40 results about "Skin erythema" patented technology

The invention discloses an application of betulinic acid 28-O-beta-D-glucoside (BA-6 for short) in preparation of a medicine for preventing and treating skin inflammation. The problems that an existing medicine for treating dermatitis is limited in curative effect, slow in effect taking, multiple in side effect, high in long-term use risk, large in individual difference, high in treatment cost, likely to cause immunoreaction and the like are solved. The invention discloses application of BA-6 in prevention and treatment of atopic dermatitis, contact dermatitis, eczema, rash, psoriasis, lupus erythematosus, papule squamous skin disease, pityriasis rosea, seborrheic dermatitis, pemphigus, celestial abscess, acne, tinea corporis, impetigo, SAPHO syndrome, hidradenitis suppurativa, dermatitis caused by drugs, lichen planus, pityriasis rubra pilaris, vitiligo, prurigo nodularis, dermatitis caused by drugs, and the like for the first time. The traditional Chinese medicine composition can be used for treating skin diseases, systemic sclerosis, hidradenitis suppurativa, granulomatous skin diseases, vitiligo, dermatomyositis, chronic skin itch and alopecia areata, and has the technical progress of obviously improving skin erythema, papule, edema, scale, moss and ulceration symptoms.

The invention discloses a modified melittin peptide, a product containing the modified melittin peptide and application, and belongs to the technical field of biological medicine. The amino acid sequence of the modified melittin is shown as Seq ID No: 2, the molecular weight of the modified melittin is 3123.5 Da, and the isoelectric point of the modified melittin is 12.64. The invention further discloses application of the modified melittin peptide in preparation of drugs or cosmetics for inhibiting inflammation and relieving skin erythema and itching. The invention also discloses application of the modified melittin peptide in preparation of drugs or cosmetics for enhancing cell activity and promoting tissue repair. The melittin modified peptide can significantly reduce the cytotoxicity of natural melittin and significantly enhance the anti-inflammatory activity and tissue repair activity of the melittin, has no sensitization and phototoxicity, and can provide key technical support for research and development of new-generation efficient and safe anti-inflammatory repair drugs, cosmetic products and related biological materials.

The disclosure relates to methods and compositions for the treatment of Cutaneous Lupus Erythematous (CLE). Specifically, the disclosure relates to methods comprising administering to a subject a type I IFN receptor inhibitor.

The invention belongs to the technical field of microorganisms, and particularly relates to a staphylococcus epidermidis H62-3 metabolite gel preparation as well as a preparation method and application thereof. The staphylococcus epidermidis H62-3 metabolite gel preparation improves skin erythema and scale symptoms of a psoriasis mouse model, remarkably reduces the skin lesion thickness, can reduce the mRNA expression level of inflammatory factors interleukin-17A, interleukin-17F and interleukin-23 at the skin lesion of the psoriasis mouse model, and can be used for treating psoriasis. The compound has a prospect of being developed into drugs for treating inflammatory dermatosis. The staphylococcus epidermidis H62-3 metabolite gel preparation disclosed by the invention is used for improving a psoriasis mouse model, and a new thought for safely and effectively treating inflammatory skin diseases by external use of viable bacteria metabolite is provided.

The invention belongs to the technical field of microorganisms, and particularly relates to application of a staphylococcus epidermidis H62-3 viable bacterium preparation in preparation of a medicine for preventing or treating psoriasis. Experimental results show that the staphylococcus epidermidis H62-3 viable bacterium preparation improves skin erythema and scale symptoms of a psoriasis mouse model, remarkably reduces the skin lesion thickness, reduces the mRNA expression level of cytokines related to psoriasis at the skin lesion position of the psoriasis mouse model, and improves the psoriasis resistance of the psoriasis mouse model. And the cell factors comprise interleukin-17A, interleukin-17F and interleukin-23. The invention also discloses a preparation method of the cell factor. Therefore, the staphylococcus epidermidis H62-3 viable bacterium preparation has the prospect of being developed into the medicine for preventing or treating psoriasis.

