40 results about "Gluconates" patented technology

The invention relates to a process for dephosphorylation of skim milk, ultra-filtered milk (UF milk) or micellar casein isolate (MCI) comprising (i) acidification of a skim milk, UF milk or MCI preferably not lower than pH 6.0, preferably between 6.0 and 6.7, (ii) cooling the acidified skim milk, UF milk or MCI to the temperature between 0° C. and 15° C., (iii) adding gluconate and / or maleate to the cooled skim milk, UF milk or MCI and, (iv) washing the skim milk, UF milk or MCI, to remove phosphorus, thus dephosphorylating the skim milk, UF milk or MCI, preferably to an extent that the total phosphorous content of the skim milk, UF milk or MCI is reduced with at least 20%, preferably 20-40%, more preferably 30-40% compared to the material provided to step (i). The invention also relates to dephosphorylated MPC, MPI or MCI obtainable by the process of the invention, and to a liquid heat-sterilized enteral nutritional composition comprising 2.0-3.0 kcal / ml wherein 16-35 en % is provided by protein, the combination of caloric content and relative protein caloric content selected such that there is 10-18 g / 100 ml protein, preferably 12-18 g / 100 ml protein in the composition, wherein the protein comprises micellar casein (MC), whey protein (WP) and optionally caseinate (CAS), wherein there is at least 70 wt % MC and less than 15 wt % WP, based on total protein content, and wherein the composition has a total amount of phosphorous less than 192 mg / 100 ml and / or 30-80 mg / 100 kcal, preferably at least 30-80 mg / 100 kcal, most preferably less than 192 mg / 100 ml and 30-80 mg / 100 kcal.

The present invention relates to a process for the dephosphorylation of skimmed milk, ultra-filtered milk (UF milk) or micellar casein isolate (MCI) comprising (i) acidifying the skimmed milk, UF milk or MCI, preferably not below pH 6.0, preferably between 6.0 and 6.7, (ii) cooling the acidified skimmed milk, UF milk or MCI to a temperature between 0 DEG C and 15 DEG C, (iii) adding gluconate and / or maleate to the cooled skimmed milk, UF milk or MCI, and (iv) washing the skimmed milk, UF milk or MCI to remove phosphorus, thereby dephosphorylating the skimmed milk, UF milk or MCI, preferably to the extent that the total phosphorus content of the skimmed milk, UF milk or MCI is reduced by at least 20%, preferably 20-40%, more preferably 30-40%, compared to the material provided to step (i). The invention also relates to a dephosphorylated MPC, MPI or MCI obtainable by the process of the invention and to a liquid enteral nutritional composition comprising 2.0-3.0 kcal / ml of heat sterilization wherein 16 en%-35 en% is provided by a protein, the combination of the calorie content and the relative protein calorie content being selected such that 10-18 g / 100 ml protein, preferably 12-18 g / 100 ml protein is present in the composition, preferably 12-18 g / 100 ml protein, preferably 12-18 g / 100 ml protein, preferably 12-18 g / 100 ml protein, preferably 12-18 g / 100 ml protein, preferably 12-18 g / 100 ml protein, preferably 12-18 g / 100 ml protein, preferably 12-18 g / 100 ml protein, preferably 12-18 g / 100 ml protein. Wherein the protein comprises micellar casein (MC), whey protein (WP) and optionally caseinate (CAS) wherein at least 70 wt% MC and less than 15 wt% WP are present, based on the total protein content, and wherein the composition has a total amount of phosphorus of less than 192 mg / 100 ml and / or 30-80 mg / 100 kcal, preferably at least 30-80 mg / 100 kcal, most preferably less than 192 mg / 100 ml and 30-80 mg / 100 kcal.

The utility model relates to the technical field of gluconate stirring, in particular to full-automatic gluconate crushing and stirring production equipment, which overcomes the defects of gluconate stirring in the prior art and comprises a stirring barrel, a motor is fixedly connected to one side of the stirring barrel, a first rotating rod is arranged on one side of the motor, and a second rotating rod is arranged on the other side of the motor. A stirring assembly is arranged on one side of the first rotating rod, a first belt wheel is fixedly connected to the surface of the first rotating rod, a fixing seat is fixedly connected to one side of the stirring barrel, a worm is rotationally connected to the interior of the fixing seat, a second belt wheel is fixedly connected to the surface of the worm, and a belt is arranged on the surfaces of the first belt wheel and the second belt wheel; a feeding opening is formed in one side of the stirring barrel, a stirring rod is rotatably connected to the interior of the feeding opening in a penetrating mode, a worm wheel is fixedly connected to the surface of the stirring rod and is in meshed connection with a worm, and a base is fixedly connected to the lower side of the stirring barrel.

