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1338 results about "Photodynamic therapy" patented technology
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Photodynamic therapy (PDT), is a form of phototherapy involving light and a photosensitizing chemical substance, used in conjunction with molecular oxygen to elicit cell death (phototoxicity). PDT has proven ability to kill microbial cells, including bacteria, fungi and viruses. PDT is popularly used in treating acne. It is used clinically to treat a wide range of medical conditions, including wet age-related macular degeneration, psoriasis, atherosclerosis and has shown some efficacy in anti-viral treatments, including herpes. It also treats malignant cancers including head and neck, lung, bladder and particular skin. The technology has also been tested for treatment of prostate cancer, both in a dog model and in human prostate cancer patients.
Therapy via targeted delivery of nanoscale particles
InactiveUS20050090732A1Destroying inhibiting vascularityAntibacterial agentsNervous disorderDiseaseProstate cancer
Disclosed are compositions, systems and methods for treating a subject's body, body part, tissue, body fluid cells, pathogens, or other undesirable matter involving the administration of a targeted thermotherapy that comprises a bioprobe (energy susceptive materials that are attached to a target-specific ligand). Such targeted therapy methods can be combined with at least one other therapy technique. Other therapies include hyperthermia, direct antibody therapy, radiation, chemo- or pharmaceutical therapy, photodynamic therapy, surgical or interventional therapy, bone marrow or stem cell transplantation, and medical imaging, such as MRI, PET, SPECT, and bioimpedance. The disclosed therapies may be useful in the treatment of a variety of indications, including but not limited to, cancer of any type, such as bone marrow, lung, vascular, neuro, colon, ovarian, breast and prostate cancer, epitheleoid sarcomas, AIDS, adverse angiogenesis, restenosis, amyloidosis, tuberculosis, cardiovascular plaque, vascular plaque, obesity, malaria, and illnesses due to viruses, such as HIV.
Owner:NANOTX INC
Microdermabrasion System with Combination Skin Therapies
A microdermabrasion system offers a combination of other skin therapies in conjunction with microdermabrasion. In an implementation, the system applies light therapy, photodynamic therapy, radio frequency and microwave energy therapy, massage therapy, or combinations of these while exfoliating the skin.
Owner:ENVY MEDICAL
Methods and apparatuses for positioning within an internal channel
InactiveUS20060135870A1Reduce congestionEliminate and reduce blockage effect of bloodStentsSurgeryPhotodynamic therapyDistal portion
Methods and apparatuses for positioning medical devices onto (or close to) a desired portion of the interior wall of an internal channel, such as for scan imaging, for photodynamic therapy and / or for optical temperature measurement. In one embodiment, a catheter assembly has a distal portion that can be changed from a configuration suitable for traversing the internal channel to another configuration suitable for scan at least a spiral section of the interior wall of an internal channel, such as an artery. In one example, the distal portion spirals into gentle contact with (or close to) a spiral section of the artery wall for Optical Coherence Tomography (OCT) scanning. The spiral radius may be changed through the use of a guidewire, a tendon, a spiral balloon, a tube, or other ways.
Owner:ABBOTT CARDIOVASCULAR
Light generating device to intravascular use
InactiveUS7252677B2High light transmittanceFacilitated DiffusionElectrotherapySurgical instrument detailsPhotodynamic therapyMedicine
Owner:LIGHT SCI ONCOLOGY
Methods for inhibiting angiogenesis
InactiveUS20060079538A1Facilitate clinical managementFacilitate continued complianceBiocideAnimal repellantsPhotodynamic therapyRadiofrequency ablation
The invention relates generally to methods for inhibiting angiogenesis. More particularly, methods for inhibiting angiogenesis comprise selectively inhibiting phosphoinositide 3-kinase delta (PI3Kδ) activity in endothelial cells. The methods may comprise administration of one or more cytotoxic therapies including but not limited to radiation, chemotherapeutic agents, photodynamic therapies, radiofrequency ablation, anti-angiogenic agents, and combinations thereof.
