87 results about "Photosensitizing Agent" patented technology

The invention is applicable to the technical field of biomedicine, and provides dipeptide-photosensitizer molecule co-assembled nanoparticles as well as a preparation method and application thereof. According to the invention, cationic diphenylalanine (CDP) and a biological cross-linking agent genipin are self-assembled to form a dipeptide carrier, and then the dipeptide carrier and a photosensitizer molecule chlorin e6 (Ce6) are co-assembled, so that nanoparticles with controllable size, controllable drug loading capacity and good biocompatibility are successfully prepared. The preparation method is simple and easy to implement, effectively solves the key problems that the traditional photosensitizer molecule Ce6 is poor in biocompatibility and easy to gather, not only can efficiently deliver Ce6, but also obviously improves the application safety and biocompatibility of Ce6. The Ce6 is almost free of dark toxicity under a dark condition, can play a strong photodynamic killing role under illumination, and greatly improves the possibility and application potential of the Ce6 in tumor photodynamic therapy by virtue of the flexible regulation and control advantages of the size and the drug loading capacity.

The present invention relates to a treatment device comprising a shaft extending between a proximal portion and a distal portion, a surgical instrument located at the distal portion, a handpiece located at the proximal portion, a treatment end located at a distal end of the surgical instrument, the treatment end being capable of applying photodynamic therapy (PDT). The treatment end comprises an applicator for applying a photosensitizing agent to a surface of a target tissue and a light emitter capable of emitting generated light therapy light to activate the photosensitizing agent to ablate the target tissue. A method for providing PDT to a target tissue, the method comprising: inserting the treatment device into a patient; applying a photosensitizing agent and light therapy light to a surface of the target tissue; and removing the device from the patient.

The invention discloses a photosensitizer, dynamic antibacterial hydrogel containing lipidosome wrapping the photosensitizer and a preparation method and application of the dynamic antibacterial hydrogel, and belongs to the technical field of biological materials. The invention provides a novel D-A-D type photosensitizer TPT which is simple in structure and simple in synthetic route, and from the angles of safety, practicability and use specificity of hydrogel dressing, modified hyaluronic acid and modified carboxymethyl chitosan are used as raw materials, cationic liposome wrapping the novel photosensitizer TPT is carried, and the hydrogel dressing is prepared. The efficient antibacterial dynamic cross-linked hydrogel material is prepared. The hydrogel disclosed by the invention has two pH response bonds, namely an imine bond and a boric acid ester bond, and has good moisture retention and biocompatibility; meanwhile, the hydrogel is loaded with the cationic liposome wrapping the novel photosensitizer TPT, so that the hydrogel has excellent active oxygen yield. The hydrogel disclosed by the invention aims to quickly resist bacteria, promote wound healing, reduce infection risk and improve the success rate of treatment through the targeted drug release function of the intelligent hydrogel.

The application provides a polyhydroxy phenolic compound, a preparation method thereof, a diazonium naphthoquinone sulfonate, a preparation method thereof and a photoresist composition. The polyhydroxy phenolic compound has the following structure shown in formula (I). The diazonium naphthoquinone sulfonate prepared by using the polyhydroxy phenolic compound provided by the application as an intermediate is applied to the photoresist composition as a photosensitive agent, and the obtained photoresist not only has clear resolution and high photosensitivity, but also has excellent thermal stability and etching resistance, and has a wide application prospect in the field of semiconductors.

The application discloses a kind of LEC cold light source application methods combined with IMD, it is related to cold light source application technical field, including the following contents, S1, cold light sheet production: polyester acrylic resin, modified polyurethane, hydroxyethyl acrylate, photosensitizer, auxiliary agent, filler, solvent slurry, dispersing agent and curing agent;S2, dielectric layer preparation;S3, circuit application;S4, correction is carried out: correction circuit carries out power factor correction to filtered mains signal, the pin of correction circuit is MOS tube drive pin, controls MOS tube switch and changes output voltage.The application compared with initial EL cold light sheet, with ultrathin, working state is not heated, light is uniform, good shock resistance, still can emit light after cutting, color is rich and recognition degree is high, easy to use, low power consumption, easy to manufacture, so that it has ultralight, ultrathin, light soft, no ultraviolet, color is various, long life, no heat, strong light and shade color adjusting ability.

