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Nano probe material for imaging, and preparation method and application thereof

A nanoprobe and imaging technology, which is applied in the field of nanoprobe materials for imaging and its preparation, can solve the problems of limited penetration depth of blue light and unfavorable precise surgical resection, and achieve high sensitivity, improved fluorescence performance, and high fluorescence penetration. The effect of depth

Inactive Publication Date: 2014-03-12
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

However, the penetration depth of blue light is limited, tissue autofluorescence is obvious, and there are light flickering and photobleaching phenomena, which are not conducive to precise surgical resection

Method used

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  • Nano probe material for imaging, and preparation method and application thereof
  • Nano probe material for imaging, and preparation method and application thereof
  • Nano probe material for imaging, and preparation method and application thereof

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Embodiment 1

[0048] Weigh 1.26mmol (382.23mg) YCl respectively 3 ·6H 2 O, 0.4 mmol (154.99 mg) YbCl 3 ·6H 2 O, 0.04 mmol (11.01 mg) TmCl 3 Powder, 0.3mmol (79.08mg) GdCl 3 ·6H 2 O, dissolve with 2mL deionized water for later use; add 15mL oleic acid and 30mL octadecene to the three-necked flask respectively, then add the pre-prepared aqueous chloride solution containing rare earth ions, stir at room temperature for 2 hours; pass in for 15min Argon gas was used to remove the air in the reaction flask; under the protection of argon gas atmosphere, slowly heated (the heating rate was controlled to be 30°C / hour), the temperature was raised to 160°C, and the temperature was kept for 1 hour to remove the water in the system; the heating was stopped, and the temperature was naturally cooled to room temperature; then dropwise added 200 mg NaOH and 296.3 mg NH 4 10 mL of methanol solution of F was stirred at room temperature for 2 hours to obtain a yellow-white solution; continued to pass arg...

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Abstract

The invention discloses a nano probe material for imaging, which is capable of efficiently breaching blood-brain barriers. Firstly, a high temperature pyrolysis method is adopted for preparing inner core NaYF4:Yb / TM / Gd hydrophobic nano-particles, then an NaGdF4 shell is formed through epitaxial growth so as to form core / casing structured NaYF4: Yb / Tm / Gd and NaGdF4 nano-particles, then hydrochloric acid hydrophilic modification and sulfhydryl PEG modification are performed, and finally, the nano probe material is prepared through Angiopep-2 grafting, and is marked as ANG / PEG-UCNPs. The material can be used for efficient blood-brain barrier breaching, magnetic resonance imaging diagnosis and positioning before an cranial cavity glioma operation, near infrared fluorescence imaging in the operation and image mediating, the imaging effect is good, the sensitivity is high, the physiological system toxicity is low, and the material plays an important significance in successful clinic glioma removing operations and the development and the application of medical image diagnostic techniques.

Description

technical field [0001] The invention belongs to the technical field of medical imaging materials, and in particular relates to a nano-probe material for imaging and a preparation method and application thereof. Background technique [0002] The blood-brain barrier (BBB) ​​refers to the structure of brain microvessels that prevent certain substances from entering the brain tissue from the blood. This special structure plays a role in preventing harmful substances in the blood circulation from entering the brain tissue, but at the same time, it also restricts the drugs from entering the brain tissue from the blood, becoming a world of clinical treatment of brain diseases (such as brain tumors, neurodegenerative diseases, etc.) sexual problems. Due to the existence of the blood-brain barrier, 98% of chemical drugs and nearly 100% of protein / peptide and gene drugs are difficult to enter the brain after routine clinical preparations are administered, which greatly limits the the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/18A61K49/10A61K49/14A61K49/00
Inventor 倪大龙步文博施剑林
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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