Owner:ICOS CORP +1
Scanning laser ophthalmoscope for selective therapeutic laser
A combination of a scanning laser ophthalmoscope and external laser sources (52) is used for microphotocoagulation and photodynamic therapy, two examples of selective therapeutic laser. A linkage device incorporating a beamsplitter (56) and collimator-telescope (60) is adjusted to align the pivot point (16) of the scanning lasers (38, 40) and external laser source (52). A similar pivot point minimizes wavefront aberrations, enables precise focusing and registration of the therapeutic laser beam (52) on the retina without the risk of vignetting. One confocal detection pathway of the scanning laser ophthalmoscope images the retina. A second and synchronized detection pathway with a different barrier filter (48) is needed to draw the position and extent of the therapeutic laser spot on the retinal image, as an overlay (64). Advanced spatial modulation increases the selectivity of the therapeutic laser. In microphotocoagulation, an adaptive optics lens (318) is attached to the scanning laser ophthalmoscope, in proximity of the eye. It corrects the higher order optical aberrations of the eye optics, resulting in smaller and better focused applications. In photodynamic therapy, a spatial modulator (420) is placed within the collimator-telescope (60) of the therapeutic laser beam (52), customizing its shape as needed. A similar effect can be obtained by modulating a scanning laser source (38) of appropriate wavelength for photodynamic therapy.
Owner:VAN DE VELDE JOZEK F
Light generating device to intravascular use
InactiveUS20050228260A1Rapid uptakeHigh light transmittanceElectrotherapySurgical instrument detailsBlood flowLinear configuration
Light generating devices for illuminating portions of vascular tissue, to render photodynamic therapy. In one embodiment, a light source array preferably including a plurality of light emitting diodes, a focusing lens, and a light diffusing element are included in a distal end of a catheter. A balloon is optionally provided to interrupt blood flow that can block the transmission of light, and to center the apparatus in a blood vessel. Optical fibers optionally direct light from the light source to the diffusing element. The light source array can have a radial or linear configuration and can produce more than one wavelength of light for activating different photoreactive agents. Linear light source elements are particularly useful to treat elongate portions of tissue in a vessel. One embodiment intended for use with a conventional balloon catheter integrates light sources into a guidewire.
Owner:LIGHT SCI ONCOLOGY
System and method for monitoring photodynamic therapy
InactiveUS20080221647A1High electromagnetic contrastHighly sensitive detection and monitoringSurgeryCharacter and pattern recognitionPhotodynamic therapyUltrasonic sensor
A system and method for monitoring photodynamic therapy of a target tissue, where the target tissue contains a photosensitizing substance, include a first light source configured to deliver light to the target tissue, the first light source having a wavelength capable of exciting the photosensitizing substance. An ultrasonic transducer receives photoacoustic signals generated due to optical absorption of light energy by the target tissue, and a control unit in communication with the ultrasonic transducer reconstructs photoacoustic tomographic images from the received photoacoustic signals to provide an indication of optical energy deposition due to the photosensitizing substance in the target tissue.
Owner:RGT UNIV OF MICHIGAN
Methods and devices for plasmon enhanced medical and cosmetic procedures
InactiveUS20050203495A1Enhanced and very confined body surgeryBetter-controlled surgery and treatment conditionsCosmetic preparationsHair removalHair removalMedical treatment
Composition of methods and devices for surface plasmon resonance-enhanced medical and cosmetic procedures are disclosed. The invention relates to the use of a nonlinear surface plasmon resonance generation source and metal nanoparticles embedded to a body to enhance medical and cosmetic procedures in the body. The methods and devices in this invention can be applied for very effective three-dimensionally localized body surgery, tattoo removal, skin pigmentation removal, hair removal, drug delivery, photodynamic therapy, thrombosis, lithotripsy and cosmetic body treatment. The present invention relates also to a method of making temporary, semi-permanent and permanent tattoos with surface plasmon resonance technique.
