunctional targeted contrast agent magnetic iron oxide / gold nanoparticles. The method comprises the following steps: synthesizing Fe3O4 nanoparticles, and entrapping nanogold particles in a targeted molecular folic acid modified dendrimer to obtain {(Au<0>)50-G5.NH2-FA}DENPs; forming a high-molecular multilayer film on the surface of each of the Fe3O4 nanoparticles, and carrying out assembly modification of the outermost layer of the multilayer film by {(Au<0>)50-G5.NH2-FA}DENPs; carrying out shell layer cross-linking to obtain composite nanoparticles Fe3O4 / Au-FA; and adjusting the Au / Fe3O4 mole ratio of the Fe3O4 / Au-FA nanomaterial, optimizing the bimodal imaging effect, and carrying out acetylation modification to obtain an Fe3O4 / Au-FA nanomaterial having a best bimodal imaging effect. The method has the advantages of simple process, mild reaction conditions, and easy operation and separation.

The invention relates to a preparation method of a hyaluronic acid modified superparamagnetic iron oxide / gold composite nanoprobe. A NaBH4 reduction method is used for preparing PEI coated Au nano-particles; Fe3O4 / Au-PEI composite nanoparticles are synthetized in one step through a modified coprecipitation method; then HA is modified on the surface of the Fe3O4 / Au-PEI composite nanoparticles, so as to prepare a Fe3O4 / Au-HA composite nanoprobe. The preparation method provided by the invention is simple in process, mild in reaction conditions, and easy to operate; the prepared Fe3O4 / Au-HA composite nanoprobe has a relatively high relaxation rate, has an excellent X-ray damping capacity, is excellent in colloidal stability and biocompatibility, and has a targeting capability of a high expression cancer cell of a specific CD44 acceptor, and has a potential application value in the field of internal tumor targeted MR / CT bimodal imaging diagnosis.

The invention relates to a method for preparing a multifunctional manganous manganic oxide nano-particle nuclear magnetic resonance contrast agent mediated by polyethyleneimine. The method comprises the following steps: preparing PEI modified Mn3O4 nano-particles by using a solvothermal method, and then separating and purifying the nano-particles; then, marking tracer molecule fluorescein isothiocyanate FI on the nano-particles; modifying polyethylene glycol PEG molecules on the amino of PEI; and finally, modifying targeted reagent folic acid FA molecules on the PEI through PEG modification and performing complete acetylation treatment to obtain the contrast agent. The contrast agent prepared in the invention can trace the phagocytosis condition of the cancer cells to nanoparticles in a cellular level, has a significant targeting function on a high-expression cancer cell strain of an FA receptor and can be used for achieving early diagnosis of cancer, meanwhile, since the preparation method of the contrast agent is simple and easy and the raw materials are cheap and easy to obtain, the contrast agent can be produced in large batches.

The invention relates to a method for loading doxorubicine (DOX) anti-cancer medicine by laponite (LAP) clay nanoparticles. The method comprises the following steps that (1) LAP water solution is prepared and is mixed with DOX, then, the stirring is carried out, and mixed solution is obtained, wherein the concentration of the DOX in the DOX water solution is 2mg / mL, and the concentration of the LAP in the concentration water solution is 2 to 8mg / mL; and (2) the mixed solution is centrifugally separated, supernate is sucked out, in addition, ultra-pure water is used for washing precipitation, and finally, LAP loaded with DOX is obtained. The method has the advantages that the condition is mild, the process is simple, the product is easy to operate and separate, the LAP / DOX obtained by the method can effectively control the release of DOX, the LAP / DOX anti-tumor activity is obviously improved through being compared with that of the pure DOX, and the application prospects are wide.

The invention relates to a phosphor-containing crown macromolecular hybrid nanometer material and a preparation method and application thereof. The phosphor-containing crown macromolecular hybrid nanometer material is characterized in that phosphonitrilic chloride trimer is used as a core to synthesize novel phosphor-containing crown macromolecules by a layered modifying method, the surface is modified with pyridine, the novel phosphor-containing crown macromolecule of which the surface contains metal ion chelating sites is obtained, and the copper ions and gold ions are directly complexed, soas to form the hybrid nanometer material for preparing anti-tumor drugs. The phosphor-containing crown macromolecular hybrid nanometer material has the advantages that the raw materials are commercialized, the molecular weight of the prepared phosphor-containing crown macromolecule is uniform, the preparation method is simple, the controllability of reaction process is high, the operation is easy, and a plurality of metal ion chelating sites is contained; the prepared hybrid nanometer material can be applied to the anti-tumor study, and the good application prospect is realized.