The present application relates to an antifungal microneedle patch and its preparation method and application, the antifungal microneedle patch includes backing layer and the needle head arranged on the surface of the backing layer;The needle head constitutes n×n array on the surface of the backing layer;The surface of the needle head includes fatty acid coating containing antibacterial drug;The inside of the needle head includes photosensitizer;The n is selected from integer.The antibacterial drug is lipophilic triazole antifungal drug.The fatty acid is selected from saturated fatty acid containing 6-12 carbon atoms.The present application innovatively combines antifungal drug itraconazole and photo-thermal agent / photosensitizer indocyanine green, loads in microneedle, can carry out painless minimally invasive local administration, through the antibacterial action, photo-thermal effect and photodynamic effect of antifungal drug released under the excitation of near-infrared light, realize the effective killing to fungi, and will not cause irreversible damage to normal tissue.

The invention discloses an antibacterial toxin-removing anhydrous dyeing and finishing powder dye as well as a preparation method and application thereof. The dye adopts a porphyrin structure-containing metal organic framework with a specific aperture as a carrier, copper phthalocyanine and an IR808 photosensitizer are loaded after modification of a silane coupling agent, and copper and zinc ions are introduced through ion exchange. By optimizing a carrier structure, surface modification and a component ratio, the dye has excellent antibacterial property, high dyeing depth and a photocatalytic function. Anhydrous dyeing and finishing are realized by adopting a supercritical carbon dioxide process, and the process is environment-friendly and efficient. The technology solves the problems of serious pollution, single function and the like of the traditional dyeing process, and has important application value in the field of textile dyeing and finishing.

The present application relates to the field of chemical synthetic materials and catalysis, and particularly relates to a metal-amorphous structure chalcogenide core-shell nanocrystal and a preparation method and application thereof.The preparation method comprises the following steps: (1) synthesizing Au nanorods through a seed growth method; (2) coating silver on the surface of the Au, and epitaxially growing a silver shell layer nanocrystal; and (3) sulfidizing the silver shell layer nanocrystal, and performing hydrothermal cation exchange to obtain a core-shell structure nanocrystal.In the metal-amorphous structure chalcogenide core-shell nanocrystal, the amorphous surface to a certain extent is conducive to adsorbing reaction substrates, and promotes the progress of the photocatalytic carbon dioxide reduction reaction.The metal-amorphous structure chalcogenide core-shell nanocrystal has excellent gas-solid phase photocatalytic carbon dioxide reduction performance, and can achieve good effects without a photosensitizer and a sacrificial agent.

The invention discloses a photoresist composition based on metal nanoparticles and application of the photoresist composition. The photoresist composition comprises metal nanoparticles, a photosensitizer, an anti-diffusion agent and a photoresist solvent, wherein the metal nanoparticles are silver nanoparticles, copper nanoparticles and gold nanoparticles. The photoresist composition has good film-forming property and excellent patterning imaging capability, photoetching patterns with different resolutions can be obtained through ultraviolet, electron beam or extreme ultraviolet exposure, and the formed patterns have good conductivity after being subjected to heat treatment and can be directly used for processing micro-nano devices.

The invention relates to the technical field of thin film materials, in particular to a PBAT degradable composite material for preparing a thin film and a preparation method and application thereof. The PBAT degradation composite material is prepared from poly (butylene adipate-co-terephthalate), modified nanocellulose and a photosensitizer through melt blending, the photosensitizer is specifically added into the preparation raw materials for preparing the PBAT degradation composite material, the photosensitizer generates active oxygen under ultraviolet light by utilizing a photo-biological synergistic degradation mechanism, ester bonds in PBAT molecular chains are preferentially attacked, and the modified nanocellulose provides microorganism attachment sites to accelerate the enzymolysis process during biological composting; compared with a film without adding the photosensitizer, the tensile strength and the elongation at break of the film prepared by the invention are improved, and the tensile strength and the elongation at break after ultraviolet aging are obviously reduced, so that the degradation of the film is facilitated.

The invention discloses a blood vessel cross-linking agent and a medical device, and relates to the technical field of blood vessel treatment. The blood vessel cross-linking agent comprises a photosensitizer and an anti-inflammatory composition, and the mass ratio of the photosensitizer to the anti-inflammatory composition is (1: 0.02)-(1: 100); wherein the anti-inflammatory composition comprises an anti-inflammatory drug and a temperature-sensitive hydrogel, and the mass ratio of the anti-inflammatory drug to the temperature-sensitive hydrogel is (1: 1)-(1: 100). According to the blood vessel cross-linking agent disclosed by the invention, collagen and elastin in a blood vessel wall can be induced to be rapidly combined and form a stent in situ by exciting the photosensitizer, so that healing and repairing of blood vessels are realized; the anti-inflammatory composition disclosed by the invention comprises the anti-inflammatory drug and the temperature-sensitive hydrogel, also has the effects of durably resisting inflammation and eliminating side effects of active oxygen, and also can reduce the risk of degradation of the anti-inflammatory drug under illumination and ensure the activity and concentration of the anti-inflammatory drug.

