41 results about "Photodynamic therapy" patented technology

The present application relates to a kind of based on photodynamic therapy and radiotherapy and chemotherapy treatment stent and its preparation method.The present application includes stent body, stent body is mesh stent, mesh stent is provided with fixed frame, fixed frame includes the 4 support frames of cross arrangement, the cross point of 4 support frames is hinged connection.The present application is simple in structure, easy to make, convenient to use, can be made into different specifications and models, applicable to different tumor size, reduce the damage to normal tissue.

The utility model discloses a kind of optical fiber support of photodynamic therapeutic instrument, belong to photodynamic medical instrument technical field;The utility model is provided with support, and the fixed platform for erecting optical fiber;The fixed platform bottom is movably connected with the support top end through first joint, to be positioned the fixed platform by universal rotation;Still include the clamping device of the clamping device that the optical fiber can penetrate and can separate with the fixed platform, and the clamping device can be clamped and fixed on the optical fiber;Wherein, the base one side of the fixed platform is elastically connected with the fixed plate of being able to lift by connecting rod assembly, for cooperating with the positioning groove on the base or releasing the optical fiber support rod of the clamping device, the utility model has good adaptability, convenient to use Advantage.

The application discloses a kind of SNPs loaded engineered escherichia coli dual-response delivery systems and its preparation method and application, the preparation method includes the engineered escherichia coli of overexpressing Flt3L and TIM-3 scFv is co-incubated with NHS-PEG-CHO, obtain aldehyde functionalized escherichia coli;After activation SNPs is reacted with TFA-hydrazine, obtain hydrazine functionalized SNPs;Aldehyde functionalized escherichia coli and hydrazine functionalized SNPs are reacted;The delivery system of the application can rely on SNPs under laser stimulation Photo-thermal effect, photodynamic effect and generate a large number of ROS, efficiently induce tumor cells to occur immunogenic cell death (ICD), and by overexpressing Flt3L and TIM-3 scFv, activate DC cell and block TIM-3 path, restore DC, T cell function, realize the efficient synergy of photodynamic therapy+photothermal therapy+immunotherapy, and then reach the effective treatment of colorectal cancer.

This invention belongs to the field of biomedical materials and nanotechnology, specifically relating to the synthesis and application of a multifunctional mesoporous nanomaterial. The inventors synthesized a core-shell structured mesoporous nanoparticle using mesoporous silica nanoparticles and dopamine via emulsion epitaxy. The core of the core-shell structured mesoporous nanoparticle is S-nitrosoglutathione supported on mesoporous silica, and the outer shell is pentafluorophenyl chlorophyll supported on mesoporous polydopamine, forming MSN / G@mPDA / F nanoparticles. These nanoparticles rapidly increase in temperature to 45°C under 808 nm laser irradiation. o At temperatures above a certain temperature, S-nitrosoglutathione decomposes to produce nitric oxide. Further irradiation at 750 nm generates a large amount of reactive oxygen species, killing bacteria. This combination of photothermal and photodynamic therapy effectively inhibits bacterial growth. Therefore, this method exhibits excellent antibacterial effects and can play a role in the future treatment of bacterial infections.

The application discloses a nano-antibody (also known as single-domain antibody) conjugated photosensitizer targeting HER2, a preparation method of the photosensitizer and application of the photosensitizer in tumor photodynamic therapy. The photosensitizer is shown in a general formula (I). In the photosensitizer, the nano-antibody (N HER2 ) serving as a targeting ligand is connected with a photosensitive moiety (PS) through a catalytic reaction mediated by a transglutaminase (MTGase). Research finds that the anti-HER2 nano-antibody conjugated photosensitizer molecule has good cell killing selectivity and tumor enrichment capacity, and can remove a subcutaneous tumor of a mouse with high HER2 expression in one administration. HER2 -PEG 1K -PS (I).

The present invention relates to an assembly comprising a carbon nanotube coated successively with: a primary coating resulting from the polymerisation of an amphiphilic diynic compound bearing an anionic or cationic group; optionally an intermediate coating of a cationic or anionic polymer; and a final coating of a porphyrin derivative which is either an anionic porphyrin or a cationic porphyrin, the coatings being linked to each other by electrostatic interactions. The present invention relates also to a method to prepare such an assembly and to its use as a photocatalyst, especially in a water medium, in particular in oxidation reactions, and for the production of singlet oxygen which is especially useful for disinfection or photodynamic therapy (PDT).

