479 results about "Photodynamic therapy" patented technology

This present disclosure is directed to poly (ADP-ribose) polymerase (PARP) inhibitor nanoparticle composition and methods of use and preparation thereof. PARP inhibitor dose reduction through combination treatment may be achieved using photodynamic therapy or photoimmunotherapy.

The invention discloses a drug-loaded liposome nano-particle, a preparation method thereof and application of the drug-loaded liposome nano-particle in treatment of brain glioma, and belongs to the technical field of biological nano-medicines. The invention provides a novel copper phthalocyanine derivative and catalase co-loaded lipidosome nanoparticle and application of the novel copper phthalocyanine derivative and catalase co-loaded lipidosome nanoparticle to treatment of brain glioma on the cellular level. The nano-particles are obtained by wrapping copper phthalocyanine derivatives and catalase with lipidosome prepared by a microfluidic method. The co-drug-loaded liposome can catalyze excessive H2O2 in brain glioma to generate oxygen, and O2 is continuously supplied to photodynamic therapy (PDT) to generate active oxygen; meanwhile, Cu < 2 + > can deplete glutathione and improve the oxidative stress level in the glioma, the reduction product Cu < + > can convert H2O2 into hydroxyl radicals with higher toxicity through a Fenton-like reaction, oxidative stress injury is doubly amplified, cascade cooperation of PDT and chemical dynamic therapy (CDT) is achieved, and the treatment effect on the glioma is remarkably enhanced.

The invention discloses a method for preparing a methylacryloyl chitosan / gelatin-based hydrogel wound dressing through 3D printing and application, and relates to a method for preparing a hydrogel wound dressing and application. The problems that existing MXene is high in photo-thermal conversion temperature, and bacteria rapidly breed again after near-infrared irradiation is closed are solved. The ZGC composite hydrogel wound dressing integrates multiple functions, can simultaneously realize hemostasis, antibiosis, anti-inflammation, vascularization promotion and cell regeneration, and is especially suitable for infectious wounds. The antibacterial performance can be achieved under the activation of near-infrared light through the dual effects of a photothermal therapy and a photodynamic therapy, and meanwhile, the antibacterial effect can be achieved in cooperation with Zn < 2 + >. The ZGC composite hydrogel wound dressing can be accurately customized and printed through a 3D printing technology according to the shape and depth of a wound, the composite dressing can achieve accurate low-temperature photo-thermal treatment, meanwhile, the continuous release of Zn < 2 + > and the physical antibacterial function of MXene are maintained, normal tissue is protected while bacteria are killed, and the healing rate of an infected wound is remarkably increased.

A system, for transcutaneous photodynamic therapy in an organ or organ segment of an organic body, includes a plurality of light applicators (9), a supply unit (23) and a placement template (39) placeable relative to the organic body for defined orientation of the light applicators. The light applicators include a needle-shaped insertion portion (15) for transcutaneous piercing along a piercing axis (E), a light-emitting applicator tip (19) at the distal end (13) of the insertion portion, and a fixing point (43) at a proximal distance d from the applicator tip. The placement template defines a plurality of fixing point receptacles (51) for fixing the light applicators with a defined fixing point and includes a first and second template parts (71, 75) defining first and second subsets (73, 77) of fixing point receptacles. The first template part is guidingly displaceable relative to the second template part along the piercing axis.

The invention relates to a structural design, synthesis and application of a biomass carbon dot modified poly L-cysteine-S-S-carboxylic acid amphiphilic polypeptide. The invention provides a structural design, synthesis and application of poly (L-cysteine-S-S-carboxylic acid) amphiphilic polypeptide (P-L-cys) modified by biomass carbon dots (CDs). Comprising synthesis of P-L-cys which contains hydrophobic groups, provides hydrophilic and functionalized carboxyl and provides reduction response by disulfide bonds, synthesis of CDs and CDs modified P-L-cys (CDs (at) P-L-cys), and the macroscopic performance change of the polypeptide is explored from regulation factors of a polypeptide secondary structure and a self-assembly nanostructure assembly mechanism. The P-L-cys and the CDs (at) P-L-cys prepared by the invention have functionalization, fluorescence imaging and dual-response drug release and have particle sizes suitable for drug delivery and enrichment, and the CDs also provide a photo-thermal and photodynamic synergistic treatment effect and have good application prospects in the fields of drug delivery, cancer resistance and the like.

