215 results about "Photosensitizing Agent" patented technology

The invention provides a diepoxy alkoxy anthracene photosensitizer, and relates to the field of photopolymerization. The invention further comprises a light-cured resin composition containing the diepoxy alkoxy anthracene photosensitizer, a light-sensitive dry film containing the diepoxy alkoxy anthracene photosensitizer and application of the light-cured resin composition and the light-sensitive dry film. The photosensitizer provided by the invention has the characteristics of low migration before curing and low precipitation after curing, and is excellent in photosensitive property and high in photobleaching efficiency; the polymer can be widely applied to the fields of photopolymerization and photocuring of dry films, paints, coatings, printing ink, forming materials and the like; in a photosensitive dry film, the photosensitizer cannot migrate to a polyethylene film, and when an electroplating process is carried out after exposure and development, fragments cannot be separated out to pollute electroplating liquid, so that undesirable phenomena of short circuit, open circuit and the like of an anti-corrosion pattern are avoided, and the yield of a product is remarkably improved.

The invention discloses a biodegradable plastic and a preparation method thereof, belongs to the field of bioplastic preparation, and aims to solve the problem that the existing plastic is slow in degradation rate in a marine environment. The biodegradable plastic is prepared from the following components in percentage by weight: 50-80% of a biomass-based high polymer material; 10 to 35% of a degradable toughening agent; 1-5% of a photosensitizer; 2-10% of a microbial inducer; 1-5% of a processing aid; after the biomass degradable plastic is subjected to ultraviolet radiation for 7-15 days in a marine environment, initial cracks with the density being larger than or equal to 20 pieces / cm < 2 > appear on the surface, the initial cracks are broken into degradation units with the particle size being 5-20 mm after being subjected to mechanical impact of sea waves for 30-60 days, and the biological decomposition rate of the degradation units is larger than or equal to 90% within 6-12 months under the action of marine microorganisms; and no micro-plastic particles with the particle size of less than or equal to 1mm exist in the residual product. Through the synergistic effect of the photosensitizer and the microbial inducer, the degradation period in the marine environment is shortened, the degradation efficiency is improved, and the method is remarkably superior to the prior art.

The invention provides anthracene methyl phenothiazine for a photosensitive resin composition, and relates to the field of photopolymerization. The invention further comprises a photosensitive resin composition containing the anthracene methyl phenothiazine, a photosensitive dry film containing the anthracene methyl phenothiazine and application of the photosensitive resin composition and the photosensitive dry film. The anthracene methyl phenothiazine disclosed by the invention has photosensitivity, can be used as a photosensitizer in the photosensitive resin composition, can improve the adhesive force of the photosensitive resin composition on various metal surfaces, and has the characteristic of low migration; the method can be widely applied to the photo-curing fields of dry films, paints, coatings, printing ink, forming materials and the like.

The invention relates to the technical field of degradable PE (polyethylene) packaging materials, and discloses a PE film, a preparation process and application in tissue packaging, and the PE film is prepared by the following steps: by taking 7-(diethylamino) coumarin-3-carboxylic acid, 2-naphthyl methanol and epoxy chloropropane as raw materials, carrying out esterification reaction and quaternization reaction to prepare an epoxidized biodegradable organic photosensitizer; based on an epoxy-hydroxyl ring-opening reaction mechanism, hydroxylated titanium dioxide nanoparticles and polyvinyl alcohol resin are respectively modified by using an epoxidized biodegradable organic photosensitizer, and compounding is performed based on a pi-pi accumulation effect between aromatic rings to prepare the ultraviolet light dependent photo-biodegradable component. According to the present invention, the ultraviolet light dependent light-biological degradation component, the compatible component and the composite auxiliary agent are added to the polyethylene matrix, and blow molding is performed to obtain the PE film, and the film product shows excellent light-biological dual degradation performance, has actual use value, and can be used in the tissue packaging field.

