243 results about "Photodynamic therapy" patented technology

The invention relates to an experimental system and method for photodynamic therapy, photothermal therapy and combined research of photodynamic therapy and photothermal therapy. The experiment system comprises an optical irradiation module which comprises a plurality of laser light sources, each laser light source can output collimated light beams, the collimated light beams are combined to form a coaxial light path, and the coaxial light paths are projected to the surface of an observation object through a light beam adjusting assembly; the light path position adjusting module comprises an electric Z-axis displacement mechanism; the temperature monitoring module comprises an active temperature control substrate, an infrared thermal imager and an optical fiber temperature probe interface; the data acquisition and control module is configured to synchronously acquire laser output power, light spot area, electric Z-axis position, temperature of the active temperature control substrate, temperature sequences of a plurality of different areas and optical fiber temperature probe data, and associatively record the data with a unified timestamp; the power density can be calculated based on the real-time output power of the laser light source and the light spot area; and when the data of any temperature monitoring channel exceeds a preset safety threshold value, the laser light source is automatically controlled to close the output.

The invention belongs to the technical field of biology, and particularly relates to a construction method of a TMV and AIE hybrid material as well as a product and application of the TMV and AIE hybrid material. By optimizing TMV purification conditions, the problems of strip dispersion, strip taking difficulty and the like after ultracentrifugation are effectively solved. After TMV is extracted and purified, AIE is dissolved in a KP buffer solution to prepare an AIE molecular solution, then the purified TMV and the AIE molecular solution are mixed and incubated according to the volume ratio of 10: 1, the hybrid material with fluorescence tracing and photodynamic therapy activity is obtained, in-vivo and in-vitro visual tracking imaging and reactive oxygen species (ROS) release functions are achieved, the diagnosis and treatment integrated potential is shown, and the application prospect is wide. And the application boundary of the TMV in the fields of precision medicine and the like is expanded.

The application discloses an iron / copper-porphyrin nanoparticle and a preparation method and application thereof, and the nanoparticle is prepared through the following steps: adding iron chloride, copper chloride, tetra(4-carboxyphenyl)porphyrin and benzoic acid into a reaction solvent N,N-dimethylformamide solution, uniformly stirring at room temperature, and reacting at high temperature; and after the reaction is completed, the iron / manganese-porphyrin nanoparticle is obtained through centrifugation and washing. The iron / manganese-porphyrin nanoparticle is prepared by using a brand-new method, the nanoparticle can be degraded in a glutathione solution and release iron ions and copper ions, is used for catalyzing hydrogen peroxide to be converted into a hydroxyl radical (•OH), and tetra(4-carboxyphenyl)porphyrin can generate singlet oxygen (O2) under 660 nm laser irradiation, and is expected to become a good nano-carrier for accelerating photodynamic therapy-chemical kinetic therapy. 1 O2).

The invention specifically discloses a beta-diketone iridium complex as well as a preparation method and application thereof, and relates to the technical field of biological medicines. The beta-diketone iridium complex provided by the invention has high phototoxicity and low dark toxicity, can be applied to tumor cells as effective PSs of PDT, and is specifically delivered to the tumor cells by taking a traditional Chinese medicine monomer tripterine as a supplement in combination with a nano-targeting delivery technology for photodynamic / immune synergistic treatment of hypoxic tumors.

To provide a topical composition for photodynamic therapy, an obstructive dressing material, a kit using them, a material for photodynamic therapy, and a method for photodynamic therapy.SOLUTION: In order to promote infiltration of a topical composition containing 5-aminolevulinic acid (ALA) applied on a treatment site for photodynamic therapy, transepidermal water loss from the treatment site is suppressed to the minimum by covering the treatment site by a low-density polyethylene barrier before phototherapy after the topical composition is applied to the treatment site.SELECTED DRAWING: Figure 3

The present application relates to a kind of based on photodynamic therapy and radiotherapy and chemotherapy treatment stent and its preparation method.The present application includes stent body, stent body is mesh stent, mesh stent is provided with fixed frame, fixed frame includes the 4 support frames of cross arrangement, the cross point of 4 support frames is hinged connection.The present application is simple in structure, easy to make, convenient to use, can be made into different specifications and models, applicable to different tumor size, reduce the damage to normal tissue.

