47 results about "Peg modification" patented technology

The invention provides a nano-drug based on atomic layer deposition and a preparation method of the nano-drug, mesoporous silica is taken as a carrier, bimetallic nanoparticles are precisely deposited through ALD, and chemotherapeutic drugs and antibacterial components are loaded by combining amination and targeted PEG modification, so that the following functions are realized: (1) H2O2 in a tumor microenvironment is catalyzed to generate reactive oxygen species (ROS); removing fusobacterium nucleatum and damaging a biological membrane of the fusobacterium nucleatum; (2) GSH is consumed through Fenton reaction, and tumor drug resistance is reversed; and (3) the drug is released in pH response, and tumor cells are accurately killed. The invention further provides application of the nano-drug based on atomic layer deposition in treatment of related drug-resistant colorectal cancer induced by fusobacterium nucleatum, the process is controllable, the biocompatibility is excellent, the treatment effect on the drug-resistant colorectal cancer is remarkably improved, and the nano-drug has wide clinical application prospects.

This invention relates to the field of acrylic resin technology and discloses a stain-resistant polyethylene glycol-graphene-grafted acrylic resin coating. TEMPO-modified graphene is used as a polymerization carrier, and TEMPO free radicals serve as initiation sites to initiate in-situ chemical grafting polymerization of monomers such as n-butyl acrylate and acrylic acid on the graphene surface, resulting in a polyethylene glycol-graphene-grafted acrylic resin. The graphene is linked to the acrylic resin through polyethylene glycol molecular chains, organically combining the graphene and acrylic resin. This improves the dispersibility of graphene, overcomes its agglomeration in the acrylic resin, and significantly enhances the tensile strength and other mechanical properties of the acrylic resin. Simultaneously, the grafted polar polyethylene glycol molecular chains improve the hydrophilicity and stain resistance of the acrylic resin.

The invention discloses an enzyme-containing anti-inflammatory composition for pet skin and hair follicle health. The enzyme-containing anti-inflammatory composition comprises an enzyme preparation, a hair follicle maintenance agent, a functional auxiliary agent and a carrier raw material. The core innovation lies in that a hair follicle targeted enzymolysis technology is adopted, and a specific enzyme modified by polyethylene glycol can efficiently dredge hair follicles; the anti-inflammatory and hair follicle repairing dual effects are achieved through anti-inflammatory-maintenance synergistic matching and adding sequence optimization; the damaged barrier is rapidly repaired by combining a composite barrier repairing agent and a gradient permeation process; enzyme activity and mildness are guaranteed by adopting a microcapsule embedding and low-temperature preparation technology. The composition can specifically solve the problems of hair follicle blockage, inflammation and unhairing, is suitable for pets of all ages and skin types, and is high in practicability.

The application relates to a carrier-free self-driven nanomotor and a preparation method and application thereof, and belongs to the technical field of biological medicines. The nanomotor is a nanometer assembly formed by co-assembly of a photothermal / light motion dual-enhanced photosensitizer and a near-infrared light response type nitric oxide donor BNN6 through intermolecular force, or is a nanometer assembly formed by co-assembly of a photothermal / light motion dual-enhanced photosensitizer and a near-infrared light response type nitric oxide donor BNN6 through intermolecular force and modified by a polyethylene glycol modifier. The application realizes a synergistic treatment mode of deep tumor penetration and high-efficiency killing by constructing a functional coupling system of "photothermal driving-NO release-motion enhancement-RNS cascade generation".

The present invention relates to nanoparticles of a metal chosen from among platinum, bismuth or a mixture thereof, which are functionalised at their surface by functionalised polyethylene glycol, comprising in particular at least one OH, COOH, NH2 or SH functional group, and to their method of preparation, which comprises of the following steps:a) Mixing a precursor of nanoparticles with a functionalised polyethylene glycol, in particular comprising at least one OH, COOH, NH2 or SH functional group, in water;b) Exposing the mixture to ionising radiation.