Owner:US PATENT & TRADEMARK OFFICE
Metallotetrapyrrolic photosensitizing agents for use in photodynamic therapy
Metallotetrapyrrolic compounds having photherapeutic properties useful in photodetection and phototherapy of target issues, particularly porphyrins and azaporphyrins that including gallium in the central pyrrolic core. Also disclosed are methods of using metallotetrapyrrolic compounds for the treatment or detection of cardiovascular disease.
Owner:MIRAVANT PHARMA
Optical apparatus for detecting and treating vulnerable plaque
InactiveUS7153299B1Easy to operateSimple, real-timeDiagnosticsSurgical instrument detailsFiberPhotodynamic therapy
An optical apparatus and methods for monitoring temperature enabling detection and treatment of a vulnerable plaque of a patient comprising an elongate catheter, a plurality of outer optical fibers deployably disposed within the lumen of the catheter and suitably expandable in an outwardly radial manner configured for forming a basket shape, the outer fibers having at least one optical grating along an axis of the fiber wherein the at least one optical grating reflects a certain wavelength or intensity of the light beam, the certain wavelength or intensity of the reflected light beam being correlated to known temperature, and a longitudinal middle optical fiber emitting a light energy suitable for photodynamic therapy.
Owner:MAXWELL SENSORS +1
Methods and formulations for photodynamic therapy
InactiveUS7094228B2Reducing and eliminating painRaise the pHElectrotherapyMedical devicesPhotodynamic therapyAnesthesia
Owner:NUVO RES
Device for irradiating tissue
InactiveUS7083610B1Minimize damageLess prone to failureSurgical instrument detailsLight therapyHair removalPhotodynamic therapy
A device for irradiating tissue includes a fluorescent element for receiving pump radiation and responsively emitting radiation having different spectral characteristics than the pump radiation. A redirector receives emitted radiation promulgated in a direction away from a tissue target and redirects the radiation toward the target. The pump radiation may be supplied, for example, by a flashlamp or frequency-doubled neodymium-doped laser. Use of the device provides an inexpensive and effective alternative to conventional dye laser-based systems for various medical therapies, including treatment of vascular and pigmented lesions, tattoo and hair removal, and photodynamic therapy (PDT).
Owner:BOSTON SCI SCIMED INC
Optical apparatus for detecting and treating vulnerable plaque
InactiveUS20050075704A1Simple, real-timeCatheterSurgical instrument detailsFiberPhotodynamic therapy
An optical apparatus and methods for monitoring temperature enabling detection and treatment of a vulnerable plaque of a patient comprising an elongate catheter, a plurality of outer optical fibers deployably disposed within the lumen of the catheter and suitably expandable in an outwardly radial manner configured for forming a basket shape, the outer fibers having at least one optical grating along an axis of the fiber wherein the at least one optical grating reflects a certain wavelength or intensity of the light beam, the certain wavelength or intensity of the reflected light beam being correlated to known temperature, and a longitudinal middle optical fiber emitting a light energy suitable for photodynamic therapy.
Owner:MAXWELL SENSORS +1
Apparatus and method for high energy photodynamic therapy of acne vulgaris and seborrhea
InactiveUS20020128695A1Increasing oxygen pressureStrong enoughElectrotherapyPhotodynamic therapySpectral emissionSpectral bands
An apparatus and method for the phototherapy of different skin conditions, particularly acne vulgaris and seborrhea. The invention transporting compounds, and / or a methylene blue solution. The apparatus includes at least one narrow spectral band light source with spectral emittance concentrated in the violet / blue spectral band and an optical system for controlling spectra and beam parameters of said light source and a mechanical fixture for holding the said light source at an adjustable distance and direction related to the skin treated area, and an electonic unit to control the duration and power and spectral bands of the emitted radiation.