This invention discloses a tandem-responsive self-assembled molecular probe and its applications. The HPO-CYFF-TPP of this invention is converted to HO-CYFF-TPP under the dephosphorylation of overexpressed ALP, restoring the intramolecular charge transfer effect. It then self-assembles into nanoparticles in situ through π-π stacking, exhibiting fluorescence signal quenching and photoacoustic signal enhancement at low viscosity. Upon laser irradiation, the NPs generate a large amount of singlet oxygen in the mitochondria, thereby achieving efficient photodynamic therapy (PDT) and leading to increased viscosity. At high viscosity, due to the suppression of the distorted intramolecular charge transfer effect of HO-CYFF-TPP, the NPs activate the FL signal with a high signal-to-noise ratio and further enhance the PA signal. Therefore, the HPO-CYFF-TPP of this invention can achieve efficient PDT and enable real-time therapeutic effect assessment through FL / PA signals.

The application belongs to the field of biological medicine, and provides a tumor microenvironment responsive nano-drug, which comprises a ferrous metal organic framework, polyethylene glycol / leafy on the modified ferrous metal organic framework and PK11195 encapsulated in the metal framework, and a structural formula of the PK11195 is as shown below. The application also provides a preparation method of the tumor microenvironment responsive nano-drug. The application also provides the use of the tumor microenvironment responsive nano-drug in the preparation of a drug for treating hepatocellular carcinoma. The nano-drug can be actively targeted to tumor cells by combining with folate receptors, under the guidance of MRI, and rich ROS is generated by the irradiation of near-infrared light, so as to induce cell ICD, which provides a prospect for promoting systemic antitumor photodynamic therapy and immunotherapy.

This invention relates to experimental systems and methods for research on photodynamic therapy, photothermal therapy, and their combinations. The experimental system includes: an optical irradiation module comprising multiple laser sources, each capable of outputting a collimated beam, which is then combined to form a coaxial optical path and projected onto the surface of the observed object via a beam adjustment component; an optical path position adjustment module including an electric Z-axis displacement mechanism; a temperature monitoring module including an active temperature control substrate, an infrared thermal imager, and a fiber optic temperature probe interface; and a data acquisition and control module configured to: synchronously acquire laser output power, spot area, electric Z-axis position, temperature of the active temperature control substrate, temperature sequences of multiple different regions, and fiber optic temperature probe data, and record the above data with a unified timestamp; calculate power density based on the real-time output power and spot area of ​​the laser sources; and automatically control the laser source to shut off its output when the data from any temperature monitoring channel exceeds a preset safety threshold.

This invention relates to the field of biomedical technology, specifically to an antifungal nanoparticle, a combination drug, and its application. The antifungal nanoparticle is prepared by covalently linking the aptamer AU1 to drug-loaded silk fibroin nanoparticles via amide bonds. The mass ratio of the drug-loaded silk fibroin nanoparticles to the aptamer AU1 is 20:0.5~2.0. The antifungal nanoparticles of this invention are prepared by a desolvation method using voriconazole-loaded silk fibroin nanoparticles, and the targeting aptamer AU1 is attached to their surface using a carbodiimide chemical cross-linking method. This allows for specific recognition of Candida albicans, increasing drug accumulation at the infection site. Further combination with methylene blue-mediated photodynamic therapy can disrupt biofilm structures, enhance nanoparticle penetration, achieve synergistic bactericidal activity, and reduce systemic toxicity, providing a novel, highly effective, and low-toxicity treatment strategy for fungal biofilm infections.

This invention discloses a carboxylesterase-activated mitochondrial-targeting fluorescent probe with photodynamic therapy properties, its preparation method, and its uses. The structure of the mitochondrial-targeting fluorescent probe is shown below. The mitochondrial-targeting fluorescent probe CML of this invention can specifically respond to different concentrations of carboxylesterases (CEs), with a detection limit as low as 0.30 U / L. Simultaneously, this probe can specifically target mitochondria, and through structural optimization (replacing the methyl group on the indole salt with a butyl group), its mitochondrial anchoring ability is significantly superior to that of methyl-substituted derivatives. Cytotoxicity experiments confirmed that the probe has good biocompatibility; confocal fluorescence imaging experiments showed that this probe can effectively monitor the fluorescence changes of endogenous and exogenous CEs in HepG2 cells. Most importantly, after being specifically activated by carboxylesterases, the probe can efficiently generate reactive oxygen species under light conditions, thereby exerting a photodynamic therapeutic effect on cancer cells.

