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454results about How to "Reduce edema" patented technology

Method and system for treating target tissue within the eustachian tube

Methods and systems for accessing a Eustachian tube of a patient are disclosed. The system includes a guide configured for passing into a nasal passage of the patient to position a distal tip of the catheter at or near a Eustachian tube, the guide having a distal tip with a bend having an angle between 30 and 90 degrees; and a guidewire configured to pass through the guide into the Eustachian tube. A device for providing therapy to the Eustachian tube is passed through the guide.
Owner:ACCLARENT INC

Method and apparatus for negative pressure therapy

Devices that employ external compression stocking-type garments in the treatment of edema, chronic wounds, deep venous thrombosis prevention or claudication all share a number of significant limitations. These include the frequent need for custom fitting to assure an appropriate fit, vigilant maintenance to assure a continued “good fit,” limited compliance with proper use by patients and difficulty of application. There is a large body of evidence demonstrating that patients often decline to wear the compressive stockings as prescribed or in the form that would be most beneficial because they find these devices to be difficult to put on and take off. Building on the limitations of existing therapies, and distilled lessons learned from the field of prosthetics and wound healing, the present invention employs vacuum-assisted negative pressure to provide compression and help pump fluid from the tissues of affected limbs. The device is embodied in the form of a flexible stocking-like garment that will utilize a pumping mechanism to generate negative pressure around the limb and thus create vacuum compression that will mobilize fluid in a limb and increase venous return to the heart. Through the use of a circumferential wrap, the present invention provides a major advance in both the distribution of vacuum and the securing of the device over the limb.
Owner:THERANOVA LLC

Therapeutic compression and cushion sock and method of making

A knitted therapeutic compression and cushion sock and a method for making such a sock include a terry-knit cushioning layer in selected bottom portions of the sock, allowing for greater ventilation and cooling in the top portion. The sock includes graduated zones of compressive pressures. Gradual changes in compressive pressures from one zone of compressive pressure to another can be provided by compression flaring, or changing the feed rate of elasticized yarn during knitting at or near the interface of two zones having different compressive pressures. Such a sock is useful for padding and compressing foot and leg areas to both prevent and treat vascular and skin conditions such as foot and leg ulcers.
Owner:CAROLON

Nanoemulsion vaccines

The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides methods and compositions for the use of nanoemulsion compounds as mucosal adjuvants to induce immunity against environmental pathogens. Accordingly, in some embodiments, the present invention provides nanoemulsion vaccines comprising a nanoemulsion and an inactivated pathogen or protein derived from the pathogen. The present invention thus provides improved vaccines against a variety of environmental and human-released pathogens.
Owner:RGT UNIV OF MICHIGAN

Method and apparatus for treating wound using negative pressure therapy

Devices that employ external compression stocking-type garments in the treatment of edema, chronic wounds, deep venous thrombosis prevention or claudication all share a number of significant limitations. These include the frequent need for custom fitting to assure an appropriate fit, vigilant maintenance to assure a continued “good fit,” limited compliance with proper use by patients and difficulty of application. There is a large body of evidence demonstrating that patients often decline to wear the compressive stockings as prescribed or in the form that would be most beneficial because they find these devices to be difficult to put on and take off.Building on the limitations of existing therapies, and distilled lessons learned from the field of prosthetics and wound healing, the present invention employs vacuum-assisted negative pressure to provide compression and help pump fluid from the tissues of affected limbs. The device is embodied in the form of a flexible stocking-like garment that will utilize a pumping mechanism to generate negative pressure around the limb and thus create vacuum compression that will mobilize fluid in a limb and increase venous return to the heart. Through the use of a circumferential wrap, the present invention provides a major advance in both the distribution of vacuum and the securing of the device over the limb.
Owner:THERANOVA LLC