The invention discloses a hydroxyl-alpha-sanshool nano preparation as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations, the hydroxyl-alpha-sanshool nano preparation is HAS-coated PEG-PLGA, the preparation method comprises the following steps: taking hydroxyl-alpha-sanshool and polyethylene glycol modified polylactic acid-glycolic acid copolymer as raw materials, and adding the hydroxyl-alpha-sanshool nano preparation and the polyethylene glycol modified polylactic acid-glycolic acid copolymer to prepare the hydroxyl-alpha-sanshool nano preparation. The preparation method comprises the following steps: preparing HAS-coated TGN-PEG-PLGA by adopting an emulsified solvent evaporation method, and further modifying by adopting TGN polypeptide, so as to prepare HAS-coated TGN-PEG-PLGA; according to the hydroxyl-alpha-sanshool nano-preparation, the encapsulation efficiency and the drug loading capacity of hydroxyl-alpha-sanshool are obviously improved, and the hydroxyl-alpha-sanshool nano-preparation has excellent stability and blood-brain barrier crossing capacity, so that the hydroxyl-alpha-sanshool nano-preparation can give full play to the treatment effects of improving learning and memory ability, cognitive ability and the like.

This invention relates to a polyethylene glycol-modified PrRP31, its preparation, and its application. The invention involves modifying PrRP31 with polyethylene glycol and testing its anti-inflammatory activity in a mouse paw edema model and its analgesic activity in a mouse water bath tail-flick experiment. Using polyethylene glycol-modified PrRP31, a mouse paw edema model, and a water bath tail-flick experiment, the anti-inflammatory and analgesic activities of polyethylene glycol-modified PrRP31 were tested. The experiments demonstrated that polyethylene glycol-modified PrRP31 possesses good anti-inflammatory and analgesic activity. In the mouse paw edema model, polyethylene glycol-modified PrRP31 inhibited inflammation by 37.09% (5 h) at a concentration of 5 mg / kg. In the mouse water bath tail-flick experiment, polyethylene glycol-modified PrRP31 produced the maximum analgesic effect at a concentration of 5 mg / kg. This invention provides an application of polyethylene glycol-modified PrRP31 as an anti-inflammatory and analgesic drug, offering beneficial assistance in the treatment of related diseases and possessing significant importance in the pharmaceutical field.

Provided are lipid nanoparticles showing excellent drug migration to the pancreas.The lipid nanoparticles according to the present invention are lipid nanoparticles for delivering a drug to a target tissue, comprising: (a) a phosphatidylcholine-type phospholipid having an unsaturated fatty acid chain with 16 to 24 carbon atoms, and (b) a polyethylene glycol-modified lipid, wherein the target tissue is the pancreas.

Provided is a method for preparing a polyethylene glycol-modified urate oxidase, at least 11 of the following amino acid sites of the polyethylene glycol-modified urate oxidase have a PEG modification: T1, K3, K4, K30, K35, K76, K79, K97, K112, K116, K120, K152, K179, K222, K231, K266, K272, K285, K291, and K293, and the preparation method includes: performing a coupling reaction between urate oxidase and polyethylene glycol, wherein the polyethylene glycol is provided in the form of an acidic solution, and a molar ratio of the urate oxidase to the polyethylene glycol is 1: (56 to 94), to obtain the polyethylene glycol-modified urate oxidase.

The invention relates to an adhesive for quickly curing a tea seed cake liquid mulching film into a film, which is characterized by comprising the following components in percentage by weight: 30-50% of tea seed cake extract; 5 to 15 percent of beet polysaccharide; 0.3 to 0.8 percent of nano SiO2; 0.05 to 0.2 percent of zinc humate; the adhesive comprises the following components in percentage by weight: 20-30% of beet polysaccharide, 10-20% of tea polyphenol, 10-20% of nano SiO2, 10-20% of nano SiO2 and 45-65% of water, the molar ratio of beet polysaccharide to tea polyphenol is 1: (1.5-2.2) so as to promote dynamic ester bond crosslinking, the nano SiO2 is modified by polyethylene glycol (PEG-4000), the zeta potential ranges from-25 mV to-35 mV, the nano SiO2 is used for regulating and controlling the surface tension gradient of a liquid film, and the adhesive can keep the dynamic crosslinking capacity for 72-80 hours when the pH value of soil ranges from 5.5 to 7.8. According to the adhesive for rapidly curing and forming the tea seed cake liquid mulching film, rapid curing for 35 + / -5 minutes is achieved through the catalysis of the zinc humate and the synergistic effect of the nano SiO2, compared with a traditional starch-based mulching film, the efficiency is improved, the farming operation interval is greatly shortened, a gradient pore structure is formed through induction of the nano SiO2, the surface layer is 5 microns / the bottom layer is 20 microns, wind erosion prevention and air permeability are both considered, the self-organization film forming thickness is 1.2 + / -0.3 mm, and the film forming efficiency is greatly improved. The coefficient of variation is less than 8%, and the film-forming property is excellent.

