209 results about "Anticarcinogenic Effect" patented technology

The present invention relates to a water soluble chitosan nanoparticle (WSC-NP) for delivering an anticancer agent and a preparing method thereof, more precisely, a water soluble chitosan nanoparticle for delivering an anticancer agent which has function of targeting on a wanted area by introducing a functional group in the location of highly reactive amine group and becomes an excellent gene carrier with the use of water soluble chitosan since the water soluble chitosan itself can combined with DNA having a negative electric charge(−) owing to the very strong positive electric charge(+) of its amine group, and a preparing method thereof. Therefore, a water-soluble chitosan nanoparticle for delivering an anticancer agent of the present invention can effectively envelope paclitaxel by introducing hydrophilic and hydrophobic groups in the position of highly reactive amine group of the water-soluble chitosan. A water soluble chitosan nanopaclitaxel prepared as the above has an excellent re-dispersion force, after freeze-drying, in distilled water and has an outstanding anticancer effect with its accumulation in tumor cells greater than that of the other anticancer agent carriers.

The invention relates to a biological fermentation composition with an anti-cancer effect. The biological fermentation composition is prepared by using a method comprising the following steps: a, preparing a culture medium mixed solution; b, sterilizing; c, cooling; d, inoculating to obtain a fermentation solution; and e, standing to obtain the biological fermentation composition with the anti-cancer effect. The composition disclosed by the invention can be used for improving the in-vivo micro-ecological environment, balancing and regulating effective microbial communities in intestinal canals, repairing damaged cells, replenishing various in-vivo active bio-enzymes, amino acids, nucleic acids, trace elements and the like, improving the immunity of a human body, preventing diseases, effectively inhibiting cancer cells and stopping the dispersion and development of the cancer cells. Meanwhile, the biological fermentation composition can be used for improving an acidic physique to be a weak alkaline physique, is particularly suitable for the cancer crowd, the crowd with hypertension, hyperlipidemia and hyperglycemia and the fat crowd, can be prepared into various dosage forms such as pills, paste, aqueous solutions and the like, and has favorable supportive therapeutic effects on cancer, diabetes, digestive system diseases and the like.

The invention discloses a traditional Chinese medicine composition for treating tumours and a preparation method thereof. The traditional Chinese medicine composition contains a bufogenin extract anda medicinal carrier, wherein the bufogenin extract is prepared by the purification of a silica gel column after being extracted by a toad venom medicinal material, the total content is not below 92%,and then the traditional Chinese medicine composition is prepared by dissolution, filtration, encapsulation and sterilization and can be further prepared into a liquor for injection or freeze-drying powder injection. The traditional Chinese medicine composition has a favorable anticancer action for lung cancer, liver cancer, mammary cancer, stomach cancer, colonic cancer and the like, can increaseleucocyte and has less side effect.

The present invention provides an inclusion compound having a cucurbituril derivative of the formula 1 as a host molecule and a metal complex of the formula 2 as a guest molecule. A pharmaceutical composition having an anticancer effect can be obtained by using the inclusion compound according to the present invention. The pharmaceutical composition can prevent effective components from being biologically degraded in vivo and can exhibit continuous drug effect for a long time just by a single dosage by controlling the release time of the platinum complex once it reaches target tumor cells.

Three pairs of C-2 epimeric xanthones isolated from Garcinia hanburyi and method for efficiently separating the xanthone compounds into individual epimers, each of which possesses varying biological effects. The compounds are useful for their anticancer effects, particularly because they are shown to be non-substrates of the multidrug-resistance transporter. Some of the epimers have significant inhibitory effects on cytochrome P450 systems. The xanthone compounds of the present invention are gambogic acid, epigambogic acid, isogambogic acid, isoepigambogic acid, 30-hydroxygambogic acid and 30-hydroxyepigambogic acid.