The invention discloses a purification device for gluconate production, and relates to the technical field of purification equipment, the purification device comprises a transfer seat and a purification separation box, a transfer box is rotatably connected in the transfer seat, and the transfer box is communicated with a feeding pipe; the purification separation box is internally provided with a synchronous separation scraping mechanism, the synchronous separation scraping mechanism comprises a driving mechanism, a rotating inner pipe and a rotating outer pipe, the rotating inner pipe is fixedly connected with the transfer box, and the driving mechanism is used for driving the rotating inner pipe and the rotating outer pipe to rotate; a purification separation net is fixed in the purification separation box, the rotating inner pipe is connected with a material distribution pipe, and a plurality of material distribution heads are arranged on the material distribution pipe; the lower end of the rotating inner pipe is connected with a hole cleaning plate, and the hole cleaning plate is used for cleaning filter holes in the purification and separation net; the rotary outer pipe is connected with a scraping seat; the scraping seat is used for collecting crystals purified on the purification separation net; and the side wall of the purification and separation box is connected with a discharge pipe. According to the invention, the purification efficiency of the gluconate raw material to be purified can be improved, and crystals can be automatically collected.

Provided are a novel gluconate repressor variant, a polynucleotide comprising the variant of the present disclosure, a microorganism of the genus Corynebacterium comprising the variant or polynucleotide of the present disclosure, and a method of producing L-arginine using the microorganism of the present disclosure.

The invention relates to the technical field of dangerous solid waste treatment and resource utilization, in particular to an aluminum electrolysis overhaul slag fluoride enhanced leaching and resource recycling method. Comprising the following steps: adding pretreated overhaul slag into a complexing reaction solution of boric acid containing a dispersing agent and gluconate, and pulping; sealing the system, heating, and implementing pulse type micro-negative pressure degassing operation in which vacuumizing and normal pressure recovery are alternated during constant-temperature leaching; after the reaction is finished, carrying out thermal-state solid-liquid separation and tailing washing, and merging to obtain clear filtrate; crystal seeds are added into the filtrate, an aluminum source solution is dropwise added, the pH value is increased, solid-liquid separation is performed after constant-temperature curing, and synthetic cryolite is obtained; and supplementing the pH buffer agent to the clear liquid and then circularly returning to the liquid preparation process. According to the method, fluorine and aluminum are cooperatively extracted under the weak acid condition, generation of silicic acid gel is inhibited, equipment corrosion is reduced, mass transfer in pores is enhanced in combination with micro-negative pressure operation, and low-energy-consumption recovery of fluoride salt and closed-loop circulation of a working solution are achieved through pH regulation and control.

The present invention relates to polymorphs of the hydrobromide salt of 5-{2-[({8-[(2,6-dimethylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyridin-6-yl}carbonyl)-amino]ethoxy}-5-oxopentanoic acid (linaprazangrate), more specifically Form A, Form B, and Form C of the HBr salt of linaprazangrate. The present invention also relates to pharmaceutical compositions containing such polymorphs and to the use of these polymorphs in the treatment or prevention of gastrointestinal inflammatory or gastric acid-related diseases, particularly erosive gastroesophageal reflux disease (eGERD).

To provide a crystal of 2 - (4-acetylbenzyl) - 3 - ((4-fluorophenyl) amino) - 577 - trimethyl-7, 8-dihydro-pyrazolo-imidazo [1, 2-a] 2H [4, 3-e] pyrimidin-4 (5H) - one.SOLUTION: Provided is a crystal of an acid addition salt form selected from, for example, succinate form, citrate form, adipate form, tartrate form (e.g., L-tartrate form), malate form, gluconate form (e.g., D-gluconate form), maleate form, fumarate form, aspartate form (e.g., L-aspartate form), hippurate form, sebacate form, glycolate form, galactarate form, benzoate form, pamoate form, oxalate form and malonate form.SELECTED DRAWING: None

The invention provides an active substance for a dipping diffusion cathode, the dipping diffusion cathode and a preparation method of the dipping diffusion cathode, and relates to the technical field of dipping diffusion cathode active materials and vacuum electronic device manufacturing. The preparation method of the active substance for dipping the diffusion cathode comprises the following steps: preparing an aqueous solution by taking at least one of water-soluble acetate, nitrate, gluconate, formate and lactate of barium, calcium, aluminum and cerium elements in a molar ratio of (25-40): (2-20): (10-25): (5-20) as a raw material; drying the aqueous solution to obtain a precursor powder material; placing the precursor powder in a protective atmosphere, and heating for 1-4 hours in an environment of 800-1000 DEG C; the invention further provides the active material for the impregnated diffusion cathode, the impregnated diffusion cathode and a preparation method of the impregnated diffusion cathode.

