58 results about "Tissue impedance" patented technology

The invention discloses an intelligent management system and method applied to a radio frequency energy output device, and belongs to the technical field of intelligent management of the radio frequency energy output device.An integrated sensor array is deployed on a radio frequency host and a hand tool electrode, and load voltage, output current, electrode temperature and tissue impedance are synchronously collected; a dynamic thermal impedance collaborative analysis model is constructed after time synchronization alignment, a three-dimensional thermal field simulation map is generated, and a thermal accumulation trend is predicted; a double-layer control framework is constructed, a first control layer generates a dynamic power adjustment rule base based on a preset treatment target and a safety threshold value and outputs an instruction, a second control layer receives the instruction and adjusts output parameters in real time, and a strategy is adjusted by combining a model prediction result in the execution process; meanwhile, the operation state is continuously monitored, a fault classification model is constructed for anomaly detection, a fault source is positioned, and a visual report is generated; and finally, constructing a mapping relation based on historical data, and generating an energy control scheme adapted to individualized requirements through iterative optimization.

Electroporation-based therapies (EBTs) employ high voltage pulsed electric fields (PEFs) to permeabilize tumor tissue, resulting in changes in passive electrical properties detectable using electrical impedance spectroscopy (EIS). Currently, commercial potentiostats for EIS are limited by impedance spectrum acquisition time (˜10 s); this timeframe is much larger than pulse periods used with EBTs (˜1 s). Fourier Analysis SpecTroscopy (FAST) is introduced as a methodology for monitoring tissue inter-burst impedance (diagnostic FAST) and intra-burst impedance (therapeutic FAST) during EBTs. FAST is a rapid-capture (<<1 s) technique which enables monitoring of inter-burst and intra-burst impedance during EBTs in real-time. FAST identified a frequency which delineates thermal effects from electroporation effects in measured impedance. Significance: FAST demonstrates the potential to perform EIS, in addition to intra-burst impedance spectroscopy, using existing pulse generator topologies.

The invention discloses a radio frequency ablation electrode control method which comprises the following steps: S1, initializing an ablation temperature target value, a safety limit value and a power adjusting range, and loading a pre-stored anal fistula ablation three-stage feature library and impedance-temperature correlation degree thresholds of all stages; s2, collecting the electrode temperature, the electrode-tissue impedance and the ablation duration in real time, and judging the current ablation stage according to the matching relationship between the ablation duration and the three-stage feature library; s3, formulating a state judgment rule according to the current stage; s4, a fuzzy PID algorithm is adopted to calculate a power basic adjusting amount, a power dynamic compensation amount is calculated, and final output power is determined; and S5, repeating the steps S2-S4 to realize closed-loop control, triggering first-level early warning when the parameters are close to the boundary, triggering second-level alarm when the parameters exceed the safety limit value, and recording abnormal data. The stage adaptability is high, the problem of temperature adjustment lag can be solved, the adjustment precision is accurate enough, and the ablation effect can be improved.

The invention discloses a dynamic test method and system for tissue frequency domain impedance characteristics, and belongs to the technical field of medical detection. The system comprises an energy generator, a bipolar scalpel, a signal generator, a radio frequency power amplifier module, a control unit, two loop switches, a sampling probe and a test unit. An electrode of the bipolar scalpel is used for being in contact with a biological tissue to be subjected to frequency domain impedance characteristic testing; the energy generator is connected with the first loop switch and is used for outputting an electric resection / electrocoagulation signal to the biological tissue so as to dynamically reproduce the state change of the biological tissue; and the signal generator inputs a broadband excitation voltage signal to the biological tissue through the radio frequency power amplifier module and the second loop switch. The control unit is used for coordinating on-off of the two loop switches. The sampling probe is used for collecting voltage and current signals of the double electrodes in real time and feeding back the signals to the testing unit. The test unit generates a real-time impedance characteristic spectrogram of the biological tissue along with frequency change. The tissue impedance change can be monitored on line in real time.