Method of neural structure stimulation by magnetic field

The present invention relates to apparatus and methods for stimulation and / or treatment of neural structure by high power time-varying magnetic field. The stimulation is followed by at least modulation of action potential of neural structure. The apparatus and methods may be used e.g. in physiotherapy, psychotherapy, psychiatry or addiction treatment.
Owner:BTL MEDICAL SOLUTIONS AS

Eustachian tube dilation balloon with ventilation path

An apparatus comprises a shaft, an expandable dilator, and at least one ventilation pathway. The shaft defines a longitudinal axis and comprises a distal and proximal ends with at least one shaft lumen. The expandable dilator comprises body with its own proximal and distal ends. The body is configured to transition between a contracted state and an expanded state. The body is configured to dilate a Eustachian tube of a patient in the expanded state. The at least one ventilation pathway is configured to provide ventilation from the distal end of the body to the proximal end of the body when the body is in the expanded state. In some examples, the ventilation pathway comprises a set of transversely oriented vent openings formed through the shaft. In some other examples, the ventilation pathway comprises a space defined between one or more radially outwardly protruding features of the expandable dilator.
Owner:ACCLARENT INC

Pulsating Inhaler and a Method of Treating Upper Respiratory Disorders

InactiveUS20080156319A1Facilitates medicament dispensingReduce edemaRespiratorsLiquid surface applicatorsDiseaseMedication Dispenser
The present invention discloses a pulsating inhaler, comprising a fluid oscillator providing a focused fluid column with a series of alternating high and low pressures zones; a medicament dispenser adapted for releasing small and constant measures of at least one medicament via said fluid column; and, at least one outlet orifice adapted to direct said focused fluid column towards the respiratory tract of a patient, wherein said small and constant measures of medicament are subjected to the patients while its respiratory tracts are gently and continuously vibrated The present invention also discloses a method of inhaling small and constant measures of medicament while gently and continuously vibrating the patient's respiratory tracks by a means of a fluid column characterized by a series of alternating high and low pressures zones.
Owner:RESPINOVA

Therapeutic agents targeting the NCCa-ATP channel and methods of use thereof

ActiveUS20060100183A1Reduces and decrease and inhibits activationInhibition is effectiveBiocideNervous disorderMedicineNeuron
The present invention is directed to therapeutic compositions targeting the NCCa-ATP channel of an astrocyte, neuron or capillary endothelial cell and methods of using same. More specifically, antagonists of the NCCa-ATP channel are contemplated. The compositions are used to prevent cell death and to treat secondary damage associated with spinal cord injury.
Owner:U S GOVERNMENT REPRESENTED BY THE DEPT OF VETERANS AFFAIRS

Antagonists of a non-selective cation channel in neural cells

InactiveUS20100092469A1Reduce mortalityReduces stroke sizeBiocideNervous disorderDiseaseNervous system
The present invention is directed to a combination of therapeutic compounds and treatment methods and kits using the combination. In particular, one of the combination affects the NCca-ATP channel of neural tissue, including neurons, glia and blood vessels within the nervous system. Exemplary SUR1 and / or TRPM4 antagonists that inhibit the NCca-ATP channel may be employed in the combination. The combination therapy also employs one or more of a non-selective cation channel blocker and / or an antagonist of VEFG, NOS, MMP, or thrombin. Exemplary indications for the combination therapy includes the prevention, diminution, and / or treatment of injured or diseased neural tissue, including astrocytes, neurons and capillary endothelial cells, that is due to ischemia, tissue trauma, brain swelling and increased tissue pressure, or other forms of brain or spinal cord disease or injury, for example. In other embodiments, there are methods and compositions directed to antagonists of TRPM4, including at least for therapeutic treatment of traumatic brain injury, cerebral ischemia, central nervous system (CNS) damage, peripheral nervous system (PNS) damage, cerebral hypoxia, or edema, for example.
Owner:THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPT OF VETERANS AFFAIRS

