9 results about "Focal volume" patented technology

A microscopy system (1) is provided for imaging a sample. The microscopy system comprises a light source system (10) configured for providing a first train of optical pulses (T1) at first optical center wavelengths (l1) and a second train of optical pulses (T2) at second optical center wavelengths (l2), both at a first repetition frequency (f1). A repetition rate multiplier (30) is configured to receive the first train of optical pulses (T1) and to output a third train of optical pulses (T3) at a second repetition frequency (f2) different from the first repetition frequency (f1), focusing optics (40) configured to direct the second train of optical pulses (T2) and the third train of optical pulses (T3) to a sample in a focal volume (5). The microscopy system comprises an optical detector (60) configured to detect a transmitted or reflected third train of optical pulses (T31) after interaction in the sample in the focal volume, and a processor (80) configured to process signal components at the first repetition frequency (f1) from the detected transmitted or reflected third train of optical pulses (T31) and to output a signal or a pixel representative of the interaction in the sample.

The invention relates to a method for producing a three-dimensional object in an optically reactive starting material, comprising: providing an optically reactive starting material (4) in a working volume (5), wherein the optically reactive starting material (4) contains active molecules of a dual-color photoinitiator; and optically processing the starting material (4) to produce a three-dimensional object by radiating with light of a first wavelength and light of a second wavelength that is different from the first wavelength. The optical processing comprises the following: a) radiating the light of the first wavelength through an opening (20) of an entrance pupil (11) located upstream of an objective (12) and through the objective (12), wherein the objective (12) focuses the light of the first wavelength in the starting material into a focus volume in a focus of the objective (12) such that active molecules that absorb the light of the first wavelength transition into an intermediate state; b) radiating the light of the second wavelength via the entrance pupil (11) and the objective (12), wherein the objective (12) focuses the light of the second wavelength in the starting material (4) into the focus volume such that active molecules within the focus volume that are in the intermediate state and absorb the light of the second wavelength transition into a reactive state and a chemical reaction is thereby triggered in the focus volume, by means of which a material property of the starting material (4) is locally changed; and c) producing the three-dimensional object by repeating steps a) and b) for further focus volumes; wherein, during radiation, the light of the first wavelength and the light of the second wavelength are radiated, on the path to the focus volume, in a spatially non-overlapping manner at least when passing through the entrance pupil (11) and when passing through the objective (12) and in a spatially overlapping manner in the focus volume. Furthermore, a device for producing a three-dimensional object in an optically reactive starting material is provided.

A method and system that substantially sharpens the depth of focus. The method includes selecting a group of frequencies where the group of frequencies include a plurality of unique frequencies, assigning one of the frequencies in the group of frequencies to two or more of a plurality of transducers, driving the plurality of transducers to generate a plurality of beamlets where each beamlet includes a wave, and emitting the plurality of beamlets toward the target thereby generating an ultrasound field with reduced focal volume. The improvement in the focal volume using this method can comprise a factor of 10 or more, depending on the frequency bandwidth available to the system. The method, which can be applied for diagnostic and therapeutic applications, is entirely non-invasive and does not require labeling or a modification of elements or objects within the target space.

A gamma camera device comprises a collimator with pinholes, the collimator enclosing an object space for receiving an object; a detector surface for detecting gamma radiation emitted by the object and passing through the pinholes of the collimator; and a controller for processing detector signals into an image of the object. The collimator and the object space have a common longitudinal axis, wherein the collimator comprises a plurality of groups, each of a plurality of pinholes having a center line. In each group, the pinholes are located in a plane perpendicular to the longitudinal axis, wherein the pinholes of the group together see a focal volume, the focal volume having a geometric center. Within each group, upon rotation around the longitudinal axis, the respective center line of each of the pinholes becomes coincident with the center line of each of the other pinholes of the group.

A method for treating presbyopia of a crystalline lens using a femtosecond laser system, operated in a parameter regime characterized by extremely short pulse duration (below 100 fs) and low pulse energy (sub-μJ) of the pulses delivered to the lens tissue. The laser beam has a small focal volume in the tissue that is achieved by the short spatial pulse length, rather than defined by the large depth of focus resulting from the low numerical aperture of the laser beam. The laser energy density within the small focal volume (below 50 μm3) is sufficiently high to induce optical breakdown of the tissue, which reduces the Young's modulus of the lens to improve accommodation, thereby reducing presbyopia. Meanwhile, the total pulse energy in the focal volume is sufficiently low, resulting in small cavitation bubbles, which reduce light scattering and other damage or undesirable effects in the treated lens tissue.