The invention relates to an estrogen receptor alpha and fibroblast activating protein dual-targeting near-infrared fluorescent probe as well as a preparation method and medical application thereof. Specifically, the probe can be used as a fluorescence probe for developing cells co-expressing the estrogen receptor alpha and the fibroblast activating protein, and can also be used as a near-infrared fluorescence imaging probe for diagnosing benign / malignant lesions such as nodules / tumors co-expressing the estrogen receptor alpha and the fibroblast activating protein. The fluorescent probe can also be applied to research on related biological events in cells for co-expressing the estrogen receptor alpha and the fibroblast activating protein, and particularly can be applied to fluorescent navigation in tumor resection operations for co-expressing the estrogen receptor alpha and the fibroblast activating protein; particularly, the composition can be applied to the synergistic treatment of an anti-estrogen therapy and a photodynamic therapy on a diseased region which co-expresses the estrogen receptor alpha and the fibroblast activating protein.

The invention relates to the technical field of pharmaceutical preparations, in particular to composite condensing gel based on photodynamic therapy and a preparation method of the composite condensing gel. The preparation method of the composite condensate gel based on photodynamic therapy comprises the following steps: preparing a BSA (Bovine Serum Albumin) solution, uniformly mixing an inulin mother solution with the BSA solution, adjusting the pH value, heating in a water bath, cooling to room temperature, adding 5-aminolevulinic acid methyl ester hydrochloride into the condensate gel, adding an acid coagulant, diluting, and filling CO2 gas. According to the invention, CO2 is added into the composite condensation gel, so that the binding force of hemoglobin and O2 in tissues absorbing the composite condensation gel is reduced, and the concentration of free oxygen is improved, so that the composite condensation gel can transfer energy to surrounding oxygen and generate singlet oxygen with strong activity, thereby killing cancer cells and achieving the effect of improving the curative effect of photodynamic therapy.

The present application relates to the technical field of cancer detection, in particular to a kind of tumor imaging guided photodynamic therapy reagent.The reagent is named ADS254BE / H2TPP NPs, which is composed of hydrophobic conjugated polymer ADS254BE and tetraphenylporphyrin H2TPP doped polymer microspheres, and the surface of the polymer microspheres also has PSMA modification layer.The reagent is prepared by uniformly mixing ADS254BE, H2TPP and PSMA solution, ultrasonic treatment, room temperature standing, and then evaporating solvent in the solution.The photodynamic diagnosis and treatment reagent provided by the present application shows bright red emission centered at 650nm, relatively large stoke shift, higher singlet oxygen generation rate, and good light stability and biocompatibility.The present application provides a feasible strategy for constructing new optical diagnosis and treatment integrated reagent, and is expected to promote the development of imaging guided photodynamic therapy.

The present application relates to the field of pharmaceutical preparations, in particular to 5-amino-ketoglutaric acid metal complex, liposome and preparation method thereof. The 5-amino-ketoglutaric acid metal complex of the present application is formed by 5-amino-ketoglutaric acid and metal ion through coordination bond, and is a photosensitizer which can be used for photodynamic therapy of tumor. After ALA forms complex with metal ion, the reaction activity of amino and ketone groups in ALA molecule is reduced, the adverse influence of external environment on the molecule is delayed, and the stability is enhanced. Moreover, the co-aggregation of ALA and copper ion (or iron ion) to target tissue, the two means of ALA photodynamic therapy of tumor and copper (iron) ion promoting tumor cell apoptosis play drug efficacy, and have synergistic anti-tumor effect. The present application further provides liposome loaded with 5-amino-ketoglutaric acid metal complex, and preparation containing 5-amino-ketoglutaric acid metal complex or liposome.