The invention relates to a preparation method of a pyridine-modified dendrimer copper complex hybrid nanomaterial. The method comprises: (1) modifying a pyridine group on a dendrimer at an amino terminal through an amido bond, acetylizing to obtain an acetylized dendrimer macromolecule-pyridine compound G5.NHAc-Pyr; (2) directly complexing a bivalent copper ion and the acetylized dendrimer macromolecule-pyridine compound G5.NHAc-Pyr in (1) to form a hybrid nanometer material G5.NHAc-Pyr / Cu. The pyridine-modified dendrimer copper complex hybrid nanomaterial prepared through the method has favorable water solubility and colloidal stability, has an inhibitive ability on tumor cells and a certain r1 relaxation rate at the same time, can be applied to chemotherapy and MR imaging of rat tumors,and has a diagnosis and treatment integration effect.

The invention belongs to the field of chemical synthesis, and relates to a synthesis method of an inhibitor containing a heterocyclic compound, especially an achiral, a Synthesis of peptide antithrombin inhibitors. The present invention uses cheap and easy-to-obtain 3-nitro-4-chlorobenzoic acid as a starting material, a highly efficient and high-yield synthetic raw material compound and a condensing agent with better effect to finally synthesize the target compound antithrombin inhibitor BIBR- 953 and BIBR-1048 and its analogs. The method of the invention has simple step operation and separation, high yield of each step, cheap and easy-to-obtain reagents, short route and high total yield of the target compound, which is nearly 50%.

The invention relates to a preparation method of γ-PGA hydrogel loaded with Au nanoparticles, comprising: adding PEI solution to activated mPEG-COOH solution to obtain PEI·NH 2 -mPEG, add chloroauric acid after being dissolved in ultrapure water, stir, add sodium borohydride aqueous solution, get (Au 0 ) 200 -PEI·NH 2 -mPEG; Add sodium bicarbonate to the activated γ-PGA solution, then add it to the DCM solution of AOT to get a W / O emulsion, add it to the PVA solution to get a W / O / W polymer emulsion; ( Au 0 ) 200 -PEI·NH 2 - Add the ultrapure aqueous solution of mPEG into the polymer emulsion drop by drop, and stir to obtain it. The invention has simple process and low cost; the prepared hydrocoagulation has good X-ray attenuation performance, remarkable imaging effect, good water solubility, colloidal stability, cell compatibility and biocompatibility.

The invention relates to a HA-targeted layered doubled hydroxide-ultrafine iron nano material and preparation and applications thereof. The preparation is as follows: synthesizing an LDH-Fe3O4 nano composite material by a coprecipitation method; covalently bonding activated hyaluronic acid on the surface of an LDH laminate through a silane coupling agent; and finally, carrying out surface loadingof an anticancer drug. The nano-material particles are uniformly distributed, and can enhance the MR imaging effect of the tumor part in an animal body. The LDH-Fe3O4-HA NPs is used as a carrier of ananticancer drug doxorubicin DOX, not only has sensitive pH response and release characteristics, but also can carry out specific recognition on tumor cells expressed by CD44 receptors so as to achieve the idealization effect of efficiently inhibiting tumors.

The invention relates to a preparation method for a dual-loaded targeted nano platform of dendrimer based on fluorescent carbon dot modification. The method includes carbon spot preparation, preparation of a drug sustained release system with fluorescent carbon spots loaded with doxorubicin, RGD-PEG-COOH preparation, RGD-targeted functional dendrimer G5-PEG-RGD preparation, G5-RGD-TPGS preparationand CDs / DOX@G5-RGD-TPGS preparation. The obtained (CDs / DOX)@G5-RGD-TPGS dual-loaded nanoparticles have good water solubility and biocompatibility, are targeted to tumor cells expressed by the integrin AlphavBeta3 receptor, have an obvious inhibitory effect on the tumor cells, can reduce the level of intracellular ATP and hinder the drug pumping, can be used for fluorescence imaging of cancer cells and have the diagnosis and treatment integration performance.