The invention relates to the technical field of treatment of eczema-like skin symptoms, in particular to an essential oil composition for treating eczema-like skin symptoms and application thereof, and the essential oil composition comprises the following components in parts by weight: 10-20 parts of lavender essential oil, 5-10 parts of tea tree essential oil, 30-40 parts of olive oil, 5-10 parts of squalane, 0.5-1 part of vitamin E and 1-5 parts of plant extract. The lavender essential oil and the tea tree essential oil are compounded, and the olive oil, the squalane, the vitamin E and the plant extract are supplemented, so that symptoms such as skin erythema, papule and pruritus caused by eczema can be effectively relieved, and good anti-inflammatory, antibacterial, moisturizing and repairing effects are achieved. The composition has the advantages of simple components, simplified preparation process, low production cost and wide application range, and can better meet clinical requirements.

The invention relates to the technical field of traditional Chinese medicine external preparations, in particular to an industrialized preparation method of an emplastrum composition capable of improving safety. The preparation method comprises the following steps: partially dissolving rubber by using gasoline A, then adding rosin, and stirring for dissolving; adding activated zinc oxide, mixing, adding lanolin, vaseline, musk wind-dispelling and pain-relieving liquid extract, belladonna liquid extract, rutin extract, menthol, borneol, camphor, methyl salicylate and a gasoline B part, and performing pH regulation to obtain musk wind-dispelling and pain-relieving paste mucilage; the activated zinc oxide is obtained by the following steps: mixing zinc oxide and liquid paraffin, and standing for 2-4 hours in an environment of 120-140 DEG C, so as to obtain the activated zinc oxide. According to the technical scheme, on the basis of keeping the treatment effect of the original medicinal components, the technical problem that the musk wind-dispelling and pain-relieving ointment contains viscous matrix components such as rosin and rubber, so that the skin is easily stimulated, and adverse reactions such as skin erythema are generated is solved, and the musk wind-dispelling and pain-relieving ointment has good market prospects and social benefits.

This invention discloses a strain of Bifidobacterium animalis subspecies TRT-2A with allergy-relieving effects and its extracellular vesicle applications. The strain TRT-2A is deposited at the China Center for Type Culture Collection (CCTCC) on November 21, 2025, with accession number CCTCC NO:M 20252645. This strain is highly acid-resistant and exhibits good tolerance to artificial gastric and intestinal fluids. It effectively inhibits bacteria, particularly Streptococcus pyogenes, Streptococcus agalactiae, and / or Escherichia coli. Experimental results show that this strain can alleviate hormone-dependent dermatitis and effectively improve dermatitis symptoms such as erythema and desquamation. Furthermore, extracellular vesicles prepared using TRT-2A can effectively improve skin elasticity and reduce wrinkles. Therefore, the Bifidobacterium animalis subspecies TRT-2A of this invention has multiple functions and is worthy of further promotion and application.

The present invention relates to the treatment of cutaneous lupus erythematosus. The problem to be solved by the invention is to provide a new pharmaceutical use of 3-[(3S,4R)-3-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3,4]octan-1-yl]-3-oxopropanenitrile. A therapeutic or preventive agent cutaneous lupus erythematosus, containing 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3,4]octan-1-yl]-3-oxopropanenitrile as an active ingredient, and a pharmaceutical formulation thereof.

The invention belongs to the technical field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine composition for treating chemotherapy-related hand-foot syndrome, which is prepared from the following raw materials in parts by weight: 50-60 parts of purslane, 20-30 parts of rhizoma atractylodis, 50-60 parts of cacumen biotae, 20-30 parts of radix sophorae flavescentis, 20-30 parts of gallnut, 15-20 parts of dandelion, 30-40 parts of folium isatidis, 20-30 parts of garden balsam stem, 10-15 parts of pericarpium zanthoxyli and 10-20 parts of fructus evodiae. The traditional Chinese medicine composition provided by the invention can obviously improve symptoms such as erythema and damage of hand and foot skins, exuded yellow pus, local skin sclerosis, pain and the like of patients with chemotherapy-related hand and foot syndromes.