Leptin was previously demonstrated to exert potent immune modulatory properties in several immune mediated disorders. The aim of the study was to determine leptin's anti-tumor effect in a murine model of human hepatocellular carcinoma (HCC). In vivo, Athymic T cell deficient (nude) mice transplanted with 1×106 human Hep3B cells, followed by administration of two daily intraperitoneal doses of 0.5 mg / gram leptin for 6 weeks. Leptin administration induced a significant reduction in tumor size and improved survival in nude mice. Histologically, tumors of leptin-administered mice featured increased inflammatory exudate in interphase areas. Leptin-induced tumor suppression was associated with a significant increase in peripheral natural killer (NK) cell number. Splenocytes from leptin-treated mice featured decreased expression of CIS mRNA. To determine which lymphocyte subset is a prerequisite for the anti tumor effect of leptin, T&B cell deficient (Scid) mice and T,B& NK deficient (Scid-Beige) mice were subcutaneously implanted with Hep3B tumor cells, with and without the daily intraperitoneal administration of 0.5 mg / gram leptin for 6 weeks. SCID mice featured leptin-associated tumor suppression similar to those of nude mice. In contrast, NK-deficient SCID-Beige mice developed larger tumors. To further establish natural killer cell's central role in mediation of leptin's anti-tumor effect, NK cells were incubated in vitro with increasing doses of leptin, demonstrating a dose-dependent increase in cytotoxic activity. Incubation of leptin with hepatoma cell line was found to induce a dose-dependent reduction in hepatoma cell proliferation, suggesting an additive direct anti-tumor effect. Further synergism in inhibition of hepatoma cell proliferation in vitro was achieved following addition of natural killer cells. HCC cells expressed leptin receptor mRNA, while addition of leptin induced increased mRMA expression of STAT2 and SOCS1 on tumor cell lines. Leptin administration induces a significant suppression of human HCC. This effect is mediated by induction of natural killer cell proliferation and activation, and by direct inhibition of tumor growth. Decreased natural killer cell expression of inhibitory CIS protein and over expression of the anti-proliferative STAT2 and SOCS1 proteins in HCC lines may underline both anti cancerous effects of leptin.

The invention discloses a gemcitabine ProTide hypoxic activation prodrug and application thereof. The chemical structural formula is shown in the description. By adopting the gemcitabine ProTide hypoxic activation prodrug, anti-tumor medicinal active substances can be specifically released in a tumor hypoxic area by virtue of difference of micro environments of tumor tissue and normal tissue, an anti-tumor function can be brought into play, toxic and side effects on other tissue can be reduced, and the prodrug has excellent anti-cancer functions on tumor and good security, and can be adopted to prepare medicines for treating tumor.

The invention relates an anticancer active part of fructus terminaliae billericae, and a preparation method of the anticancer active part. The invention comprises extraction of the part containing active components, study of a process for enriching by adopting macroporous absorption resin, identification of the active components in the active part, and use of the active part in in-vivo or in-vitroinhibition of liver cancer HepG2, lung cancer A549, lung adenocarcinoma NCI-H1703, gastric cancer BGC823, osteosarcoma cell MG-63, colorectal cancer HCT116, breast cancer MCF-7, neuroblastoma cells shsy5y, kidney cancer ACHN, normal liver cells L02, human breast ductal carcinoma cells ZR75-1, human colorectal adenocarcinoma cells Colo-205, human breast ductal carcinoma cells BT-474, human breastcancer cells T-47D, human cervical cancer cell line HeLa, liver cancer cells H22, and the like. The enrichment method applying the macroporous absorption resin to the anti-cancer active part of the fructus terminaliae billericae is simple in process, safe, non-toxic and low in production cost, and can be used for industrial production, thus having a great economic benefit and higher generalizationperformance.

The invention discloses a medicine compound with an anticancer effect, a preparation technology and a quality detection method thereof. The medicine compound is composed of thirty-four Chinese herbs such as motherwort, ginseng, Radix Paeoniae Alba and the like. By methods of decoction, wet distillation, ethanol precipitation and the like, effective components of the Chinese herbs are fully performed. In the meanwhile, the invention also provides a detection method of the medicine compound content. The detection method has high specificity and good precision, stability and reproducibility.

The invention relates to a phenothiazine compound and a preparation method thereof. The invention further relates the application of the phenothiazine compound in anti-cancer drug preparation and anti-cancer drugs using the compound as the effective component. The phenothiazine compound has the advantages that the compound with broad-spectrum anti-cancer effect is obtained by modifying phenothiazine ternary interlink parent nucleuses, synthesizing method is simple, and high yield is achieved; the phenothiazine compound has certain restraining effect on human breast cancer cells line MCF-7 and human hepatoma cell line Hep-G2, and a new thought is provided to new drugs satisfying clinic requirements.

Disclosed are a method for detecting liver cancer capable of detecting liver cancer with high specificity and a diagnostic therefor, as well as a novel therapeutic drug for cancer having an excellent anticancer effect. The method for detecting liver cancer cells in a sample utilizes as an index the expression of dlk gene. The expression of dlk gene may be measured by immunoassay using an anti-dlk antibody or by measuring mRNA of dlk gene. The therapeutic drug for cancer comprises as an effective ingredient an antibody which undergoes antigen-antibody reaction with Dlk expressing on surfaces of cancer cells and which exerts anticancer action against the cancer cells.

