26 results about "Sample volume" patented technology

This application belongs to the field of fluorescence microscopy imaging, and more specifically, relates to a dual-gel system suitable for dilatational microscopy of large-volume biological tissues. This dual-gel system achieves uniform expansion and morphological stability of tissue samples through a dilatational gel, and then imparts high mechanical strength using a stabilizing gel. This allows millimeter-scale large-volume biological tissue samples to possess both high expansion ratio and excellent mechanical stability, achieving 3-5 times linear expansion with a Young's modulus of not less than 300 kPa. It can stably adapt to vibrational cutting operations and support cutting of 100-500 μm thick layers, with intact cut surfaces and good interlayer consistency, greatly improving the efficiency and quality of three-dimensional data acquisition. Furthermore, the hydrogel sections obtained from the cutting have intact morphology and can be used as independent slides for multidimensional analysis. This application overcomes the limitations of traditional dilatational microscopy techniques in terms of sample volume and mechanical stability, providing an efficient and reliable solution for the three-dimensional reconstruction of millimeter-scale biological tissues.

Described herein are systems and methods that combine at least three different detection modalities to characterize the stability of drug formulations, and sample plates for use with the systems and methods. The systems may include a clamp configured to apply a force to the sample plates that trap and pressurize air above an inlet and / or outlet of sample holders included in the sample plates. Measurements of various parameters of the samples may be obtained in tandem or simultaneously with a single instrument, which reduces sample volume requirements.

This application provides a liquid analyzer and its automatic pipette tip selection detection method and storage medium. The method includes: acquiring consumable information and detection task information; the consumable information includes pipette tip model, available quantity of pipette tips, mixing cup specifications, and available quantity of mixing cups; the detection task information includes the detection items to be performed and the sample type; determining the sample volume and sample processing liquid volume that meet the pipetting conditions based on the detection task information and the detection method corresponding to the detection items; obtaining the pipetting coefficient of variation based on the sample type, sample volume, and sample processing liquid volume; selecting a target pipette tip model that meets preset detection conditions based on the pipetting coefficient of variation and the consumable information; and selecting the corresponding target pipette tip to perform the detection task and obtain the detection result. This method can reduce detection errors caused by improper pipette tip selection and effectively improve the accuracy and efficiency of detection.

This utility model belongs to the field of medical device technology and relates to an unfoldable nasopharyngeal swab. The unfoldable nasopharyngeal swab of this utility model includes: an outer protective sleeve with an arc-shaped curved front end and a handle at the rear end; a three-headed sampling swab composed of three parallel sampling swabs, each including a flexible swab rod and a sampling head; the central sampling swab passes through an inverted cone-shaped body to expose its front end swab rod and sampling head, while the two lateral sampling swabs extend from the sides of the inverted cone-shaped body, thus separating the sampling heads of the three sampling swabs; and a push handle connected to the rear end of the three-headed sampling swab. The unfoldable nasopharyngeal swab of this utility model solves the problems of small sampling range, easy missed sampling, and high operational risk in existing technologies through its three-headed coordinated unfolding design. It can accurately cover high-risk areas of nasopharyngeal carcinoma, significantly improve sampling efficiency and sample volume, and enhance the sampling effect and safety of nasopharyngeal swabs.

The present disclosure relates to a sensor device, comprising: a measurement chamber having at least a first wall, the measurement chamber including a plurality of analyte sensors; wherein the measurement chamber allows a fluid to be analyzed to interact with each of the plurality of analyte sensors when the fluid is accommodated within the measurement chamber; the measurement chamber having an inlet configured to receive the fluid to be analyzed and an outlet configured to allow the fluid to exit the measurement chamber after having interacted with the plurality of analyte sensors; the measurement chamber defining a sample volume for accommodating the fluid to be analyzed, the sample volume extending at least between the inlet and the outlet; a heating element configured to heat the fluid accommodated within the measurement chamber.