This disclosure relates to a photovoltaic module cleaner and a method for cleaning photovoltaic modules. The photovoltaic module cleaner comprises gluconate, ethylenediaminetetraacetate, diethylenetriaminepentaacetate, and water. The gluconate content is 0.5-4.0% by weight, the ethylenediaminetetraacetate content is 0.5-4.0% by weight, the diethylenetriaminepentaacetate content is 0.5-4.0% by weight, and the water content is 88.0-98.5% by weight, relative to the total weight of the photovoltaic module cleaner. The cleaner of this disclosure can quickly remove dirt, scale, and mineral deposits from the surface of photovoltaic modules without damaging the surface.

The invention discloses a chemical mechanical polishing solution for 316L stainless steel. The chemical mechanical polishing solution comprises an abrasive, an oxidant, a surface modifier, a pH regulator, a stabilizer, a corrosion inhibitor and other solvents, the grinding material adopts 5-25 wt% of Al2O3, the oxidizing agent adopts 3-15 wt% of H2O2 and 0.02-0.2 M of KIO4, the surface modifier adopts 0.5-5 wt% of a silane coupling agent (KH-550) and 0.2-3 wt% of PVA (the molecular weight is 20000), the pH regulator adopts 0.05-0.15 M of aluminum nitrate and 1-3 wt% of citric acid, the stabilizer adopts 0.1-0.5 wt% of urea, the corrosion inhibitor adopts 1-2 wt% of sodium phytate and 1-3 wt% of sodium gluconate, and the other solvents adopt absolute ethyl alcohol and deionized water. Compared with the prior art, the method has the advantages that the sodium phytate, the gluconate and other biodegradable corrosion inhibitors and waste liquid CODlt are adopted; and the strain can be directly subjected to biochemical treatment, and is excellent in environmental protection property.

This application provides an activated carbon treatment device and method for gluconate solution, relating to the technical field of gluconate production equipment. The method includes: acquiring activated carbon addition amount and initial flow rate data based on production information; adding activated carbon according to the specified addition amount; determining the initial addition gas pressure based on the initial flow rate data; acquiring measured flow rate data, establishing a unit addition amount analysis model, and determining the actual addition gas pressure; and adjusting the addition gas pressure based on the actual addition gas pressure. This method can first determine the required activated carbon amount based on production information, and obtain the relationship between the addition pressure and the leakage value of activated carbon from the addition mechanism under pressure, thereby determining the actual amount of activated carbon to be added, ensuring that the amount of activated carbon added meets the decolorization requirements of the gluconate solution in real time.

The present invention relates to a polymorph of the maleate salt of 5-{2-[({8-[(2,6-dimethylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyridin-6-yl}carbonyl)-amino]ethoxy}-5-oxopentanoic acid (linaprazangrate), more particularly to linaprazangrate maleate Form 1. The present invention also relates to pharmaceutical compositions comprising such polymorph and to the use of this polymorph in the treatment or prevention of gastrointestinal inflammatory or gastric acid-related diseases, particularly erosive gastroesophageal reflux disease (eGERD).

The application provides a kind of calcium gluconate co-catalytic production equipment and method, it is related to gluconate production equipment technical field.The device reaction chamber, reaction rotating cylinder, air pump, circulating flow guide pipe, injection pipe, driving device and circulating pump;Reaction rotating cylinder is set in reaction chamber, and reaction rotating cylinder is rotatably connected with driving device;Reaction rotating cylinder is rotatably connected with the top of reaction chamber;The top of reaction chamber is provided with suction port;Air pump is communicated with suction port;Circulating flow guide pipe's flow guide inlet is communicated with reaction chamber;The flow inlet of circulating flow guide pipe is connected with circulating pump;Injection pipe's injection inlet is connected with the flow outlet of circulating pump;Injection pipe's injection outlet corresponds with liquid inlet;Gas inlet is formed in the side wall of reaction chamber.The device can efficiently improve the contact effect of oxygen and solution, and effectively utilize the oxygen generated by reaction to achieve the effect of improving oxygen utilization rate.