The invention provides a toad skin extract, a traditional Chinese medicine composition, a traditional Chinese medicine gel ointment, a preparation method and application, and belongs to the technical field of traditional Chinese medicine extraction and traditional Chinese medicine preparations. The preparation method of the toad skin extract comprises the following steps: mixing dried toad skin with an ethanol solution, performing reflux extraction to obtain a toad skin extracting solution, performing centrifugation to obtain supernate, and performing concentration and drying to obtain the toad skin extract. According to the preparation method, the content of bufalin, cinobufagin, resibufogenin and indole alkaloid extracted from the toad skin is increased, the preparation method is stable and feasible, and the prepared toad skin extract can inhibit bacteria. The traditional Chinese medicine gel ointment is easy to coat, smooth and bright in ointment body, good in skin following performance and uncovering and pasting performance, free of residues in stripping, good in adhesiveness, excellent in overall quality and good in reproducibility, has the effects of diminishing swelling and treating acne, is free of acute toxicity, does not cause the conditions of skin erythema and edema, is free of irritation to skin and is high in safety.

The invention discloses application of an Aldicanol compound in preparation of a medicine for treating chronic skin inflammation, and belongs to the technical field of medicines. In order to solve the problem that a method for effectively treating chronic scytitis lacks in the prior art, the invention provides an application of an Aldicanol compound in preparation of a medicine for treating chronic scytitis, the Aldicanol compound is extracted from dryopteris fragrans glandular hair, and the Aldicanol compound has the effects of remarkably improving skin erythema caused by chronic scytitis, reducing scales, improving the curative effect of chronic scytitis, improving the curative effect of chronic scytitis and the like. The spleen index is reduced; the skin epidermis thickness caused by chronic skin inflammation is obviously reduced, inflammatory cell infiltration is reduced, and hair follicle inflammation is obviously weakened; proinflammatory factors can be effectively inhibited, and expression of anti-inflammatory factors can be effectively promoted; the Aldicanol compound can be applied to the treatment of chronic skin inflammation.

The invention discloses a rutin-containing mink oil skin care composition and a preparation method thereof. The preparation method comprises the following steps: fully dissolving rutin and lecithin in ethanol to form a uniform solution; dropwise adding the uniform solution into preheated mink oil, then removing ethanol, adding vitamin E and phytosterol, and homogenizing to obtain the mink oil composition. The composition prepared according to the invention can effectively inhibit self-oxidation of the mink oil, continuously remove oxidative stress products in the skin after being used, and relieve skin erythema and injury caused by lipid peroxidation.

The invention discloses application of vicenin-2 in preparation of a pharmaceutical preparation for treating and / or preventing rosacea, and belongs to the technical field of biological medicines. Vitin-2 blocks conduction of an IL-17 signal channel through targeted regulation and control of an IL-17RA / ACT1 / TRAF6 axis, further inhibits activation of an NF-kappa B signal channel, reduces levels of inflammatory factors TNF alpha, IL-6, IL-1beta and IL-8 induced by LL-37, inhibits expression of mRNA of TNF alpha, IL-6 and IL-1beta, inhibits phosphorylation of key protein of the channel, reduces protein expression levels of MMP1 and MMP3 at the downstream of the channel, and further inhibits activation of an NF-kappa B signal channel. Further, the effect of resisting the acne rosacea inflammatory response is achieved. Besides, the external vicenin-2 solution can relieve back erythema and angiotelectasis of a rosacea-like mouse model, pathological tissue section HE staining shows that the external vicenin-2 solution can relieve LL-37-induced skin inflammation infiltration, and the weight of a mouse is not obviously reduced compared with that before treatment; and the skin erythema and scales of mice are not generated by external use of the vicainin-2 solution.

The present invention discloses the use of a plant extract containing geniposide in inhibiting and / or improving angiogenesis, as well as the use of a plant extract containing geniposide in preparing a cosmetic having the efficacy of inhibiting and / or improving angiogenesis, and provides a cosmetic containing a plant extract containing geniposide and a method for inhibiting and / or improving angiogenesis. By adopting the technical solution provided by the present invention, angiogenesis in the skin can be inhibited and / or improved, thereby improving problems such as telangiectasia, skin erythema, dark circles under the eyes, etc. caused by angiogenesis.