The invention provides a cobalt-iridium metal complex, nanoparticles, a preparation method and application, and belongs to the technical field of photodynamic therapy drugs. The structural formula of the cobalt-iridium metal complex is shown as a formula (I). The invention also provides a preparation method of the cobalt-iridium metal complex. The invention also provides nanoparticles, the cobalt-iridium metal complex prepared by the invention has a chemiluminescence property, so that the cobalt-iridium metal complex can simultaneously realize photo-thermal, photodynamic and ultrasonic synergistic thrombolysis treatment effects, and the oxidation resistance of the cobalt-iridium metal complex has a remarkable curative effect on a vascular injury part. The complex provided by the invention has good photo-thermal, photodynamic and ultrasonic response capabilities, and can overcome the problems of short excitation wavelength of exciting light and limited light penetration depth required by the existing metal iridium complex. Experiments show that the material has a good treatment effect on thrombus.

The invention provides a light irradiation head of a photodynamic therapy machine, which belongs to the field of medical auxiliary instruments and comprises a power supply support component and a plurality of irradiation systems. The irradiation system comprises an irradiation box with an opening and a plurality of irradiation units arranged in the irradiation box in an array mode. The irradiation unit comprises four integrated boards which are arranged in an array mode, and the surface of each integrated board is provided with irradiation light sources in an array mode. Four telescopic assemblies; one end of each telescopic assembly is matched with a back joint of one integrated plate, and the other end of each telescopic assembly is matched with a bottom joint of the irradiation box; the four groups of elastic connecting pieces are respectively arranged between the adjacent integrated boards, so that the side surfaces of every two integrated boards are elastically connected; and the posture fine-tuning telescopic rod is located at a central point position formed by the four integrated boards, the fixed end of the posture fine-tuning telescopic rod is fixedly connected with the bottom of the irradiation box, and the telescopic end of the posture fine-tuning telescopic rod is a sphere. The light irradiation head can adapt to light irradiation treatment requirements of different forms such as points, lines, rings and surfaces, the intensity of an illumination area can be dispersed and focused, and a precise treatment tool is provided for doctors.

The invention discloses a load ICGamp. The invention discloses ZIF-8 nano-particles of CBF, and belongs to the technical field of preparation of nano-drug particles. The multifunctional nanoparticles are formed by simultaneously encapsulating indocyanine green (ICG) and cinobufagin (CBF) components by ZIF-8, and the drug loading capacities of the two drugs are both not lower than 5%. The preparation method comprises the following steps: slowly adding a solution containing cinobufagin and zinc nitrate into a mixed solution containing indocyanine green, bovine serum albumin and 2-methylimidazole, and carrying out centrifugal filtration, washing and drying on a reaction product to obtain the cinobufagin zinc oxide. The multifunctional nano-particles prepared by a one-step synthesis method are uniform in particle size and good in stability, indocyanine green and cinobufagin are uniformly distributed in a carrier, the multifunctional nano-particles have pH and near-infrared light dual response drug release characteristics, triple synergy of chemotherapy, photothermal therapy and photodynamic therapy can be realized, and the multifunctional nano-particles are simple in preparation process and suitable for popularization and application.

Methods and systems for detection and diagnosis of oral lesions and application of treatment are described. One example mobile intraoral system includes an intraoral probe with a plurality of windows and a first plurality of light sources positioned in its distal section. The intraoral probe also includes one or more additional light sources operable at one or more wavelengths in the range 600 nm to 700 nm, one or more heat sinks, and one or more optical waveguides coupled to the additional light sources. The mobile intraoral system is selectively operable in a first mode of operation for imaging and diagnosis of suspicious regions in the oral cavity, and a second mode of operation for administering photodynamic therapy (PDT). The intraoral probe's distal section is bendable to allow insertion in the oral cavity and targeting a particular location of the oral cavity for administration of the PDT.

The utility model discloses a kind of optical fiber support of photodynamic therapeutic instrument, belong to photodynamic medical instrument technical field;The utility model is provided with support, and the fixed platform for erecting optical fiber;The fixed platform bottom is movably connected with the support top end through first joint, to be positioned the fixed platform by universal rotation;Still include the clamping device of the clamping device that the optical fiber can penetrate and can separate with the fixed platform, and the clamping device can be clamped and fixed on the optical fiber;Wherein, the base one side of the fixed platform is elastically connected with the fixed plate of being able to lift by connecting rod assembly, for cooperating with the positioning groove on the base or releasing the optical fiber support rod of the clamping device, the utility model has good adaptability, convenient to use Advantage.