The invention relates to a nano-liposome preparation, which is characterized in that a liposome prepared from distearoyl phosphatidyl glycerol (DSPG), cholesterol and Biotin-PEG3000-cholesterol is used as a carrier, the surface of the nano-liposome preparation is modified with an ICAM-1 monoclonal antibody, and the nano-liposome preparation is loaded with an AIE photosensitizer and Nicodil. The nano-liposome prepared by the invention has targeting and responsive drug delivery to infected lesions, the enrichment of drugs at bacterial infected parts is improved, nano-system components can be cut by phospholipase in an infected microenvironment, responsive release of the drugs at the bacterial infected parts can be realized, and the treatment effect is improved. According to the invention, a hydrophobic shell layer and a hydrophilic core of the liposome are utilized, and hydrophobic NO donor molecules and a hydrophilic AIE photosensitizer are loaded at the same time, so that synergistic treatment of bacterial infection by a photodynamic therapy and a gas therapy is realized, and a better killing effect on drug-resistant bacteria is achieved.

The invention discloses composite gel with ROS and pH dual responsiveness and a preparation method and application thereof.The preparation method comprises the steps that gold nanoparticles are prepared, gold nanostars GNS grow, a surfactant and biguanide drugs are added to obtain drug-loaded gold nanostars GM, a metal organic framework is introduced to obtain drug-loaded nanoparticles GMZ of a core-shell structure, and the composite gel is prepared. And reacting with a TSPBA solution, an astaxanthin solution and a polyvinyl alcohol PVA solution for crosslinking to obtain the ROS and pH dual responsive composite gel. According to the invention, the gold nanostars are used as a photosensitizer to construct the multifunctional composite gel, and the metal organic framework structure degrades under a slightly acidic condition of a psoriasis epithelium microenvironment to release released zinc ions, so that the gel is endowed with various treatment effects, excellent photo-thermal treatment performance and controlled release performance of the zinc ions and drugs. The gel has ROS responsiveness, can remove excessive ROS in a psoriasis microenvironment, and realizes the treatment of oxidation resistance, inflammation resistance and keratinocyte proliferation inhibition of psoriasis by combining with a nano drug delivery system.

The invention is applicable to the technical field of biomedicine, and provides dipeptide-photosensitizer molecule co-assembled nanoparticles as well as a preparation method and application thereof. According to the invention, cationic diphenylalanine (CDP) and a biological cross-linking agent genipin are self-assembled to form a dipeptide carrier, and then the dipeptide carrier and a photosensitizer molecule chlorin e6 (Ce6) are co-assembled, so that nanoparticles with controllable size, controllable drug loading capacity and good biocompatibility are successfully prepared. The preparation method is simple and easy to implement, effectively solves the key problems that the traditional photosensitizer molecule Ce6 is poor in biocompatibility and easy to gather, not only can efficiently deliver Ce6, but also obviously improves the application safety and biocompatibility of Ce6. The Ce6 is almost free of dark toxicity under a dark condition, can play a strong photodynamic killing role under illumination, and greatly improves the possibility and application potential of the Ce6 in tumor photodynamic therapy by virtue of the flexible regulation and control advantages of the size and the drug loading capacity.

A resin composition for colored coating on an optical fiber contains a photopolymerizable compound, a photopolymerization initiator, a photosensitizer, and an organic pigment, in which the photosensitizer includes at least one selected from the group consisting of an anthracene-based photosensitizer and a naphthalene-based photosensitizer, and a content of the photosensitizer is 0.01 parts by mass or more and less than 3.00 parts by mass with respect to 100 parts by mass of the total amount of the photopolymerizable compound.

The invention discloses construction of ROS response type self-delivery carrier-free nanoparticles and application of the ROS response type self-delivery carrier-free nanoparticles in breast cancer treatment, firstly, a TLR agonist R848 synthesizes a dimer TKdR through an ROS sensitive bond in one step, then the dimer TKdR and a free photosensitizer Ce6 are co-assembled to form a nano self-assembly body (psTKdR NAs), and an R848 dimer-based photoactivatable supramolecular self-assembly multi-drug delivery system is constructed, pDT can effectively induce ICD to stimulate an autoimmune system, meanwhile, Ce6 can generate ROS under activation of specific light and further induce breakage of TK to release drugs, and R848 can drive cellular immune response and cause polarization of M1 macrophages and is used for tumor immunotherapy. The ROS-responsive intelligent prodrug is designed and introduced into the construction of a nano system, so that the stability of the drug and the sensitivity of a disease site can be improved, and the synergistic curative effect of an intelligent drug delivery system or a traditional drug combination therapy is expected to be realized.

