189 results about "Anticarcinogenic Effect" patented technology

The present invention relates to a water soluble chitosan nanoparticle (WSC-NP) for delivering an anticancer agent and a preparing method thereof, more precisely, a water soluble chitosan nanoparticle for delivering an anticancer agent which has function of targeting on a wanted area by introducing a functional group in the location of highly reactive amine group and becomes an excellent gene carrier with the use of water soluble chitosan since the water soluble chitosan itself can combined with DNA having a negative electric charge(−) owing to the very strong positive electric charge(+) of its amine group, and a preparing method thereof. Therefore, a water-soluble chitosan nanoparticle for delivering an anticancer agent of the present invention can effectively envelope paclitaxel by introducing hydrophilic and hydrophobic groups in the position of highly reactive amine group of the water-soluble chitosan. A water soluble chitosan nanopaclitaxel prepared as the above has an excellent re-dispersion force, after freeze-drying, in distilled water and has an outstanding anticancer effect with its accumulation in tumor cells greater than that of the other anticancer agent carriers.

The invention relates to a biological fermentation composition with an anti-cancer effect. The biological fermentation composition is prepared by using a method comprising the following steps: a, preparing a culture medium mixed solution; b, sterilizing; c, cooling; d, inoculating to obtain a fermentation solution; and e, standing to obtain the biological fermentation composition with the anti-cancer effect. The composition disclosed by the invention can be used for improving the in-vivo micro-ecological environment, balancing and regulating effective microbial communities in intestinal canals, repairing damaged cells, replenishing various in-vivo active bio-enzymes, amino acids, nucleic acids, trace elements and the like, improving the immunity of a human body, preventing diseases, effectively inhibiting cancer cells and stopping the dispersion and development of the cancer cells. Meanwhile, the biological fermentation composition can be used for improving an acidic physique to be a weak alkaline physique, is particularly suitable for the cancer crowd, the crowd with hypertension, hyperlipidemia and hyperglycemia and the fat crowd, can be prepared into various dosage forms such as pills, paste, aqueous solutions and the like, and has favorable supportive therapeutic effects on cancer, diabetes, digestive system diseases and the like.

Three pairs of C-2 epimeric xanthones isolated from Garcinia hanburyi and method for efficiently separating the xanthone compounds into individual epimers, each of which possesses varying biological effects. The compounds are useful for their anticancer effects, particularly because they are shown to be non-substrates of the multidrug-resistance transporter. Some of the epimers have significant inhibitory effects on cytochrome P450 systems. The xanthone compounds of the present invention are gambogic acid, epigambogic acid, isogambogic acid, isoepigambogic acid, 30-hydroxygambogic acid and 30-hydroxyepigambogic acid.

The invention discloses a medicine compound with an anticancer effect, a preparation technology and a quality detection method thereof. The medicine compound is composed of thirty-four Chinese herbs such as motherwort, ginseng, Radix Paeoniae Alba and the like. By methods of decoction, wet distillation, ethanol precipitation and the like, effective components of the Chinese herbs are fully performed. In the meanwhile, the invention also provides a detection method of the medicine compound content. The detection method has high specificity and good precision, stability and reproducibility.

The invention relates to a phenothiazine compound and a preparation method thereof. The invention further relates the application of the phenothiazine compound in anti-cancer drug preparation and anti-cancer drugs using the compound as the effective component. The phenothiazine compound has the advantages that the compound with broad-spectrum anti-cancer effect is obtained by modifying phenothiazine ternary interlink parent nucleuses, synthesizing method is simple, and high yield is achieved; the phenothiazine compound has certain restraining effect on human breast cancer cells line MCF-7 and human hepatoma cell line Hep-G2, and a new thought is provided to new drugs satisfying clinic requirements.

The invention relates to a probiotic expressed multi-target nanobody (Nb or VHH) polymeric linker which is formed by connecting specific VHH monomer nanobodies aiming at target spots HER2 (Human Epidermal Receptor 2), EGFR (Epidermal Growth Factor Receptor) and VEGF (Vascular Endothelial Growth Factor) through polypeptide chain connection Linker, and DNA (Deoxyribonucleic Acid) of the multi-target nanobody polymeric linker is transferred and loaded into oral probiotics. Strains of the oral probiotics can live in a gastrointestinal system of a human body for certain time, and a polymeric linked multi-target nanobody is expressed and released to treat gastric cancer. The nanobody polymeric linker provided by the invention exerts the advantages of small size of the nanobody, high stability, acid and alkali environment resistance and capability of penetrating through human body tissues; the defect that the half-life period of the nanobody in the human body is short is overcome; and a new way for treating the gastric cancer through orally taking antibody medicines is created. The nanobody polymeric linker provided by the invention exerts a multi-target cancer cell growth inhibiting effect, and the anti-cancer effect is enhanced by dozens of times even hundreds of times when being compared with the effect of simple random mixing of monomer antibodies.

