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Tissue-specific and pathogen-specific toxic agents and ribozymes

InactiveUS6271359B1Rapidly and effectively expressedImprove stabilityVirusesSugar derivativesCancer cellBiology
The present invention relates to the discovery, identification and characterization of toxic agents which are lethal to pathogens and methods for targeting such toxic agents to a pathogen or pathogen infected cells in order to treat and/or eradicate the infection. In particular, the present invention relates to toxic agents which target bacteria at different stages of the bacterial life cycle, which are delivered alone or in combination to bacteria or bacteria-infected cells. The invention relates to toxic agents which are lethal to diseased cells and methods for targeting such toxic agents to a diseased cell in order to treat and/or eradicate the disease. The present invention relates to promoter elements which are pathogen-specific or tissue-specific and the use of such promoter elements to achieve pathogen-specific or tissue-specific expression of the toxic agent(s) and/or ribozyme(s) of the present invention. Specifically, the invention relates to the delivery of one or more toxic gene products, antisense RNAs, or ribozymes, or combination thereof. The invention provides a novel system by which multiple pathogenic targets may be simultaneously targeted to cause the death of a pathogen, or cell infected with a pathogen. Further, the invention has important implications in the eradication of drug-resistant bacterium and bacterial pathogens. The invention provides a novel system by which multiple targets may be simultaneously targeted to cause the death of a diseased cell. The invention also has important implications in the eradication of drug-resistant pathogens and drug-resistant diseased cells (such as cancer cells).
Owner:MUSC FOUND FOR RES DEV +1

System and method for model-driven dashboard for business performance management

A system, method, and framework resulting therefrom, for a model-driven dashboard for business performance management, which includes capturing business dashboard model requirements at a business model level by providing at least one user-customizable model for capturing functionality of a dashboard, and after the user defines the functionality of the dashboard using the at least one user-customizable model, automatically generating code for a deployable dashboard application.
Owner:IBM CORP

Advanced discovery of cloud resources

A non-transitory computer-readable storage medium has tangibly embodied thereon and accessible therefrom instructions interpretable by at least one data processing device. The instructions are configured for causing the at least one data processing device to perform a method comprising creating a resource group for providing cloud services, receiving a request to increase a quantity of the virtual machines of the resource group; and instantiating one or more additional virtual machines within the resource group in response to receiving the request. The resource group includes one or more virtual machines that all have virtual machine specifications of a particular configuration. Instantiating the one or more additional virtual machines includes providing each one of the one or more additional virtual machines with virtual machine specifications of the particular configuration.
Owner:HCL TECH LTD

Method and system for detecting anomalies in a bipartite graph

A method of detecting anomalies from a bipartite graph includes analyzing the graph to determine a row-cluster membership, a column-cluster membership and a non-negative residual matrix, and in a processor, detecting the anomalies from the non-negative residual matrix.
Owner:IBM CORP

Entertainment venue data analysis system and method

A system and method for analyzing entertainment venue data for improved venue management, comprising conventional computer hardware and including compatible software application for compiling and manipulating event consumer and sales data as well as third party consumer demographic data, including classification of event data into a plurality of event-type clusters, correlation of consumer data and event cluster data, and performing manipulations of said data in response to user queries and displaying query results. In a preferred embodiment, associative query logic database technology is used to create a data cloud of event venue consumer and sales data as well as third-party sourced demographic data.
Owner:NERENHAUSEN MARK +3
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