The preparation method specifically comprises the following steps: (1) respectively preparing mother liquor containing a photosensitizer and mother liquor containing an annihilation agent by taking tetrahydrofuran as a solvent; (2) heating and volatilizing the prepared mother liquor containing the photosensitizer and the annihilation agent, then adding a polymeric monomer and a photochemical deoxygenization organic medium, then adding a photoinitiator, heating and stirring the obtained mixed system to enable solids to be fully dissolved in an organic phase so as to prepare a gel precursor; and (3) irradiating the prepared gel precursor by ultraviolet light or visible light to carry out crosslinking reaction. According to the preparation method provided by the invention, photochemical deoxidizing media PEG, DMSO and TMSO are taken as organic solvent matrixes and are crosslinked with multiple groups of polymer monomers (such as PEGDA and HEA) to form a gel network, and the gel system with up-conversion emission performance in the air environment is successfully prepared. In addition, the photo-activated deoxidizing gel prepared by the method can be successfully applied to information encryption and anti-counterfeiting technologies.

The present invention relates to a treatment device comprising a shaft extending between a proximal portion and a distal portion, a surgical instrument located at the distal portion, a handpiece located at the proximal portion, a treatment end located at a distal end of the surgical instrument, the treatment end being capable of applying photodynamic therapy (PDT). The treatment end comprises an applicator for applying a photosensitizing agent to a surface of a target tissue and a light emitter capable of emitting generated light therapy light to activate the photosensitizing agent to ablate the target tissue. A method for providing PDT to a target tissue, the method comprising: inserting the treatment device into a patient; applying a photosensitizing agent and light therapy light to a surface of the target tissue; and removing the device from the patient.

The invention relates to a synthesis method of a branched chain type allyl alcohol compound, which comprises the following steps: under the protection of nitrogen, taking different substituted terminal alkyne and formalin as raw materials, taking metal cobalt salt and an organic ligand as catalysts, taking Hanus ester as a reducing agent, and carrying out a reaction in the presence of an organic solvent and a photosensitizer to obtain the branched chain type allyl alcohol compound. And carrying out illumination reaction to obtain the branched chain type allyl alcohol compound. According to the method, reaction raw materials and reagents are simple and easy to obtain, conditions are mild and easy to control, atom economy is high, precious metal catalysis is not needed, the substrate application range is wide, regioselectivity is high, and wide application prospects are achieved.

A composition includes particles for use in a method for the treatment of a vitreous disease or a vitreous disorder as a light sensitizing agent. Each particle has a surface selected for or adapted for providing mobility of the particle in the vitreous and for binding to collagen aggregates, such as floaters.

The invention belongs to the technical field of chemical synthesis, and particularly relates to a difluoroalkylated tetrahydropyridazine compound and a preparation method thereof. The preparation method of the difluoroalkylated tetrahydropyridazine compound comprises the following steps: by taking an acethydrazide compound and a difluoroalkyl compound as reaction raw materials, mixing the reaction raw materials, a photosensitizer, reaction alkali and a solvent under a nitrogen condition, and reacting under blue light to obtain the difluoroalkylated tetrahydropyridazine compound. A difluoroalkyl compound is reduced by a photosensitizer to generate a difluoroalkyl free radical, and the difluoroalkyl free radical and an acethydrazide compound are subjected to an addition reaction to obtain the difluoroalkylated tetrahydropyridazine compound. The method does not need to additionally add a metal catalyst or an oxidizing agent or a reducing agent, and is simple to operate, mild in reaction condition, wide in substrate universality, green and environment-friendly.