Provided is a resin composition which comprises: a resin that is a polyimide or a polyimide precursor and that has a structure represented by formula (A-1); and a photosensitizing agent. Also provided are: a cured product which is obtained by curing the composition; a method for producing the cured product; a laminate which comprises the cured product; a method for producing the laminate; a semiconductor device; a method for producing the semiconductor device; and a novel resin.

This invention relates to the field of catalyst technology, and particularly to a method for preparing and applying a self-photosensitive organic molecular catalyst. The method for preparing the self-photosensitive organic molecular catalyst includes the following steps: deprotonating tetrathione with a non-nucleophilic strong base to obtain deprotonated tetrathione; subjecting the deprotonated tetrathione to a nucleophilic substitution reaction to obtain a monotin-substituted tetrathione; subjecting the monotin-substituted tetrathione to a Stille coupling reaction with 5-bromo-isophthalaldehyde to obtain a tetrathione derivative containing multiple aldehyde groups; and reacting the tetrathione derivative containing multiple aldehyde groups with a polyamine via a Schiff base reaction to obtain the self-photosensitive organic molecular catalyst. The self-photosensitive organic molecular catalyst of this invention achieves a synergistic reaction of CO2 reduction and organic molecule oxidation without the need for additional photosensitizers and sacrificial agents.

The invention discloses an ionic elastomer photoelectric sensor based on triplet-triplet annihilation up-conversion and a preparation method of the ionic elastomer photoelectric sensor, and belongs to the technical field of functional materials and photoelectric sensing. The photosensitizer and the luminescence agent form a triplet state-triplet state annihilation up-conversion system. The preparation method comprises the following steps: respectively forming the ionic conductive phase and the optical active phase, mixing the ionic conductive phase and the optical active phase to form a homogeneous system, and curing and molding through photo-initiation polymerization. Under the optical excitation condition of a specific wave band, the ion elastomer can generate measurable electric signal output, so that conversion from an optical signal to an electric signal is realized. The flexible photoelectric sensor can be prepared by curing the material on the surface of an electrode, can work under the condition of no external bias voltage or low bias voltage, has the characteristics of good wavelength selectivity, excellent flexibility and stretchability and the like, and has an application prospect in the fields of wearable sensing and flexible electronics.

The invention discloses a photoresponsive antibacterial hydrogel, which comprises a photosensitizer, acrylamide, potassium 3-sulfopropyl methacrylate, chitosan quaternary ammonium salt, an additive and a cross-linking agent, and the structure of the photosensitizer (PD-Se) is shown in the specification. A photosensitizer (PD-Se) is added into hydrogel, the positive charge characteristic of QSA hydrogel remarkably improves the local enrichment concentration of PD-Se in thalli by enhancing the binding force with the bacterial surface, unsaturated fatty acid in a bacterial membrane lipid bimolecular layer is oxidized after photoinduced ROS is generated, guanine bases in a DNA double-helix structure are attacked at the same time, and therefore the bioactivity of the bacterial membrane lipid bimolecular layer is improved. The gel is endowed with photodynamic antibacterial ability, has an excellent sterilizing effect on escherichia coli, staphylococcus aureus and methicillin-resistant staphylococcus aureus, and can be used for preparing hydrogel dressing for wound repair.

The application discloses a UV-LED curing intaglio printing ink, and raw materials for preparing the UV-LED curing intaglio printing ink include 20-40 wt% of a prepolymer, 20-60 wt% of a monomer, 2-50 wt% of a pigment, 3-8 wt% of a photoinitiator, 0.2-0.4 wt% of a photosensitizer, 0.5-6 wt% of a dispersant and 0.5-1 wt% of an antifoaming agent, the monomer containing a hydroxyl group or / and an acidic group accounts for 1-10 wt% of the total raw material mass of the ink, the photoinitiator is a cleavage type acyl phosphine oxide, and the photosensitizer is a photosensitizer with a benzalacetone free radical group. The application adopts the cleavage type acyl phosphine oxide as the photoinitiator, and simultaneously combines the photosensitizer with the benzalacetone free radical group to carry out a combination structure and function, so that the initiation efficiency of the ink is obviously improved while the ink has good viscosity and adhesion, and then the curing speed of the printing ink is greatly improved.