The application belongs to the field of photodynamic therapy, and specifically discloses a vitamin K co-crystal material for photodynamic therapy and a preparation method thereof. The vitamin K co-crystal material takes vitamin K as an electron acceptor, and the two carbonyl groups at the para positions of the vitamin K quinoid six-membered ring make the vitamin K exhibit electron deficiency, form an organic charge transfer complex with the electron acceptor, and self-assemble to form a co-crystal, so that the absorption spectrum of the system is widened, a wider wave band of light is more effectively utilized, the photodynamic therapy response wavelength of the vitamin K is adjusted from the ultraviolet region to the visible region and the near infrared region, the problem of low penetration depth and light damage caused by photodynamic therapy using light in the ultraviolet region is avoided, and the vitamin K has excellent photodynamic performance and good application prospects in surface sterilization and disinfection, treatment of body surface infection, and directional cancer treatment based on visible light or near infrared light.

The utility model provides a kind of head fixing device for cheek skin photodynamic therapy, including mounting plate, hinged with movable plate on mounting plate, the head pad of liftable is provided on movable plate, first elastic member is provided between head pad and movable plate, arc-shaped fixing pad is provided in the both sides of head pad, driving mechanism connected with head pad and two groups of fixing pad is provided on movable plate, the lifting of head pad is converted into driving two groups of fixing pad opening and closing by driving mechanism, locking assembly connected with head pad is provided on movable plate, the position of head pad is selectively locked or unlocked by locking assembly. The device can quickly fix the head of patient in multiple points without tedious adjustment process and fixing steps when using, effectively improve the treatment efficiency, reduce the time waste of medical staff, improve the practical value of the device.

The application discloses a multifunctional nanodiagnosis and treatment probe and a preparation method and application thereof, and belongs to the technical field of nanobiomedicine and tumor molecular diagnosis and treatment. The multifunctional nanodiagnosis and treatment probe is prepared by the following steps: coating mesoporous silica on the surface of a core-shell structure upconversion nanoparticle, then adsorbing platinum particles and methylene blue into the mesoporous silica, then modifying polydopamine to the surface of the mesoporous silica coated core-shell structure upconversion nanoparticle on which the platinum particles and the methylene blue are adsorbed, and finally linking nucleic acid PH1 chains and EH2 dendrites to the surface of the upconversion nanoparticle and dispersing and preparing by using a PBS buffer. The multifunctional nanodiagnosis and treatment probe prepared by the application can not only realize specific recognition, quantitative detection and in-situ imaging of a target microRNA, but also can form a synergistic tumor treatment mode of "photodynamic therapy-optical thermal therapy-oxygen enhancement", and has a wide application prospect in early tumor screening, curative effect evaluation and individualized treatment.

The application discloses a kind of composite drug-loaded nanoparticles based on calcium peroxide carrier, which is formed by the surface of hyaluronic acid modified calcium peroxide nanoparticles loaded with polylysine-dihydrophenophor e6 (Ce6) as carrier. pll The composite drug-loaded nanoparticles CaO2@HA / Ce6 are spherical particles with a particle size of about 100nm. pll In the application, Ce6 is converted into Ce6 by polylysine modification, and then combined with hyaluronic acid modified calcium peroxide nanoparticles. pll Ce6 is uniformly loaded on the surface of the composite drug-loaded nanoparticles CaO2@HA / Ce6. pll The application solves the problem that Ce6 cannot be attached to the surface of CaO2 nanoparticles. pll The prepared nanocomposite particles have uniform particle size and high specific surface area. pll After the combination of Ce6 and CaO2@HA, as a good bacterial microenvironment response material, the anoxic condition of bacterial site can be improved, and the photodynamic therapy can be enhanced. On the other hand, the biocompatibility and delivery efficiency of Ce6 are improved, so that significant bactericidal effect can be achieved at low dose.