The invention discloses a nanosecond steep pulse excitation system and a nanosecond steep pulse excitation method. The nanosecond steep pulse excitation system comprises a high-voltage pulse generation module, a controller, an impedance detection module and a treatment electrode, the high-voltage pulse generation module is used for receiving a control signal monitored by the controller and outputting a high-voltage pulse to the treatment electrode; the impedance detection module comprises a measuring electrode, tissue impedance data are collected through the measuring electrode, and the impedance data are dynamically fed back to the controller; the controller dynamically adjusts parameters of the high-voltage pulse generation module according to impedance data to form closed-loop control, the Marx circuit is optimized, the high-voltage pulse generation efficiency is high, nanosecond-level accurate triggering is achieved through embedded control, effective deposition of high-frequency energy is ensured, transient voltage spikes are reduced, impedance changes are detected in real time through the impedance detection module, and the control precision is improved. The pulse width or amplitude is dynamically adjusted, pulse parameters are adjusted in real time based on impedance changes, and excessive ablation or insufficient treatment is avoided.

The invention discloses a double-rod current phase difference energy control method and system, and relates to the technical field of electrosurgery, and the method comprises the steps: collecting a tissue impedance signal in real time, carrying out the anti-interference processing of an improved conditioning circuit, and calculating the impedance change rate. And when the change rate exceeds a threshold value, acquiring basic information of the suborgan tissues to carry out phase difference matching so as to obtain an optimal phase difference, and abandoning a single fixed phase difference output mode in the prior art. The phase difference is dynamically adjusted according to the tissue impedance signals collected in real time and the basic information of the suborgan tissue, complex changes of tissue characteristics are accurately adapted, and the problem that phase difference decision-making precision is insufficient is effectively solved. Meanwhile, the thermal injury risk can be remarkably reduced through accurate phase difference control, the operation safety is improved, the operation efficiency is optimized, and more reliable technical support is provided for clinical operation.

The invention relates to the technical field of equipment control, and discloses a control method of a wave conduction health care instrument capable of outputting different waveforms based on symptoms, and the method comprises the steps: transmitting a 1-10MHz multi-frequency detection wave to a target treatment area, calculating tissue impedance distribution through a reflected wave, and obtaining a focus boundary coordinate based on an impedance difference threshold; on the basis of the impedance-frequency response curve, an inverse phase compensation waveform is generated through a time reversal algorithm, the inverse phase compensation waveform comprises a phase delay component in negative correlation with the impedance curve, and tissue scattering distortion is counteracted; synchronously starting the electrical stimulation module and the ultrasonic module; the focus coordinates are repeatedly updated every 30 seconds, and the electrical stimulation focusing position is adjusted; the concentration of lactic acid and the concentration of prostaglandin E2 in tissue fluid are detected in real time through a microfluidic sensor, and correction is triggered when any concentration exceeds the limit, specifically, lactic acid ultralimit switching electrical stimulation is 50-100 Hz damped oscillatory waves (larger than or equal to 5 minutes), prostaglandin E2 ultralimit switching ultrasound is in a pulse mode, and the electrical stimulation amplitude is increased. The treatment effect of the waveform treatment equipment can be improved.

An ultrasonic surgical instrument and method for identifying tissue state and energizing the surgical instrument includes an end effector having an ultrasonic blade and an RF electrode, a shaft assembly, a body, and a power controller. A first ultrasonic energy input is configured to be actuated from a first unactuated energy input state to a first actuated energy input state. A trigger input is configured to be actuated from an unactuated trigger input state to an actuated trigger input state. The power controller is operatively connected to the ultrasonic blade, the RF electrode, the first ultrasonic energy input, and the trigger input and configured to direct at least one of the ultrasonic blade or the RF electrode to be selectively driven according to a predetermined drive function based on the tissue impedance, the state of the first energy input, and the state of the trigger input.

The application discloses an intelligent electronic otoscope control system and method based on electrical impedance detection, which contains an ear canal impedance signal collection unit, a weak signal conditioning unit, a multi-modal data processing unit, an intelligent analysis and decision unit, a man-machine interaction presentation unit and a closed-loop automatic control unit. A low-power multi-frequency impedance sensor array collects ear canal tissue impedance data at different frequencies, which is processed by the weak signal conditioning unit. The multi-modal data processing unit, combined with an edge computing gateway, completes analog-to-digital conversion and preliminary fusion. The intelligent analysis and decision unit uses an optimized impedance detection algorithm and a multi-dimensional heterogeneous data analysis model to deeply analyze the data, judges the ear health condition, and visualizes the results through the man-machine interaction presentation unit. The closed-loop automatic control unit realizes automatic adjustment of the detection process. The system and method can accurately detect ear health and improve the efficiency and accuracy of ear disease diagnosis.