The invention discloses a force-induced discoloration elastic material based on a holographic photocuring technology and a preparation method. The force-induced discoloration elastic material comprises the following components in percentage by mass: 48%-90% of a polymer matrix, 0.3%-4% of a photo-initiation system and 6%-50% of a recording component, the polymer matrix comprises the following components in percentage by mass: 73%-89% of an acrylate monomer, 10%-25% of a thiol monomer and 0.5%-3% of a catalyst; the photo-initiation system comprises a photosensitizer and a co-initiator, and the dosages of the photosensitizer and the co-initiator respectively account for 0.05%-1% and 0.2%-3% of the total mass of the mechanochromic elastic material; the recording component comprises the following components in percentage by mass: 62%-85% of first fluorine-containing acrylate, 10%-35% of second fluorine-containing acrylate and 0-6% of a cross-linking agent. The mechanochromic elastic material has excellent mechanical properties and optical properties, can provide an important material basis for a new generation of intelligent flexible optical devices, and has a wide application prospect.

Resin composition comprising at least three components (a), (b) and (c); wherein component (a) is a polymer having a structure represented by the following formula (1), component (b) comprises thermal crosslinking agent (b1) and thermal crosslinking agent (b2), and component (c) is a photosensitizer, wherein R1 and R2 are independently selected from groups containing at least one atom other than hydrogen; and R3 and R4 are independently selected from a hydrogen atom or an organic group having 1 to 20 carbon atoms, and n is an integer selected from 1 to 10, wherein the thermal crosslinking agent (b1) is selected from a low-temperature thermal crosslinking compound having a thermal crosslinking temperature of 120 to 180 °C, and from a structure represented by the following formula (2), wherein R8 is selected from an organic group containing 2 to 30 carbon atoms;R9 is selected from an organic group containing 1 to 10 carbon atoms; s is an integer selected from 1 to 4, p is an integer selected from 1 to 16, and s + p > 2, wherein the thermal crosslinking agent (b2) is selected from a thermal crosslinking compound with a thermal crosslinking temperature of 180 to 400 °C and from a structure containing an acrylic acid with one or more structures represented by the following formula (5), wherein R10 is selected from an organic group containing 2 to 25 carbon atoms, and z is an integer selected from 1 to 10, wherein the photosensitizer of component (c) is a photoacid former.

The invention discloses a near-infrared light response ester exchange resin composition as well as a preparation method and application thereof, and relates to the field of dynamic covalent polymer materials formed by ester exchange of glass-like polymers. The composition comprises matrix resin containing an ester group, a hydroxyl-containing reactive diluent, a thermal initiator or a near-ultraviolet / visible light initiator, a near-infrared photosensitizer and a photoacid generator, the matrix resin and the reactive diluent can be polymerized under heating or irradiation of light with the wavelength of 380-780 nm to generate cured resin, and the photoacid generator is kept stable in the process; under irradiation of near-infrared light with the wavelength larger than 780 nm, the near-infrared photosensitive agent and the photoacid generator act to achieve an in-situ acid production catalytic reaction, cured resin is driven to form a dynamic covalent polymer material through ester exchange, and the dynamic covalent polymer material has the characteristic that precise space-time regulation and control can be achieved.

The invention discloses a drug-loaded nanoparticle as well as a preparation method and application thereof. The drug-loaded nanoparticles comprise active components and a carrier, wherein the active components comprise a hydrophobic small-molecule inhibitor and PAEMA; the carrier comprises an amphiphilic polymer bonded with a photosensitizer; the amphiphilic polymer bonded with the photosensitizer is coated with a hydrophobic small-molecule inhibitor and PAEMA (Polyacrylamide); wherein the amphiphilic polymer bonded with the photosensitizer comprises the photosensitizer, a hydrophilic chain segment and a hydrophobic chain segment. Precise drug delivery is achieved through characteristic transformation of the nano-carrier driven by tumor acidity, M2 type macrophages can be removed, dendritic cells can be induced to be mature, tumor cells can be killed, and therefore the synergistic anti-tumor effect of photodynamic therapy and immunotherapy is enhanced. Therefore, various drugs can be accurately delivered to target cells with different spatial distributions, so that the cell killing level and the antigen presenting cell mediated immunocompetence are enhanced at the same time.