The invention discloses a targeted nano delivery system based on curcumin (Cur) and near-infrared aggregation-induced emission (AIE) molecule BDTA and application of the targeted nano delivery system in treatment of glioblastoma (GBM), and belongs to the field of biomedicine. The nano platform is composed of nanoparticles (MPMs (at) Cur-BDTA NPs) modified by a macrophage membrane, curcumin and BDTA are combined by adopting a coprecipitation method, and the targeting property of the nano platform to tumors is enhanced through modification of the macrophage membrane. The nanometer platform combines the functions of photo-thermal therapy (PTT), photodynamic therapy (PDT) and chemotherapy, and can achieve multiple treatment effects. The curcumin improves PTT sensitivity by down-regulating expression of heat shock protein HSP-70 in the platform, and effectively improves photothermal conversion efficiency (87.6%) and singlet oxygen generation amount (1.7 times higher than that of a control group) through a Foster resonance energy transfer (FRET) mechanism. In a glioblastoma in-vitro experiment, the nano platform shows a synergistic treatment effect of photo-thermal, photodynamic and chemotherapy. The invention provides an intelligent treatment platform integrating photo-thermal treatment, photodynamic treatment and chemotherapy, and provides an efficient and safe innovative treatment strategy for precise treatment of glioblastoma.

The invention belongs to the technical field of medicines, and discloses a near-infrared cyanine probe for detecting penicillin G acylase as well as a preparation method and application of the near-infrared cyanine probe. According to the research, a near-infrared fluorescent probe Cy-NEO-PA responding to penicillin G acylase (PGA) is developed, so that the influence of environmental factors on the formation of an acinetobacter baumannii biological membrane is observed. Research results show that glucose inhibits the generation of PGA to enhance the formation of a biological membrane, while phenylacetic acid (PAA) stimulates the generation of PGA and inhibits the formation of the biological membrane. The observation results highlight the excellent capability of Cy-NEO-PA in accurately measuring PGA kinetics, and reveal the key effect of PGA in biological membrane development. In addition, the Cy-NEO-PA has good biocompatibility, strong active oxygen generation, efficient photo-thermal conversion and bacterial targeting ability, so that the Cy-NEO-PA becomes a promising drug for resisting bacterial infection and promoting wound healing through photo-thermal / photodynamic therapy.

The embodiment of the invention discloses a photodynamic therapy device and an endoscope system, and relates to the technical field of endoscopes. The photodynamic therapy device comprises: a light source for providing therapy light; the incident end of the light guide part is coupled with the light source, and the light guide part is used for guiding out treatment light; the focus-adjustable lens group is arranged at the emergent end of the light guide part and is used for adjusting the divergence angle of the treatment light emitted from the light guide part according to the control signal; and the controller is respectively connected with the light source and the focus-adjustable lens group, and is configured to drive the focus-adjustable lens group according to the received signal containing the target divergence angle, so that the treatment light is emitted according to the target divergence angle. Based on the scheme, the photodynamic therapy operation process can be simplified, the operation burden of a doctor is reduced, and the treatment efficiency is improved.

The invention discloses photo-thermal conversion wood-based hydrogel and a preparation method thereof in the technical field of nano materials and biological materials, and the preparation method comprises the following steps: synthesizing a conjugated polymer CP, dissolving the CP in THF, and adding DSPE-PEG2000 and hemin to obtain CP-Hemin nano powder; and compounding the CP-coated Hemin nano powder, flexible wood and PVA (Polyvinyl Alcohol) to obtain the wood-based hydrogel. The wood-based hydrogel provided by the invention has high photothermal conversion efficiency, can be rapidly heated under laser induction of a near-infrared second region, releases reactive oxygen free radicals at the same time, can be applied to photothermal therapy and photodynamic therapy, and has a prospect of being applied to the fields of catalysis, medical treatment and the like.

