33754results about How to "Improve versatility" patented technology

Medical devices and related methods for closing a perforation in a bodily wall are provided. The medical device generally includes an introducer device having a base defining a plurality of recesses formed therein. Visceral staples are disposed within the recesses in a delivery state and are biased toward a deployed state. A holding mechanism retains the staples in the delivery state, and the holding mechanism is moveable relative to the base to allow the staples to extend out of the recesses. The biased nature of the staples will cause them to transition into the deployed state after the staples have been released, such that the staples will thereby pierce adjacent tissue and remain closed. The holding mechanism can be retractable or pivotable out of engagement with the staples. The introducer device can include upper and lower jaws or a slidable cover relative to the base.

A catheter includes a cryoablation tip with an electrically-driven ablation assembly for heating tissue. The cryoablation tip may be implemented with a cooling chamber through which a controllably injected coolant circulates to lower the tip temperature, and having an RF electrode at its distal end. The RF electrode may be operated to warm cryogenically-cooled tissue, or the coolant may be controlled to conductively cool the tissue in coordination with an RF treatment regimen, allowing greater versatility of operation and enhancing the lesion size, speed or placement of multi-lesion treatment or single lesion re-treatment cycles. In one embodiment a microwave energy source operates at a frequency to extend beyond the thermal conduction depth, or to penetrate the cryogenic ice ball and be absorbed in tissue beyond an ice boundary, thus extending the depth and / or width of a single treatment locus. In another embodiment, the cooling and the application of RF energy are both controlled to position the ablation region away from the surface contacted by the electrode, for example to leave surface tissue unharmed while ablating at depth or to provide an ablation band of greater uniformity with increasing depth. The driver or RF energy source may supply microwave energy at a frequency effective to penetrate the ice ball which develops on a cryocatheter, and different frequencies may be selected for preferential absorption in a layer of defined thickness at depth in the nearby tissue. The catheter may operate between 70 and minus 70 degrees Celsius for different tissue applications, such as angioplasty, cardiac ablation and tissue remodeling, and may preset the temperature of the tip or adjacent tissue, and otherwise overlay or delay the two different profiles to tailor the shape or position where ablation occurs or to speed up a treatment cycle.

Optical elements such as a vari-focal lens element, a vari-focal diffractive optical element and a variable declination prism usable as spectacle lens elements and so on.

A mold system for blow molding hollow plastic containers includes an extruder for providing a hollow tube of plastic material having a longitudinal axis. Three mold segments include at least two mold segments that are movable against the third mold segment, in directions perpendicular to the tube axis, between a closed position in which the mold segments form a hollow mold cavity in which the tube is captured and an open position spaced from the tube axis. A blow pin is disposed on one of the mold segments to pierce the tube in the closed position of the mold segments. One of the mold segments may be a mold core movably mounted on a second of the mold segments, and cylinders are mounted on the second mold segment for moving the mold core between an extended position and a retracted position with respect to the second mold segment. The blow pin may be movably mounted on the mold core.

The present invention relates to a wireless home automation system having controllers for controlling a broad variety of functions via two-way communication with a plurality of devices. More specifically, the invention relates to sharing information related to the system between controllers, e.g. by updating a second controller with the newly learned information of a first controller, or by replicating a controller by making a second controller a complete copy of a first controller. The information can be shared by generating and transmitting, with a first controller, a list of device identifiers of devices controlled by the first controller to a second controller. The list is received by the second controller and stored in a memory of the second controller dedicated to store device identifiers of devices controlled by the second controller. This function proves advantageous when new controllers are introduced or if a controller is lost, worn out, or destroyed.

A method and system are disclosed for the mapping of energy delivery devices to energy sources. Energy capable of affecting a measurable property of the system is delivered through the energy delivery devices from the energy sources. A change in a property when the energy is delivered is measured using measuring devices that are associated in a known way with the energy delivery devices. A profile of the change is compared to a profile of the energy output in order to determine which energy sources produce an output capable of affecting the property measurable by each measuring device and, because of the association between measuring devices and energy delivery devices, each energy delivery device.

The present invention provides multifunctional magnetic nanoparticle probe compositions for molecular imaging and monitoring, comprising a nucleic acid or polypeptide probe, a delivery ligand, and a magnetic nanoparticle having a biocompatible coating thereon. The probe compositions may further comprise a fluorescent or luminescent resonance energy transfer moiety. Also provided are compositions comprising two or more such multifunctional magnetic nanoparticle probes for molecular imaging or monitoring. In particular, the nucleic acid or polypeptide probes bind to a target and generate an interaction observable with magnetic resonance imaging (MRI) or optical imaging. The invention thereby provides detectable signals for rapid, specific, and sensitive detection of nucleic acids, polypeptides, and interactions thereof in vivo.

An easy to use, inexpensive fastener device that is generally shaped like the letter “H,” or similar cross-connected structure, which is used for bundling multiple items in conjunction with a closed loop band. The multi-purpose fastening device has a simple structural design such that a continuous length of cord or elastic may be looped around one of the uprights of the “H,” wrapped around a bundle of items, and then looped around the other upright of the “H,” thus holding the items together. The clip may be constructed of plastic, metal, or other rigid material and may be of varying size, thickness, and tensile strength, depending on the weight to be supported.