The invention provides a traditional Chinese medicine composition resistant to liver cancer, made by adopting oldenlandia diffusa, selfheal, herba solani nigri, garden balsam stem, polygonum cuspidatum, sculellaria barbata, rhizoma sparganii, curcuma zedoary, airpotato yam rhizome, cowherb seed, pariphyllin, ligusticum chuanxiong hort, oriental wormwood, oriental waterplantain rhizome, costus root, grifola, poria, radix curcumae, radix bupleuri, rheum officinate, fructus aurantii, centipede, scorpio, borneol, yellow lead and storax as raw materials. The invention also discloses medicine coat made by the composition, the medicine coat is made by the process of socking, decocting, socking again, decocting again and drying in the shade. The medicine coat resistant to liver cancer of the invention not only is resistant to liver caner but also has the function of treating liver cirrhosis and cleaning liver virus, has the effects of cancer prevention, cancer resistance, apocatastasis dissipate blood stasis, inhibiting cancer cell diffusion and improving liver micro circulation, has no toxic or side effect and is effective in control and curative effect on early and mid-term liver cancer.