The utility model relates to the technical field of calcium glucarate production, and discloses a precipitation device convenient for internal cleaning and used for calcium glucarate production, which comprises a tank body, a driving motor, a cross rod, a rubber scraper blade and a vibration motor, a top plate is fixed to the top in the tank body through bolts, a driving motor is installed on the top of the top plate through an installation frame, an output shaft, located in the tank body, of the driving motor is connected with a vertical rod through a connecting sleeve, connecting plates are welded to the two sides of the vertical rod at equal intervals, and side plates are fixed to one ends of the connecting plates through bolts. Rubber scrapers are fixed to the sides, away from the connecting plates, of the side plates through bolts. According to the device, D-gluconate after reaction in the tank body is vibrated through the vibration motor and the spring, the precipitation speed of the D-gluconate is increased, the rubber scraper on one side of the side plate is driven by the driving motor to clean and scrape the inner side of the tank body, the purpose of cleaning the interior of the tank body is achieved, and the device is suitable for being widely popularized and used.

The invention provides the use of a modified saccharide as a water-reducing additive for concrete, wherein the modified saccharide is selected from glucose syrup, high maltose corn syrup, high fructose corn syrup, dextrins, sugar alcohols and combinations thereof. The modified saccharide is used together with one or more supplemental active agent comprising a metabisulphite salt, optionally in combination with a gluconate. The modified saccharide makes up 50 wt % or more of the active agents used as water-reducing additives.

The invention discloses a preparation method of a fast-charging sodium-ion battery negative electrode carbon nanosheet, which comprises the following steps: 1) uniformly mixing gluconate, a pore-forming agent and an organic matter containing N and S, and then carrying out heat treatment; and 2) uniformly grinding the primary carbonized product, performing heat treatment again, and then performing washing and vacuum drying. According to the negative electrode carbon nanosheet, gluconate is adopted as a carbon source, an oxygen source and an in-situ template agent, CO2, SO2, NO2 and other gases generated in the hybridization decomposition process of a sulfur source and alkali metal bicarbonate at a high temperature are utilized, the interlayer spacing of carbon is optimized, and the prepared negative electrode carbon nanosheet has excellent electrical properties in a sodium ion half-cell; and the coulombic efficiency of the first circle reaches 83.9% under the 0.1 C multiplying power. After full activation, the reversible specific capacity is stabilized at about 340mAh / g under the current density of 0.5 C, and the material can work at the high rate of 20C and can circulate for more than 10000 circles.

The invention provides a high-corrosion-resistance nickel-copper-tin alloy replacing electroplating solution, a surface treatment method of rolled copper foil and the rolled copper foil. The copper-tin alloy electroplating solution comprises the following components: main salt, a coordination agent and a brightening agent. The main salt comprises copper salt and tin salt. The coordination agent comprises potassium methanesulfonate, an auxiliary coordination agent, ethylenediamine tetraacetic acid disodium salt and tetrahydroxypropyl ethylenediamine; the auxiliary coordination agent comprises at least one of gluconate, glycine, tartrate and citrate. The brightening agent comprises a primary brightening agent, sodium allysulfonate and benzotriazole; the primary brightener comprises polyethylene glycol and / or gelatin. When the electroplating liquid is used, the whole electroplating process can be environment-friendly and cyanide-free, the problems that a traditional cyanide-free copper and tin plating liquid is unstable and the performance of a plating layer is poor are solved, and a low-cost and high-performance nickel replacing scheme is provided for products needing high corrosion resistance, such as electronic connectors and antennas.

The application relates to the field of batteries, and discloses a gluconate-derived hard carbon negative electrode material, a preparation method thereof, a negative electrode and a lithium ion battery. The hard carbon negative electrode material is obtained by the following steps: after a first heat treatment of gluconate in an inert gas atmosphere, the intermediate is obtained by soaking in an acid solution; and the intermediate is subjected to a second heat treatment in an inert gas atmosphere. The first heat treatment process comprises a first-step heat treatment and a second-step heat treatment, the temperature of the first-step heat treatment is 400-600 DEG C, the time is 1-2 h, and the temperature of the second-step heat treatment is higher than that of the first-step heat treatment. The second heat treatment process comprises a third-step heat treatment and a fourth-step heat treatment, the temperature of the third-step heat treatment is higher than that of the second-step heat treatment and lower than that of the fourth-step heat treatment, the temperature of the fourth-step heat treatment is 1300-1500 DEG C, and the time is 50-150 min. The method is simple, the cost is low, and the prepared negative electrode material has a higher lithium storage capacity in an ether-based electrolyte.