The invention discloses a cathepsin B activated chemiluminescent nanoparticle. The cathepsin B activated chemiluminescent nanoparticle is prepared from cat B-C-550, hypericin and DSPE-mPEG2000 (Distearoyl Phosphate Polyethylene-mPEG (Polyethylene Glycol) 2000 in a self-assembly manner; the structure of the cat B-C-550 is as shown in a formula I in the specification. The invention discloses an application of cat B enzyme activated chemiluminescent nanoparticles in preparation of reagents or drugs for screening or diagnosing tumors. The invention discloses an application of cat B enzyme activated chemiluminescent nanoparticles in preparation of a cancer imaging reagent and / or a medicine for treating tumors. According to the invention, chemiluminescence imaging and in-situ cancer PDT treatment without external exciting light are realized. The cat B enzyme response type chemiluminescent nanoparticles are high in stability and can be effectively targeted and enriched at tumor focus parts.

The utility model discloses a photodynamic therapy dosing device for cervix uteri, and relates to the field of medical equipment, the dosing device comprises a supporting rod, a dosing section arranged at the top of the supporting rod, and an expansion section arranged below the dosing section, the dosing section comprises two parts, one part is a dosing head used for stretching into the cervix uteri, and the other part is an expansion head used for stretching into the cervix uteri. The other part is a medicine support used for applying medicine to the cervix uteri outside the cervix uteri; the expansion and contraction section is of a structure capable of expanding and contracting and is used for expanding to support the vagina and prevent the medication part from slipping off after the medication part is sent to a designated position and contracting after medication is finished, and the dosing device is convenient to take out. According to the utility model, the medicine is prevented from being polluted, the use difficulty of medical personnel is reduced, the discomfort of a patient is relieved, and the risk that foreign matters are left in the body of the patient when being taken out is reduced.

The invention relates to the technical field of fluorescent probes, in particular to a cell membrane targeted near-infrared AIE fluorescent probe as well as a preparation method and application of the cell membrane targeted near-infrared AIE fluorescent probe. Dithieno [2, 3-b: 2 ', 3'-d] thiophene is adopted as a bridging structure, a triphenylamine unit is connected with a pyridinium salt unit, and the compound is specially used for targeted cell membrane localization and photodynamic tumor treatment. The near-infrared AIE fluorescent probe disclosed by the invention can be combined with a cell membrane to realize an effect of accurately and rapidly positioning cells; and under light stimulation, I-type / II-type ROS can be generated, the cell membrane structure can be destroyed, the cell membrane vacuolation can be realized, the effective killing of in-vivo and in-vitro tumor cells can be realized, and the method has important significance on tumor treatment.

The application discloses a lung cancer dual-targeting photodynamic synergistic ferroptosis diagnosis and treatment integrated probe and a preparation method and application thereof. The probe is dual-targeted on integrin receptors and high-order sulfonic acidization characteristics which are highly expressed in tumor cells, realizes efficient enrichment and long-term retention of the probe in a tumor site. Meanwhile, by integrating photodynamic therapy and ferroptosis therapy, the degree of lipid peroxidation of cells is promoted, the progress of tumors is effectively inhibited, and diagnosis and treatment integration of the tumors is realized.

The application discloses a kind of SNPs loaded engineered escherichia coli dual-response delivery systems and its preparation method and application, the preparation method includes the engineered escherichia coli of overexpressing Flt3L and TIM-3 scFv is co-incubated with NHS-PEG-CHO, obtain aldehyde functionalized escherichia coli;After activation SNPs is reacted with TFA-hydrazine, obtain hydrazine functionalized SNPs;Aldehyde functionalized escherichia coli and hydrazine functionalized SNPs are reacted;The delivery system of the application can rely on SNPs under laser stimulation Photo-thermal effect, photodynamic effect and generate a large number of ROS, efficiently induce tumor cells to occur immunogenic cell death (ICD), and by overexpressing Flt3L and TIM-3 scFv, activate DC cell and block TIM-3 path, restore DC, T cell function, realize the efficient synergy of photodynamic therapy+photothermal therapy+immunotherapy, and then reach the effective treatment of colorectal cancer.