The invention discloses a preparation method and application of multifunctional antibacterial gel, and relates to the technical field of biomedical injectable hydrogel materials with antibacterial activity. The cationic guar gum (CG) is used as a cross-linked network and is loaded with a water-soluble Fe (II)-based metal organic metal cage (Fe-1SO4), and through in-situ chemical dynamic therapy (CDT) and photodynamic therapy (PDT) induced under irradiation of 660 nm laser, rapid healing of surface wounds is promoted through synergistic antibiosis. Fe-1SO4 is a water-soluble metal cage which takes Fe (II) as a metal node and 5, 10, 15, 20-tetra (4-aminophenyl)-21H, 23h-porphyrin (TAPP) as an organic ligand, and can be quickly degraded within 5 days in a biological environment. According to the present invention, with the application of the fenton-like reaction in the preparation of the antibacterial agent, the obvious PDT effect can be provided under the irradiation of 660 nm laser so as to generate a large amount of singlet oxygen (1O2), and the fenton-like reaction can convert H2O2 generated by bacterial infection into toxic hydroxyl radicals (OH) in situ, such that the excellent antibacterial activity can be provided in vivo and in vitro, and the wound healing can be promoted. The invention provides a simple strategy for the design of the rapidly degradable antibacterial hydrogel dressing, and is an important step for the clinical application of biological materials.

The invention discloses an anti-tumor intelligent double-crosslinking hydrogel drug delivery system based on a purple phosphorus nanosheet and a preparation method and application thereof, the system comprises a hydrogel carrier, a photodynamic carrier material and a drug, and the hydrogel carrier is a drug delivery carrier formed by crosslinking polydimethyldiguanide with Fe < 3 + > and a crosslinking agent; the photodynamic carrier material is a purple phosphorus nanosheet; the medicine is a medicine with two effects of inhibiting hypoxia-inducible factor-1 alpha and lowering PD-L1 down. According to the invention, the purple phosphorus nanosheet and the polydimethyldiguanide / Fe < 3 + > bi-crosslinking hydrogel are taken as carriers to prepare the tumor microenvironment response type hydrogel drug delivery system with good pH responsiveness, injectability and self-healing property, so that an effective solution is provided for tumor precise drug delivery mediated by a new material, namely the purple phosphorus nanosheet, as a nano-drug carrier; the invention also provides an effective photodynamic therapy strategy for anti-tumor application of the intelligent double-crosslinking hydrogel and precise treatment of breast cancer.

The invention belongs to the technical field of antitumor drugs, and particularly discloses a preparation method and application of a compound for near-infrared fluorescence imaging and photothermal-photodynamic synergistic treatment. The compound for near-infrared fluorescence imaging and photothermal-photodynamic synergistic treatment is shown in the following structural formula: # imgabs0, the molecular skeleton of the compound contains a triphenylamine unit and an N, N-dimethylaniline fragment, intramolecular rotation limitation and intramolecular vibration limitation can be generated, and obvious aggregation-induced emission (AIE) performance is shown. The function-integrated phototherapy agent has high active oxygen generation efficiency, photothermal conversion efficiency and near-infrared fluorescence quantum yield, and is beneficial to obtaining ideal photothermal-photodynamic therapy effect for deep tumors. The phototherapy agent is novel in structure, the preparation method is easy in raw material obtaining, the synthesis condition is mild, the preparation method is simple, purification is convenient and fast, implementation is easy, and the phototherapy agent has great application prospects.