This invention discloses the application of gluconate compounds in the preparation of drugs for the prevention and treatment of ovarian cancer. The gluconate compounds include at least one of sodium gluconate, potassium gluconate, calcium gluconate, and zinc gluconate. The invention also discloses the application of gluconate compounds in the preparation of inhibitors of the interaction between TMEM87A protein and CHP1 protein. This invention is the first to discover and demonstrate that gluconate compounds possess significant anti-ovarian cancer activity, effectively inhibiting the proliferation and metastasis of ovarian cancer cells. It also reveals for the first time a novel anti-cancer mechanism by which sodium gluconate directly binds to TMEM87A protein and disrupts the functional complex formed between TMEM87A and CHP1 protein. This invention overcomes the technical prejudice commonly held by those skilled in the art that gluconates are merely nutritional supplements or chelating agents, providing a novel, safe, and widely available class of candidate drugs for the treatment of ovarian cancer.

The invention relates to an immediate release oral formulation of linaprazan glurate, comprising a therapeutically effective amount of linaprazan glurate, or a pharmaceutically acceptable salt thereof, and hydroxypropyl methylcellulose acetate succinate (HPMC-AS). The formulation provides a rapid release of the active ingredient and furthermore improves the bioavailability. The invention also relates to the use of the oral formulation in the treatment or prevention of a gastrointestinal inflammatory or a gastric acid related disease, such as gastroesophageal reflux disease (GERD), erosive gastroesophageal reflux disease (eGERD) or H. pylori infection.

The invention belongs to the technical field of inorganic cementing materials, and particularly relates to high-strength water-resistant magnesium oxychloride cement and a preparation method thereof.The high-strength water-resistant magnesium oxychloride cement is prepared from, by weight, 95-100 parts of magnesium oxide, 60-65 parts of magnesium chloride hexahydrate, 35-40 parts of water, 2-3 parts of tartaric acid and 0.15 part of nano silicon dioxide. 0.2-1 part of ethyl orthosilicate, 1 part of talcum powder and 1 part of gluconate; the preparation method of the magnesium oxychloride cement comprises the following steps: S1, weighing the components in percentage by weight, adding tartaric acid and gluconate into water, dissolving, adding nano silicon dioxide, ultrasonically dispersing uniformly, adding ethyl orthosilicate, and stirring a first solution at room temperature; s2, adding magnesium chloride hexahydrate into the first solution, adding magnesium oxide and talcum powder, and uniformly stirring to obtain slurry; s3, pouring the slurry into a mold, compacting, curing and demolding; and S4, curing after demolding. The raw materials are low in price and rich in source, the preparation method is simple, the mechanical property and the water resistance of the prepared magnesium oxychloride cement are improved at the same time, and industrial production is easy.

The present invention provides methods of preparing compound of Formula (I), wherein the compounds are represented by the structure of Formula (I) wherein: R1 each is independently F, Cl, Br, I, OCH3, CN or NO2; R2 each is independently identical or different C1-C5 alkyl; n1 is an integer between 1 and 5; and n2 is an integer between 1 and 4. In addition, the present invention provides a compound represented by the following structures: Compound (1a) and Compound (2), wherein X comprises: chloride, acetate, adipate, alginate, ascorbate, aspartate, benzoate, benzenesulfonate, bisulfate, borate, butyrate, citrate, camphorate, camphorsulfonate, cyclopentanepropionate, digluconate, dodecylsulfate, ethanesulfonate, fumarate, glucoheptanoate, glycerophosphate, hemisulfate, heptanoate, hexanoate, hydroiodide, maleate, 2-hydroxyethanesulfonate, lactate, methanesulfonate, 2-naphthalenesulfonate, nicotinate, nitrate, oxalate, pectinate, persulfate, 3-phenylpropionate, phosphate, picrate, pivalate, propionate, salicylate, succinate, sulfate, sulfonate, tartrate, thiocyanate, toluenesulfonate, or undecanoate salt, or any combination thereof.