A method for treating presbyopia of a crystalline lens using a femtosecond laser system, operated in a parameter regime characterized by extremely short pulse duration (below 100 fs) and low pulse energy (sub-µJ) of the pulses delivered to the lens tissue. The laser beam has a small focal volume in the tissue that is achieved by the short spatial pulse length, rather than defined by the large depth of focus resulting from the low numerical aperture of the laser beam. The laser energy density within the small focal volume (below 50 µm3) is sufficiently high to induce optical breakdown of the tissue, which reduces the Young's modulus of the lens to improve accommodation, thereby reducing presbyopia. Meanwhile, the total pulse energy in the focal volume is sufficiently low, resulting in small cavitation bubbles, which reduce light scattering and other damage or undesirable effects in the treated lens tissue.

The present invention proposes a photothermal microscopy system (1) for analysing a sample, comprising a pulse light source system (10) configured for providing a first train of optical pulses (B1) at first optical center wavelengths (λ1) and a second train of optical pulses (B2) at second optical center wavelengths (λ2) in a burst mode, wherein the microscopy system is a stimulated Raman photothermal microscopy system with a Stokes beam and a pump beam. A probe light source (30) provides a probe beam (P) at a third wavelength (λ3), the third wavelength different from the first and second wavelengths. The system comprises focusing optics (40) configured to direct the first train of optical pulses (B1), the second train of optical pulses (B2) and the probe beam (P) to a sample in a focal volume (5), an optical detector (60) configured to detect a transmitted or reflected probe beam (P1) after interaction in the sample in the focal volume, and a processor (80) configured to process signal components from the detected transmitted or reflected probe beam (P1) and to output a signal or a pixel representative of the interaction in the sample.

The invention relates to an electron imaging apparatus (23) configured to be connected to an energy analyzer apparatus. The electron imaging apparatus comprises a receiving aperture (22), a control unit, and a field generating unit (65). The receiving aperture is configured for receiving electrons from a focal volume (200) which form an electron beam (25). The control unit is configured for providing a control signal to the field generating unit based on a desired height of the electron beam in an energy dispersive direction (y) of the energy analyzer apparatus at a proximal end (90) of the electron imaging apparatus and a desired angular distribution (α p ) in the energy dispersive direction at the proximal end. The field generating unit is configured for generating at least one electrostatic, magnetic, or electrostatic and magnetic field based on the at least one control signal such that the at least one electrostatic, magnetic, or electrostatic and magnetic field is configured for exerting a force on the electrons of the electron beam in the energy dispersive direction such that a height of the electron beam in the energy dispersive direction at the proximal end corresponds to the desired height in the energy dispersive direction at the proximal end and an angular distribution in the energy dispersive direction at the proximal end corresponds to the desired angular distribution in the energy dispersive direction at the proximal end.

The application discloses a single / dual-frequency array transducer for sound field and focal volume multiple regulation, which comprises a transducer shell, one end of the transducer shell is provided with a prismatic baffle, the surface of the prismatic baffle is provided with a multi-array piezoelectric layer, the multi-array piezoelectric layer is provided with variable sound-transparent rubber, the projection surface of the multi-array piezoelectric layer is a circle, the projection surface is divided into three concentric circular rings, and the three concentric circular rings are arranged in the form of a single / dual-frequency curved surface split array with m+n+k, the projection surface of the m, n and k arrays is the three concentric circular rings, different resonance frequencies are obtained by driving different arrays, and due to the single / dual-frequency curved surface split array arrangement mode, the application provides a split array phase regulation and focusing vortex topological charge regulation mode for changing the size of a sound field focal volume, a multiple vortex sound field regulation mode for force field control and a dual-frequency split array and vortex regulation mode for cavitation intensity and distribution efficiency, and the mode has high cavitation activity intensity, easy inertial cavitation and fast temperature rise.