A 13-deoxy anthracycline and a taxane can be administered to a patient simultaneously, separately, sequentially, or consecutively to produce a therapeutic anticancer effect with reduced toxicity and side effect profile, compared to the administration of equieffective amounts of either compound alone. A composition or preparation of a 13-deoxy anthracyclines and a taxane for producing a potent anticancer therapeutic effect is also provided.

The invention relates to a probiotic expressed multi-target nanobody (Nb or VHH) polymeric linker which is formed by connecting specific VHH monomer nanobodies aiming at target spots HER2 (Human Epidermal Receptor 2), EGFR (Epidermal Growth Factor Receptor) and VEGF (Vascular Endothelial Growth Factor) through polypeptide chain connection Linker, and DNA (Deoxyribonucleic Acid) of the multi-target nanobody polymeric linker is transferred and loaded into oral probiotics. Strains of the oral probiotics can live in a gastrointestinal system of a human body for certain time, and a polymeric linked multi-target nanobody is expressed and released to treat gastric cancer. The nanobody polymeric linker provided by the invention exerts the advantages of small size of the nanobody, high stability, acid and alkali environment resistance and capability of penetrating through human body tissues; the defect that the half-life period of the nanobody in the human body is short is overcome; and a new way for treating the gastric cancer through orally taking antibody medicines is created. The nanobody polymeric linker provided by the invention exerts a multi-target cancer cell growth inhibiting effect, and the anti-cancer effect is enhanced by dozens of times even hundreds of times when being compared with the effect of simple random mixing of monomer antibodies.

The invention discloses a traditional Chinese medicine cancer toxin prescription for treating liver cancer and application thereof in the preparation of medicaments for resisting liver cancer. The cancer toxin prescription is prepared in accordance with the cancer toxin theory proposed by traditional Chinese medicine master Professor Zhou Zhongying, and is prepared from hedyotidis herba, muscardine silkworm, centipede, akebia fruit, pseudostellaria root, dwarf lilyturf root and rhizoma pleionis according to a certain weight ratio. The prescription has the main functions of eliminating pathogens, eliminating cancer and detoxicating and the auxiliary function of strengthening healthy qi. By using mice with liver cancer H22 transplantation tumor as materials, the pharmacological experiment result shows the cancer resistance effect of the cancer toxin prescription: the tumor inhibition rates of a low-dose group, an intermediate-dose group and a high-dose group are respectively 24.5%, 42.8% and 21.1%, thereby showing the effect of inhibiting the growth of H22 tumor mass; the tumor mass cell apoptosis rates of the low-dose group, the intermediate-dose group and the high-dose group are respectively 47.16%, 60.52% and 57.59%, thereby showing the effect of inducing tumor cells to die; and the cancer toxin prescription can block the high expression of TLR4, block the MyD88 dependent pathway of TLR4 intracellular signal transduction and inhibit the expression of downstream NF-kB proteins. Experiment shows that the cancer toxin prescription can be used for preparing medicaments for resisting liver cancer.

The present invention relates to a novel retinoid derivative compound represented by the formula I: wherein X, R<1>, R<2 >and R<3 >are as defined herein or pharmaceutically acceptalbe salts thereof. Also, the present invention relates to processes for producing the compound of the formula I and to an anti-cancer composition comprising the compound of the formula I. The compound of the formula I according to the present invention exerts high anti-cancer effects while not causing undesirable side effects.

A series of complexes made by γ-polyglutamic acid (γ-PGA) and cisplatin, their preparation and applications in biomedical field, specifically in cancer treatment. The complexes may be made by binding free cisplatin on small molecule γ-PGA through the reaction between carboxylic group of γ-PGA and Cl of cisplatin. The complexes show effective anticancer effect and are easy and cost effective to prepare.

The invention discloses a monoclonal antibody hybrid tumor cell strain KGH-R1 of broad spectrum anti-human p21Ras protein and a monoclonal antibody, belongs to the field of medical biology, and in particular relates to the monoclonal antibody hybrid tumor cell strain KGH-R1 of broad spectrum anti-human p21Ras protein and the monoclonal antibody. The hybrid tumor is preserved in a China center for type culture collection in September 23rd 2011, and has the preservation number of CCTCCNO: C201197. A mouse monoclonal antibody which has synchronous antagonism to three types of active Ras protein is finally obtained; and the monoclonal antibody which aims at a p21Ras protein target can be used for protein clinical test, can also construct an intracellular antibody, has an active tumor prevention function by inhibiting tissue vicious transformation through resisting overexpressed Ras protein, and has an active target antitumous effect on the tumor which corresponds to the overexpressed Ras protein.