The application discloses a preparation method of a fast-charging type sodium ion battery negative electrode carbon nanosheet, and comprises the following steps: 1) uniformly mixing gluconate, a pore forming agent and N and S containing organic matter, and then performing heat treatment; 2) uniformly grinding the primary carbonization product, and then performing heat treatment again, and then performing washing and vacuum drying, and the method is completed. In the application, the gluconate is used as a carbon source, an oxygen source and an in-situ template agent, and the CO2, SO2 and NO2 gases generated in the hybrid decomposition process of the sulfur source and the alkali metal bicarbonate at high temperature are utilized, so that the interlayer spacing of the carbon is optimized, the prepared negative electrode carbon nanosheet has excellent electrical performance in the sodium ion half battery, the first cycle coulombic efficiency reaches 83.9% at a 0.1C rate, and after sufficient activation, the reversible specific capacity is stabilized at about 340mAh / g at a 0.5C current density, and the cycle can be over 10000 times at a high rate of 20C.

The invention relates to the non-therapeutic use of a substance (c) selected from GDL, a gluconate salt, gluconic acid or from a mixture thereof, said substance being intended to be taken orally. The invention also relates to a substance (c) selected from GDL, a gluconate salt, gluconic acid or from a mixture thereof, for use as an oral medicament.

The present invention relates to an aqueous suspension, its preparation and use as an accelerator for mineral binders, comprising: a) 5 to 65% by weight of calcium hydroxide in the form of suspended nanoparticles, relative to the total weight of the aqueous suspension; b) optionally at least one organic compound for stabilizing the aqueous suspension against settling; and c) at least one salt of an alkali metal or alkaline earth metal, preferably at least one of the hydroxides, nitrates, nitrites, phosphates, phosphites, sulfates, thiocyanates, carbonates, bicarbonates, silicates, aluminates, formates, acetates, lactates, citrates, tartrates and / or gluconates of alkali metals or alkaline earth metals.

Liquid detergent, containing, based on its total weight, a) 22 to 50 wt% anionic surfactant; b) 0.1 to 8 wt% gluconic acid salt; c) 0 to 2% by weight antioxidant; d) 5 to 25 wt.% organic solvent; e) 0.1 to 15 wt.% water; f) less than 0.1 wt% organic phosphonate and g) 0.01 to 5% by weight perfume composition.

The application discloses a kind of biological base intumescent water-based fire-retardant coating with strong adhesion and preparation method thereof, the coating is made of the following weight parts of raw materials: deionized water 100-300 parts, gluconate 10-40 parts, chitosan salt 10-30 parts, phytic acid 40-45 parts, anti-aging agent 1-2 parts, anti-freezing and thawing aid 0.3-0.4 parts.The fire-retardant coating of the application is suitable for a variety of substrates, solves the problem of short service life of coating caused by weak bonding force between coating and substrate;The fire-retardant coating has high fire-retardant efficiency, and the coating thickness of about 200 μm can effectively flame-retard polypropylene, vertical combustion passes UL-94 V-0 level, limiting oxygen index (LOI) is 46.1%, the coating rapidly expands about 100 times after fire, the carbon layer is honeycomb-shaped inside, the carbon layer surface is continuous and dense, and the condensed phase fire-retardant effect is remarkable;The preparation method of the coating is simple, the coating is highly transparent and smooth, has the advantages of easy processing, energy saving and emission reduction, wide application, etc.

The invention relates to a method for leaching rare earth elements in rare earth rock of a permian system unification Xuanwei group, which relates to the field of rare earth extraction, and comprises the following steps: carrying out advanced oxidation activation on raw ore, and then carrying out light rare earth leaching and / or heavy rare earth leaching; a leaching agent used in the light rare earth leaching comprises one or a combination of at least two of alpha-hydroxy carboxylic acid, alpha-hydroxy carboxylate, oxalic acid, oxalate, gluconic acid or gluconate; a leaching agent used in heavy rare earth leaching comprises an amino carboxylic acid chelating agent and a passivation inhibitor. According to the leaching method provided by the invention, through reasonable design of the leaching agent in the leaching process, the limitation of co-dissolution of light / heavy rare earth in the prior art is broken through, step-by-step leaching of the light rare earth and the heavy rare earth is realized through a staged targeted extraction mechanism, and the key metal recovery efficiency is remarkably improved.

A cleaning composition including a preservative formulation having a lactic acid salt, a gluconic acid salt, a polyhydric alcohol and optionally a phospholipid complex is disclosed. The cleaning composition can be loaded on a cleaning wipe and used for personal care. The lactic acid salt, gluconic acid salt and polyhydric alcohol provide a synergistic preservative effect to a cleaning composition incorporating the preservative formulation.