An implantable neurostimulator for delivering one or more stimulation pulses to a target region within a patient's body. The implantable neurostimulator including a housing and an energy storage feature. There is also a lead coupled to the hermetic housing and a plurality of electrodes located proximate to a distal end of the lead. The neurostimulator includes stimulation circuitry that includes an adjustable resistance element. A voltage of the electric signal derived from the energy storage feature and a resistance of the adjustable resistance element are both adjusted based on a measurement of a value indicative of a tissue impedance of the target region to provide a desired value of a stimulation current for the one or more stimulation pulses.

Systems and methods for enhancing surgical outcomes by providing generators having optimal RF output for sealing, fusing and / or cutting tissue or vessels under all dynamic conditions are described. Examples of dynamic conditions may include varying tissue impedance load due to electrosurgical operations or tissue affects, any operational conditions and commands determined by the surgeon, surgical procedure and / or device script. This is achieved by implementing a digital closed-loop control system within the electrosurgical generator to regulate voltage, current, and power of the RF output. The digital closed-loop control system may include an RF amplifier for generating RF energy, a feedback system for constantly monitoring the electrical characteristics, e.g., voltage, current, and power, of the supplied RF energy to a connectable electrosurgical instrument and a microcontroller for processing measurement data from the feedback system and adjusting the output of the RF amplifier to meet a desired regulation target under any varying conditions.

The invention discloses an electrosurgical tissue impedance measurement system and method based on frequency domain analysis. The system comprises a main energy generation module, a modulation signal generation module, an output superposition module, a signal acquisition module, an impedance calculation module and a feedback control module. The main energy generation module outputs a high-frequency main waveform for tissue cutting or blood coagulation; the modulation signal generation module is used for generating a modulation signal, and the modulation signal comprises one of a multi-cosine signal or a multi-frequency sweep-frequency signal and a pseudo-random sequence; the output superposition module is used for superposing the modulation signal into the main waveform; the signal acquisition module synchronously acquires tissue voltage and current signals after the modulation signal is loaded; the impedance calculation module is used for performing frequency domain analysis on the voltage and current signals acquired by the signal acquisition module, extracting frequency components corresponding to modulation signals by using fast Fourier transform (FFT), phase lock detection (PLL) or a time-frequency analysis algorithm, and performing frequency domain analysis on multi-cosine signals or frequency sweep signals; by comparing the amplitude ratio and the phase difference of the corresponding frequency components of the modulation signal output end and the response end, the impedance Z = RZ < Z of the measured tissue is inverted according to the known reference impedance, and Z is the impedance of the measured tissue; rZ is the amplitude of the measured impedance and reflects the magnitude of the impedance; < Z represents the phase difference between the voltage and the current; for a pseudo-random sequence signal, a matched filter is used for carrying out related detection on an input signal, and a pseudo-random sequence value is extracted so as to obtain a system signal and control data; a feedback control module adjusts the output power or the cutting / coagulation mode of the electrosurgical equipment in real time according to the tissue impedance obtained through calculation and the dynamic change of the tissue impedance; wherein the dynamic change is a group of dynamic sequence values of the impedance of the measured tissue from the time dimension. By means of the design, real-time accurate measurement can be achieved, the anti-interference capability is high, errors are small, and efficient and safe cutting / blood coagulation can be achieved.

A system includes an energy-based surgical instrument having an end effector with two electrodes. One of the electrodes has multiple electrode portions. A generator coupled to the surgical instrument supplies radio frequency (RF) energy to the electrode portions for a tissue coagulation process, and further supplies RF energy at a higher voltage or current to the other electrode portion for a tissue transection process. Control elements monitor tissue impedance or tissue temperature. Other embodiments are described and claimed in this invention.