The invention provides an anticancer traditional Chinese medicine composition, belonging to the technical field of medicines. The traditional Chinese medicine composition comprises bezoar, sweet wormwood herb, musk, root of China creeper and all-grass of nerved twayblade. The traditional Chinese medicine composition has the beneficial effects that through a reasonable ratio of the five medicinal raw materials, the traditional Chinese medicine composition has synergetic effects and the double effects of directly inhibiting cancer cell growth and proliferation and enhancing the immune function; through clinical research trials, the traditional Chinese medicine composition can selectively inhibit and kill cancer cell proliferation to achieve the anticancer effect, can also promote differentiation of T and B lymphocytes and activate NK cells to enhance the body immunity, has quick treatment effects on cancers, does not have toxic or side effect, has a wide anticancer spectrum, especially has obvious curative effects on lung cancers, liver cancers, gastric cancers, intestinal cancers, lymph cancers, brain tumors, nasopharynx cancers, esophagus cancers, pancreatic cancers and cervical cancers, and does not have any impact on body cells, tissues, organ functions and hemogram in the medication period.

The invention discloses a novel adenine bisphosphonate, a preparation method and the application in the preparation of pharmaceutical preparations for the treatment of the metabolic bone diseases. A compound is (2-(6-amino-purine-9-yl)-1-hydroxy-phosphono-ethyl)phosphonate and 3-((6-amino-purine-9-yl)-1-hydroxy-phosphono-propyl)phosphonate. The compound can be used for the treatment of hypercalcemia, bone pains and other metabolic bone diseases caused by osteoporosis, osteitis deformans and bone metastasis of the malignant tumor, and the invention has an anti-cancer effect at the same time.

The invention discloses a triptolide liposome preparation for treatment of small cell lung cancer (SCLC) and a preparation method thereof. The preparation is a liposome preparation prepared from a Chinese medicinal active ingredient triptolide for treating small cell lung cancer. According to the preparation method, an ethanol injection method is employed to prepare the liposome, thus obtaining the triptolide liposome preparation for treatment of small cell lung cancer provided in the invention. Animal in-vivo anticancer pharmacological experiments show that the triptolide liposome preparation has an obvious inhibitory effect on small cell lung cancer growth, and its anticancer activity is significantly higher than that of a chemotherapeutic drug cisplatin. The anticancer effect of the triptolide liposome preparation is higher than that of triptolide non-liposome preparations.

The invention relates to a pyrimidine derivative with an anticancer effect, belonging to the field of chemical medicines. The invention provides an application of a compound as shown in a formula I which is described in the specification or pharmaceutically acceptable salt of the compound in preparation of drugs used for treatment and / or prevention of cancers. Biological experiment results show that the series of compounds show good inhibition effect on histone arginine demethylase, wherein the IC50 of part of the compounds is at a micromolar level and show good inhibition effect on a varietyof clinically common tumor cell strains; and the IC50 of all the compounds is smaller than 1 [mu]M. The compound provided by the invention also shows good effect in vivo, and can significantly inhibittumor growth in mice. In conclusion, the pyrimidine derivative provided by the invention provides a new effective choice for developing a new generation of targeting drugs for tumor treatment, and has good application prospect.

The invention relates to chemical compounds, or pharmaceutically acceptable salts thereof of the formula which possess CSF 1R kinase inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.

The invention discloses a novel application of mulgedium tataricum. A water extraction product of the asteraceae mulgedium plant mulgedium tataricum which can both be adopted as a medicine and as a food can strongly inhibit the growth of lung cancer cell H1299 and A549. With the plant, cancer cell mitochondrial membrane potential is reduced, intracellular reactive oxygen level is increased, and a series of physiological responses such as apoptosis is further caused. The discovery of the anticancer effect of the edible herb provides good basis for clinical medicines and the developments of novel medicines or health-care products.

