34 results about "Neostigmine" patented technology

The invention relates to a pharmaceutical composition based on an active ingredient that is enclosed in liposomes for topical, transdermal application. The interior of said liposomes comprises an acidic, aqueous medium containing at least one cholinesterase inhibitor, preferably from the group containing donepezil, rivastigmine, galantamine, physostigmine, heptylphysostigmine, phenserine, tolserine, cymserine, thiatolserine, thiacymserine, neostigmine, huperzine, tacrine, metrifonate and dichlorvos, or an enantiomer or derivative of at least one of said compounds. In addition, the invention relates to a method for producing said composition, optionally in a sterile form and also to the use of the liposomes charged with the active ingredient in various galenic formulations for topical, transdermal application with a depot effect in the epidermis, for the prophylaxis and/or treatment of cutaneous neuropathic pain or the loss of cutaneous sensory function as a result of neuropathy.

The Chinese medicine composition for treating intestinal irritable syndrome is prepared with gallnut, nutmeg, red ginseng, deglued antler powder, dark plum and myrobalan fruit as material and through the technological process including water extraction, extracting volatile oil, inclusion with cyclodextrin, grinding into fine powder and other steps. The pharmacological experiments show that the medicine of the present invention can inhibit the motion of small intestine, resist the sthenic motion of small intestine caused by Neostigmine, resist diarrhea caused by rhubarb, promote the absorption of water inside intestine caused by mannitol, etc. and has relatively high anti-diarrhea effect and high safety.

The invention belongs to the field of a pharmaceutic preparation, and relates to a neostigmine bromide muhivescular liposome formula and a preparation method thereof. The neostigmine bromide muhivescular liposome prepared by the method can achieve slow release of a medicine, and prolongs the medicine effect time and the effective medicine duration.

The present invention discloses compound aspartate, vitamin B6 and dipotassium glycyrrhetate eye drops which do not contain bacteriostat and a preparing method thereof, wherein the compound aspartate, vitamin B6 and dipotassium glycyrrhetate eye drops comprises aspartic acid, vitamin B6, dipotassium glycyrrhetate, naphazoline hydrochloride, neostigmine methysulfate, chlorpheniramine maleate, pH modifying agent, isoosmotic agent, stabilizing agent, thickening agent, algefacient, etc. The preparing method adopts an aseptic manipulation filling technique. Furthermore the eye drops of the invention adopt a disposable single-dose independent packaging. The sterilized performance of product is guaranteed. The product is safer, more reliable, easier and more sanitary.

The invention discloses a neostigmine methyl sulfate injection and a preparation method thereof. It includes the following steps: 1. add water for injection and mix 225.0 g of neostigmine methylsulfate into the preparation tank, stir to dissolve, dilute with water for injection to the full amount, and stir evenly; 2. The ether sulfone microporous membrane is filtered back to clarity; 3. Sampling to test the intermediate content and pH value, if the intermediate content is in the range of 95.0-105.0%, and the pH is in the range of 5.2-6.8, the medicinal liquid is qualified, and the medicinal liquid is filtered. Put into the liquid storage tank; ④ The medicinal liquid in the liquid storage tank is filtered by two 0.22μm polyethersulfone microporous membranes, and after sampling and passing the inspection of visible foreign matter, it is input into the filling buffer tank for filling and sealing; ⑤ Potting and sealing; Bacteria: 100°C, 30 minutes. The preparation method of the invention adopts secondary sterilization filtration, reduces the visible foreign matter of the medicine, and the whole process is sterile, and the product quality is guaranteed.

The invention provides a neostigmine bromide composition freeze-dried tablet and a preparation method thereof and relates to the technical field of medicines and medicine production. The neostigmine bromide composition freeze-dried tablet is prepared from the following components including neostigmine bromide, starch and sucrose. According to the neostigmine bromide composition freeze-dried tablet provided by the invention, with the starch and the sucrose as auxiliary materials, heating process treatment is carried out on common corn starch, so that the actions of adhesion and disintegration of the starch in a tablet and the formability of the tablet are improved, and the neostigmine bromide composition freeze-dried tablet only needs two of the starch and the sucrose serving as the auxiliary materials. The neostigmine bromide composition freeze-dried tablet is prepared by adopting the freeze drying technology with twice cooling and twice temperature raising, wherein with twice cooling and twice temperature raising, the formability of the tablet is good, the dissolution of the tablet is improved, and thus the bioavailability of the tablet is improved. With the adoption of the neostigmine bromide composition freeze-dried tablet, the disadvantages of the common neostigmine bromide tablet are overcome, the species and the dosages of the auxiliary materials in the neostigmine bromide tablet are reduced, the dissolution of the tablet is large, the bioavailability of the tablet is high, and the curative effect and the safety of clinical medication are ensured.