The invention provides a patterning composition, a patterning film, a patterning method and application thereof. Specifically, the patterning composition includes a polymer and a compound represented by the following general formula (1). The patterning composition is used as a photosensitizer, the patterning composition can improve the sensitivity under the exposure condition on the premise of preserving the advantage of high resolution, and the problems that an existing patterning composition is poor in sensitivity and low in resolution are solved. General formula (1)

The invention relates to the technical field of biological medicines, and particularly discloses a nanocapsule SMCPM and application thereof in medicines for treating or preventing osteosarcoma and pulmonary metastasis. The SMCPM is composed of a photosensitizer Ce6 carried by mesoporous silicon oxide-manganese oxide particles, an NRF2 inhibitor ML385 and an OS targeting peptide PT-7. Experiments prove that the SMCPM is high in penetrating power and strong in cell killing effect; by down-regulating NRF2 expression and reversing nuclear translocation, a biochemical inhibitory microenvironment can be effectively repaired, the tolerance of cells to active oxygen and epithelial-mesenchymal transition activated and induced by a NOTCH1 signal axis are remarkably reduced, the oxidative stress level of the cells is enhanced, and PIT-induced immunogenic cell death is promoted; the released Mn < 2 + > and double-stranded DNA can regulate and control an immunosuppressive microenvironment by activating an STING pathway in cells, thereby inhibiting the growth of osteosarcoma and preventing lung metastasis.

The invention belongs to the field of tumor nano immunotherapy, and particularly relates to a nano immunotherapeutic agent cooperating with I / II type photodynamic and multiple cell death and anti-tumor application of the nano immunotherapeutic agent. The invention successfully constructs the nanoparticles (HMB) capable of targeting mitochondria and simultaneously exciting the photodynamic effects of the type I and the type II. Based on in-vitro and in-vivo experiments of a system, it is verified that ferroptosis and pyroptosis can be effectively triggered through photodynamic therapy mediated by the combination of the HMB and a ferroptosis inducer sulfasalazine. The multi-mode cell death network constructed by combining HMB with salazosulfapyridine represents a novel promising cancer treatment method, so that a novel strategy with transformation potential is provided for solid tumor treatment; and an important theoretical and practical basis is provided for deeply understanding a tumor cell death mechanism and designing a new-generation intelligent photosensitizer system according to the death mechanism.

The invention discloses a method and device for guiding photodynamic therapy through microscopic endoscopic imaging, and belongs to the technical field of diagnosis and treatment integration of photodynamic therapy. The method comprises the steps that a tissue surface microstructure is marked through a photosensitizer; tissue surface microstructure information is collected; tumor boundary identification is assisted by tissue microstructure information; the invention relates to photodynamic therapy guided by microscopic endoscopic imaging. The device comprises an excitation light module, an imaging optical fiber bundle module, a fluorescence imaging module and a treatment light module. The microscopic endoscopic fluorescent contrast agent suitable for a photodynamic therapy scene is developed through a new use strategy of old medicines; selecting an optical fiber bundle made of a glass material to collect a tissue microstructure displayed by a photosensitizer on the surface of an organ, and performing auxiliary judgment on a tumor boundary in a white light image; a photodynamic therapy strategy under the guidance of microscopic endoscopic imaging is realized, and clinical transformation application value of diagnosis and treatment integration is realized.

Provided are: a photosensitive resin composition which contains a photosensitizing agent and at least one resin that is selected from the group consisting of polyimide precursors and polyimides, and which satisfies the requirements (i) to (v) described below; a cured product; a laminate; a method for producing a cured product; a method for producing a laminate; a method for producing a semiconductor device; and a semiconductor device. (i) The transmittance at a wavelength of 365 nm is 20% or more. (ii) The film dissolution rate is 0.8 µm / sec or less. (iii) The ethylenically unsaturated group value of the resin is 2.3 mmol / g or less. (iv) The elongation at break of a cured product thereof is 60% or more. (v) The Young's modulus of a cured product thereof is 3.5 GPa or more.

The application relates to a micro light-emitting structure and a preparation method thereof. The method comprises the following steps: providing a light-emitting chip; coating a compound material in a target grid area of a grid substrate with a barrier wall and a tunnel, to obtain a first material layer on the top of the barrier wall and a second material layer in the tunnel, the thickness of the first material layer being smaller than the thickness of the second material layer, wherein the compound material comprises light-emitting particles emitting at least one target color, a resin system, a photosensitizer and a crosslinking agent; based on the photosensitizer, performing exposure treatment on the first material layer and the second material layer, and performing developing treatment on the first material layer and the second material layer after the exposure treatment, to remove the first material layer and part of the second material layer; based on the crosslinking agent, performing crosslinking and solidification on the remaining part of the second material layer, to solidify the light-emitting particles and the resin system in the tunnel, to obtain a grid pattern; and arranging the grid pattern on the light-emitting side of the light-emitting chip, to form the micro light-emitting structure.