The invention discloses a traditional Chinese medicine cancer toxin prescription for treating liver cancer and application thereof in the preparation of medicaments for resisting liver cancer. The cancer toxin prescription is prepared in accordance with the cancer toxin theory proposed by traditional Chinese medicine master Professor Zhou Zhongying, and is prepared from hedyotidis herba, muscardine silkworm, centipede, akebia fruit, pseudostellaria root, dwarf lilyturf root and rhizoma pleionis according to a certain weight ratio. The prescription has the main functions of eliminating pathogens, eliminating cancer and detoxicating and the auxiliary function of strengthening healthy qi. By using mice with liver cancer H22 transplantation tumor as materials, the pharmacological experiment result shows the cancer resistance effect of the cancer toxin prescription: the tumor inhibition rates of a low-dose group, an intermediate-dose group and a high-dose group are respectively 24.5%, 42.8% and 21.1%, thereby showing the effect of inhibiting the growth of H22 tumor mass; the tumor mass cell apoptosis rates of the low-dose group, the intermediate-dose group and the high-dose group are respectively 47.16%, 60.52% and 57.59%, thereby showing the effect of inducing tumor cells to die; and the cancer toxin prescription can block the high expression of TLR4, block the MyD88 dependent pathway of TLR4 intracellular signal transduction and inhibit the expression of downstream NF-kB proteins. Experiment shows that the cancer toxin prescription can be used for preparing medicaments for resisting liver cancer.

A series of complexes made by γ-polyglutamic acid (γ-PGA) and cisplatin, their preparation and applications in biomedical field, specifically in cancer treatment. The complexes may be made by binding free cisplatin on small molecule γ-PGA through the reaction between carboxylic group of γ-PGA and Cl of cisplatin. The complexes show effective anticancer effect and are easy and cost effective to prepare.

The invention discloses a monoclonal antibody hybrid tumor cell strain KGH-R1 of broad spectrum anti-human p21Ras protein and a monoclonal antibody, belongs to the field of medical biology, and in particular relates to the monoclonal antibody hybrid tumor cell strain KGH-R1 of broad spectrum anti-human p21Ras protein and the monoclonal antibody. The hybrid tumor is preserved in a China center for type culture collection in September 23rd 2011, and has the preservation number of CCTCCNO: C201197. A mouse monoclonal antibody which has synchronous antagonism to three types of active Ras protein is finally obtained; and the monoclonal antibody which aims at a p21Ras protein target can be used for protein clinical test, can also construct an intracellular antibody, has an active tumor prevention function by inhibiting tissue vicious transformation through resisting overexpressed Ras protein, and has an active target antitumous effect on the tumor which corresponds to the overexpressed Ras protein.

The invention discloses a novel application of mulgedium tataricum. A water extraction product of the asteraceae mulgedium plant mulgedium tataricum which can both be adopted as a medicine and as a food can strongly inhibit the growth of lung cancer cell H1299 and A549. With the plant, cancer cell mitochondrial membrane potential is reduced, intracellular reactive oxygen level is increased, and a series of physiological responses such as apoptosis is further caused. The discovery of the anticancer effect of the edible herb provides good basis for clinical medicines and the developments of novel medicines or health-care products.

The invention relates to a stent coating with ultrasonic intelligent controlled release and a preparation method and an application thereof. The invention also provides a drug-loaded stent with ultrasonic intelligent controlled release and a preparation method and an application thereof. The advantages of the invention are that: a new stent coating with the effect of ultrasonic intelligent controlled release is successfully constructed and synthesized; ultrasound is first found and confirmed to have control effect on the temperature-sensitive release of loaded drugs; and a new method is provided for future drug intelligent controlled release; a drug-loaded biliary tract stent with ultrasonic intelligent drug controlled release is synthesized, and a possible and feasible treatment means is provided for the treatment of malignant tumors of hollow organs; ultrasound is first found and confirmed to have significant effect on promoting the release of drugs coated by a temperature-sensitive material by changing the spatial structure of the temperature-sensitive material. By using ultrasound, the effect of drug intelligent controlled release at a designated site is achieved; local anticancer effect is brought into play; the toxic and side effect of anticancer drugs on important human tissue is reduced; and high clinical application value is provided.

The invention relates to the technical field of medicines and provides application of cepharanthine and salts thereof as a ferroptosis inducer in preparation of an anti-tumor drug. As found, natural products, namely cepharanthine and salts thereof, which are already applied clinically for many years can induce ferroptosis of prostate cancer cells in expressive ways of active oxygen increase, accumulation of lipid peroxides, decrease in the expression level of GPX4, structural changes in mitochondria, etc. Therefore, cepharanthine and salts thereof have good anti-cancer effects and provide a new effective therapeutic drug for tumor disease patients.

An orally-applied dropping pill of anticancer alkaloid contains camptothecine or taxol or harringtonine or homoharringtonine and matrix of dropping pill. Its preparing process includes proportioning,thermal fusion, stirring, and dropping it at 60-150 deg.c in condensing agent at speed of 20-100 drops per min, and removing condensing agent.