The application provides an organic phosphorus poisoning relief composite enzyme and application thereof, and belongs to the technical field of biological medicine. The organic phosphorus poisoning relief composite enzyme provided by the application comprises polyethylene glycol modified organic phosphorus hydrolase and butyrylcholine esterase, and the mass ratio of the polyethylene glycol modified organic phosphorus hydrolase to the butyrylcholine esterase is (4-8):(2500-10000). The rat acute organic phosphorus poisoning treatment result shows that the organic phosphorus poisoning relief composite enzyme provided by the application fully plays the efficient catalytic hydrolysis capacity of the enzyme as a catalyst, efficiently removes organic phosphorus and acetylcholine by using the organic phosphorus hydrolase and the butyrylcholine esterase respectively, provides a drug combination for treating the cause for the organic phosphorus poisoning injury first aid, and the treatment effect is significantly better than that of the single drug.

The invention relates to the technical field of drug synthesis, and particularly provides a phospholipid-polyethylene glycol modified mono-iodine aza-BODIPY photosensitizer as well as a synthesis method and application thereof, and the phospholipid-polyethylene glycol modified mono-iodine aza-BODIPY photosensitizer has good photosensitization activity and tumor inhibition activity, and can be used for preparing drugs for treating tumors. The compound can be developed into efficient cell membrane targeted photodynamic antitumor drugs, and can be used for photodynamic therapy of non-specific wide tumors, such as pancreatic cancer, cervical cancer, brain glioma, lung cancer, gastric cancer, bladder cancer, ovarian cancer, colon cancer, skin cancer, prostatic cancer and the like.

The present application is suitable for the technical field of tumor treatment drugs, and provides a metal cobalt-based single-atom nanozyme particle loaded with siRNA and a preparation method and application thereof. The particle is formed by electrostatic combination of siRNA for knocking down a c-Myc gene and a polyethylene glycol modified cobalt-based single-atom nanozyme, wherein the cobalt-based single-atom nanozyme is prepared by calcining Co-doped ZIF-8, cobalt elements are dispersed in a nitrogen-doped carbon carrier in the form of single atoms, and cobalt-nitrogen coordination active sites are formed. The preparation process includes three steps of synthesis of the cobalt-based single-atom nanozyme, polyethylene glycol modification and siRNA loading, and is simple in process, convenient in operation, does not require complex and expensive equipment, and is easy for industrialized production. It is verified by experiments that the particle has reliable safety and significant effectiveness in the treatment of cholangiocarcinoma, can effectively inhibit the growth of cholangiocarcinoma solid tumors, is suitable for the treatment of malignant tumors, and has a broad application prospect.

The invention belongs to the technical field of active polypeptides, and particularly relates to a polyethylene glycol modified anti-tumor active polypeptide and application thereof. The modified polypeptide provided by the invention has unexpected better anti-tumor activity, in-vivo stability and low hemolytic activity, and has good application potential.

The present application relates to the technical fields of nanomedicine and functional nanomaterials, and discloses a mesoporous core-shell structure nanoenzyme with multiple enzyme activities as well as a preparation method and application thereof, the nanoenzyme takes gold nanorods as an inner core and iridium and its oxide as an outer shell, the outer shell is modified by polyethylene glycol and then loaded with a photosensitizer chlorin e6 to form an AuNR@Ir / IrO2-PEG / Ce6 nanoenzyme, the nanoenzyme has high catalase (CAT) activity, can decompose hydrogen peroxide (H2O2) in a tumor microenvironment and generate oxygen (O2) in situ, effectively improves the treatment effect of photodynamic therapy (PDT), and through the synergistic effect of photodynamic therapy (PDT) and photothermal therapy (PTT) combined with photoacoustic imaging function, provides a brand-new diagnosis and treatment integrated solution for efficient treatment and microenvironment regulation of tumors, and effectively makes up for the defects of insufficient enzyme activity and low photothermal conversion efficiency of the prior art.