The invention discloses a photosensitizer, dynamic antibacterial hydrogel containing lipidosome wrapping the photosensitizer and a preparation method and application of the dynamic antibacterial hydrogel, and belongs to the technical field of biological materials. The invention provides a novel D-A-D type photosensitizer TPT which is simple in structure and simple in synthetic route, and from the angles of safety, practicability and use specificity of hydrogel dressing, modified hyaluronic acid and modified carboxymethyl chitosan are used as raw materials, cationic liposome wrapping the novel photosensitizer TPT is carried, and the hydrogel dressing is prepared. The efficient antibacterial dynamic cross-linked hydrogel material is prepared. The hydrogel disclosed by the invention has two pH response bonds, namely an imine bond and a boric acid ester bond, and has good moisture retention and biocompatibility; meanwhile, the hydrogel is loaded with the cationic liposome wrapping the novel photosensitizer TPT, so that the hydrogel has excellent active oxygen yield. The hydrogel disclosed by the invention aims to quickly resist bacteria, promote wound healing, reduce infection risk and improve the success rate of treatment through the targeted drug release function of the intelligent hydrogel.

The application provides a polyhydroxy phenolic compound, a preparation method thereof, a diazonium naphthoquinone sulfonate, a preparation method thereof and a photoresist composition. The polyhydroxy phenolic compound has the following structure shown in formula (I). The diazonium naphthoquinone sulfonate prepared by using the polyhydroxy phenolic compound provided by the application as an intermediate is applied to the photoresist composition as a photosensitive agent, and the obtained photoresist not only has clear resolution and high photosensitivity, but also has excellent thermal stability and etching resistance, and has a wide application prospect in the field of semiconductors.

The application discloses a kind of LEC cold light source application methods combined with IMD, it is related to cold light source application technical field, including the following contents, S1, cold light sheet production: polyester acrylic resin, modified polyurethane, hydroxyethyl acrylate, photosensitizer, auxiliary agent, filler, solvent slurry, dispersing agent and curing agent;S2, dielectric layer preparation;S3, circuit application;S4, correction is carried out: correction circuit carries out power factor correction to filtered mains signal, the pin of correction circuit is MOS tube drive pin, controls MOS tube switch and changes output voltage.The application compared with initial EL cold light sheet, with ultrathin, working state is not heated, light is uniform, good shock resistance, still can emit light after cutting, color is rich and recognition degree is high, easy to use, low power consumption, easy to manufacture, so that it has ultralight, ultrathin, light soft, no ultraviolet, color is various, long life, no heat, strong light and shade color adjusting ability.

The present application relates to an antifungal microneedle patch and its preparation method and application, the antifungal microneedle patch includes backing layer and the needle head arranged on the surface of the backing layer;The needle head constitutes n×n array on the surface of the backing layer;The surface of the needle head includes fatty acid coating containing antibacterial drug;The inside of the needle head includes photosensitizer;The n is selected from integer.The antibacterial drug is lipophilic triazole antifungal drug.The fatty acid is selected from saturated fatty acid containing 6-12 carbon atoms.The present application innovatively combines antifungal drug itraconazole and photo-thermal agent / photosensitizer indocyanine green, loads in microneedle, can carry out painless minimally invasive local administration, through the antibacterial action, photo-thermal effect and photodynamic effect of antifungal drug released under the excitation of near-infrared light, realize the effective killing to fungi, and will not cause irreversible damage to normal tissue.

The present invention discloses a near-infrared photosensitizer-based nanotherapeutic agent, its preparation method, and application. The near-infrared photosensitizer-based nanotherapeutic agent comprises a protein and a near-infrared prodrug bound to a hydrophobic cavity of the protein. The near-infrared prodrug comprises a near-infrared photosensitizer connected to a cupric sulfide bond and a chemotherapy drug bound to the near-infrared photosensitizer connected to the cupric sulfide bond via a thioketone bond. The near-infrared photosensitizer-based nanotherapeutic agent provided by the present invention significantly improves the solubility and bioavailability of the chemotherapy drug and the near-infrared photosensitizer, achieves tumor targeting and selectivity, thereby increasing the drug accumulation at the tumor site, improving the therapeutic effect, and reducing toxic side effects. This solves the problems of existing near-infrared fluorescent dyes, which have limited targeting and selectivity and low therapeutic effect.