The invention relates to an NMR-DNP probe comprising a sample holder, a temperature control device, a microwave guide and an illumination device, characterized in that the temperature control device comprises a VT channel through which a temperature control fluid can be supplied to the sample container for temperature control of the sample substance in NMR measurement mode, a sample-side end of the light guide is arranged in the VT channel, and a deflection mirror is arranged in the VT channel between the sample-side end of the light guide and the sample container, which directs the light exiting the light guide onto the sample substance in the sample volume of the sample container. This allows additional light excitation with adjustable beam width to illuminate the NMR test sample within the probe without negatively affecting the magnetic field or RF. Furthermore, optical excitation in the UV range can also be realized. The optical fiber is integrated into the probe with a very small bending radius. The invention also relates to a bearing bushing for use in an NMR-MAS probe and to an NMR spectrometer.

This invention provides a needle for bone and soft tissue tumor biopsy, comprising a needle body, a ring-taking probe, and a pusher. The needle body includes an outer cannula and a core. A channel is formed through the inner part of the outer cannula. The core is inserted into and exits the channel during puncture. The two ends of the outer cannula are a first end and a second end, respectively. The two ends of the core are a third end and a fourth end, respectively. The third end is a needle tip that extends beyond the first end, and the fourth end is used to engage with the second end to form a handle. A depth fixation device is installed on the outer wall of the outer cannula for adsorption onto the tissue surface. The ring-taking probe is inserted into the channel of the outer cannula after the core is removed to extract tissue samples. The distal inner wall surface of the ring-taking probe has a barbed structure. The pusher is inserted into the outer cannula after sample extraction to completely push out any remaining tissue from the outer cannula. This invention can improve the accuracy and comfort of bone and soft tissue tumor biopsy, reduce the sampling failure rate during puncture, and increase the sample volume.

The utility model relates to the field of agricultural land soil heavy metal pollution monitoring technology discloses a soil underground percolate collection device suitable for heavy metal output flux calculation, which comprises a catchment plate inserted into soil, a catchment pipe buried in soil, a water storage tank and a vertical pipe, one end of the catchment pipe is in communication with the catchment plate, a liquid level sensing assembly is arranged in the water storage tank, the liquid level sensing assembly comprises a float ball type liquid level switch, the float ball type liquid level switch is arranged in the water storage tank, the float ball on the float ball type liquid level switch floats within a range from 1 / 3 height to 2 / 3 height of the highest liquid level of the water storage tank, and the upper half of the vertical pipe is located above the soil. The utility model can ensure that the minimum volume of water in the water storage tank is 500ml, can meet the sample volume of heavy metal detection, the catchment plate is designed in a wedge shape, can be directly inserted into soil from the soil profile, does not disturb the soil above the catchment plate, and the data authenticity is improved.

Systems and methods for simultaneous acquisition of pulsed-wave Doppler and color Doppler for retrospective analysis of cardiovascular function are disclosed. In aspects, imaging techniques are used for acquisition of raw partly processed ultrasound data. The ultrasound data is stored in its raw form, synchronized with a simultaneously acquired physiological signal. The stored ultrasound data can then be accessed and processed according to pulsed-wave Doppler and color Doppler imaging techniques to provide both a full frame, or sequence of frames of color Doppler images and a post-acquisition pulsed-wave Doppler signal of a sample volume at one or more locations within the acquisition area using the color Doppler image. Such locations can be selected automatically or by a user, and a pulsed-wave spectrum for the selected location is displayed. As the user moves the sample volume around, the pulsed-wave spectral data is recomputed and redisplayed.

This invention discloses a highly sensitive method for detecting troponin I. This method utilizes the reusable nature of a biosensor to perform multiple fluorescence signal reads. Based on these multiple reads, it selects the most accurate concentration range for determining concentrations in the low-to-medium concentration range, achieving higher resolution detection results in both low and medium concentration areas. Furthermore, it incorporates chemiluminescence detection, employing higher-resolution chemiluminescence to determine the final concentration in the high-concentration region. Ultimately, this method achieves better resolution detection results across high, medium, and low concentration regions, enabling accurate identification of sample concentrations across all concentration ranges. It boasts a sensitivity of 0.824 ng / L and a detection range of 0.824 ng / L–100,000 ng / L. The method significantly reduces sample volume, requiring only 20 μL for accurate detection, thus reducing blood volume and improving blood collection efficiency in physical examinations.