The present application relates to the field of biological medicine, and more particularly to a nano-composite system for treating vitiligo, an intelligent controlled-release microneedle patch and a preparation method thereof, wherein the nano-composite system contains enzyme-responsive micelles and polyethylene glycol modified polydopamine nanoparticles; the enzyme-responsive micelles are formed by glyceryl monostearate encapsulating ginseng root-derived exosomes; and the polyethylene glycol modified polydopamine nanoparticles are formed by covalent connection of a polydopamine core and methoxy-polyethylene glycol-amine. Compared with the prior art, the nano-composite system of the present application can realize the spatiotemporal programmed release of drugs in response to the pathological microenvironment, wherein the polydopamine nanoparticles provide instant antioxidant effect, and the exosome micelles trigger release under the condition of overexpression of matrix metalloproteinase-9, thereby synergistically exerting anti-inflammatory and promoting pigment regeneration effects; animal experiments have proved that the patch can effectively reverse the white spots and realize the recoloring of hair and skin. The microneedle patch thus prepared can realize transdermal self-administration, is convenient and painless.

The application discloses a slow-release injectable conductive hydrogel and a preparation method and application thereof, and belongs to the technical field of biomedical materials, wherein the components of the slow-release injectable conductive hydrogel comprise crocetin modified by polyethylene glycol with different molecular weights, sodium alginate and bioactive glass; the crocetin modified by polyethylene glycol is prepared by an amidation reaction of crocetin and methoxypolyethylene glycol amine, and different molecular weight crocetin modified by polyethylene glycol is obtained by changing the molecular weight of the methoxypolyethylene glycol amine. The hydrogel can realize gradient slow release of the active ingredient crocetin, matches the conductivity with the natural myocardial tissue, can bridge the electrical signal conduction of the infarction area, realizes the electrophysiological-histological synergistic repair in the treatment of myocardial infarction, and provides an effective treatment strategy for the treatment of myocardial infarction.

The application provides a preparation method of rod-shaped and four-foot-shaped gold nanocapsules, and belongs to the field of interface modification. The method first prepares CTAB-stabilized rod-shaped / four-foot-shaped gold nanoparticles, replaces the CTAB with a mercapto-polyethylene glycol amino ligand to obtain polyethylene glycol modified gold nanoparticles with amino groups at the ends, then adds N-hydroxysuccinimide acrylate into the solution to react with the amino groups on the surface of the gold nanoparticles to obtain polyethylene glycol modified gold nanoparticles with double bonds at the ends, and finally adds a reaction monomer, a crosslinking agent and an initiator into the solution to perform in-situ radical polymerization to prepare the gold nanocapsules with a core-shell structure. The application modifies a crosslinked polymer shell layer on the surface of the rod-shaped and / or four-foot-shaped gold nanoparticles, so that the gold nanoparticles have high stability and can maintain the structural integrity in a physiological environment.

The application provides a 1,2-dithiolane-based dynamic covalent hemostatic hydrogel and a preparation method and application thereof, the dynamic covalent hemostatic hydrogel is composed of a cross-linked dynamic polymer network, the cross-linked dynamic polymer network is prepared through ring-opening polymerization of a mixture containing the following components: a polyethylene glycol modified thioctic acid derivative TA-PEG, a tris(hydroxymethyl)aminomethane modified thioctic acid derivative TA-Tris, and a thioctic acid derivative TOS modified with a sulfonic acid group and a quaternary ammonium cation. The application provides a multifunctional dressing capable of considering the ultra-high swelling liquid absorption capacity, the strong wet surface interfacial adhesion, the structural mechanical stability and the persistent broad-spectrum antibacterial performance in a complex, dynamic and large amount of exudate accompanied wound surface environment.

The application discloses a method for hydrophilic modification of halenaquinone by carboxyl polyethylene glycol with a benzo cyclooctyne group to obtain benzo cyclooctyne-polyethylene glycol-halenaquinone (CPH) with good biocompatibility, and uses CPH for anti-tissue fibrosis treatment through glycometabolism engineering and orthogonal click chemistry. Compared with halenaquinone small molecules, CPH has negligible cytotoxicity. CPH has good therapeutic effect on tissue fibrosis in combination with glycometabolism engineering.