The invention discloses an antibacterial toxin-removing anhydrous dyeing and finishing powder dye as well as a preparation method and application thereof. The dye adopts a porphyrin structure-containing metal organic framework with a specific aperture as a carrier, copper phthalocyanine and an IR808 photosensitizer are loaded after modification of a silane coupling agent, and copper and zinc ions are introduced through ion exchange. By optimizing a carrier structure, surface modification and a component ratio, the dye has excellent antibacterial property, high dyeing depth and a photocatalytic function. Anhydrous dyeing and finishing are realized by adopting a supercritical carbon dioxide process, and the process is environment-friendly and efficient. The technology solves the problems of serious pollution, single function and the like of the traditional dyeing process, and has important application value in the field of textile dyeing and finishing.

To form more devices.SOLUTION: A method for processing a semiconductor wafer includes a wafer preparation step 101 for preparing a semiconductor wafer having no notch part and a circular horizontal cross-sectional shape, a photosensitive agent layer formation step 102 for coating a photosensitive agent onto the semiconductor wafer, and forming a photosensitive agent layer, an exposure step 105 for irradiating the photosensitive agent layer with light through a mask and a light modulator, and transferring a pattern onto the photosensitive agent layer, and a crystal orientation detection step 103 for detecting a crystal orientation of the semiconductor wafer, before the exposure step 105 is performed, wherein the exposure step 105 positions the semiconductor wafer to the pattern in a predetermined direction on the basis of the crystal orientation of the semiconductor wafer.SELECTED DRAWING: Figure 3

The present application relates to the field of chemical synthetic materials and catalysis, and particularly relates to a metal-amorphous structure chalcogenide core-shell nanocrystal and a preparation method and application thereof.The preparation method comprises the following steps: (1) synthesizing Au nanorods through a seed growth method; (2) coating silver on the surface of the Au, and epitaxially growing a silver shell layer nanocrystal; and (3) sulfidizing the silver shell layer nanocrystal, and performing hydrothermal cation exchange to obtain a core-shell structure nanocrystal.In the metal-amorphous structure chalcogenide core-shell nanocrystal, the amorphous surface to a certain extent is conducive to adsorbing reaction substrates, and promotes the progress of the photocatalytic carbon dioxide reduction reaction.The metal-amorphous structure chalcogenide core-shell nanocrystal has excellent gas-solid phase photocatalytic carbon dioxide reduction performance, and can achieve good effects without a photosensitizer and a sacrificial agent.

The photodynamic therapy device of the present disclosure is a photodynamic therapy device that irradiates light from a light source onto blood that has been taken out of a patient's body and is flowing in the blood tube, the blood having absorbed a photoreactive agent, to destroy an undesirable component in the blood or affect the component. The photodynamic therapy device includes the irradiation unit that includes a light source and irradiates the blood in the blood tube with light, and the circuit cooling block that cools the blood in the blood tube. The circuit cooling block is connected to the pump that circulates cooling water in the circuit cooling block, the reservoir tank, and the cooling unit that cools water by the water flow path for flowing the cooling water.

The invention discloses a photoresist composition based on metal nanoparticles and application of the photoresist composition. The photoresist composition comprises metal nanoparticles, a photosensitizer, an anti-diffusion agent and a photoresist solvent, wherein the metal nanoparticles are silver nanoparticles, copper nanoparticles and gold nanoparticles. The photoresist composition has good film-forming property and excellent patterning imaging capability, photoetching patterns with different resolutions can be obtained through ultraviolet, electron beam or extreme ultraviolet exposure, and the formed patterns have good conductivity after being subjected to heat treatment and can be directly used for processing micro-nano devices.

This invention discloses a photosensitizer, an i-line photoresist containing the photosensitizer, and a preparation method thereof. The preparation method of the i-line photoresist composition disclosed in this invention includes the following steps: uniformly mixing the components of the i-line photoresist composition, wherein the i-line photoresist composition includes the following components: phenolic resin, photosensitizer, silicone leveling agent, and organic solvent; wherein the photosensitizer is composed of photosensitizer A and photosensitizer B. The i-line photoresist composition prepared using the photosensitizer of this invention produces photoresist patterns with high photosensitivity and resolution when used in i-line lithography.