This utility model belongs to the technical field of sampling and testing equipment, specifically relating to a solution tube structure of an integrated sampling and detection device, including: a tube body, a base plate, and a scraping structure; the base plate is disposed at the bottom of the tube body, and cooperates with the tube body to form a dissolution space with a top opening, the dissolution space being filled with solution, and the scraping structure is disposed in the lower half of the tube body, such that the scraping structure is immersed in the solution; for the collection of samples with small sample volumes, this application provides a solution that is easy to operate and can improve sample dissolution efficiency and increase sample concentration.

The utility model discloses a chemical solution concentration detector, including at least one sample container, at least one liquid container, concentration sensor is different with passageway switching device's interface intercommunication respectively, and sample container, liquid container are communicated with concentration sensor through passageway switching device, passageway switching device still has the quantitative ring, and passageway switching device action makes the one end of quantitative ring and sample container or liquid container intercommunication, other end and concentration sensor intercommunication or not intercommunication. The utility model discloses a chemical solution concentration detector utilizes the structure of quantitative ring and passageway switching device, has realized the effective control to the detection sample volume, utilizes liquid / sample and pushes sample from quantitative ring to concentration sensor, and sample forms continuous flow, has guaranteed the integrity of detection and has improved the accuracy of detection, and simultaneously still can utilize liquid to clean quantitative ring, effectively reduces the cross -contamination, and still significantly reduces the cleaning difficulty.

Systems and methods are provided that facilitate laser-based spatially-resolved ablation and ionization of a material, with low sample volume and little or no fragmentation. Sub-nanosecond pulses are directed onto a sample with a delay of less than 1 ns. Within an initial 50 fs after the onset of sample irradiation, one of the pulses generates an initial free electron density, and after the initial 50 fs, the other pulse increases the free electron density such that ablation occurs, resulting in an ablation volume having a sub-diffraction-limited lateral area that is smaller than a diffraction-limited 1 / e2 spot size of at least one of the first laser pulse and the second laser pulse, and a depth of less than 1 micron. The pulse intensities are provided such that ablation occurs without substantial analyte fragmentation, facilitating, for example, analysis and identification via mass spectrometry.

This invention relates to an ADT (Advanced Design Theory) optimization design method for minimum accelerated stress and sample uncertainty, comprising: calculating the expected influence factor under different candidate minimum accelerated stresses based on product prior information and acceleration models; calculating the relative error of sample size caused by sample constraints under different sample size allocation schemes based on the inverse Gaussian degradation process and incremental box (I-box) to quantify the cognitive uncertainty of sample size; constructing a multi-objective optimization model with the optimization objectives of minimizing the asymptotic variance (Avar) of the lifetime quantile under normal service stress conditions, maximizing the expected influence factor, and minimizing the total experimental cost, and with the relative error of sample size being less than or equal to a preset threshold as a hard constraint; and solving the multi-objective optimization model using a multi-objective evolutionary algorithm to output a Pareto optimal experimental scheme set that satisfies the hard constraints. This scheme provides a flexible decision-making basis for scenarios with different resource constraints.

The present application relates to the technical field of radiochemistry analysis, and particularly relates to a rapid analysis and determination method of thorium in water, which comprises a step of pretreating a water sample to be measured to obtain a concentrated solution and a step of analyzing and determining the thorium content in the concentrated solution; wherein the method for pretreating the water sample to be measured comprises the following steps: taking the water sample to be measured, placing it in a rotary evaporator to perform vacuum distillation, distilling part of the water in the water sample to be measured, taking out the water sample in the flask after vacuum distillation, washing the flask with nitric acid, and combining the washing liquid with the taken-out water sample to prepare the concentrated solution. The rapid analysis and determination method of thorium in water provided by the present application uses a rotary evaporator to perform rotary evaporation on the sample to be measured as pretreatment to reduce the sample volume, optimizes the subsequent analysis process, can shorten the analysis and determination time to about 5 hours, greatly reduces the time consumption of the entire analysis process, and improves the work efficiency.