The invention relates to the field of biological medicine, in particular to a nano-composite system and an intelligent controlled-release microneedle patch for treating leucoderma and a preparation method of the nano-composite system and the intelligent controlled-release microneedle patch. The enzyme responsive micelle is formed by encapsulating a ginseng root exosome with glyceryl monostearate; the polyethylene glycol modified polydopamine nano particles are formed by covalent linkage of a polydopamine core and methoxyl-polyethylene glycol-amine. Compared with the prior art, the nano-composite system disclosed by the invention can respond to a lesion microenvironment to realize space-time programmed controlled release of a drug, the polydopamine nano-particles provide an instant anti-oxidation effect, and exosome micelles are triggered to release under an overexpression condition of matrix metalloproteinase-9 so as to synergistically exert anti-inflammatory and pigment regeneration promoting effects; animal experiments prove that the patch can effectively reverse white spots and realize color recovery of hair and skin. The prepared microneedle patch can realize transdermal self-administration, and is convenient and painless.

The invention relates to a polyethylene glycol modified fullerene derivative as well as a preparation method and application thereof. The invention provides a polyethylene glycol modified fullerene derivative, the polyethylene glycol modified fullerene derivative has a fullerene skeleton and a polyethylene glycol derivative, the fullerene skeleton is one or more fullerene molecules containing C2n1, 2n1 is the number of carbon atoms, n1 is more than or equal to 30 and less than or equal to 60, and the polyethylene glycol derivative is covalently connected with the fullerene skeleton. The polyethylene glycol modified fullerene derivative is clear in molecular structure and good in water solubility, and has good biocompatibility and oxidation resistance.

The application provides a kind of double drug co-loading intelligent liposome and its preparation method and purposes, belong to the field of biological medicine.The double drug co-loading intelligent liposome includes the following raw materials: curcumin, near-infrared type photosensitizer, phospholipid A, sterol compound, polyethylene glycol modified targeting lipid;The polyethylene glycol modified targeting lipid is sequentially connected by phospholipid B, responsive link, polyethylene glycol and tumor targeting ligand.The application constructs double drug co-loading liposome system with active targeting and tumor microenvironment responsiveness, forms the efficient synergistic treatment strategy of "vascular normalization+PDT", realizes drug precise delivery and enrichment, has excellent ability to inhibit tumor growth, induce tumor vascular normalization and relieve tumor hypoxia, has synergistic effect in inhibiting HIF-1 alpha expression, significantly improves the treatment effect, and provides a new scheme for efficient and safe treatment of tumor.

A lipid nanoparticle composition for nucleic acid drug delivery, a preparation method therefor, and use thereof. A composition prepared by mixing a steroid-cationic lipid compound with an auxiliary phospholipid and a polyethylene glycol-modified phospholipid has relatively good stability and transfection efficiency. By using lipid nanoparticles for delivering a nucleic acid, such as mRNA, a nucleic acid drug can be efficiently and stably delivered to a target cell or organ. Moreover, such LNPs can be used for the atomized inhalation administration of mRNA and the development of lyophilized formulations of mRNA. A relatively high specific antibody response can be induced in experimental animals, and the compound has better safety.

The invention provides a microwave hyperthermia sensitization polyamino acid material. The polyamino acid material is selected from at least one of polyamino acid, polyamino acid salt or polyethylene glycol modified polyamino acid. According to the polyamino acid material provided by the invention, the microwave heat production temperature is remarkably increased by 5-8 DEG C compared with that of a traditional mode, and the excellent biological safety of the material is utilized to realize the application of efficient fat decomposition, so that the core problems of low fat dissolving efficiency and insufficient energy conversion rate in an existing microwave fat dissolving technology are solved; finally, the purposes of reducing treatment times and improving clinical effects are achieved.

The application discloses a polyethylene glycol modified iridium coordination compound and a preparation and application thereof. The polyethylene glycol modified iridium coordination compound has the structure shown in the following formula I. The polyethylene glycol modified iridium coordination compound can self-assemble to form nanomicelles, and can be used for precise positioning of tumors after intravenous injection. The polyethylene glycol modified iridium coordination compound can also be combined with a polyethylene glycol modified indocyanine green to form a composition, the composition can self-assemble to form composite nanomicelles, and can be used for precise positioning of tumors after intravenous injection, and can be further used for photothermal treatment of tumors.