The invention belongs to the field of biomedical luminescent composite materials, and particularly relates to a rare earth up-conversion nanocrystalline particle-hydrogen bond organic framework composite material and a preparation method thereof.The rare earth up-conversion nanocrystalline particle NaGdF4: Yb / Er serves as a core of the composite material, a hydrogen bond organic framework serves as a shell of the composite material, and the rare earth up-conversion nanocrystalline particle-hydrogen bond organic framework composite material is prepared. The advantages of the rare earth up-conversion nanocrystal particles and the hydrogen bond organic framework are ingeniously combined, the rare earth up-conversion nanocrystal particles and the hydrogen bond organic framework form a synergistic system, active oxygen is generated under excitation of 980 nm near-infrared light during photodynamic therapy, meanwhile, generation of the active oxygen is more efficient, the killing efficiency on tumor cells is improved, and the application prospect is wide. The rare earth up-conversion nanocrystal particle is suitable for deep tumor (such as brain glioma) treatment, meanwhile, the porphyrin core of TCPP is matched with the visible light emission spectrum of the rare earth up-conversion nanocrystal particle, efficient energy transfer is achieved, and the singlet oxygen yield is remarkably higher than that of a traditional PDT material.

The invention relates to an experimental system and method for photodynamic therapy, photothermal therapy and combined research of photodynamic therapy and photothermal therapy. The experiment system comprises an optical irradiation module which comprises a plurality of laser light sources, each laser light source can output collimated light beams, the collimated light beams are combined to form a coaxial light path, and the coaxial light paths are projected to the surface of an observation object through a light beam adjusting assembly; the light path position adjusting module comprises an electric Z-axis displacement mechanism; the temperature monitoring module comprises an active temperature control substrate, an infrared thermal imager and an optical fiber temperature probe interface; the data acquisition and control module is configured to synchronously acquire laser output power, light spot area, electric Z-axis position, temperature of the active temperature control substrate, temperature sequences of a plurality of different areas and optical fiber temperature probe data, and associatively record the data with a unified timestamp; the power density can be calculated based on the real-time output power of the laser light source and the light spot area; and when the data of any temperature monitoring channel exceeds a preset safety threshold value, the laser light source is automatically controlled to close the output.

The invention discloses a para-substituted heptamethine quinone cyanine dye as well as a synthesis method and application thereof, the structural general formula of the para-substituted heptamethine quinone cyanine dye is shown as I, that is, by introducing a specific quinone structure and a substituent group, the near-infrared light absorption and triplet excited state generation capability is optimized. The dye efficiently absorbs light within the wavelength range of 600-700 nanometers, the intersystem crossing efficiency is remarkably improved, and the photo-initiation effect is enhanced. According to the dye, heavy atoms are not used, and the solubility and the environmental protection property are improved. The synthesis method is simple, low in cost, mild in condition and suitable for large-scale production. The key steps comprise formation of quaternary ammonium salt, preparation of a condensing agent and synthesis of a final product, and parameters of each step are optimized to ensure high yield. The dye is suitable for photodynamic therapy, photoinitiation of photopolymerization materials, biological imaging and the like, and has a wide application prospect.

The invention belongs to the technical field of biology, and particularly relates to a construction method of a TMV and AIE hybrid material as well as a product and application of the TMV and AIE hybrid material. By optimizing TMV purification conditions, the problems of strip dispersion, strip taking difficulty and the like after ultracentrifugation are effectively solved. After TMV is extracted and purified, AIE is dissolved in a KP buffer solution to prepare an AIE molecular solution, then the purified TMV and the AIE molecular solution are mixed and incubated according to the volume ratio of 10: 1, the hybrid material with fluorescence tracing and photodynamic therapy activity is obtained, in-vivo and in-vitro visual tracking imaging and reactive oxygen species (ROS) release functions are achieved, the diagnosis and treatment integrated potential is shown, and the application prospect is wide. And the application boundary of the TMV in the fields of precision medicine and the like is expanded.