This invention belongs to the field of biomedical materials and nanotechnology, specifically relating to the synthesis and application of a multifunctional mesoporous nanomaterial. The inventors synthesized a core-shell structured mesoporous nanoparticle using mesoporous silica nanoparticles and dopamine via emulsion epitaxy. The core of the core-shell structured mesoporous nanoparticle is S-nitrosoglutathione supported on mesoporous silica, and the outer shell is pentafluorophenyl chlorophyll supported on mesoporous polydopamine, forming MSN / G@mPDA / F nanoparticles. These nanoparticles rapidly increase in temperature to 45°C under 808 nm laser irradiation. o At temperatures above a certain temperature, S-nitrosoglutathione decomposes to produce nitric oxide. Further irradiation at 750 nm generates a large amount of reactive oxygen species, killing bacteria. This combination of photothermal and photodynamic therapy effectively inhibits bacterial growth. Therefore, this method exhibits excellent antibacterial effects and can play a role in the future treatment of bacterial infections.

Provided are a fluorine-18-labeled positron emission tomography (PET) radiotracer for diagnosing neuroinflammation, stroke or cerebral infarction and a method for diagnosing cancer in a subject including administering a fluorine-18-labeled PET radiotracer a subject, obtaining in vivo PET images of the uptake of the fluorine-18-labeled positron emission tomography (PET) radiotracer in a lesion in the subject, and evaluating the uptake of the fluorine-18-labeled radiotracer in the lesion.

The application discloses a nano-antibody (also known as single-domain antibody) conjugated photosensitizer targeting HER2, a preparation method of the photosensitizer and application of the photosensitizer in tumor photodynamic therapy. The photosensitizer is shown in a general formula (I). In the photosensitizer, the nano-antibody (N HER2 ) serving as a targeting ligand is connected with a photosensitive moiety (PS) through a catalytic reaction mediated by a transglutaminase (MTGase). Research finds that the anti-HER2 nano-antibody conjugated photosensitizer molecule has good cell killing selectivity and tumor enrichment capacity, and can remove a subcutaneous tumor of a mouse with high HER2 expression in one administration. HER2 -PEG 1K -PS (I).

The invention discloses a preparation method of a selenium-rich polymer nano photosensitizer and application of the selenium-rich polymer nano photosensitizer in tumor photodynamic therapy, and belongs to the technical field of fine chemical engineering. The polymer photosensitizer (PEG-b-PSeMet) is obtained by directly polymerizing an n-phenoxycarbonyl functionalized amino acid (NPC) derivative. The polymer photosensitizer can be self-assembled into nano particles (PolySe NPs) in an aqueous solution, and shows good tumor targeting property. Wherein the PolySe NPs remarkably improves the intersystem crossing efficiency of the photosensitizer pyropheophorbide-a (PPa) through the action of intermolecular heavy atoms, and compared with a polymer nano photosensitizer (PolyC NPs) without heavy atoms, the PolySe NPs shows that the ROS generation is enhanced by 1.6 times, and the killing power on various cancer cells is improved by about 1.4 times. Compared with small molecule PPa, the polymer nano photosensitizer can obviously improve the tumor targeting property of PPa and greatly enhance the concentration of the photosensitizer at a tumor part, so that the solid anti-tumor effect of photodynamic therapy is improved.

The present invention relates to a local targeting photodynamic therapy device for treating cancer. In more detail, an endoscope is disposed at the center of the end of a probe for photodynamic therapy, and a plurality of optical fibers are disposed along the edge to irradiate a plurality of lights to a lesion site, wherein the plurality of optical fibers of the probe receive light from independent light sources to independently perform light irradiation. The present invention is a device for minimizing damage to unnecessary normal tissue by adjusting the light irradiation area, i.e., each independent light source determines a light irradiation area including a lesion site in a real-time image provided by an endoscope disposed at the end of the probe, and only causes the independent light source that irradiates the determined light irradiation area to emit light, thereby achieving local light irradiation, etc. The local targeting photodynamic therapy device of the present invention can treat a variety of cancers or tumors, including cervical cancer, female cancers (endometrial cancer, ovarian cancer, breast cancer), skin cancer, brain cancer, etc., which are small and can be treated locally.