The invention relates to platinum (IV) anticancer compounds with a dihydrogen phosphate radical as an axial ligand. The chemical structure of the compounds is shown in the description. In the structure, a carrier group 2A is an ammonia / amine liand, and comprises 2NH3, 1R,2R-cyclohexanediamin, 1,2-bis(aminomethyl)cyclobutane, NH3 / cyclopentamine and NH3 / cyclohexylamine; and leaving groups 2X are the leaving groups of platinum (II) anticancer compounds existing at present, and comprise 2Cl<->, an oxalate radical, a 1,1-cyclobutanedicarboxylate radical and a propane dicarboxylate radical. Phosphoric acid bonding is helpful for running of compounds to cancer cell nuclei, improving the selectivity of cancer cells, and makes the compounds mediate compound targeting osteocarcinoma and have very strong anticancer effect. The compounds have the advantages of good water solubility and stability, and are highly suitable for being used as anticancer drugs.

An object of the present invention is to provide a conditionally replicating adenovirus having a strong anticancer effect. A conditionally replicating adenovirus to replicate specifically in a cancer cell and express REIC protein or REIC C domain protein, wherein the conditionally replicating adenovirus is obtained by inserting full-length REIC DNA or REIC C domain DNA into a conditionally replicating adenovirus comprising an ITR (inverted terminal repeat) sequence of an adenovirus type 5 genome and insertion of an HRE sequence, an hTERT promoter, a decorin-encoding DNA, and a DNA encoding a peptide comprising an RGD sequence.

The present invention discloses a lung cancer (non-small-cell lung carcinoma and small cell lung cancer) treatment bufalin liposome preparation and a preparation method thereof, wherein the lung cancer treatment bufalin liposome preparation is a liposome preparation prepared from a lung cancer treatment traditional Chinese medicine active effective component bufalin. The preparation method comprises: adopting an ethanol injection method to prepare liposomes to obtain the lung cancer treatment bufalin liposome preparation. According to the bufalin liposome preparation, in vivo animal anti-cancer pharmacological experiment results show that: significant growth inhibition effects are provided for lung cancers (non-small-cell lung carcinoma and small cell lung cancer), and anti-cancer activity of the lung cancer treatment bufalin liposome preparation is significantly higher than anti-cancer activity of the chemotherapy drug paclitaxel. In addition, the bufalin liposome preparation provides a higher anti-cancer effect than the bufalin non-liposome preparation.

The invention relates to a stent coating with ultrasonic intelligent controlled release and a preparation method and an application thereof. The invention also provides a drug-loaded stent with ultrasonic intelligent controlled release and a preparation method and an application thereof. The advantages of the invention are that: a new stent coating with the effect of ultrasonic intelligent controlled release is successfully constructed and synthesized; ultrasound is first found and confirmed to have control effect on the temperature-sensitive release of loaded drugs; and a new method is provided for future drug intelligent controlled release; a drug-loaded biliary tract stent with ultrasonic intelligent drug controlled release is synthesized, and a possible and feasible treatment means is provided for the treatment of malignant tumors of hollow organs; ultrasound is first found and confirmed to have significant effect on promoting the release of drugs coated by a temperature-sensitive material by changing the spatial structure of the temperature-sensitive material. By using ultrasound, the effect of drug intelligent controlled release at a designated site is achieved; local anticancer effect is brought into play; the toxic and side effect of anticancer drugs on important human tissue is reduced; and high clinical application value is provided.

The invention discloses a polyketone compound, a preparation method and uses thereof, wherein the polyketone compound has a structure formula represented by I. The preparation method comprises: obtaining a fermentation product containing a polyketone compound by carrying out fermentation culture on Hahellasp. HK-22 having a preservation number of CGMCC No.17574, extracting with ethyl acetate, andcarrying out evaporating drying to obtain a crude extract; and separating and purifying the crude extract through pressure reducing silica gel column chromatography, gel column chromatography, mediumpressure column chromatography and reverse phase semi-preparative high performance liquid chromatography to obtain the product. According to the present invention, the polyketone compound has anticancer effect, and can be used as a new drug component for inhibiting the proliferation of cancer cells.

The invention relates to the technical field of medicines and provides application of cepharanthine and salts thereof as a ferroptosis inducer in preparation of an anti-tumor drug. As found, natural products, namely cepharanthine and salts thereof, which are already applied clinically for many years can induce ferroptosis of prostate cancer cells in expressive ways of active oxygen increase, accumulation of lipid peroxides, decrease in the expression level of GPX4, structural changes in mitochondria, etc. Therefore, cepharanthine and salts thereof have good anti-cancer effects and provide a new effective therapeutic drug for tumor disease patients.