Owner:CURELIGHT
Combined apparatus for detection of multispectral optical image emitted from living body and for light therapy
InactiveUS20110270092A1Simple structureRaman/scattering spectroscopyDiagnostics using fluorescence emissionFluorescenceDisplay device
The present invention provides a fluorescence detection and photodynamic therapy apparatus including: a combined light source unit 10 including a plurality of coherent and non-coherent light sources 11, 12 and 13 configured to irradiate light onto a to-be-observed object while performing continuous illumination; an optical imaging unit 20 configured to form an image of the to-be-observed object 70 and project the image to an image processing / controlling system 34; a multispectral imaging unit 30 including a one-chip multispectral sensor and the image processing / controlling system 34; a blocking filter 40 installed between the to-be-observed object 70 and the one-chip multispectral sensor 32, the blocking filter being configured to block some light reflected off from the to-be-observed object 70 while allowing some light and fluorescent light to pass therethrough; a computer system 50 configured to process, analyze, reproduce and store the image acquired from the multispectral imaging unit 30, and transfer the image to a display device 60 and control the overall operation of all the related elements; and the display device 60 configured to display a processing result of the image by the computer system 50.
Owner:KOREA ELECTROTECH RES INST
Multispectral therapeutic light source
ActiveUS20140288351A1High cost-effectiveHigh quantum-efficiencyElectrotherapySurgeryUltravioletPeak value
A light source apparatus including light spectrum-converting materials that emit light primarily over large portions of the 360 nm-480 nm and the 590-860 nm spectral range is provided. This apparatus provides a cooled, high-luminance, high-efficiency light source that can provide a broader spectrum of light within these spectral ranges than has been cost-practical by using many different dominant peak emission LEDs. Up to 15% of the output radiant power may be in the spectral range 350-480 nm in one embodiment of this device, unless a specific separate source and lamp operating mode is provided for the violet and UV. Control methods for light exposure dose based on monitoring and controlling reflected or backscattered light from the illuminated surface and new heat management methods are also provided. This flexible or rigid light source may be designed into a wide range of sizes or shapes that can be adjusted to fit over or around portions of the bodies of humans or animals being treated, or mounted in such a way as to provide the special spectrum light to other materials or biological processes. This new light source can be designed to provide a cost-effective therapeutic light source for photodynamic therapy, intense pulsed light, for low light level therapy, diagnostics, medical and other biological applications as well as certain non-organic applications.
Owner:JONES GARY W
Methods and devices for epithelial protection during photodynamic therapy
InactiveUS7220778B2Avoid damageReduce circulationBiocideElectrotherapyPhotodynamic therapyPhotosensitizer
Methods for preventing damage to epithelial tissue during PDT induced using a photosensitizing agent or pre-photosensitizing agent are provided. The methods of the present invention utilize spatial confinement to control photoactivation of the photoactive species to protect the epithelial tissue. In one embodiment, epithelial tissue surrounding a targeted treatment site can be protecting by decreasing the oxygen-content in the tissue, thereby preventing the conversion of the photosensitizer into the phototoxic species in the epithelial tissue.
Owner:THE GENERAL HOSPITAL CORP
Light diffuser and process for producing the same
ActiveUS20090318912A1Producing the light diffuser accordingEasy to adjustSurgical instrument detailsPhotodynamic therapyLiquid state
A light diffuser (10), which is particularly suitable for introducing diffuse light into a tissue, is produced by interpenetration of a diffuser material in a liquid state into a boundary layer (4) of a porous shaping material, by which process a diffuser surface is formed having a surface structure which represents essentially a negative of the pore structure of the shaping material and includes undercut structures induced by a surface tension. The light diffuser (10) is e.g. produced by introducing a diffuser blank (1) including material which is liquefiable through mechanical vibration into the shaping material and simultaneously stimulating it with mechanical vibrations, such that the liquefiable material liquefies at least there where it is in contact with the shaping material and is pressed into the shaping material. An in situ production of the diffuser is particularly advantageous for photodynamic therapy in bone tissue (20).
Owner:WOODWELDING
Liposome compositions of porphyrin photosensitizers
Liposomal pharmaceutical formulations incorporating porphyrin photosensitizers useful for photodynamic therapy or diagnosis of malignant cells. The liposomal formulations comprise a porphyrin photosensitizer, particularly the hydro-mono benzoporphyrins (BPD) having light absorption maxima in the range of 670-780 nanometers, a disaccharide or polysaccharide and one or more phospholipids.