The application provides an antitumor drug, a preparation method and application thereof, and belongs to the technical field of medicines. 4 The Fe3O NPs are deposited with polydopamine on the surface, then a COF layer is formed on the surface through a one-pot method, and an antitumor compound is loaded; further, doxorubicin is loaded on the surface, and then the antitumor drug is prepared by reacting with F127 coupled with folate and oligomeric hyaluronic acid. The antitumor drug prepared by the application has high anticancer activity and drug resistance reversal, high drug loading rate, is not prone to aggregation, has good biocompatibility, good targeting and slow release, and has good application in chemotherapy, photodynamic therapy, photothermal therapy and nuclear magnetic imaging, so that the antitumor drug becomes a new generation of diagnosis and treatment integrated reagent.

Diagnostic and treatment methods for onychomycosis are disclosed. The diagnostic method includes applying a Methylene Blue composition to nails suspected of onychomycosis infection and visually assessing the methylene blue staining on the nail following a diagnosis waiting period, as an indication of onychomycosis infection and severity. The severity of infection may be assessed qualitatively by comparison against a color guide and / or assessed quantitively by UV-Visual spectroscopy and correlating the spectral peak intensity and / or spectral shift to a quantitative onychomycosis severity scale. The diagnostic method may be combined with the photosensitizer activity of Methylene Blue to further provide a photodynamic regimen for treating onychomycosis, and a maintenance regimen for preventing re-infection of the nail.

This present invention and its embodiments relates to methods for reducing pain during photodynamic therapy of actinic keratosis. The present invention also relates to methods of treating actinic keratosis with reduced pain during photodynamic therapy of actinic keratosis.

This invention relates to novel, highly efficient subcellular targeted drug delivery conjugates, their preparation methods, compositions, and uses. The conjugates include a carrier module, a controlled-release module, a connecting arm, a subcellular targeting module, and a pharmacodynamic module. The conjugates of this invention can be used in applications such as highly efficient photodynamic therapy, chemotherapy, and immunotherapy targeting organelles, or in combination thereof.

This invention relates to the field of photodynamic therapy for keloids, and discloses a mitochondrial-targeted photodynamic keloid therapeutic agent based on platinum complexes and its application. The agent is prepared by coordinating the organic ligand TBQQ with an activated cisplatin derivative in a 1:1 molar ratio, followed by column chromatography purification to produce a high-purity TBQQPt powder with an active ingredient purity ≥98%. The prepared TBQQPt powder is then administered through a standardized drug formulation, intratumoral administration, and photo-activation process, combined with a multi-dimensional efficacy monitoring and safety evaluation system. Leveraging the D-A type planar square coordination structure of TBQQPt, which endows it with type I / II mixed photodynamic reaction characteristics, mitochondrial targeting, and photocatalytic oxidation of NADH, it synergistically exerts a dual effect of energy deprivation and genome disruption, effectively inducing mitochondrial dysfunction and apoptosis of keloid fibroblasts, and inhibiting their proliferation.

This invention relates to exosome formulations loaded with atomically precise metal nanoclusters, their preparation, and applications, belonging to the field of biomedical technology. This invention uses atomically precise metal nanoclusters as the imaging optical signal unit and photothermal / photodynamic therapy unit of the formulation, and exosomes as the biological functional unit of the formulation. The optical signal of the formulation in the 400nm-1700nm wavelength band can trace the delivery pathway of exosomes; its photothermal / photodynamic properties can enhance the therapeutic effect of exosomes at the cellular and tissue levels, and improve the therapeutic activity of exosomes. Simultaneously, this formulation also exhibits renal clearance properties. The nanoformulations provided by this invention can achieve non-destructive labeling of exosomes, and possess the functions of characterizing exosome in vivo transport pathways, improving target site enrichment efficiency, and enhancing cell and tissue therapeutic performance, significantly improving the diagnostic and therapeutic efficacy and biosafety of exosomes.