Thermal personal care systems and methods

Devices and methods for the treatment of skin conditions and lesions are disclosed herein. A thermal device can be used to heat or cool a personal care pack that can then be used to cleanse, treat, and rejuvenate the skin. The personal care pack can be formulated with smooth or abrasive material and can contain a variety of liquids, lotions or gels. Application of the personal care pack, at the desired temperature to the skin can stimulate deeper blood circulation, clear pores, diminishes or removes deep and fine wrinkles, accelerate acne clearing, treat blemished skin, decrease edema and erythema of the skin, and reduce puritis of various etiologies.
Owner:DA SILVA LUIZ B +2

Collateral-dredging antihyperlipidemic product containing dark tea active substance and preparing method thereof

The invention provides a collateral-dredging lipid reduction product comprising active materials of black tea and a preparation method; the product consists of extracts of Anhua Red Tea and drug-food homologous substances; the preparation method of the invention produces a special and brand-new preparation method resulting from the formula specialty; the invention has the comprehensive functions of collateral dredging, lipid reduction, sugar reduction, decompression and weight reduction.
Owner:贺志弘

Metal complex, preparation method and application thereof

The invention discloses a metal complex and its preparation method as well as its application. The metal complex comprises a metal complexant and metal ions. A composition, composed of the metal complex and used for eliminating chemical injuries and chemical hazards, comprises by weight: 0.2-20 parts of metal complex, 1-10 parts of amino acid, 0.1-5 parts of NaC1, 0.1-10 parts of organic acid calcium salt and 0.01-2 parts of bacterial depressant. Non-irritating, non-corrosive and non-allergic to the skin, the composition containing the metal complex is not only used for eliminating hazardous chemicals in the human body, but also used for neutralizing and eliminating leaked hazardous chemicals in the environment.
Owner:陈郁

Compounds and methods of treating hypertension

InactiveUS20140303144A1Speed up the flowDecreasing sodium reabsorptionBiocideOrganic chemistryDiseaseBlood flow
Hydrogenated pyrido[4,3-b]indoles, pyrido[3,4-b]indoles and azepino[4,5-b]indoles are described. The compounds may bind to and are adrenergic receptor α2B antagonists. The compounds may also bind to and antagonize adrenergic receptor α2B. The compounds may find use in therapy, e.g., to (i) reduce blood pressure and / or (ii) promote renal blood flow and / or (iii) decrease or inhibit sodium reabsorption. The compounds may also be used to treat diseases or conditions that are, or are expected to be, responsive to a decrease in blood pressure. Use of the compounds to treat cardiovascular and renal disorders is particularly described.
Owner:MEDIVATION TECH INC

Compounds and methods for treatment of hypertension

Hydrogenated pyrido[4,3-b]indoles, pyrido[3,4-b]indoles and azepino[4,5-b]indoles are described. The compounds may bind to and are adrenergic receptor α2B antagonists. The compounds may also bind to and antagonize adrenergic receptor α1B—The compounds may find use in therapy, e.g., to (i) reduce blood pressure and / or (ii) promote renal blood flow and / or (iii) decrease or inhibit sodium reabsorption. The compounds may also be used to treat diseases or conditions that are, or are expected to be, responsive to a decrease in blood pressure. Use of the compounds to treat cardiovascular and renal disorders is particularly described.
Owner:MEDIVATION TECH INC

PYRIDO[4,3-b]INDOLE AND PYRIDO[3,4-b]INDOLE DERIVATIVES AND METHODS OF USE

This disclosure is directed to pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and / or a neuronal disorder. The compounds may bind to and antagonize receptor α2B, α1B or α2A. The compounds may find use in therapy, e.g., to (i) reduce blood pressure and / or (ii) promote renal blood flow and / or (iii) decrease or inhibit sodium reabsorption, or to regulate blood glucose level, increase insulin secretion and treat diseases or conditions that are, or are expected to be, responsive to an increase in insulin production. The compounds may also be used to treat diseases or conditions that are expected to be responsive to a decrease in blood pressure. Use of the compounds to treat cardiovascular, renal disorders or type 2 diabetes is particularly described.
Owner:MEDIVATION TECH INC

