The invention discloses a multi-cyano offset substituted pentamethine
cyanine dye and a synthesis method and application thereof, and the dye has the following general formula structure: # imgabs0. According to the multi-cyano offset substituted pentamethine
cyanine dye disclosed by the invention, the absorption emission
wavelength is increased by introducing an offset substitution structure; the dye has near-
infrared first-area imaging and treatment performance, so that the optimal excitation and emission
wavelength can be flexibly selected, the dye shows obvious
Stokes shift, reduction of self-absorption and scattering effects is facilitated, the imaging definition and depth are improved, the
molar extinction coefficient of the prepared dye is up to 190000, and the dye can be applied to near-
infrared first-area imaging and treatment of the near-
infrared first-area imaging and treatment of the near-infrared first-area imaging and treatment of the near-infrared first-area imaging. According to the present invention, with the application of the dye, the
light energy utilization degree of the dye is substantially improved, the
long wavelength light with the deeper
penetration depth can be strongly absorbed, the
light energy capture and conversion can be effectively achieved, the
photosensitizer efficiency can be improved, the
light dose can be reduced, the
phototoxicity can be reduced, the high absolute
fluorescence quantum yield can be represented, and the
biological imaging effect can be substantially improved; and the
imaging quality is higher.