1. Name of the product in this design: Photodynamic Therapy Mask. 2. Purpose of this design: For the treatment of facial acne. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D rendering 2.

This utility model relates to the field of photodynamic therapy devices, and more particularly to an adjustable photodynamic therapy device, comprising a base, with universal wheels at the bottom of the base having a limiting function, a main unit fixed on the base, a control panel on the right side of the main unit, a crossbeam extending to the left at the top of the main unit, a vertical sleeve on the lower left end of the crossbeam, an n-shaped frame with circumferentially adjustable angle inside the sleeve, a treatment head with vertically rotatable adjustable angle inside the n-shaped frame, and a detachable protective structure on the outside of the treatment head. It is simple to operate, convenient to use, and suitable for various patients.

This invention relates to the field of nitric oxide donor technology, and particularly to a porphyrin-fused nitric oxide donor, its preparation method, and its application. The method includes the following steps: mixing an aromatic aldehyde containing a halomethyl group, potassium carbonate, and a solution of 3-trifluoromethyl-4-nitrophenol, reacting the mixture, extracting and washing, drying the organic phase, and concentrating under vacuum; purifying the first crude product by column chromatography; dissolving the NO donor intermediate, adding pyrrole for degassing, adding trifluoroacetic acid, then adding a solution of 2,3-dichloro-5,6-dicyanobenzoquinone; after the reaction is complete, adding triethylamine; recrystallizing and dissolving the second crude product, adding petroleum ether for sealing and freezing; filtering, washing the precipitate, drying, and purifying by column chromatography to obtain the porphyrin-fused nitric oxide donor. This method achieves spatial confinement and fixation of the NO donor group, integrating photodynamic therapy, gas therapy, and fluorescence tracer functions, and solves the problems of low spatial and temporal control precision, difficulty in balancing stability and release efficiency, and limited functionality of existing NO donors.

The application discloses a multimodal antibacterial biological heterojunction, a preparation method and application thereof, and comprises the following steps: S1, preparing a dispersion liquid of single-layer Ti3C2 nanosheet; S2, preparing Fe and Cu doped metal organic framework material: FeCu-MOF; S3, compounding the single-layer Ti3C2 nanosheet and the FeCu-MOF to prepare the multimodal antibacterial biological heterojunction. The MXene / FeCu-MOF heterojunction is innovatively constructed, the band structure and near-infrared plasmonic effect are regulated, the directional transfer of electric charges is effectively promoted, the chemical dynamic therapy (CDT) and photodynamic therapy (PDT) effects are significantly enhanced, and the synergistic effect with photothermal therapy (PTT) is generated. The application designs a new multimodal non-antibiotic treatment strategy, which can realize efficient killing and removal of methicillin-resistant Staphylococcus aureus.

The present invention relates to a reduced graphene oxide nanocomposite for targeting multiple drug-resistant cancer cells capable of simultaneously performing enhanced photothermal therapy and photodynamic therapy, and a method for manufacturing the same. The nanocomposite of the present invention comprises reduced graphene, poly(N-isopropylacrylamide)-acrylic acid, and folic acid, thereby exhibiting excellent targeting function for multiple drug-resistant cancer cells. In particular, when an anticancer agent including indocyanine green is encapsulated internally, it exhibits a synergistic effect of photothermal and photodynamic therapy against multiple drug-resistant cancer.

The application discloses an NGR peptide coupled ruthenium complex and a preparation method and application thereof, and belongs to the technical field of tumor photodynamic therapy. The application couples NGR peptide and a two-photon active ruthenium complex to construct a double-targeted photosensitizer. The NGR oligopeptide can specifically combine with CD13 receptors which are highly expressed on the surface of tumor vascular endothelial cells and tumor cells, realize double targeting of'vessel+tumor cell', and significantly improve the tumor enrichment efficiency of drugs. The NGR peptide coupled ruthenium complex provided by the application can efficiently generate active oxygen under the excitation of 820 nm near-infrared light, specifically kill CD13 positive target cells, and the tissue penetration depth can reach 250 microns, which is suitable for deep tumor treatment. Meanwhile, the NGR peptide coupled ruthenium complex can efficiently destroy the pipe forming ability of vascular endothelial cells, and significantly inhibit tumor angiogenesis.