Premix feed specially for high yield cow in perinatal period and the method of producing the same

The invention discloses a special premix for heavy milker perinatal period, which comprises the following steps: drying traditional medicine additive; grinding; sieving with 200 order; mixing evenly; mixing vitamin evenly; mixing the traditional medicine additive and vitamin evenly; mixing microelement and health products evenly; getting mixture; adding into slow release agent; sieving with 80 order sieve; getting the product. This premix possesses distinctive curative effect and low cost.
Owner:韩凌云

Compositions and methods for treatment of lymphatic and venous vessel arterialization

The present invention is directed to methods and compositions that may be used in disrupting the association of smooth muscle cells with lymphatic endothelial cells and in correcting the valvular dysfunction in veins and lymphatic vessels. Such compositions are useful for therapeutic and prophylactic treatment of impaired lymphatic and venous function, particularly for the treatment of lymphedema distichiasis or chronic venous insufficiency.
Owner:VEGENICS PTY LTD

Methods and Compositions for Treating Dry Eye Disease and Other Eye Disorders

The present invention discloses pharmaceutical preparations for treatment of eye disorders containing an alpha 2 adrenergic agonist, to processes for producing the pharmaceutical preparations and methods for treatment of various eye disorders including dry eye and Meibomian gland dysfunction and a medicinal applicator for topical application of an alpha 2 adrenergic agonist to a subject, a package assembly for the medicinal applicator and methods of using the medicinal applicator to treat eye disorders.
Owner:OCUGEN INC +1

Anastomat for gastrointestinal tract anastomosis surgery and production method thereof

The invention provides an anastomat for gastrointestinal tract anastomosis surgery and a production method thereof. The anastomat comprises an anastomosis nail and a base and is divided into two types, namely a combined type and an independent type. The anastomat is composed of degradable materials and medical barium sulfate and can be finally disintegrated to be powder to be removed from the body after being used up. An envelope is formed on the outer surface of the anastomat through polyacrylic resin and contains medicines such as sulfonamides and quinolones antisepsis and anti-inflammation medicines and adrenobazonum, dicynone and other hemostasis medicines, and the envelope can selectively perform medicine slow release and controlled release according to different pH physiological environments of gastrointestinal tracts.
Owner:HANGZHOU MEDZONE BIO-TECH CO LTD

Feed additive for sows in perinatal period

The invention relates to a feed additive for sows in a perinatal period, which comprises cowherb seed 13-17 parts, angelica sinensis 11-13 parts, rhizoma atractylodis macrocephalae 5-8 parts, ligusticum wallichii 5-8 parts, fenugreek 5-8 parts, myrrh 4-5 parts, astragalus mongholicus 4-5 parts, pericarpium citri reticulatae 4-5 parts, red flower 2-3 parts, dandelion 2-3 parts, liquorice 2-3 parts, leonurus 1-2 parts and scirpus yagara 1-2 parts and is prepared by drying the materials for 2-3 days, smashing and mixing the materials. The feed additive for sows in the perinatal period can promote milk secretion postpartum sows and enable piglets to develop healthily.
Owner:常熟市润丰农业有限公司

Aquaporin modulators and methods of using them for the treatment of edema and fluid imbalance

Compounds, including 3-carboxy aryl sulfonamide compounds, which agonize or antagonize aquaporin channels and methods of using them to treat disorders or diseases mediated by aquaporins.
Owner:THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIV OF ARIZONA

Preserving fluid of hepatic cells for biological artificial liver and preparation method thereof