The invention discloses a compound asparticitin gutta and making method, which comprises the following parts: aspartic acid, vitamin B6, glycyrrhizin dipotassium, naphazoline hydrochloride, neostigmine methylsulfate, maleic chlorobenzenenamin, polysorbate 80, sodium chloride, menthol, benzachloridamine, sodium hydroxide solution and injecting water. The invention paves basis for scaling manufacturing of the compound asparticitin gutta further, which improves the productivity with stable content of maleic chlorobenzenenamin.

The invention relates to a neostigmine methylsulfate frozen-dried preparation for injection and a preparation method of the neostigmine methylsulfate frozen-dried preparation. Neostigmine methylsulfate injection is instable when meeting light and heat, and a mainly degradation impurity namely 3-hydroxy tricresylamine neostigmine methylsulfate has a genotoxicity warning structure. In order to improve stability, the inventor improves the preparation formulation, and the frozen-dried preparation is prepared. Through recipe screening and process improvement, the frozen-dried preparation product isobtained. The obtained product is good in appearance, good in redissolution properties and good in clarity, and the main degradation impurity namely 3-hydroxy tricresylamine neostigmine methylsulfateis greatly reduced, so that the product safety and stability are improved.

The invention discloses a Chinese patent medicine oral preparation promoting recovery of postoperative gastrointestinal motility. The Chinese patent medicine oral preparation is prepared from poria cocos, rhizoma atractylodis macrocephalae, rhizoma alismatis, rhizoma zingiberis, rhizoma zingiberis recens, rhizoma pinelliae, cortex magnoliae officinalis, liquorice root, fructus amomi, and pericarpium citri reticulatae through decocting and concentrating, wherein 20g of fructus amomi is used and 50g of pericarpium citri reticulatae is used. In treatment, a patient takes no food and no water andreduce pressure of the stomach and intestinal tract constantly, thereby enabling the stomach to rest thoroughly; the patient needs to lie with face downward and raise the lower part of the body, so asto eliminate pressure on the horizontal part of the dodecadactylon, further, 0.5mg of neostigmine is injected into muscle for six times each day; fluid infusion for maintenance, aqueous electrolyte is corrected and acid-base balance is kept, enough heat, protein, vitamin and trace element are supplemented, and negative nitrogen balance is corrected; the preparation is decocted and concentrated to350-500ml according to the quantity, the patient takes three preparations each day for three times through a gastric canal or an oral route, and the postoperative gastrointestinal motility function can be recovered after the patient takes 50 preparations consecutively. In terms of treatment of postoperative gastroparesis, the Chinese patent medicine oral preparation has the characteristics of having definite curative effect, being economical, helping recovering overall function of the patient, having no side effects, and having shorter treatment course.

The present invention describes the use of a NK1-antagonist, in constant combination with neostigmine, to facilitate the treatment of a patient suffering from myasthenia gravis by providing a therapeutically effective neostigmine bromide or methylsulfate daily dose without the dose-limiting gastrointestinal adverse effects.

The present invention describes the use of a 5HT3-antagonist, in combination with neostigmine, to facilitate the treatment of a patient suffering from myasthenia gravis or other myasthenic syndromes by providing a therapeutically effective neostigmine bromide or methylsulfate daily dose that attenuates or even abrogates the dose-limiting gastrointestinal adverse effects of neostigmine.

The invention provides a novel preparation of neostigmine and derivatives thereof. The preparation comprises a sublingual mucosa preparation, a nasal mucosa preparation, a rectum mucosa preparation, a vagina and uterus mucosa preparation and an oral buccal mucosa preparation which take neostigmine or neostigmine derivatives as active ingredients. The preparation is administered through any mucosa pathway of oral buccal mucosa, sublingual mucosa, nasal mucosa, rectum mucosa or vagina and uterus mucosa. The preparation has a great clinical application value in preparation of drugs for treating myasthenia gravis, postoperative abdominal distension and urinary retention, supraventricular paroxysmal tachycardia and detoxification in the case of excessive tupistrine.

The invention provides a traditional Chinese medicine composition for abdominal enhancement and a preparation method and application thereof, and relates to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition for abdominal enhancement comprises the following raw materials in parts by weight: 10-30 parts of codonopsis pilosula, 10-30 parts of white wood, 10-30 parts of poria cocos, 10-25 parts of radix aucklandiae, 10-30 parts of fructus amomi and 10-30 parts of pericarpium citri reticulatae. The traditional Chinese medicine composition prepared by the invention inhibits gastric emptying and small intestine peristalsis of normal animals, can resist hyperfunction of gastrointestinal motility caused by neostigmine or acetylcholine, and inhibits intestinal spasm caused by histamine and barium chloride. The traditional Chinese medicine composition prepared by the invention not only can inhibit gastrointestinal tract peristalsis, but also can enable gastrointestinal tracts to be in a full state, and also has the efficacy of protecting intestines and stomach, and a patient is treated and protected while being subjected to CT abdominal enhancement.