The invention belongs to the technical field of a nanometer luminous material, and discloses a multicolor luminous carbon quantum dot as well as a preparation method and application thereof. The method comprises the following steps that citric acid, oxalic acid and urea are dissolved in water; the mixture is mixed with polyethylene glycol, and is then put into a hydrothermal reaction kettle; the hydrothermal reaction kettle is put into a drying box to be heated to be any one temperature between 120 DEG C to 200 DEG C; constant temperature reaction is performed for 4h to 12h; then, stilling standing and cooling are performed to room temperature; the obtained solution is centrifugally separated to obtain a centrifugal precipitate; then, the obtained centrifugal precipitate is added into ethyl alcohol to be uniformly mixed; then, secondary centrifugation is performed; obtained supernatant liquid is dried in a vacuum drying box; yellow and green carbon quantum dots are obtained; the obtained precipitates are dried in air under the natural condition; the blue light giving carbon quantum dot is obtained. The process of the preparation method is simple; the reaction time is short; the yield is relatively high; the particle diameter is small; the environment-friendly effect is achieved; the obtained carbon quantum dot has the advantages of luminous stability, low toxicity and the like.

The invention relates to the technical field of synthesis processes of insecticides, and discloses a preparation method of chlorantraniliprole, which comprises the following steps: 1) adding 4-8 partsof maleic anhydride and 4-8 parts of methanol into a single-necked bottle, stirring the mixture, heating to 50 DEG C, and carrying out heat preservation reaction for 0.5-1.5 hours to obtain monomethyl maleate; and 2) cooling 80-120 parts of a hydrogen bromide-glacial acetic acid solution to 0 DEG C, then dropwise adding 3-5 parts of the monomethyl maleate, after addition is completed, carrying out heat preservation and stirring for 3-7 min, so that a large amount of a yellow viscous substance appears, and the monomethyl 3-bromomaleate can be prepared. The invention discloses a preparation method of chlorantraniliprole. The maleic anhydride, 2,3-dichloropyridine and 2-amino-3-methylbenzoic acid are adopted as starting materials to synthesize the target compound chlorantraniliprole througha convergent reaction. The structure is determined through HNMR, the route is mild in reaction condition, easy and convenient to operate and separate, raw materials are easy to obtain, special equipment is not needed, industrial production is easy to achieve, the action mechanism is novel and unique, and wide application and development prospects are achieved.

The invention relates to a preparation method for a PEI-coated bimodal contrast agent, i.e., a ferriferrous oxide-gadolinium hydroxide magnetic nanoparticle. The preparation method comprises the following steps: (1) dissolving an Fe source in ultrapure water, then adding NH3.H2O, carrying out stirring in the air to realize oxidation, then adding an aqueous solution of polyethylene imine (PEI) and an aqueous solution of Gd(NO3)3 and carrying out natural cooling to room temperature after completion of a reaction so as to obtain Fe3O4-Gd(OH)3-PEI; and (2) subjecting Fe3O4-Gd(OH)3-PEI and methoxypolyethylene glycol carboxylic acid to pegylation. The preparation method provided by the invention has the advantages of simple process, mild reaction conditions and easy operation and separation; the prepared ferriferrous oxide-gadolinium hydroxide magnetic nanoparticle (Fe3O4-Gd(OH)3-PEI-PEG) has good biocompatibility, good relaxation effects at T1 and T2 and a latent application value in the field of MRI imaging diagnosis.

The invention relates to an experimental method for inducing directional differentiation of neural stem cells into neuron cells by Gd:Fe3O4@RA nanoparticles. The experimental method includes the following steps of putting a cover slip pre-treated with polylysine into a culture plate, and inoculating culture holes with primary and passaged neural stem cells derived from rat embryonic brain hippocampus at 1 is multiplied by 10<7> L<-1>, removing basic fibroblast growth factors from a complete culture solution of the neural stem cells, adding 1.0 ml of Gd:Fe3O4@RA complex nano ions with the concentration of 1 mg / ml and fetal bovine serum with the volume fraction of 5% to promote neural stem cell differentiation, performing culture for 6 days, continuing culture for 6 days in a neural stem cell culture medium containing the fetal bovine serum with the volume fraction of 5%, and taking out the cover slip after the cell morphology is mature.

