58 results about "Skin erythema" patented technology

The present invention is directed to the treatment of skin erythema as exhibited in rosacea and other conditions characterized by increased erythema (redness) of the skin. These conditions exhibit dilation of blood vessels due to a cutaneous vascular hyper-reactivity. In particular, the present invention is directed to a novel composition and method for the treatment of skin erythema using α₁-adrenergic receptor (α₁-adrenoceptor) agonists incorporated into cosmetic, pharmacological or dermatological compositions for topical application to the skin.

This invention relates to compositions, and methods of use thereof, for (i) reducing ultraviolet (UV)-induced skin erythema and/or photoaging, and for (ii) improving skin quality, each method comprising orally administering to a subject in need thereof, certain polyphenols described herein such as flavanols, procyanidins, or pharmaceutically acceptable salts or derivatives thereof.

Embodiments relating to gels comprising imidazoline alpha agonists, such as, without limitation, oxymetazoline or a pharmaceutically acceptable salt thereof, and methods for treating diseases, such as, without limitation, rosacea, including, for example, erythematotelangiectatic rosacea, papulopustular rosacea, phymatous rosacea, ocular rosacea or combinations thereof; and symptoms associated with rosacea, including, for example, papules, pustules, phymas (skin thickening), telangiectasias or erythema or redness associated with rosacea, other skin erythemas, telangiectasias, purpura or the like, and other manifestations associated therewith or combinations thereof using such gels are described herein.

A method for measuring skin erythema and determining the efficacy of skin care treatment products utilizing digital images.

The invention relates to the technical field of medical plastic surgery, in particular to the technical field of facial filling and anti-wrinkle, in particular, it is an injection filling cosmetic modification anti-aging, skin beautification and facial rejuvenation material. The preparation formula of the present invention includes hyaluronic acid, collagen, vitamin E and PLGA. The preparation method comprises: 1) preparing high-viscosity gel; 2) preparing PLGA nano-microspheres; 3) fully mixing high-viscosity gel and PLGA nano-microspheres; 4) sterilizing and filling. Compared with the prior art, the present invention has the beneficial effect that: the combined use of collagen and hyaluronic acid reduces skin erythema, swelling, hardening or itching, muscle pain, urticaria or Other symptoms such as rash. It reduces the probability of severe complications such as peripheral blood circulation embolism, skin necrosis, retinal artery embolism, and cardiocerebral artery embolism that may be caused by simple hyaluronic acid injection, and the safety of product use is improved.

The present invention provides a skin external-use agentia combination which contains more than one of a lotus extract and a dark plum extract serving as effective components and has an antioxidant activity. The skin external-use agentia combination of the present invention has an excellent antioxidant effect, and can be applied to cosmetic material combinations or pharmic combinations. In addition, the skin external-use agentia combination of the present invention also can effectively prevent erythema, improve colour of the skin, and prevent skin from aging.

The invention belongs to the field of daily chemical industry, especially relates to a daily skin care product and particularly relates to a multi-effect moisturizing and softening composition which can be used for regularizing skin, maintaining the water balance of skin, curing inflamed skin and erythema phenomena, prompting skin regeneration, refreshing and the like. The multi-effect moisturizing and softening composition comprises the following ingredients: oat glucan, bean collagen, aloe extract, microcapsule-coated ultraviolet absorbent, phytosterols, hydrogenated rosin glycerin ester, jojoba oil, natural squalane, siloxane, a natural an emulsifier, a water-phase thickener, a chelating agent, Ethylhexylglycerin, pentylene glycol, phenoxyethanol and water. The invention designs a temperate and multi-effect and high plant-content multi-effect moisturizing and softening composition through reasonably using and matching all ingredients. The multi-effect moisturizing and softening composition mainly aims at erythema, inflammation, crack, scratch and other problems, has the effects of moisturizing, softening, moisturizing, prompting skin regeneration, refreshing and the like, thus being an necessary daily caring and traveling skincare product.

The present invention provides a composition containing tangeretin as an active ingredient for external application to the skin. The present invention also provides a composition containing tangeretin and EGCG for external application to the skin. The present invention also provides a composition for external application to the skin, comprising, as an active ingredient, mandarin peel extracts containing tangeretin. The present invention also provides a composition for external application to the skin comprising mandarin peel extracts containing tangeretin and further comprising green tea extracts containing Epigallocatechin gallate (EGCG). The composition has excellent antioxidative effects, and therefore can be applied as a cosmetic composition, a pharmaceutical composition or a health food composition. Furthermore, the composition may have superior effects of preventing skin erythema, improving skin tone and preventing skin aging.