The invention relates to an application of alkannin and its derivative in the preparation of a gene therapy sensitizer. The alkannin and its derivative as a gene therapy sensitizer has small toxicity; and when the alkannin and its derivative and gene therapy are combined to carry out malignant tumor treatment, the superposing of the anticancer effect of the alkannin and its derivative and the enhanced gene therapy effect maximally display an antitumor effect.

[PROBLEMS] To provide a fraction containing the active ingredient contained in plant worms. To provide a means efficacious in immunopotentiation, an effective means of preventing or treating cancer and a composition useful in producing health foods. [MEANS FOR SOLVING PROBLEMS] It is intended to provide a precipitation fraction obtained by extracting plant worms mycelium with hot water and adding ethanol to the thus obtained extract. It is also intended to provide a composition for oral intake which contains the above precipitation fraction. It is further intended to provide foods, drinks, immunopotentiators, anticancer agents and so on containing the above composition for oral intake which are characterized by having an anticancer effect, an effect of preventing cancer or an immunopotentiation effect. It is furthermore intended to provide a method of effectively producing the above-described composition for oral intake.

The invention relates to a 3-vinyl indazole derivative as well as a preparation method and application thereof, and belongs to the field of chemical medicines. The invention provides a compound represented by a formula I, an optical isomer of the compound, and a pharmaceutically acceptable salt of the compound or the optical isomer of the compound. Biological experiments prove that the 3-vinyl indazole derivative provided by the invention has a remarkable inhibition effect on the activity of FGFR kinase, can effectively inhibit proliferation of various cancer cells such as breast cancer, lungcancer and gastric cancer, and has a broad-spectrum anti-cancer effect; besides, the 3-vinyl indazole derivative also has an obvious inhibiting effect on proliferation of fibroblasts, the effect of the 3-vinyl indazole derivative is equivalent to that of a drug Nintedanib for treating pulmonary fibrosis clinically at present, and the anti-fibrosis curative effect is remarkable. The 3-vinyl indazole derivative provides a new choice for development and application of anti-cancer and anti-fibrosis drugs.

The invention discloses Mongolian oak leaf extractive with anti-cancer effect and a preparation method and application thereof. The preparation method includes the following steps of firstly, conducting extracting on Mongolian oak leaves through extracting agents to obtain extract liquid, and evaporating and concentrating the extract liquid to obtain a concentrated solution; secondly, adding water to thin up the concentrated solution obtained in the first step, and conducting ultrafiltration to obtain Mongolian oak leaf extract with the molecular weight smaller than or equal to 5000 Dr; thirdly, freeze-drying the extract liquid obtained in the second step to obtain freeze-dried powder, namely, the Mongolian oak leaf extractive. The experiment research on the Mongolian oak leaf extractive with the anti-cancer effect is conducted for the first time, the Mongolian oak leaf extractive fills in the blank in the field, and the prepared Mongolian oak leaf extractive can restrain growth of various cancer cells both inside and outside living bodies and has the strong anti-cancer effect. The process flow is simple, the device input is small, industrial production can be easily achieved, and no pollution is caused in the preparation process.

The invention discloses a solanesol-modified paclitaxel prodrug and a preparation method and application thereof. A prodrug self-assembled nano-drug delivery system is prepared on the basis of the solanesol-modified paclitaxel prodrug, has a uniform particle size (about 100 nm) and can efficiently load paclitaxel; a preparation method of the prodrug self-assembled nano-drug delivery system is simple in process and high in repeatability; long-chain PEG is modified on the surface of the nanometer preparation through vitamin E polyethylene glycol succinate (TPGS), so the in-vivo circulation of drugs can be effectively prolonged, and the stability of the nanometer preparation can be improved; besides, the solanesol-paclitaxel prodrug connected through a disulfide bond can specifically releasethe drugs in a reduction environment, so targeted accumulation of paclitaxel at a tumor site is expected to be achieved, anti-tumor effect is improved, and toxic and side effects on normal tissue arereduced; and solanesol is a natural active drug, has the effects of inhibiting tumor cells, increasing the sensitivity of cancer cells to anti-cancer drugs and the like, and is expected to enhance theanti-cancer effect of paclitaxel.

The invention relates to the field of medicines, and specifically discloses a pharmaceutical composition with anticancer effect. The pharmaceutical composition comprises the following active ingredients: resibufogenin, cinobufagin and bufotalin; wherein the weight ratio of resibufogenin, cinobufagin and bufotalin is 1-2:1-5:1-3. Tests show that after combination of the resibufogenin, the cinobufagin and the bufotalin, a synergistic anti liver cancer, lung cancer and nasopharyngeal carcinoma effect can be played, when the weight ratio of resibufogenin, cinobufagin and bufotalin is 1:1.5-2.5:1-2, the synergistic anti liver cancer effect is best, the anti liver and lung cancer effect of the pharmaceutical composition is equivalent to that of positive control drug cisplatin, and the anti nasopharyngeal carcinoma effect of the pharmaceutical composition better than that of the positive control drug cisplatin, so that the resibufogenin, the cinobufagin and the bufotalin can be combinedly used as a new anticancer drug.