An integrated
system for the monitoring and treating diabetes is provided, including an integrated
receiver / hand-held medicament injection pen, including
electronics, for use with a continuous glucose sensor. In some embodiments, the
receiver is configured to receive continuous glucose sensor data, to calculate a medicament therapy (e.g., via the integrated
system electronics) and to automatically set a bolus
dose of the integrated hand-held medicament injection pen, whereby the user can manually inject the bolus
dose of medicament into the host. In some embodiments, the integrated
receiver and hand-held medicament injection pen are integrally formed, while in other embodiments they are detachably connected and communicated via mutually engaging
electrical contacts and / or via
wireless communication.