This invention relates to the field of biomedical technology, specifically to the application of an organic photosensitive acid generator in the preparation of antitumor drugs. In this invention, an organic photoresponsive molecular system is constructed. The organic photosensitive acid generator possesses the synergistic effect of photoacid therapy (PAT) and photodynamic therapy (PDT), enhancing the efficacy of photoactivated therapy and improving the reliability and effectiveness of tumor treatment. Under ultraviolet light irradiation of a specific wavelength, the organic photosensitive acid generator produces a large amount of H₂. + Reactive oxygen species (ROS) can damage the DNA, proteins, and lipids of tumor cells, thereby inducing cell death.

An intraoperative probe combines Raman spectroscopy, shear wave elastography (SWE), and photodynamic therapy (PDT), preferably in a single hand-held device with real-time machine learning analysis. The machine learning independently analyzes and then fuses the data from different modalities for real-time cancer diagnostic predictions. The approach herein leverages simultaneous (or near-simultaneous) collection and real-time processing of Raman and SWE data for immediate cancer diagnostic feedback and therapeutic action. The hand-held device is precisely configured to target the same focal point with three different modalities—Raman, SWE, and PDT—by positioning the modalities within the device into the same location, either with an array of mirrors or an automatic or manual rotation mechanism.

This invention relates to a D-A-D structured NIR-II photothermal material, its preparation method, and its applications. Specifically, the photothermal material of this invention has a simple structure, is easy to synthesize, is easy to purify, and has a high yield. Furthermore, due to its large conjugated system, the molecular structure is stable and not easily degraded under NIR-II light irradiation. In addition, the photothermal material of this invention has excellent optical properties, good photothermal conversion efficiency, extremely low biotoxicity, and broad ultraviolet absorption in the 800-1000 nm range. Therefore, it has great application prospects in near-infrared photodynamic therapy and tumor treatment.

The present application relates to a kind of hollow structure fluorescent powder, specifically a kind of hollow structure rare earth doped bismuth vanadate fluorescent powder, preparation method and application, belong to the technical field of environment-friendly rare earth luminescent inorganic fluorescent powder.The chemical composition of the fluorescent powder of the present application is as follows: (Bi) x (Re1) y (Re2) 1‑x‑y VO4, wherein Re is a rare earth ion, 20≤x≤99.9 mol%, 0.01≤y≤80 mol%, and Re1 and Re2 are different.The preparation method of the present application is mainly based on the Kendall effect combined with hydrothermal sacrificial template method.The hollow structure rare earth doped bismuth vanadate fluorescent powder prepared has the characteristics of uniform morphology, high crystallinity, controllable shell number, etc., and realizes the accurate control of the hollow structure of the fluorescent powder in the template sacrifice process.Compared with the prior art and products, the rare earth doped bismuth vanadate fluorescent powder provided by the present application has low cost, large specific surface area, many active sites, low density, good repeatability and good dispersion performance, and has potential application value in the fields of anti-counterfeiting, small molecule detection, photodynamic therapy, biological imaging and CT imaging potential contrast agent, etc.

1. Name of the product in this design: Abdominal Fitness Belt (EMS Photodynamic Therapy Instrument S9Pro+). 2. Purpose of this design: for waist massage and abdominal massage. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

This invention discloses the application of albumin-loaded drug-eluting nanoparticles for dual-phototherapy in the preparation of drugs for treating cervical cancer, belonging to the field of pharmaceutical technology. The albumin-loaded drug-eluting nanoparticles of this invention are formed by loading indocyanine green and hydroxyalizarin onto albumin; the nanoparticle system simultaneously contains ICG and purpurin; the ICG photothermal agent can not only convert light energy into heat energy through photothermal action, but also generate reactive oxygen species through photodynamic therapy to inhibit cell activity, while purpurin inhibits GDH1 activity, disrupting intracellular redox homeostasis and cutting off the nutrient supply to cancer cells. Based on the above three anti-tumor mechanisms, this invention overcomes the shortcomings of single-treatment chemotherapy, such as high toxicity and low therapeutic effect. By combining the nanosystem with photodynamic and photothermal therapy, the therapeutic effect of hydroxyalizarin on cervical cancer cells is improved, providing a new solution to the technical challenges of high recurrence and mortality rates in cervical cancer.