The invention relates to a maxillofacial medicament paste capable of treating snore and sleep apnea syndrome. The maxillofacial medicament paste is composed of a pressure-sensitive adhesive plaster and a medicinal emulsifiable paste. The medicament paste is in a rectangle shape, the middle of the medicament paste is provided with a recess, and neostigmine emulsion is contained in the recess. The neostigmine emulsion is respectively attached to the adhesion position of the masseter muscle of a patient and the surface of the skin at the position of the musculus genioglossus between the chin and the Adam's apple before sleep, neostigmine is slowly released by the skin and enters the muscle groups of the masseter muscle, the musculus genioglossus and the like, the destruction and the removal of acetylcholin esterase to acetylcholine are slowed up, a certain tension of the muscle groups of the masseter muscle, the musculus genioglossus and the like is maintained, mouth breathing and glossocoma are avoided, and the smoothness of the air duct behind the tongue can be kept; ephedrine, nikethamide and precortisyl emulsion are contained and are respectively attached to the surface of the skin at the outer side faces of the nosewings at both sides of a patient before sleep, the medicines are slowly released by the skin and enter the nasal cavity, the ephedrine can lighten the hyperaemia of the nasal cavity, the precortisyl can lighten the inflammation of the nasal cavity and ensure the breathing of the nasal cavity effectively, and the nikethamide can excite the respiratory centre. The sleep apnea syndrome is treated by percutaneous administration.

The invention relates to the technical field of scald treatment, compound anisodamine is composed of a neostigmine injection and an anisodamine injection according to the proportion of 1: 500, and the proportion has good effects on hemorrhagic shock, allergic shock and increase of tolerance of mice to lethal dose endotoxin in the previous research of the unit. The pharmacological basis of the compound preparation is as follows: neostigmine is a reversible cholinesterase (AChE) inhibitor, temporarily inhibits cholinesterase activity, and increases the amount of acetylcholine (ACh) in vivo to excite an M receptor and an N receptor; a large dose of anisodamine has the effects of improving microcirculation and blocking M receptors, blocking of the M receptors enables N receptors to be more fully excited, in the excited N receptors and subtypes of the N receptors, after alpha 7 is excited, release of inflammatory factors can be reduced, and therefore it is proved that the compound anisodamine injection can remarkably reduce the mortality rate of serious scalds, and the compound anisodamine injection can be used for treating the severe scalds. The survival time after injury is prolonged.

The invention relates to the technical field of medicine synthesis, in particular to a synthesis method of neostigmine bromide. The synthesis method comprises the following steps of 1) selecting m-aminophenol of a formula (1) to react with halogenated methane to obtain halogenated quaternary ammonium salt methyl ether of a formula (2), 2) adding a catalyst into the halogenated quaternary ammonium salt methyl ether in the formula (2), and removing methyl ether to obtain m-phenolic hydroxyl quaternary ammonium salt in a formula (3), 3) forming a compound shown in a formula (4) from the m-phenolic hydroxyl quaternary ammonium salt shown in the formula (3) under a strong alkali condition, and 4) carrying out esterification reaction on the compound in the formula (4) and dimethyl carbamoyl bromide to obtain neostigmine bromide in a formula (5). According to the method, the m-aminophenol is adopted as the starting material, the price of the m-aminophenol is only one hundred of that of m-dimethylaminophenol, the cost of the neostigmine bromide can be greatly reduced when the m-aminophenol is used for synthesizing the neostigmine bromide, and mass production can be achieved.

The invention belongs to the technical field of traditional Chinese medicine preparation, and relates to a traditional Chinese medicinal composition for preventing and treating postpartum urinary retention as well as a preparation method and application thereof. The traditional Chinese medicinal composition is prepared from the following components in parts by weight: 3 to 30 parts of rhizoma zingiberis recens, 3 to 30 parts of fistular onion stalk, 0.5 to 5 parts of fine salt, 2 to 30 parts of raw radix astragali powder, 2 to 30 parts of poria cocos powder and 2 to 30 parts of motherwort herbpowder. Through half an hour of umbilical application, the traditional Chinese medicinal composition has a significant effect on preventing postpartum urinary retention, and greatly reduces the incidence of urinary retention. The traditional Chinese medicinal composition has a remarkable prevention effect, and the therapeutic effect is more obvious than that of neostigmine and other Western medicines. The traditional Chinese medicinal composition has no obvious toxic and side effects, is economical, practical and convenient to operate, shortens the hospitalization time of patients, can reducethe occurrence of post-operative urinary tract infection and postpartum hemorrhage, provides reliable clinical evidence for the popularization of application of traditional Chinese medicine to Shenque acupoint on umbilicus, and has clinical and basic medical institution popularization and application value.