Owner:QLT INC
Continuous low irradiance photodynamic therapy system and method
InactiveUS20070288071A1Avoid damageComfortable and convenient for patientDiagnosticsLight therapyPhotodynamic therapyFiber
Systems and methods are providing for treating a patient with continuous low irradiance photodynamic therapy. A disclosed method includes applying a photosensitizer to the patient; applying a conformable skin facing light applicator to the patient; and providing continuous low irradiance photodynamic therapy through the light applicator. A disclosed system includes a light applicator having a fiber optic cloth. The light applicator is conformable so that it can be worn against a patient's skin and the fiber optic cloth has a two dimensional surface that emits light in a direction toward a patient's skin. In this aspect, the power of the light emitted from the two dimensional surface in a direction toward a patient's skin is less than or equal to about 5 mW / cm2.
Owner:ROGERS SCI
Apparatus for photodynamic therapy and photodetection
ActiveUS20100145416A1Effective therapyRaman/scattering spectroscopyDiagnostics using lightDiseaseFluorescence
The present invention provides an apparatus for photodynamic therapy and fluorescence detection, in which a combined light source is provided to illuminate an object body and a multispectral fluorescence-reflectance image is provided to reproduce various and complex spectral images for an object tissue, thus performing effective photodynamic therapy for various diseases both outside and inside of the body.For this purpose, the present invention provides an apparatus for photodynamic therapy and photodetection, which provides illumination with light of various wavelengths and multispectral images, the apparatus including: an optical imaging system producing an image of an object tissue and transmitting the image to a naked eye or an imaging device; a combined light source including a plurality of coherent and non-coherent light sources and a light guide guiding incident light emitted from the light sources; a multispectral imaging system including at least one image sensor; and a computer system outputting an image of the object tissue to the outside. Thus, the apparatus for photodynamic therapy and photodetection of the present invention can effectively perform the photodynamic therapy and photodetection by means of the combined light source capable of irradiating light having various spectral components to an object tissue and the multispectral imaging system capable of obtaining images from several spectral portions for these various spectral ranges at the same time, thus improving the accuracy of diagnosis and efficiency of the photodynamic therapy.
Owner:KOREA ELECTROTECH RES INST
Imaging system having a fine focus
A new high resolution confocal and non-confocal scanning laser macroscope is disclosed which achieves fine focus and control of focus position by moving a lens in the intermediate optics. This arrangement is particularly useful for imaging specimens where it is difficult to focus by changing the distance between the scan lens and the specimen, for example for in-vivo imaging, photodynamic therapy, and image-guided surgery. It is also important to keep the lens-to-specimen distance constant when a liquid-immersion scan lens is used, in order to maintain a constant thickness of liquid between the lens and the specimen. In addition to being useful for confocal slicing, motion of the intermediate lens under computer control also enables dynamic focus and the ability to move the focal spot along a general path inside the specimen. Several applications of the imaging system are described. The macroscope images macroscopic specimens in reflected light, transmitted light, fluorescence, photoluminescence and multi-photon fluorescence.
Owner:HURON TECH INT
Laser system using ultrashort laser pulses
ActiveUS7450618B2Easy to set upEasy to useLaser detailsMaterial analysis by optical meansFemto second laserCharacterization test
A laser system using ultrashort laser pulses is provided. In another aspect of the present invention, the system includes a laser, pulse shaper and detection device. A further aspect of the present invention employs a femtosecond laser and a spectrometer. Still another aspect of the present invention uses a laser beam pulse, a pulse shaper and a SHG crystal. In yet another aspect of the present invention, a multiphoton intrapulse interference phase scan system and method characterize the spectral phase of femtosecond laser pulses. Fiber optic communication systems, photodynamic therapy and pulse characterization tests use the laser system with additional aspects of the present invention.