Devices and methods for collecting oral fluids and determining a sufficiency of the fluid collected. The device includes a handpiece, a sample volume adequacy indicator, and a clamping means for holding a collection pad during collection and ejecting the collection pad after sufficient fluid has been collected in the collection pad.

The present application belongs to the technical field of coal reservoir gas pressure measurement, and discloses a coal reservoir pore gas pressure rapid measurement method and system. The system comprises a sampling site automatic desorption module, a dead volume calibration module, a gas loss amount reduction module, a coal sample volume reduction module and a control system. The coal sample tank is a piston container, which is divided into a coal sample cavity and a pressurizing cavity. The dead volume calibration module calibrates the system empty volume, and the gas loss amount reduction module realizes automatic compensation of multiple components. The coal sample volume reduction module injects oil to compact the shaft and restore the pore volume. The measurement method comprises the following steps: downhole coal sample sampling, automatic measurement and conversion of loss amount, system access and vacuum pumping, dead volume calibration, automatic compensation of gas loss amount, coal sample compaction and pore volume restoration, reading of pressure value after adsorption equilibrium, etc. The present application realizes rapid, efficient, accurate and safe measurement of coal seam gas pressure under the condition of free hole sealing, effectively improves the gas pressure measurement efficiency and data reliability.

This invention provides a continuous testing device for the three-dimensional volumetric shrinkage characteristics of soil, belonging to the technical field of geotechnical testing equipment. It includes: a transparent outer casing to form a sealed testing space; a graduated inner measuring cylinder containing a polymer solution for measuring sample volume, which also has a weighing function; a sample placement rod with a hydrophobic coating sprayed on both the inside and outside of the testing space, and a lifting handle; the sample can be completely immersed in or pulled out of the polymer solution by adjusting its longitudinal position; a fixing ring for fixing the position of the sample placement rod; and a base for supporting the upper device. This invention features a simple structure, reliable performance, and high testing accuracy. The test data can more accurately reflect the shrinkage characteristics of the soil under test. If the transparent outer casing is connected to a temperature and humidity controller, the testing device can obtain the shrinkage characteristics of soil under different temperature and humidity environments without disturbing the soil, effectively reducing errors during the testing process and improving testing efficiency.

A milk analysis system (100) for counting individual somatic cells (410a, 410b) in a milk sample. The system comprises a measuring chamber (220) with an inlet (231), outlet (241), first plate (281), second plate (282), and wall element (283) forming an enclosed volume. A sensor (160) captures an image (270) through a transparent portion of the first plate. A controller (200) processes the image to determine a region of interest (275), counts individual somatic cells, applies a correction factor, calculates sample volume, and determines cell concentration. The controller controls the sensor, processes the image, counts cells, applies the correction factor, calculates volume, and determines cell concentration per volume based 10 on the corrected count and calculated volume.

A method for compensating analyte measurements in cases of low sample volumes of fluid samples deposited onto a test strip having first and second working electrodes and a reference electrode. At least one test voltage is applied between the first and second working electrodes and the reference electrode, and the current at each working electrode is measured at predetermined time points. The measured current difference is compared to a stored threshold. If the measured current difference is within the stored threshold, the current measurement is used at a final test time to determine the analyte of interest. If the measured current difference is not within the stored threshold, at the final test time, only the measured current of the appropriately calibrated first working electrode is used to determine the analyte of interest.