The invention discloses an H-aggregation type I photosensitizer as well as a preparation method and application thereof. The structural formula of the H-aggregation type I photosensitizer disclosed by the invention is # imgabs0. The H-aggregation type I photosensitizer disclosed by the invention is characterized in that aminophenylboronic acid and 5-bromothieno [3, 2-b] thiophene-2-formaldehyde are subjected to a reaction to obtain an intermediate product NBSCHO, and the NBSCHO and 3-(dicyanomethylene) indanone IC are subjected to a reaction to obtain the H-aggregation type I photosensitizer. The photosensitizer disclosed by the invention has a D-pi-A type molecular structure, and due to a well-designed plane characteristic between a pi structure and an A structure, the photosensitizer has relatively strong pi-pi accumulation capacity, and formation of H-aggregation accumulation of the photosensitizer is driven, so that the active oxygen generation effect of molecules, especially generation of I type active oxygen, is improved. The material can efficiently generate I-type active oxygen under the irradiation of white light or near-infrared laser, so that tumor cells are efficiently killed, and an efficient photodynamic therapy effect is shown.

The invention discloses a preparation method and application of a porous GelMA microneedle for delivering AIE molecules based on HSF derived exosome. The preparation method comprises the following steps: S1, preparing TTMN molecules; s2, dispersing DPPC and Chol in chloroform, performing water bath evaporation at 50 DEG C to form a thin film, hydrating the thin film in PBS, incubating to enable DPPC and Chol to form a liposome structure again, and uniformly dispersing TTMN molecules in the liposome structure to obtain TL; s3, extracting an exosome from the HSF cells; s4, loading the TL into the exosome by utilizing an electroporation technology, so as to obtain TE; s5, preparing the GelMA; and S6, mixing the GelMA with the TE, so that the TE is uniformly dispersed in the GelMA to obtain a mixed solution, injecting the mixed solution into a microneedle mold, and irradiating with 405nm laser to obtain the porous GelMA microneedle. According to the invention, high-efficiency treatment of hypertrophic scars is realized, and the system has a remarkable drug delivery effect, an innovative photodynamic therapy, a high-efficiency scar tissue remodeling effect and good biological safety and stability, and has important clinical application value and market prospect.

The invention relates to a photodynamic therapy system for treating bladder cancer, and belongs to the technical field of photodynamic therapy. The system comprises a treatment catheter assembly used for performing laser energy delivery and biosensing signal acquisition on a bladder lesion area; the central control unit is used for data processing and control signal generation, and the central control unit can obtain tissue oxygen partial pressure and singlet oxygen concentration according to the biosensing signals collected by the treatment catheter assembly and generate control signals used for regulating and controlling laser energy delivery operation of the treatment catheter assembly according to the tissue oxygen partial pressure and the singlet oxygen concentration; the treatment catheter assembly can perform laser energy delivery operation on tumor tissue in a bladder lesion area in an intermittent mode, the interval time length and applied illumination parameters are changed based on the real-time concentration change condition of singlet oxygen, and the illumination parameters comprise light intensity and wavelength.

The invention discloses a fluorescent / photoacoustic dual-mode diagnosis and treatment probe for detection and photodynamic removal of senescent cells, a preparation method and application, the probe takes a sulfur-substituted hemicyanine dye as a parent structure, a novel bromo-glycoside ligand is covalently coupled, and a blue-green solid is obtained after gradient purification. The probe system shows a remarkable optical response characteristic on beta-galactosidase (beta-Gal) and ideal singlet oxygen (1O2) generation efficiency; an optical signal and a photodynamic therapy effect of the probe can be specifically activated by beta-galactosidase (beta-Gal) overexpressed in cancerous cells and senescent cells under a light excitation condition; the result is successfully verified in a palbociclib-induced senescence melanoma model. According to the probe disclosed by the invention, collaborative regulation and control of dual-mode visual monitoring and precise photodynamic therapy of beta-Gal enzyme activity are realized for the first time, a novel tool is provided for researching a molecular mechanism of cell aging and developing a diagnosis and treatment strategy of aging-related diseases, and the probe has a remarkable application value in the fields of anti-tumor treatment and degenerative diseases.

Methods and systems are described for implementing a photodynamic therapy. An example method may comprise determining, during photodynamic therapy and using a plurality of optical probes spatially distributed within a patient, data indicative of one or more of a photodynamic therapy dosage, a fluence rate of a photodynamic therapy treatment light, or a reactive oxygen species concentration associated with corresponding locations of the plurality of optical probes. The example method may comprise changing, based on the data, one or more treatment parameters associated with providing a photodynamic therapy.