The invention relates to a preparation method of a G2.NH2 based manganese-based MR / CT (Magnetic Resonance / Computerized Tomography) dual-mode imaging contrast agent with an RGD (arginine-glycine-aspartic acid) targeting function. The preparation method comprises the following steps: mixing G2.NH2 and NOTA and reacting to obtain G2-NOTA; then mixing COOH-PEG-MAL and RGD and reacting to obtain COOH-PEG-RGD; after carrying out activation treatment, reacting with the G2-NOTA to obtain G2-NOTA-PEG-RGD; reacting with a chloroauric acid solution and a pre-cooled sodium borohydride solution to obtain G2-NOTA-PEG-RGD@Au; mixing G2-NOTA-PEG-RGD@Au with MnSO4 and reacting to obtain a product. The MR / CT contrast agent prepared by the preparation method has good colloid stability, excellent biocompatibility, relatively long blood circulation time and relatively high relaxation rate; the MR / CT contrast agent has a specific targeting effect on in-situ brain glioma of a mouse and a good thought is provided for developing a novel dual-mode nano contrast agent.

The invention relates to a phosphorus-containing crown macromolecular hybrid nano material as well as preparation and application thereof. The structural formula of the hybrid nano-material is shown as a formula I in the specification. The raw materials are commercialized sources, the prepared phosphorus-containing crown macromolecules are uniform in molecular weight, the preparation method is simple, the controllability of the reaction process is high, and the operation is easy. The nano material prepared by the invention can be used for tumor chemotherapy and gene combined therapy research,and has a good application prospect.

The present invention provides process of synthesizing (2R, 3S)-3-alkyl siloxy-2-allyl-1-alkoxy carbonyl-pyridine as one key intermediate for synthesizing antimalarial febrifugin and RU-19110. The present invention synthesizes (2R, 3S)-3-alkyl siloxy-2-allyl-1-alkoxy carbonyl-pyridine with cheap facile material (L)-glutamic acid as main material and common reagent as assistant. The synthesizing process is convenient and short, and has high selectivity, high yield and low cost.

The invention relates to a method for preparing manganese oxide supported hybrid sodium alga acid nanogel. The method comprises the following steps: performing EDC / NHS activation on sodium alga acid,and performing double emulsification to obtain W / O / W polymer emulsion; adding a polyethyleneimine (PEI) modified solution of manganese oxide nano-particles PEI-Mn3O4 serving as a cross-linking agent into the emulsion, and performing chemical cross-linking, thereby obtaining the manganese oxide supported hybrid sodium alga acid nanogel. The method disclosed by the invention is simple, easy to operate and separate, low in cost, wide in raw source, low in price and biodegradable and has excellent development prospects; the prepared manganese oxide supported hybrid sodium alga acid nanogel is small in particle size and uniform in distribution, has excellent water solubility, colloidal stability and cellular compatibility, does not have any adverse effect on a living organism, has high r1 relaxation rate and excellent contrast effect and has potential application value in the field of magnetic resonance imaging contrast agents.

The invention relates to a reduction response type carbon dot drug-loaded nanocluster coated with a cell membrane, and the preparation and application of the reduction response type carbon dot drug-loaded nanocluster. The preparation method comprises the following steps: the preparation of fluorescent carbon dots, the preparation of a reduction response type carbon dot nanocluster solution, the preparation of an adriamycin-loaded carbon dot nanocluster, the preparation of a B16 cell membrane suspension, and the preparation of the reduction response type carbon dot drug-loaded nanocluster coated with the cell membrane. The method is simple in process, simple in reaction condition and easy to operate and separate, and has good development prospects. The prepared reduction response type carbon dot drug-loaded nanocluster coated with the cell membrane has remarkable anti-tumor effects after entering a mouse body through caudal vein injection, and has potential clinical application value.

The invention relates to a preparation method of a radiotherapy sensitization type hypoxia bimodal contrast agent based on dendritic macromolecules. The method includes directly complexing trivalent gold ions with functionalized dendritic macromolecules G5.NH2-DOTA and reducing to form hybrid gold nanoparticles (Au0)100-G5.NH2-DOTA; and modifying nitroimidazole-modified polyethyleneglycol on the hybrid gold nanoparticles through amide bonds to obtain functionalized gold nanoparticles (Au0)100-G5.NH2-DOTA-PEG-Ni, and then chelating and acetylating gadolinium ions to obtain a functionalized hybrid nano material Gd-Au DENPs-Ni. The material has good imaging performance and stability, and the prepared nano material achieves a radiotherapy sensitization effect by combining radiotherapy and hasa good application prospect.