The invention relates to an application of a traditional Chinese medicine component brusatol in preparing a medicament for preventing or/and treating inflammatory diseases, and in particular to an application of the brusatol in preparing a medicament for preventing or/and treating psoriasis. According to the invention, the brusatol is applied to medicament for treating related diseases to inhibita signal transduction pathway of NF-kappa B, so that overexpression of cytokines such as IL-6, IL-8, IL-1beta, IL-1alpha, TNF-alpha, ICAM-1 and the like can be obviously reduced. According to the invention, inflammatory reactions of skins are improved, the skin lesion degree is reduced, and symptoms such as erythema, scale, and infiltration of skins are relieved, so that the epidermis layer is relatively complete and the thickness of skin lesion is reduced.

The invention relates to a medicinal and dietary composition for alleviating fever, nourishing blood, activating blood flow, treating skin erythema, local swelling and fever, as well as the preparing process, wherein the composition is prepared mainly from corktree bark, coix seed, poria cocos, dandelion, wild chrysanthemum flower, bark of peony root, radix paeoniae rubrathe, achyranthes and cyathula root, atractylodes rhizome, honeysuckle flower, clematis stem, frankincense, goldthread root and rehmannia root, the medicament can also be used as a conventional health dietary preparation having no side effects easy administering.

A topical skin composition that includes a complex containing an effective amount of selected components to provide a defense against the various pathway mechanisms of reactive oxygen species. The composition is directed to the prevention of the adverse or detrimental effects of reactive oxygen species. The figure shows the results of skin erythema of a subject exposed to UV radiation after an application of the formulation in example 4.

The invention discloses a skin-care matrix as well as a preparation method and application thereof. The skin-care matrix comprises the following components in percentage by mass: 5-20% of butanediol,5-15% of 1,2-pentanediol, 1-10% of a lactobacillus fermentation lysate, 10-20% of beta-glucan, 5%-15% of nicotinamide, 1-8% of a rosa centifolia flower extract, 0.4-1% of dipotassium glycyrrhizinate,and the balance of water. According to the skin-care matrix disclosed by the invention, all the components interact with one another, from the perspective of skin micro-ecology balancing, the formation of harmful microorganisms such as propionibacterium acnes biofilms is reduced, inflammatory responses are reduced, the self-repairing and healing of the skin are enhanced, and the barrier function of the skin can be effectively improved. The matrix can improve skin erythema and control acne growth, can increase cuticle water content by 24.70% and reduce percutaneous water loss by 21.50%, has a remarkable skin water retention effect, can increase a skin color L value by 5.13% and reduce a skin color a* value by 19.51%, and has a remarkable effect of improving skin redness.

The invention provides a children emollient containing a lactobacillus fermentation extract and a preparation method of the children emollient. The children emollient is prepared from the following raw materials of butyrospermum parkii fruit fat, hydrolyzed yeast protein, xylitol, glucose, hydroxyphenyl propionamide benzoic acid, coconut oil, shea butter, olive fruit oil, squalane, simmondsia chinensis seed oil, white oil, cetostearyl alcohol, glucoside, polyglycerol, provitamin B5, glycerol, xanthan gum, a preservative, a thickening agent, a skin barrier repairing agent, a repairing composition and the balance of water; and the skin barrier repairing agent is prepared from ceramide, phytosterol and fatty acid. The children emollient prepared by the invention can care and moisten delicate skin of children in multiple directions, for example, after sunburn, the skin erythema index is effectively reduced, the water content of the skin is increased, and the damaged skin is repaired. In addition, the product has a waterproof function, the skin protection requirements of children under various situations are met, and the damaged skin of the children can be better repaired through the synergistic effect of various repairing components.