The invention discloses a Nile blue dye and a preparation method thereof, a preparation method of a packaging film based on the prepared dye and application of the dye and the packaging film, and belongs to the technical field of food monitoring and preservation. Based on a Nile blue parent structure, different heavy atoms are introduced into a meso-position, and alkyl chains with different chain lengths are introduced into an amino position, so that various photosensitive dyes with pH response and photodynamic therapy capability are constructed. By comparing various heavy atom substitution structures, the dye I and the dye II have certain sensitivity to the pH value of a solution, and the sulfo-dye packaging film and the seleno-dye packaging film both show excellent antibacterial ability to escherichia coli. The dye I packaging film and the dye II packaging film have excellent bacteriostatic activity on escherichia coli. Visual detection of the rotting process of fresh shrimps and preservation of bananas can be realized.

The invention belongs to the technical field of biological medicine and nanotechnology, and particularly relates to nanoparticles loaded with curcumin and antibacterial peptide as well as a preparation method and application of the nanoparticles. The nanoparticles loaded with the curcumin and the antibacterial peptide are prepared by the following steps: taking PEI-PLGA and the curcumin as raw materials, and preparing PEI-PLGA-Cur nanoparticles; pEI-PLGA-Cur nanoparticles and the antibacterial peptide are used as raw materials, and the nanoparticles loaded with the curcumin and the antibacterial peptide are prepared. The nanoparticles loaded with the curcumin and the antibacterial peptide provided by the invention have a photodynamic therapy effect, the drug loading capacity of the curcumin in the nanoparticles is relatively high, the loading rate of the antibacterial peptide is relatively large, auxiliary materials are safe, the preparation process is simple, the particle size of the nanoparticles is relatively small and uniform, the blood compatibility is good, the nanoparticles can be used for treating infection of drug-resistant bacteria, and the application prospect is wide. The potential of becoming a novel nano antibacterial drug and the clinical application prospect are realized.

The invention discloses a triarylmethane type I photosensitive dye as well as a synthesis method and application thereof. The structure of the dye is shown as a general formula I; intramolecular charge separation is optimized by regulating substituent groups, and the generation efficiency of superoxide anions and hydroxyl radicals is remarkably improved. According to the synthesis method, 4-diphenylaminobenzaldehyde or 4-vinyl benzaldehyde is used as a raw material, efficient preparation is achieved through the steps of condensation, oxidation and the like, the raw material is easy to obtain, and operation is easy and convenient. The dye has strong absorption at the wavelength of 600-630 nm, is suitable for red light triggered photodynamic therapy (PDT), especially keeps high reactive oxygen yield under the hypoxic condition, and breaks through the oxygen dependence limitation of traditional PDT. Experiments show that the dye can induce ferroptosis of tumor cells, has the functions of fluorescence imaging and treatment, and has wide application prospects in the fields of antitumor drugs, in-vivo fluorescence labeling, photoresponsive functional preparations and the like.

The invention relates to a composite drug-loaded nano particle based on a calcium peroxide carrier, which is a composite drug-loaded nano particle CaO2 (at) HA / pllCe6 formed by loading polylysine-chlorin e6 (pllCe6) on the surface of a calcium peroxide nano particle modified by hyaluronic acid serving as a carrier, and the composite drug-loaded nano particle is a spherical particle with the particle size of about 100nm. Ce6 is converted into plCe6 through polylysine modification, then the plCe6 is compounded with hyaluronic acid modified calcium peroxide nanoparticles, the plCe6 is uniformly loaded on the surface of the plCe6, the self-oxygen-supply composite nano drug-loaded particle CaO2 (at) HA / plCe6 is formed, the problem that Ce6 cannot be attached to the surface of CaO2 nanoparticles is solved, the prepared nano composite particle is uniform in particle size and high in specific surface area, and after plCe6 and CaO2 (at) HA are compounded, the self-oxygen-supply composite nano drug-loaded particle has a good drug-loading effect. As a good bacterial microenvironment response material, the material can improve the hypoxia condition of bacterial parts and enhance photodynamic therapy; on the other hand, the biocompatibility and the delivery efficiency of Ce6 are improved, so that a remarkable bactericidal effect is achieved at a low dosage.