The embodiment of the invention discloses a high-frequency electrotome control device and a high-frequency electrotome control system. A specific embodiment of the device comprises a control unit configured to control a high-frequency power generator to output high-frequency electric energy; the data acquisition unit is configured to perform multi-dimensional data acquisition on human tissues; the signal acquisition unit is configured to perform signal acquisition on sound waves and perform feature extraction on sound wave signals; the feature extraction unit is configured to perform feature extraction on the tissue impedance information sequence and the human tissue image sequence; the feature fusion unit is configured to perform feature fusion on the acoustic wave feature tensor, the tissue impedance feature tensor and the human tissue feature tensor; the generation unit is configured to generate a high-frequency electrotome control instruction; and the adjusting unit is configured to adjust the output power and perform waveform modulation on the high-frequency electric energy. According to the implementation mode, excessive heat injury in the operation process can be reduced or the cutting and blood coagulation efficiency can be improved.

The invention discloses a steep pulse generator for high-frequency irreversible electroporation, which is characterized in that a pulse generation module simultaneously conducts positive and negative Sic MOSFETs (Metal Oxide Semiconductor Field Effect Transistor) through a bipolar push-pull structure to ensure that the rising / falling time, amplitude and pulse width of positive and negative pulses are strictly symmetrical and reduce tissue damage or non-uniform energy distribution caused by waveform asymmetry. Meanwhile, an adopted voltage closed-loop feedback control network can automatically compensate energy loss caused by tissue impedance fluctuation, it is ensured that the electric field intensity is stable, the penetration depth of the electric field can be accurately controlled, and the system is suitable for scenes with high treatment precision requirements. And multi-path output is expanded through the decoder, and flexible configuration of different electrode arrays is supported. Different modules are arranged independently in a split-board mode, high-voltage and low-voltage circuits are designed in a full-isolation mode, whole machine repair is not needed when faults occur, the equipment maintenance cost is reduced, and the expansibility of the modules is high.

The invention discloses a dual-mode ablation treatment system based on tissue characteristic automatic matching, and the system comprises a power conversion circuit which is used for converting a 220V AC commercial power into a DC power required by the system and meeting the EMC standard; the system control circuit is used for scheduling each module to work, receiving a processing instruction and controlling a machine to respond; the parameter display circuit is used for displaying system parameters and states; the system has the advantages that radiofrequency ablation and microwave ablation technologies are innovatively integrated, tissue impedance signals are collected in real time through the impedance detection circuit, the focus characteristics are automatically judged through the system control circuit, and when impedance is small, the system is automatically switched to a microwave ablation mode; when the impedance is too large, the radio frequency ablation mode is automatically switched to; manual equipment replacement or manual mode switching is not needed, the problem that independent equipment is low in treatment efficiency is solved, and incomplete ablation or normal tissue damage caused by manual judgment deviation is avoided.

The present application relates to the technical field of ultrasonic knife equipment, and discloses a multifunctional ultrasonic dissecting knife, which comprises a piezoelectric transducer, a variable amplitude rod, a frequency generating module, a working head, a detection part and a control part, and further comprises: the detection part is configured to obtain tissue information of a region to be dissected, wherein the tissue information comprises tissue load information and tissue impedance information; the control part is electrically connected with the detection part, the variable amplitude rod, the frequency generating module and the piezoelectric transducer respectively, and is configured to determine a preset output amplitude of the variable amplitude rod according to the tissue information, and determine an electric signal frequency of the frequency generating module according to the output amplitude. By acquiring the tissue load and impedance information in real time, the output amplitude of the variable amplitude rod and the electric signal frequency of the frequency generating module are intelligently adjusted, the dynamic adaptability and precise control of the energy output of the ultrasonic dissecting knife are realized, and the operation efficiency and safety are improved.

The invention provides an electrical stimulation equipment output parameter adaptive adjustment method based on biofeedback, and the method comprises the steps: collecting a baseline interference response signal of a calibration stimulation pulse after the attachment of an electrode assembly is completed, and extracting the amplitude, rising edge slope, decay time, waveform distortion and other reference interference response characteristics. Interference response signals corresponding to the treatment stimulation pulses are collected in real time in the treatment process, and treatment process interference response characteristics corresponding to the reference characteristics are calculated. By comparing the deviation degree of the interference response characteristic and the reference characteristic in the treatment process, the current electrode contact state is dynamically evaluated, the corresponding local tissue impedance state is deduced, and grading recognition of the states such as good contact, general contact and abnormal contact is achieved. On the basis, according to the electrode contact state and the tissue impedance state, the safety upper limits of output parameters of the stimulation current, the stimulation voltage, the pulse conduction time and the waveform rise time are calculated in a self-adaptive mode.