Methods of use and compositions useful for reducing lines and wrinkles, evening skin tone, lightening skin tone, increasing skin radiance, elasticity, skin barrier function, and/or skin firmness, reducing photodamage, reducing sagging skin, inhibiting anti-oxidant capacity in skin, MMP-1, MMP-3, MMP-9, pro-inflammatory cytokines (e.g., lipoxygenase, IL-6, Il-8, TNF-α, or VEGF), and/or elastase expression in skin, and/or increasing collagen expression in skin, elastin expression in skin, laminin expression in skin, and/or fibronectin expression in skin are disclosed herein. The compositions can additionally reduce or mitigate unwanted side effects shown in other retinol products such as erythema or redness in skin, skin dryness, peeling or flaking of skin, and/or skin irritation including without limitation, burning, stinging, itching, or tingling. The composition includes a combination of one or more of Rosmarinus officianalis leaf extract, Morus alba fruit extract, tetrahexyldecyl ascorbate, retinol, Acmella oleracea extract, Alpinia galanga leaf extract, Argania spinosa oil, and/or saccharide isomerate.

The invention relates to Chinese medicinal herb beautifying and whitening acne and speckle removal facial mask cream, and belongs to the technical field of health-care beautifying plant ointments for skin. A proper amount of egg white serving as a blending substrate is added into angelica dahurica, pearl, giant typhonium rhizome and bletilla, so that the mixture is blended to form paste. When used, the facial mask cream is blended uniformly, is applied to a face uniformly to form a thin layer (the thickness is between 0.5 and 1 millimeter), and is washed by warm water about 15 to 20 minutes later. The facial mask cream has the obvious effects of skin whitening and acne and speckle removal, and has the obvious curative effect on brown speckles, malar rashes, allergic skin erythema, age pigments, acne and dermatitis. In the facial mask cream, according to theories such as the blood circulation promoting, blood stasis removal, wind dispelling wind, detoxification, skin nourishing and the like in traditional Chinese medical science of China, an enhanced Chinese medicinal herb mixture is prepared by processing Chinese medicinal herbs serving as raw materials in a scientific formula according to the compatible principle of monarch medicaments, ministerial medicaments, adjuvant medicaments and conductant medicaments, so the facial mask cream has high pertinence and comprehensiveness, is suitable for various skins, does not have side effects, and has the comprehensive effect of healthy beautifying, nutritional skin care, prevention and treatment.

The invention discloses an antibacterial anti-inflammatory medical gel. The antibacterial anti-inflammatory medical gel is prepared from agarose, sodium alginate, nopol, rue oil, artemisia apiacea oil, diallyl disulfide, terpinene, sodium diacetate, histidine, sodium lactate, silymarin, cyanobacteria extract, magnesium chloride, vitamin P, tween-20, glycerin, and water. The invention also discloses a preparation method of the antibacterial anti-inflammatory medical gel. The antibacterial anti-inflammatory medical gel possesses excellent antibacterial anti-inflammatory effect; inhibition rate on staphylococcus aureus, pseudomonas aeruginosa, trichophyton rubrum, and candida albicans is 93.5% or higher; it is confirmed by rabbit skin test that no skin erythema, or edema, or irritation is caused by the antibacterial anti-inflammatory medical gel, and the antibacterial anti-inflammatory medical gel is safe and reliable to use.

The invention relates to the field of polymer composite materials, and discloses a preparation method of a skin health monitoring bracelet with visual sunlight irradiation intensity. The preparation method comprises the following steps: using composite temperature-sensitive hydrogel as a raw material, directly initiating free radical polymerization of the composite temperature-sensitive hydrogel by using an ultraviolet irradiation photocatalyst, adsorbing dyes, and carrying out vacuum packaging to obtain the bracelet. The principle is as follows: under sunlight irradiation, methylene blue dyeadsorbed is degraded by utilizing a photocatalyst uniformly loaded in the bracelet to realize color change of the bracelet, namely a fading process, so as to indicate whether a sunlight irradiation threshold value of human skin is reached or not. The skin health monitoring wristband has the advantages of being easy to prepare, sensitive in indication, low in cost and wearable. Therefore, the skinhealth monitoring bracelet disclosed by the invention can effectively prevent skin diseases such as erythema, sunburn and even skin cancer of human skin caused by excessive sunlight irradiation.

Compounds of formula (I): wherein X, Y, R₁ and R₃-R₁₁ are as herein defined, and salts thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosis, and psoriasis.