This application discloses the use of an amphibian active peptide, Ha-CATH1, in preparing a preparation for alleviating inflammatory skin diseases, and the preparation for alleviating inflammatory skin diseases. The application relates to the biomedical field, and the amino acid sequence of the active peptide, Ha-CATH1, is as shown in SEQ ID NO: 1. Experimental verification has shown that the amphibian active peptide, Ha-CATH1, can alleviate symptoms such as skin erythema and scaling caused by inflammatory skin diseases, reduce local and systemic inflammatory responses, and can be used to improve inflammatory skin diseases. The amphibian active peptide, Ha-CATH1, is effective at low concentrations, has high efficacy, and its metabolites are non-toxic. It can be used to prepare preparations for alleviating inflammatory skin diseases.

To provide a method for treating disease.SOLUTION: The present disclosure relates generally to specific compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of an autoimmune disease and / or inflammatory condition, including systemic lupus erythematosus and cutaneous lupus erythematosus. As described in detail and specifically demonstrated herein, it is surprisingly found that, the present invention achieves remarkable effects, which could not have been easily predicted by those skilled in the art based on the prior art.SELECTED DRAWING: None

The invention discloses a method for establishing a rat radiodermatitis model. The method comprises the following steps: S1, setting a control group, a low-dose group, a medium-dose group, a high-dose group and a false irradiation group; the control group is not irradiated, and the skin state of the rats under the condition that the rats are not damaged by radiation is observed; the total irradiation dose of the low-dose group is 35Gy; the total irradiation dose of the medium dose group is 40Gy; the total irradiation dose of the high-dose group is 45Gy; s2, selecting rats, shaving and cleaning radiation parts of the rats, and performing anesthesia treatment on the rats; s3, a 6MeV electron accelerator is adopted for radiation irradiation, the irradiation time of a low-dose group is 5.83 minutes, the irradiation time of a medium-dose group is 6.67 minutes, and the irradiation time of a high-dose group is 7.5 minutes; s4, after irradiation is completed, the rats are removed and transferred into a clean cage, the reaction of the rats after irradiation is observed, and the initial conditions of skin injuries including erythema and swelling are recorded; experiments should regularly record the health condition of the rat.

The invention discloses a skin erythema optical phantom and a preparation method thereof, and relates to the technical field of biomedical optical technology and skin erythema detection. The skin erythema optical phantom comprises the following components: a red dye, a black dye, a yellow dye, a scattering medium, a solidification medium and a preservative. The difference between the skin erythema optical phantom prepared by the invention and the tissue optical parameters (such as mu a and mu's) of human skin is lt; 5%; the diffuse reflection spectrum contact ratio gt with human skin erythema at the wave band of 500-600nm; 90%; the differences with L *, a * and b * values of human skin erythema in the Lab color space are all lt; and 10%. The skin erythema optical phantom can be used as a reference standard for calibration of erythema detection equipment and comparison calibration of erythema indexes.

To provide a composition for suppressing or preventing disturbances of the expression rhythm of the clock gene; a composition for preventing erythema of the skin induced by ultraviolet light and the like; and a composition for preventing generation of glycated products by the reaction of a protein and a sugar.SOLUTION: The present invention discloses a composition for suppressing or preventing disturbances of the expression rhythm of the clock gene, an anti-inflammatory agent, and an anti-glycation agent, each of which contains Albizia julibrissin extract.SELECTED DRAWING: None

A composition including a synergistic combination of a vitamin D3 or a derivative or precursor thereof and hyaluronic acid or derivate thereof encapsulated in a lipid based colloidal carrier system (preferably lipid based vesicles such as liposomes, niosomes, tranferosomes) and topical formulations thereof, as well as their use in the prevention and / or treatment of inflamed skin and mucous membrane, especially in the prevention and / or treatment of skin photodamage, in particular in the prevention and / or treatment of skin erythema (skin inflammation) and actinic keratosis, as well non melanoma skin cancer.