The invention discloses a preparation method and application of polyethylene glycol modified ultra-small tantalum oxide nano-particles. The preparation method comprises the following steps: synthesizing ultra-small hydrophobic oleic acid coated tantalum oxide (Ta2O5-OA) nano-particles; and carrying out ligand exchange on the Ta2O5-OA nano particles. According to the invention, the ultra-small tantalum oxide nanoparticles modified by polyethylene glycol (PEG) on the surface are constructed through a simple and low-cost synthesis strategy, so that small-volume and high-concentration synthesis is realized, the tantalum element yield is increased, long-circulation blood vessel CT imaging is realized, and the requirements of large animal experiments are met. According to the strategy, the blood circulation time is remarkably prolonged, the immunogenicity is reduced, the biological safety is improved, meanwhile, high water solubility and uniform particle size of the nanoparticles are guaranteed, the material cost and the operation difficulty are reduced, and a feasible technical solution is provided for research, development and clinical transformation of iodine-free, low-toxicity and efficient CT contrast agents.

This invention discloses a podophyllotoxin-9-fluorenylmethanol small molecule prodrug nanoparticle, its preparation method, and its applications. The podophyllotoxin-9-fluorenylmethanol small molecule prodrug co-assembled nanoparticles are either polyethylene glycol-modified podophyllotoxin-9-fluorenylmethanol small molecule prodrug co-assembled with gossypol, or podophyllotoxin-9-fluorenylmethanol small molecule prodrug co-assembled with gossypol and loaded with hydrophobic fluorescent substances. The podophyllotoxin-9-fluorenylmethanol small molecule prodrug is prepared by linking podophyllotoxin and its compounds with 9-fluorenylmethanol via disulfide bonds. This invention is the first to construct a carrier-free hybrid nanoassembly of gossypol and PPT oxidation-sensitive prodrug. Gossypol-mediated prodrug co-assembled nanoparticles can be used for precision cancer chemotherapy in tumor treatment, precisely achieving PPT "enhancement," improving the therapeutic efficiency of PPT prodrugs, opening an ultra-low-dose chemotherapy window for PPT, and solving the problems of delayed and insufficient prodrug activation.

The present application relates to the technical field of protein delivery, and specifically discloses a condensate for intracellular delivery of protein as well as a preparation method and application thereof. After methoxypolyethylene glycol is dissolved, a methoxypolyethylene glycol solution is obtained. After protein is dissolved, a protein solution is obtained. After the methoxypolyethylene glycol solution and the protein solution are uniformly mixed, an amidation reaction occurs. After the reaction is completed, dialysis and freeze-drying are performed to obtain polyethylene glycol modified protein. After the polyethylene glycol modified protein is dissolved, a polyethylene glycol modified protein solution is obtained. After the polyethylene glycol modified protein solution and a polyphenol solution are uniformly mixed, a condensate loaded with protein is assembled. The present application processes protein by using methoxypolyethylene glycol and assembles a condensate by using polyphenol, thereby significantly improving the loading efficiency of protein in the condensate and the stability of the condensate and improving the protein loading efficiency.

The invention relates to the field of biological materials, in particular to a preparation method for wrapping vitamins with artificially synthesized needle-shaped silicon dioxide, which comprises the following steps: performing ultrasonic impurity removal on the artificially synthesized needle-shaped silicon dioxide by using a sodium carbonate aqueous solution, and cleaning by using deionized water; mixing a polyethylene glycol modifier with deionized water according to a ratio of 1: 30-1: 50, adding the mixture into needle-like silicon dioxide, carrying out ultrasonic treatment, and then carrying out ultrasonic washing with deionized water; and mixing the vitamin solution with the needle-like silicon dioxide, heating, stirring for a period of time, and naturally drying to obtain the needle-like silicon dioxide coated with the vitamin. The preparation method has the beneficial effects that the vitamin-coated needle-like silicon dioxide which is good in coating effect, stable in performance and capable of being industrially produced on a large scale is obtained.