The invention provides preserving fluid of hepatic cells for a biological artificial liver and a preparation method thereof. The preserving fluid is a solution compounded by ultrapure water. The solution contains the following components within the concentration range: 15-25mmol / L of disodium hydrogen phosphate, 1-10mmol / L of sodium hydrogen phosphate dehydrate, 4-6mmol / L of potassium citrate monohydrate, 10-30mmol / L of sodium chloride, 5-10mmol / L of magnesium chloride hexahydrate, 3-10mmol / L of disodium adenosine triphosphate, 1-5mmol / L of reducing glutathione, 0.1-0.5mmol / L of alpha-lipoic acid, 100-150mmol / L of trehalose (C6H12O5), 200 / 0.510-50g / L of hydroxyethyl starch and 2-10mg / L of matrine. The preparation method of the preserving fluid comprises the following steps of: accurately weighing all components according to the concentration requirements of the components, wherein the alpha-lipoic acid is weighed in a dark place; completely dissolving the other components except the alpha-lipoic acid by using the right amount of ultrapure water; sufficiently dissolving the alpha-lipoic acid in the dark place; and adding the ultrapure water to full dose. The preserving fluid can well protect the cell activity of the hepatic cells for the biological artificial liver and the special functions of the hepatic cells at low temperature so as to satisfy the short-term low temperature preservation of a large-scale hepatic cell bank for the biological artificial liver and / or the hepatic cell protection in the long-distance transportation process.
Owner:ZHUJIANG HOSPITAL SOUTHERN MEDICAL UNIV

Custom-formable knee immobilizer product, knee immobilizer and method

A custom-formable knee immobilizer product for being custom-formed to the shape of a knee while flexible and upon hardening providing a rigid, knee-supporting custom fit. The knee immobilizer product includes an outer container formed of moisture-impervious material and a plurality of elongate knee splint segments positioned in the container in substantially moisture-free conditions and sealed therein against entry of moisture until use. Each of the knee splints includes an elongate substrate, a reactive system impregnated into or coated onto the substrate. The system remains stable when maintained in substantially moisture-free conditions and hardens upon exposure to moisture to form a rigid, self supporting structure. A flexible protective outer cover is positioned over the substrate along its length to enclose the substrate. The substrate and outer cover thus form a unitary structure for being molded while flexible to an aspect of the knee and adjacent thigh and calf portions of the leg. A bandage is provided for being positioned on and held in a closely-conforming configuration around the knee and adjacent thigh and calf portions of the leg. Splint supports cooperate with the splints and the bandage for maintaining the plurality of splints on the bandage in closely conforming position in vertically spaced-apart relation around the knee for substantially immobilizing the knee in a predetermined recovery position.
Owner:BSN MEDICAL INC

Organ preservation solution and method for preparing same

ActiveCN102726366AAvoid damageDisadvantages of Avoiding PrecipitationDead animal preservationPhosphateArginine
The invention relates to an organ preservation solution and a method for preparing the same. The method comprises the following steps of: (1) adopting double buffer pairs of citric acids and phosphates to enable the PH value of a solution to be maintained in a range of 7.5 to 8; (2) adding active ingredients such as adenosine, L-arginine, tryptophan, ligustrazine hydrochloride, reduced glutathione and the like and keep the solution stable; (3) to maintain a hypertonic property of the preservation solution with an osmotic pressure of 350-380 mOsm/L, adopting trehalose and gluconolactone as impermeable substances to effectively prevent cellular edema; and (4) adopting polyethylene glycol with a large molecular weight as a colloidal substance to effectively prevent extracellular space from expanding. Compared with the prior art, the method employs raw materials which are all homemade medicinal components and meet the standards of national pharmacopoeia, and are cheap and free of incompatibility; the organ preservation solution prepared is a colorless and transparent liquid which has stable properties, and can be sterilized by high temperature and high pressure, stored at normal temperature or low temperature, and refrigerated, and thus preparation, transportation, storage and usage of the organ preservation liquid are all very easy and convenient.
Owner:SHANGHAI GENEXT MEDICAL TECH
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