This disclosure relates to a method for determining bioeffective
dose, wherein the method includes: detecting the
boron concentration C of each
voxel in the target at multiple time points. B ; Calculate C B The corresponding
biological effect value (RBE) B Determine C B and RBE B The first association relationship, based on the first association relationship, determines the connection through C. B Characterized RBE B ; Calculate C B The corresponding first physical
absorbed dose rate D B And other physical
absorbed dose rates corresponding to
dose components other than
boron, and physical
dose rate distribution D
phy According to RBE B and D B The product of the other dose components and the product of other
biological effect values and other physically
absorbed dose rates is used to calculate C. B The combined
biological effect value (CBE); based on CBE and D
phy Calculate the biologically effective dose D bio According to this disclosure, it is beneficial to determine the appropriate
irradiation time for different voxels during BNCT in order to obtain better therapeutic effects.