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Transcutaneous photodynamic treatment of targeted cells

The present invention is drawn to methods and compounds for photodynamic therapy (PDT) of a target tissue or compositions in a mammalian subject, using a light source that preferably transmits light to a treatment site transcutaneously. The method provides for administering to the subject a therapeutically effective amount of a targeted substance, which is either a targeted photosensitizing agent, or a photosensitizing agent delivery system, or a targeted prodrug. This targeted substance preferably selectively binds to the target tissue. Light at a wavelength or waveband corresponding to that which is absorbed by the targeted substance is then administered. The light intensity is relatively low, but a high total fluence is employed to ensure the activation of the targeted photosensitizing agent or targeted prodrug product. Transcutaneous PDT is useful in the treatment of specifically selected target tissues, such as vascular endothelial tissue, the abnormal vascular walls of tumors, solid tumors of the head and neck, tumors of the gastrointestinal tract, tumors of the liver, tumors of the breast, tumors of the prostate, tumors of the lung, nonsolid tumors, malignant cells of the hematopoietic and lymphoid tissue and other lesions in the vascular system or bone marrow, and tissue or cells related to autoimmune and inflammatory disease.
Owner:LIGHT SCI ONCOLOGY

Cone sand making machine and sand making method

The invention relates to a cone sand making machine and a sand making method with high efficiency, low energy consumption and high sand making yield. A big bevel gear is sleeved on an eccentric shaft sleeve which is sleeved in an axle hole in the centre of a lower shell through a copper jacket; a main shaft is positioned in the eccentric shaft sleeve through an inner copper sleeve; a spherical seat is positioned on a shell supporting ring of the positioning axle hole in the lower shell; a movable cone is sleeved on the main shaft through a spherical copper bearing bush and pushed by the main shaft to swing; a movable sleeve bushing is sleeved on the conical surface of the movable cone; an anti-wear movable sleeve is sleeved on the conical surface of the movable sleeve bushing; an inserteris sleeved on the main shaft and locked by a locking nut; an upper shell and the lower shell are connected together and three or more adjusting oil cylinders are arranged between the outer turned edges of the upper and lower shells; the inner wall of the upper shell is provided with annular spiral sawteeth which are engaged with those on the outer wall of an adjusting screw sleeve; and the adjusting screw sleeve has a double-trumpet structure, the lower trumpet-shaped wall of the adjusting screw sleeve is connected with an anti-wear fixed sleeve through a fixed sleeve bushing, and the upper trumpet-shaped wall of the adjusting screw sleeve is used for supporting a hopper assembly.
Owner:ZHEJIANG SHUANGJIN MACHINERY HLDG

Compound catalytic material for purifying harmful gas

ActiveCN101474419ANo secondary pollutionNo light catalytic purification effectDeodrantsSide effectClearance rate
The invention relates to a compound catalytic material for purifying harmful gas. Deionized water is used as dispersant to compound nano-catalytic material, rare earth compound, p-type semiconductor, antimicrobial, plant extract and anion powder. The compound catalytic material can fast and thoroughly eliminate free formaldehyde, benzene homologue, ammonia and TVOC harmful gas. The compound catalytic material does not require ultraviolet light, has simple use and low cost and does not have toxic side effect and secondary pollution, and the purification effect can last for more than five years without rebound. At the same time, the compound catalytic material prevents bacteria, germina and mildew from invading human body, removes peculiar smell, odor, smoke, leather flavour, paint flavour and the like, increases anion and far infrared ray which are beneficial to human body and improves indoor air environmental quality comprehensively. The experiment detection shows that formaldehyde clearance rate within 24 hours is 91.6 percent; benzene clearance rate is 88.9 percent; ammonia clearance rate is 90.5 percent; TVOC clearance rate is 87.6 percent; sterilization and bacteriostasis rate is 99.99 percent; mould prevention is 0 grade; and acute oral toxicity is tested as actually nontoxic class.
Owner:HENAN MUBO INDAL
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