2 results about "Galantamine" patented technology

The application belongs to the technical field of biological medicine, and relates to a bipyridine compound, a preparation method thereof and application of the bipyridine compound in preparation of an AChE inhibitor. A chemical structural formula of the bipyridine compound is provided. The bipyridine compound provided by the application has AChE inhibitory activity, and the AChE inhibitory activity of the bipyridine compound is significantly higher than that of an existing clinical drug (such as galantamine), thereby providing a drug with better effect for treatment of Alzheimer's disease.

This invention discloses a galantamine nasal spray and its preparation method. The galantamine nasal spray is prepared from raw materials comprising the following components: galantamine or galantamine salt, viscosity modifier, pH adjuster, chelating agent, absorption enhancer, osmotic pressure regulator, preservative, and water, wherein the viscosity modifier is polyvinylpyrrolidone. This galantamine nasal spray has suitable viscosity, reasonable osmotic pressure and pH range, good flight stability, and a small spray area and plume angle, which can effectively improve the deposition rate of galantamine in the nasal olfactory region and effectively enhance the naso-brain drug delivery efficiency, thereby improving its therapeutic effect on Alzheimer's disease.