Owner:BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIV
Treating cancer using electromagnetic fields in combination with photodynamic therapy
A light generating circuit is implanted in a subject's body and aimed at a target region such as a tumor. A photosensitizer is introduced into the target region, and an AC electric field is induced in the region. The field causes the light generating circuit to generate light, which activates the photosensitizer; and at certain field strengths and frequencies, the field itself has a beneficial effect. The beneficial effects of the field and the activated photosensitizer are thereby obtained simultaneously.
Owner:NOVOCURE GMBH
Preparation method of heteroatom doped multifunctional carbon quantum dot and application thereof
InactiveUS20150218001A1High-temperature carbonizationEasy to modifyUltrasonic/sonic/infrasonic diagnosticsMaterial nanotechnologyPhotocatalytic water splittingCarbonization
The present invention discloses a method for preparing heteroatom doped carbon quantum dot, and application thereof in fields of biomedicine, catalysts, photoelectric devices, etc. The various kinds of heteroatom doped carbon quantum dots are obtained by using a conjugated polymer as a precursor and through a process of high temperature carbonization. These carbon quantum dots contain one or more heteroatoms selected from the group consisting of N, S, Si, Se, P, As, Ge, Gd, B, Sb and Te, the absorption spectrum of which ranges from 300 to 850 nm, and the fluorescence emission wavelength of which is within a range of 350 to 1000 nm. The carbon quantum dot has a broad application prospect in serving as a new type photosensitizer, preparing drugs for photodynamic therapy of cancer and sterilization, photocatalytic degradation of organic pollutants, photocatalytic water-splitting for hydrogen generation, organic polymer solar cell and quantum dot-sensitized solar cell.
Owner:TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
Methods and formulations for photodynamic therapy
InactiveUS20030093057A1Reducing and eliminating painRaise the pHElectrotherapyMedical devicesPhotodynamic therapyAnesthesia
An apparatus to rapidly deliver a drug to a patient, the invention comprising the method of locating a drug beneath a patient's skin in a drug depot site, placing a heating component near the drug depot site and generating heat in and near the drug depot site. A control component connected to the heating component is used to control the magnitude and duration of heat generated by the heating component.
Owner:NUVO RES
Multispectral therapeutic light source
ActiveUS8858607B1High cost-effectiveHigh quantum-efficiencyElectrotherapySurgical instrument detailsUltravioletPeak value
Owner:JONES GARY W
Conjugates of rgd peptides and porphyrin or (bacterio) chlorohyll photosynthesizers and their uses
Conjugates of porphyrin, chlorophyll and bacteriochlorophyll photosensitizers with RGD-containing peptides or RGD peptidomimetics are provided that are useful for photodynamic therapy (PDT), particularly vascular-targeted PDT (VTP), of tumors and normeoplastic vascular diseases such as age-related macular degeneration, and for diagnosis of tumors by different techniques.
Owner:YEDA RES & DEV CO LTD
Concentric, detachable and replaceable multifunctional targeted tumor scalpel
InactiveCN101579256AUltrasonic/sonic/infrasonic diagnosticsIncision instrumentsPhotodynamic therapyMultiple therapy
The invention discloses a concentric, detachable and freely replaceable multifunctional targeted tumor scalpel used for treating various tumor treatments, which comprises an inner ring pipe and an inner pipe that are concentric. The mutual locations of the inner pipe and the outer ring pipe can be axially adjusted, and the inner pipe can be fixed on a handle through a connecting bar and can be detached from the outer ring pipe. The invention includes multifunctional applications of cold therapy, radio frequency ablation therapy, microwave ablation therapy, endothermknife therapy, laser ablation therapy, chemical therapy, radiation therapy, immunization therapy, gene therapy, photodynamic therapy, electrochemotherapy and the like. Meanwhile, the inner pipe of the multifunctional targeted tumor scalpel can also be used as a diagnosis monitoring device, such as a temperature sensor, a biopsy needle, a micro ultrasonic probe, an endoscope and the like. The multifunctional targeted tumor scalpel can realize the combination of single and / or multiple therapy methods.
Owner:ACCUTARGET MEDIPHARMA (SHANGHAI) CO LTD
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