The invention relates to a photocuring continuous carbon fiber composite material formula and a 3D printing head device, and the photocuring continuous carbon fiber composite material formula comprises the following components in parts by weight: 50-90 parts of carbon fiber and epoxy resin, 1-5 parts of a photoinitiator, 0-3 parts of a photosensitizer, 5-20 parts of an alicyclic epoxy compound, and 5-20 parts of an oxygen heterocyclic compound. 0-5 parts by weight of a thixotropic agent and 0-20 parts by weight of an active diluent. The 3D printing head comprises a resin injection part, a fiber feeding part, an in-situ impregnation tank, a point light source bracket part, an anti-overflow part and a preimpregnated continuous carbon fiber discharging part; according to the photocuring continuous carbon fiber composite material formula and the 3D printing head device, protonic acid and gelation can be rapidly initiated on the surface through illumination, protonic acid is diffused into fibers by means of the heat effect to achieve deep curing, and therefore 3D printing of the photocuring continuous carbon fiber reinforced epoxy resin composite material is achieved.

The invention discloses a degradable dynamic cross-linked silicone rubber composition and a preparation method thereof, and belongs to the technical field of organic silicon materials. The composition is prepared from the following components in parts by mass: 100 parts of methyl vinyl silicone rubber raw rubber, 10 to 30 parts of dynamic cross-linking agent (siloxane copolymer containing disulfide bonds), 10 to 30 parts of biodegradable block (polycaprolactone-siloxane copolymer), 3 to 10 parts of modified cellulose nanocrystal, 0.1 to 2 parts of photosensitizer (benzophenone derivative) and 0.05 to 0.5 part of platinum catalyst. The dynamic cross-linking agent is an addition product of tetra (3-mercaptopropyl) siloxane and diacrylate siloxane, and the disulfide bond density of the dynamic cross-linking agent is 2-5 mmol / g. According to the invention, through the synergistic effect of the dynamic disulfide bond and the polycaprolactone block, efficient self-repairing and controllable enzymatic / photopromoted degradation of the material at room temperature are realized. After the nanocrystalline of the modified cellulose is introduced, the tensile strength is greater than 8.5 MPa, and the elongation at break reaches 680%.

The invention relates to the technical field of thin film materials, in particular to a PBAT degradable composite material for preparing a thin film and a preparation method and application thereof. The PBAT degradation composite material is prepared from poly (butylene adipate-co-terephthalate), modified nanocellulose and a photosensitizer through melt blending, the photosensitizer is specifically added into the preparation raw materials for preparing the PBAT degradation composite material, the photosensitizer generates active oxygen under ultraviolet light by utilizing a photo-biological synergistic degradation mechanism, ester bonds in PBAT molecular chains are preferentially attacked, and the modified nanocellulose provides microorganism attachment sites to accelerate the enzymolysis process during biological composting; compared with a film without adding the photosensitizer, the tensile strength and the elongation at break of the film prepared by the invention are improved, and the tensile strength and the elongation at break after ultraviolet aging are obviously reduced, so that the degradation of the film is facilitated.

A flexible article formed from a fibrous liquid slurry having surface features and a method for making the same is provided. The article is formed from a slurry comprised of an aqueous solution containing a plurality of fibers and a photoreactive agent. The slurry is formed into a three-dimensional solid fibrous molded part. The solid fibrous molded part is exposed to a light source such that the light reacts with the photoreactive agent to create at least one surface feature. The surface feature can be, for example, a texture or color change.

The invention discloses a gallic acid-based cationic photodynamic antibacterial agent with sterilizing, anti-infection and wound healing promoting effects and a preparation method thereof, and belongs to the technical field of antibacterial agent synthetic chemistry. The cationic photodynamic antibacterial agent EY-QEGDM-MG is prepared by taking a natural compound gallic acid as a raw material and carrying out ring opening polymerization and quaternization reaction with photosensitizer eosin EY and ethylene glycol diglycidyl ether (EGDE), and the polymer shows an excellent antibacterial effect on escherichia coli and multi-drug-resistant MRSA germs under the action of illumination, and can be used for preparing a cationic photodynamic antibacterial agent EY-QEGDM-MG. The polymer has good blood compatibility and cell compatibility, in addition, the polymer can kill bacteria around infected wounds and can rapidly promote wound healing, and therefore the polymer can provide a new method for photodynamic antibacterial agents for treating the infected wounds in hospitals.