The present invention addresses the problem of providing: a curable functional paste having excellent depth curability in a curing method using light irradiation; an adhesive, a sealing material, or a coating agent which contains the same; a cured product of the same; a semiconductor device or an electronic component which includes said cured product; and a curing method, an adhering method, a sealing method, and a coating method which use said curable functional paste.　Provided are: a curable functional paste comprising (A) a polymerizable compound, (B) a photopolymerization initiator, (C) a photosensitizer, and (D) a luminous body, wherein the (C) photosensitizer is present in the curable functional paste so as to absorb light having a wavelength of greater than 500 nm, cause triplet-triplet energy transfer to the (D) luminous body, and induce decomposition by means of light having a wavelength of greater than 500 nm; an adhesive, a sealing material, or a coating agent which contains the same; a cured product of the same; a semiconductor device or an electronic component which includes said cured product; and a curing method, an adhering method, a sealing method, and a coating method which use said curable functional paste.

This invention discloses a thermoplastic polyolefin waterproof membrane and its preparation method, belonging to the field of polymer membrane materials. The thermoplastic polyolefin waterproof membrane includes a waterproof surface layer and a thermoplastic softening and permeating layer. The waterproof surface layer comprises the following components in parts by weight: 100 parts polyolefin elastomer, 25-28 parts polypropylene polyol, 8-9 parts toughening agent, 4-6 parts thermally conductive modifier, 0.8-1.5 parts antioxidant, and 1-1.2 parts light stabilizer. The thermoplastic softening and permeating layer comprises the following components in parts by weight. The composition comprises: 25-30 parts of a silane coupling agent containing isocyanate functional groups, 13-15 parts of epoxy polyurethane modified porous C5 petroleum resin microspheres, 0.15-0.25 parts of an organotin catalyst, and 10-12 parts of a photosensitizing reactant; wherein the photosensitizing reactant is a microcapsule formulation; the shell material of the microcapsule formulation includes hydroxyl-terminated polycaprolactone and ethylene-vinyl acetate copolymer; the core material of the microcapsule formulation comprises the following components by weight fraction: 84-85 parts of the photosensitizing reactant and 4-6 parts of a photosensitizer. This application can be applied to the reinforcing sealing of welds in thermoplastic polyolefin waterproof membranes.

This invention discloses a nanomedicine and its application in the four-modal synergistic treatment of ER+ breast cancer, encompassing gas therapy, photothermal therapy, photodynamic therapy, and combined therapy, relating to the fields of biotechnology and new medicine. This nanomedicine uses an amphiphilic polymer as a carrier and organic compounds and photosensitizers as drug loading agents. Through the synergistic effects of four modes—photothermal, photodynamic, gas therapy, and combined therapy—it effectively inhibits the growth and metastasis of breast cancer cells. The amphiphilic polymer, based on PHHM-ADT, is modified with hydrogen sulfide gas as a donor, and its amphiphilicity allows for spontaneous assembly into nanoscale hollow, regular spheres. Utilizing the high permeability and retention effect (EPR effect) at the tumor site, it achieves efficient drug accumulation in tumor tissue. The prodrug PSF couples fulvestrant and pabuxiparin via disulfide bonds, and the photosensitizer IR808 integrates photothermal and photodynamic therapy. The synergistic effect of multiple mechanisms of action enhances the therapeutic effect.

This invention relates to a thermoplastic elastomer material, its preparation method, and its applications, belonging to the technical field of polymer compound compositions. The thermoplastic elastomer material of this invention, by weight, comprises the following components: 28-42 parts PBAT resin, 20-30 parts TPEE resin, 20-30 parts SEBS elastomer, 10-20 parts naphthenic oil, 10-20 parts biodegradable filler, 3-8 parts compatibilizer, and 1.8-5.2 parts degradation control agent; the biodegradable filler has a particle size D50 of 10 μm to 20 μm; the degradation control agent is a mixture of photosensitizer, chitin, and polycarbodiimide. This thermoplastic elastomer material possesses excellent mechanical properties, adhesive bonding properties, and biodegradability.