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine compound sustained-release patch for treating senile constipation and application thereof.The patch is prepared from 10 parts of fructus evodiae, 10 parts of fresh ginger, 15 parts of codonopsis pilosula, 10 parts of water chestnuts, 10 parts of white pepper, 8 parts of clove, 15 parts of folium artemisiae argyi, 10 parts of dried ginger and 2 parts of borneol. According to the traditional Chinese medicine compound sustained-release patch for treating the senile constipation and the application of the traditional Chinese medicine compound sustained-release patch, targeted absorption of the medicine is enhanced by utilizing the characteristics of the Shenque acupoint, the medicine is continuously released within 12-24 hours, the clinical total effective rate is 95.0% and is obviously higher than 78.9% of a lactulose control group, and the traditional Chinese medicine compound sustained-release patch has the advantages that the traditional Chinese medicine compound sustained-release patch is suitable for being used for treating the senile constipation and the application of the traditional Chinese medicine compound sustained-release patch. The traditional Chinese medicine composition is free of systemic adverse reaction, only has 3.3% of transient skin erythema, can improve defecation frequency, consumed time and excrement characters, regulate intestinal flora and fill the medicine blank of over 80-year-old super-elderly patients, and is suitable for old patients with deficiency-cold type functional constipation.

The invention discloses a skin erythema relieving ointment smearing nursing device and an operation method, and relates to the field of nursing devices. According to the skin erythema relieving ointment applying and nursing device and the operation method, the handle and the mounting shell are arranged, and the massaging roller is arranged in the mounting shell, so that when the ointment needs to be quickly and uniformly applied to an erythema area for acting, the ointment can be applied to the erythema area firstly, and then a patient holds the handle by hand to press the mounting shell downwards; the massage rollers are pressed through the mounting shell, the transmission motor, the transmission shaft and the connecting plate, the massage rollers are stretched towards the two sides after being stressed, the telescopic pull rods are stretched, when a patient drives the mounting shell to move upwards through the handle, the stretched telescopic pull rods reset to drive the massage rollers on the two sides to get close to the middle, and repeated opening and closing of the massage rollers are achieved; the ointment is evenly smeared on the skin erythema area through the action of the kneading roller, and rapid absorption of the ointment is promoted through kneading.

The invention discloses a Roseomonas mucosa, further discloses a bacterial formulation containing the Roseomonas mucosa above and an exopolysaccharide of the Roseomonas mucosa, and also discloses applications of the Roseomonas mucosa and the exopolysaccharide of the Roseomonas mucosa in prevention and / treatment of inflammation-related and / or T / B cell overactivation diseases, treatment or relief of cutaneous lupus erythematosus, treatment of psoriasis and atopic dermatitis, relief of UVB-induced skin damage, and preparation of a product for improving a skin condition. In the invention, a skin commensal bacteria strain is screened from skin of healthy people and has broad application prospects.

The present invention relates to a cosmetic composition containing a Cyperus rotundus extract extracted by heating microbubbles. The extract has excellent anti-inflammatory effects by suppressing the production of nitric oxide (NO) and the expression of inflammation-inducing factors IL-6 (interleukin 6), COX-2 (cyclooxygenase-2), IL-1β (interleukin-1β), and TNF-α (tumor necrosis factor-α). It also enhances the expression of skin impact and moisturizing genes AQP-3 (aquaporin-3), HAS-2 (hyaluronan synthase 2), CLDN-1 (claudin-1), CDH1 (cadherin 1), FLG (filaggrin), and IVL (involucrin). When used as a cosmetic, it has excellent effects on skin soothing, moisturizing, improving the skin barrier, easing irritation such as skin erythema, and relieving itching, and can be usefully used as a multi-care product that improves skin condition.

The invention belongs to the technical field of cosmetics, and particularly relates to application of perilla scapes in preparation of cosmetics with functions of preventing or repairing skin light damage and consolidating skin barrier. According to the application, it is found for the first time that the perilla scapes can effectively avoid skin tissue light damage caused by ultraviolet light, and skin cell sunburn symptoms such as skin erythema, edema, punctiform vascular structure and capillary dilatation, dermatoglyph thickening, epidermis desquamation, cuticle thickening and corium layer diffuse inflammatory cell infiltration caused by the skin tissue light damage are reduced. Meanwhile, the perilla lees can also up-regulate oxidative stress related factors in skin tissues, so that the effect of improving the oxidative injury of the skin is achieved. In addition, the perilla lees can effectively up-regulate the expression level of skin barrier related proteins, and can well participate in differentiation of epidermis cells and formation of skin barriers, so that the perilla lees have the function of consolidating the skin barriers. The perilla lees are used for preparing cosmetics or skin care products for repairing skin light damage, and the perilla lees have wide market application prospects.