This invention relates to the field of neuroelectric stimulation technology, specifically a method and system for current regulation during neuroelectric stimulation. The method identifies the target nerve location and depth based on tissue impedance distribution data and patient characteristic parameters, using a deep neural network model to obtain a recommended initial stimulation current value and a personalized target amplitude. It acquires the deviation between the evoked potential amplitude and the personalized target amplitude, and analyzes this deviation with waveform characteristic parameters to obtain a first current regulation step value to adjust the coarse stimulation current until the evoked potential amplitude exceeds the personalized target amplitude. At this point, the current coarse stimulation current value is recorded as the optimized stimulation current value, and a comprehensive quality score is obtained. Based on the comprehensive quality score, a second current regulation step value is dynamically calculated to adjust the fine-tuned stimulation current value. When the comprehensive quality score exceeds a preset quality score threshold, the final stimulation current value is obtained. This effectively improves the accuracy of current regulation during neuroelectric stimulation for different patients.

A surgical system includes electrodes configured to deliver radiofrequency energy to tissue, and a processor configured to control delivery of the RF energy with increasing power, monitor tissue impedance, calculate tissue impedance slope, compare the tissue impedance to a predetermined impedance threshold, and compare the tissue impedance slope to a predetermined impedance slope threshold. The processor is configured to, in response to determining that the tissue impedance is not greater than the predetermined impedance threshold or that the tissue impedance slope is not greater than the predetermined impedance slope threshold, control the delivery of the RF energy to continue with increasing power. The processor is also configured to, in response to determining that the tissue impedance is greater than the predetermined impedance threshold and that the tissue impedance slope is greater than the predetermined impedance slope threshold, control the delivery of the RF energy with a predetermined constant voltage.

This disclosure related to a 3D biomimetic bioreactor platform. The 3D biomimetic bioreactor platform induces and quantifies cardiac fibrosis through synchronized multi-modal stimulation, maintaining native tissue preservation and inducing fibrosis from zero to any predefined ratio. The system combines electrical, mechanical, and biochemical cues to modulate tissue behavior, with real-time data acquisition on conduction velocity, tissue impedance, and strain-response curves. Advanced technologies, including vascularized microjet and 3D magnetic actuator, enable precise control over mechanical stretching and temporal modulation of strain. This innovative platform empowers researchers to study cardiac fibrosis mechanisms, assess treatment efficacy, and optimize therapeutic strategies for associated cardiovascular disorders, revolutionizing the field of cardiovascular research.

Disclosed is a method of adapting energy modality due to a short circuit or tissue type grasped in the jaws of an end effector of a surgical instrument and a system with a control circuit configured to execute the method. The method includes determining a first and second electrode of an array of segmented electrodes are shorted to each other, blending monopolar and bipolar RF energy to the array of segmented electrodes, and determining that the first and second electrodes remain shorted after the blending step. Additionally, or alternatively, the method may include determining that the first and second electrodes are no longer shorted after the blending step, sensing an electrical parameter of tissue grasped within jaws of the end effector, and determining an energy sealing and cutting procedure based on the sensed electrical parameter of the tissue.

The invention provides a voltage-controlled current source electrical stimulation circuit based on a standard 5V process, and the circuit is characterized in that the circuit comprises a voltage-controlled current conversion module, a stacked transistor output and control module, and a charge pump boost circuit module. The circuit works under external 5V power supply, adopts a standard 5V process, and can drive a wide-range load from 1k omega to 5k omega and output a wide-range adjustable current from 50mu A to 2mA. The circuit has the remarkable advantages that the circuit structure is simple, a special high-voltage process or an external high-voltage assembly is not needed, the manufacturing cost and the design complexity are reduced, and high integration and miniaturization are easy to realize. The wide load range characteristic of the circuit can stably drive common dynamic change tissue impedance in bioelectrical stimulation; the wide current output characteristic can adapt to various stimulation intensity schemes. Due to the characteristics, the device is highly matched with electrical stimulation application, and an effective technical approach is provided for developing low-cost and high-performance portable electrical stimulation medical equipment.