This utility model discloses a quantitative microfluidic reagent card, relating to the field of microfluidic reagent card technology. It includes a plate and a quantitative component. The plate has microchannels inside, with vent holes at the ends of the microchannels. The quantitative component is located in the center of the plate and includes a rotating shaft, a quantitative cylinder, a flared ring, an anti-slip sleeve, and a through-hole. The rotating shaft is rotatably connected to the middle of the plate, and the quantitative cylinder is fixed to the top of the rotating shaft. Through the quantitative component, before use, rotating the anti-slip sleeve rotates the quantitative cylinder, misaligning the through-hole with the ends of the microchannels. When the sample is dropped into the quantitative cylinder, the flared ring widens the opening, guiding the sample droplet and facilitating accurate entry into the quantitative cylinder, preventing spillage and sample volume deviation. After dropping, rotating the quantitative cylinder with the anti-slip sleeve aligns the through-hole with the ends of all microchannels simultaneously.

The invention discloses a carbon dioxide enhanced salt water exploitation multi-objective optimization method, and belongs to the technical field of carbon dioxide capture, utilization and storage and underground water resource development, and the method comprises the following steps: S1, constructing a CO2-EWR multi-field coupling numerical simulation model, and determining a multi-objective optimization basic framework; s2, solving through a multi-objective optimization algorithm to obtain a Pareto frontier solution set; s3, screening through a feature selection algorithm to obtain an optimal feature subset; s4, expanding the sample size through a data enhancement technology, and completing the training of the proxy model through an optimization algorithm; s5, realizing transparency of an optimization mechanism through an interpretability analysis method; and S6, calculating the closeness between each scheme and the ideal solution through a multi-objective decision method, and screening to obtain a final optimization scheme. By adopting the method, the problems that multiple targets are difficult to cooperate, the calculation cost is high, the model lacks interpretation, and the precision and efficiency are influenced by sample and feature problems in the carbon dioxide enhanced saline water exploitation process are solved.

This application discloses a method and related equipment for evaluating the cleanliness of a horizontal wellbore in deep coal and gas formations, relating to the field of horizontal wellbore cleanliness evaluation technology. The method includes: acquiring drilling parameters of the horizontal well and a sample to be tested within the wellbore; identifying the sample to be tested based on infrared spectral scanning to obtain sample classification data; measuring the sample to be tested to obtain sample volume and sample density, the sample density including sample dry density and sample wet density; determining cuttings parameters based on the sample classification data, the sample volume, and the sample density using a trained artificial intelligence model; determining downhole cuttings bed parameters based on the drilling parameters and the cuttings parameters; and generating a wellbore cleanliness evaluation result based on the downhole cuttings bed parameters.

An NMR probe head (1) for performing high-resolution, liquid-state DNP-NMR comprises a corrugated waveguide (3) for mw transmission, arranged along a longitudinal axis Z of the probe head; a system of at least two of mw reflecting mirrors (4-7) for mw beam transmission, focusing and reshaping the beam to match for a sample geometry; at least one RF coil (11,12) for NMR detection mounted in a way to allow mw passage to the sample area, characterized by a cooling system comprising a flow dewar tube (8) for feeding cryogenic fluid mounted at the side of the probe head and parallel to the corrugated waveguide and a thermally isolated sample chamber (26) surrounded by a chamber dewar (9); a sample spinning arrangement being configured to achieve uniform irradiation over a sample volume, to increase the sample volume under mw irradiation, and to reduce sample heating; a sample assembly (13) comprising concentric circular tubes or rods (15, 16) forming constraints for a sample layer (14). This arrangement is capable of exciting in particular even large sample volumes up to ~40 μL.

An NMR-DNP probe head comprises a probe holder for receiving a sample vessel containing a sample substance surrounded by an RF coil, a temperature control device for maintaining the temperature of the sample substance, a microwave guide for supplying microwave radiation into the sample volume, and an illumination device comprising an optical fiber for photoinduced electron excitation of the sample substance in the sample volume. The temperature control device comprises a VT channel through which temperature control fluid can be supplied to the sample vessel during NMR measurement to maintain the temperature of the sample substance, the sample-side end of the optical fiber is arranged in the VT channel, and a deflecting mirror is arranged in the VT channel between the sample-side end of the optical fiber and the sample vessel that directs light exiting the optical fiber onto the sample substance in the sample volume of the sample vessel.