The invention relates to an application of sanggenone G in preparation of a medicine for treating psoriasis. In the embodiment of the invention, the sanggenone G can remarkably improve the skin inflammatory response of an imiquimod-induced mouse psoriasis model animal, reduce the skin lesion degree, relieve the symptoms of erythema, scales, infiltration and the like of the skin, enable the epidermal layer to be complete and reduce the skin lesion thickness. The Sanggenone G can also significantly reduce the level of inflammatory factors IL-17 and INF-gamma related to psoriasis in splenic lymphocyte supernatant of model mice. Therefore, the Sanggenone G can effectively improve the condition of the psoriasis model mouse, has a prospect of being developed into the medicine for treating psoriasis, and has important social benefits and economic benefits.

The invention discloses application of a BCL-2 inhibitor to treatment of senescence-related skin diseases and a pharmaceutical composition for treating the senescence-related skin diseases, and belongs to the technical field of medicines. The research finds that the pharmaceutical composition containing the BCL-2 inhibitor can significantly improve skin erythema, scales and other symptoms of an imiquimod-induced psoriasis mouse model, significantly reduce the skin lesion thickness, and can reduce the expression of senescence-related proteins p16 and p21 and the mRNA expression level of genes p16, p21 and the like at the skin lesion of the psoriasis mouse model, and in addition, the pharmaceutical composition containing the BCL-2 inhibitor can significantly reduce CD4 + T cell infiltration and mRNA expression levels of skin lesion inflammatory factors such as IFN-gamma, IL-17A, IL-22, IL-23 and the like at skin lesion dermis of the psoriasis mouse model. The pharmaceutical composition is superior to a traditional intraperitoneal injection method. Therefore, the BCL-2 inhibitor and the pharmaceutical composition can effectively improve the condition of the psoriasis mouse model, and have the prospect of being developed into drugs for treating psoriasis and the senescence-related skin diseases.

A composition including a synergistic combination of a vitamin D3 or a derivative or precursor thereof and hyaluronic acid or derivate thereof encapsulated in a lipid based colloidal carrier system (preferably lipid based vesicles such as liposomes, niosomes, tranferosomes) and topical formulations thereof, as well as their use in the prevention and/or treatment of inflamed skin and mucous membrane, especially in the prevention and/or treatment of skin photodamage, in particular in the prevention and/or treatment of skin erythema (skin inflammation) and actinic keratosis, as well non melanoma skin cancer.

The invention discloses application of a compound Nib1, a pharmaceutically acceptable salt, a solvate, a solvate of the pharmaceutically acceptable salt or a crystal form thereof in preparation of a medicine for treating autoimmune skin diseases caused by inflammation, improving skin erythema, improving skin decrustation, reducing skin thickening, reducing epidermal hyperplasia, improving angiectasis and/or reducing immune cell infiltration. The chemical formula of the Nib1 is C28H29F2N3O. The compound provided by the invention is a new treatment mechanism aiming at autoimmune skin diseases (such as psoriasis diseases) caused by inflammation, is small in side effect and convenient in administration route, can achieve the balance of safety and effectiveness, can be used for a long time, andimproves the life quality of patients. The compound can significantly improve clinical symptoms of autoimmune skin diseases caused by inflammation, such as erythema cutanea, skin peeling, skin thickening, epidermal hyperplasia, improve angiectasis and reduce immune cell infiltration and the like.

The invention discloses a double-layer comfortable paper diaper and a processing method thereof. The paper diaper comprises a paper diaper body, a rear waistline, a front waistline, a first elastic net, a second elastic net, fixing bands, hook-and-loop fasteners, a middle part, a three-dimensional guard, a third elastic net, a concave part, a front waist tape, air holes, fixing parts, a connectingpart, a non-woven fabric outer layer, an elastic spandex filament layer, a hot air surface layer, a first hot air non-woven fabric layer, a first adhesive tape, a second adhesive tape, a second hot air non-woven fabric layer, an upper layer, a monofilament layer, a lower layer, a composite core layer, a water-repellent non-woven fabric layer, a breathable basement membrane, flow guide grooves andbamboo charcoal chips, the rear waistline is bonded to one end of the paper diaper body, the front waistline is bonded to the other end of the paper diaper body, the hook-and-loop fasteners are bonded to the two corresponding ends of one side of the rear waistline through the fixing bands respectively, and each fixing part is arranged at one end of each fixing band. The paper diaper is comfortable to wear, good in urine absorption effect, good in air permeability and capable of effectively preventing skin erythema.