The invention relates to the technical field of daily chemicals, in particular to a cosmetic composition with multiple repairing effects, a cosmetic and application. The cosmetic composition is prepared from a radish seed extract, glycolipid, phytosphingosine and a centella asiatica extract. The composition is further added with plant source active ingredients such as centella asiatica extract, radish seed extract and glycolipid, has good anti-inflammatory and antioxidant activity, and can effectively inhibit release of inflammatory factors, relieve uncomfortable reactions such as erythema and itching of skin and improve tolerance of sensitive skin. The lipid sealing agent, such as cetyl ethyl hexanoate, octyldodecanol and the like, has good compatibility with stratum corneum natural lipid, can form a sebum-like layer on the skin surface, assists in constructing a bionic'brick wall structure ', improves the moisture retention ability, reduces transdermal moisture loss (TEWL), and realizes long-acting moisture retention and environmental protection.

The invention discloses an application of betulinic acid 28-O-beta-D-glucoside (BA-6 for short) in preparation of a medicine for preventing and treating skin inflammation. The problems that an existing medicine for treating dermatitis is limited in curative effect, slow in effect taking, multiple in side effect, high in long-term use risk, large in individual difference, high in treatment cost, likely to cause immunoreaction and the like are solved. The invention discloses application of BA-6 in prevention and treatment of atopic dermatitis, contact dermatitis, eczema, rash, psoriasis, lupus erythematosus, papule squamous skin disease, pityriasis rosea, seborrheic dermatitis, pemphigus, celestial abscess, acne, tinea corporis, impetigo, SAPHO syndrome, hidradenitis suppurativa, dermatitis caused by drugs, lichen planus, pityriasis rubra pilaris, vitiligo, prurigo nodularis, dermatitis caused by drugs, and the like for the first time. The traditional Chinese medicine composition can be used for treating skin diseases, systemic sclerosis, hidradenitis suppurativa, granulomatous skin diseases, vitiligo, dermatomyositis, chronic skin itch and alopecia areata, and has the technical progress of obviously improving skin erythema, papule, edema, scale, moss and ulceration symptoms.

The invention discloses a coral-derived polypeptide as well as a composition and application thereof. The amino acid sequence of the polypeptide is an amino acid sequence (AE1802) as shown in SEQ ID NO: 1, the molecular weight of the polypeptide is 2201.51 Da, and the isoelectric point of the polypeptide is 9.84; the active ingredients of the composition comprise the polypeptide. The polypeptide can be applied to preparation of cosmetics or drugs for inhibiting inflammation and / or relieving skin erythema and itching. Or is applied to preparation of cosmetics or medicines for promoting skin or tissue injury repair. The polypeptide is free of cytotoxicity and sensitization, has the effects of resisting inflammation, relieving and promoting skin or tissue damage repair, and provides a safe and efficient natural effect type polypeptide active ingredient for the cosmetic industry and the pharmaceutical industry.

The invention relates to the technical field of cosmetic evaluation, and discloses a cosmetic efficacy evaluation method under a capsaicin solution induced skin erythema model, comprising the following steps: step 101, collecting skin state data of a subject; step 102, establishing an erythema image moment prediction model, and outputting first time; step 103, acquiring a first image and a second image based on the acquired first time; 104, calculating change parameters of the erythema areas in the first image and the second image; step 105, establishing a cosmetic efficacy evaluation model, inputting the difference of the change parameters of the erythema areas in the first image and the second image into the cosmetic efficacy evaluation model, and outputting the efficacy score of the tested cosmetic; by predicting the first time when the skin erythema of the subject arrives at the most serious moment, the first image at the time and the second image after the preset time are obtained, the efficacy of the cosmetics can be evaluated more accurately, and the error rate is low.