The invention discloses a novel supramolecular cyanine dye contrast agent for enhancing photoacoustic, and a preparation method and application thereof. Wherein the molecular pair cyanine dye is composed of a cationic indocyanine dye and an anionic tricyanofurancyanine dye. The dye is subjected to J-aggregation in water, so that the absorption wavelength is subjected to red shift to a near-infrared region, and excellent photothermal conversion efficiency (10-80%) and singlet oxygen quantum yield (10-50%) are shown. The photoacoustic imaging performance is excellent, and the intensity of a photoacoustic signal generated under the concentration of 25.0 mu M is 7.1 times that of ICG; the photo-thermal treatment effect is obvious, the photo-thermal conversion efficiency is as high as 66%, and the temperature is rapidly increased to 48 DEG C. In addition, the dye shows excellent light stability and photobleaching resistance, the absorbance is only attenuated by 25% under strong laser, and the dye has good biocompatibility and safety. The multi-mode application comprises photoacoustic and fluorescence imaging, photothermal and photodynamic therapy and the like, and has a good application prospect.

The application discloses an iron / copper-porphyrin nanoparticle and a preparation method and application thereof, and the nanoparticle is prepared through the following steps: adding iron chloride, copper chloride, tetra(4-carboxyphenyl)porphyrin and benzoic acid into a reaction solvent N,N-dimethylformamide solution, uniformly stirring at room temperature, and reacting at high temperature; and after the reaction is completed, the iron / manganese-porphyrin nanoparticle is obtained through centrifugation and washing. The iron / manganese-porphyrin nanoparticle is prepared by using a brand-new method, the nanoparticle can be degraded in a glutathione solution and release iron ions and copper ions, is used for catalyzing hydrogen peroxide to be converted into a hydroxyl radical (•OH), and tetra(4-carboxyphenyl)porphyrin can generate singlet oxygen (O2) under 660 nm laser irradiation, and is expected to become a good nano-carrier for accelerating photodynamic therapy-chemical kinetic therapy. 1 O2).

The invention specifically discloses a beta-diketone iridium complex as well as a preparation method and application thereof, and relates to the technical field of biological medicines. The beta-diketone iridium complex provided by the invention has high phototoxicity and low dark toxicity, can be applied to tumor cells as effective PSs of PDT, and is specifically delivered to the tumor cells by taking a traditional Chinese medicine monomer tripterine as a supplement in combination with a nano-targeting delivery technology for photodynamic / immune synergistic treatment of hypoxic tumors.

To provide a topical composition for photodynamic therapy, an obstructive dressing material, a kit using them, a material for photodynamic therapy, and a method for photodynamic therapy.SOLUTION: In order to promote infiltration of a topical composition containing 5-aminolevulinic acid (ALA) applied on a treatment site for photodynamic therapy, transepidermal water loss from the treatment site is suppressed to the minimum by covering the treatment site by a low-density polyethylene barrier before phototherapy after the topical composition is applied to the treatment site.SELECTED DRAWING: Figure 3

The present invention discloses a lipid droplet nanocomposite for treating tumors, and a preparation method and application thereof. In the present invention, NRF‑2 protein inhibitor and ferritin targeting peptide are first loaded onto a two-dimensional nanosheet, and then the lipid droplets are wrapped on the surface of the two-dimensional nanosheet, and then the tumor targeting peptide is modified on the surface of the lipid droplets to obtain the nanocomposite for treating tumors. The nanocomposite can effectively inhibit tumor proliferation, metastasis and postoperative recurrence of tumors by cooperating with multiple therapies such as photodynamic therapy, ferroptosis and oxidative stress, and can effectively promote the death of tumor cells under hypoxic conditions, improve the effect of tumor treatment, and provide a new strategy for the treatment of cancer.