The invention discloses an electrotome system and a control method thereof, and belongs to the technical field of medical instruments. The invention aims to solve the problems of slow response and poor precision when an existing electrotome controls energy by adjusting voltage. A first aspect of the present invention provides an electrotome system whose control unit is configured to: calculate tissue impedance () and rate of change thereof; when the rate of change exceeds a predetermined predicted intervention slope, the pulse frequency is predictively adjusted to a safe cooling frequency to actively prevent tissue carbonization before the tissue reaches a carbonization impedance threshold. The second aspect of the invention provides an electrotome system, and the control unit of the electrotome system is configured to adjust the pulse frequency according to a preset lookup table storing the corresponding relation between tissue impedance and target pulse frequency. Energy is controlled by dynamically adjusting the pulse frequency (not voltage), the response speed is high, control is accurate, and the safety, efficiency and accuracy of an operation are remarkably improved through a predictive algorithm or a lookup table scheme.

This invention relates to the field of medical device technology, specifically to an intelligent energy control method and system for an electrosurgical energy platform. The method includes: real-time acquisition of multi-dimensional electrophysiological parameters at the tissue-electrode contact point during electrosurgical procedures, including tissue impedance, voltage, current, and phase difference; inputting the acquired multi-dimensional electrophysiological parameters into a pre-trained tissue type recognition model to identify the currently contacting tissue type and determine its corresponding energy safety threshold; dynamically calculating the optimal energy output parameters based on the identified tissue type and surgical operation mode; and real-time monitoring of tissue state changes, automatically adjusting energy output or triggering a safety protection mechanism when the tissue state reaches a preset critical value. This invention achieves adaptive intelligent control of the electrosurgical energy platform through a combination of multi-parameter fusion sensing and artificial intelligence algorithms, improving surgical safety and accuracy, reducing tissue thermal damage, and lowering the risk of surgical complications.

A method includes: transmitting a first set of radio-frequency (RF) pulses to an implantable wireless stimulator device such that electric currents are created from the first set of RF pulses and flown through a calibrated internal load on the implantable wireless stimulator device; in response to the electric currents flown through a calibrated internal load, recording a first set of RF reflection measurements; transmitting a second set of radio-frequency (RF) pulses to the implantable wireless stimulator device such that stimulation currents are created from the second set of RF pulses and flown through an electrode of the implantable wireless stimulator device to tissue surrounding the electrode; in response to the stimulation currents flown through the electrode to the surrounding tissue, recording a second set of RF reflection measurements; and characterizing an electrode-tissue impedance by comparing the second set of RF reflection measurements with the first set of RF reflections measurements.

The invention provides a tissue coagulation state judgment method and system for a high-frequency electrotome, and relates to the technical field of high-frequency electrotomes. The method comprises the following steps: initializing operation parameters; voltage and current between two electrodes of the high-frequency electrotome are collected in real time, real-time impedance of tissue between the two electrodes is calculated, and an impedance sequence in the latest period of time is formed; performing a Mangkendall trend test on the impedance sequence to obtain a standardized statistical magnitude; and judging the change trend of tissue impedance based on the standardized statistics, and determining the tissue coagulation state according to the change trend. According to the method disclosed by the invention, the Mangkendall trend test based on data statistics is adopted, so that the decreasing and increasing trends of tissue impedance and the significance degree of the trends can be effectively judged, and the accuracy and the reliability of judging the tissue coagulation state are improved.

A system includes an energy-based surgical instrument with an end effector having two electrodes. One of the electrodes has multiple electrode portions. A generator coupled to the surgical instrument supplies radio-frequency (RF) energy to an electrode portion for a tissue coagulation process and further supplies RF energy at a higher voltage or current to another electrode portion for a tissue transection process. A control element may monitor tissue impedance or tissue temperature. Other embodiments are described and claimed.

A method and pulsed field ablation (PFA) system configured to provide variable impedance paths for delivery of electric fields to patient tissue using a PFA catheter are disclosed. According to one aspect, a method includes determining a current for each of a plurality of circuit paths, each circuit path including two electrodes. Each current may be determined based at least in part on: a desired voltage between the two electrodes; a tissue impedance between the two electrodes; and a parasitic impedance associated with the circuit path. The method also includes determining at least one of an excitation voltage and an input resistance for each circuit path of the plurality of circuit paths based at least in part on the determined current for the circuit path, parasitic impedances associated with the circuit path and a tissue impedance between the two electrodes in the circuit path.