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Neostigmine bromide composition freeze-dried tablet and preparation method thereof

A technology of neostigmine bromide and composition is applied in the field of neostigmine bromide composition freeze-dried tablet and preparation thereof, and achieves the effects of good formability, high bioavailability and shortening disintegration time

Inactive Publication Date: 2015-04-22
HAINAN WEI KANG PHARMA QIANSHAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Starch is the basic excipient of oral solid preparations. It is formed by the polymerization of glucose molecules. It is often used as a binder, diluent and disintegrating agent in tablets. It is cheap and easy to obtain, and is safe for the human body. However, starch is used alone as an excipient There is no report on the production of bromyostigmine freeze-dried tablets by freeze-drying process

Method used

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  • Neostigmine bromide composition freeze-dried tablet and preparation method thereof
  • Neostigmine bromide composition freeze-dried tablet and preparation method thereof
  • Neostigmine bromide composition freeze-dried tablet and preparation method thereof

Examples

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Effect test

Embodiment 1

[0026]

[0027] A. Weigh 100g of cornstarch, add 900ml of purified water and stir, use a pH regulator to control the pH of the solution at 6.5, then heat to 72°C and keep for 120 minutes to make 9% (W / V) corn starch solution.

[0028] B. Measure 45ml of purified water, boil, add 85g of sucrose, stir, after dissolving, continue heating to 100°C, filter with refined cotton, wash the filter with an appropriate amount of hot distilled water, combine the lotion and filtrate, let cool, add Add appropriate amount of distilled water to make the whole volume into 100mL, stir well to obtain B solution.

[0029] C. Mix the solution obtained in step A with the solution obtained in step B, fully stir for 30 minutes, and then lower the solution to normal temperature to obtain a corn-sucrose solution.

[0030] D. Weigh 15 g of neostigmine bromide, add it into 1 L of corn-sucrose solution, and stir for 30 minutes.

[0031] E. After measuring the content of brominostigmine in the medicina...

Embodiment 2

[0034]

[0035] A. Weigh 130g of cornstarch, add 900ml of purified water and stir, use a pH regulator to control the pH of the solution at 4-5, then heat to 72°C and keep for 120 minutes to make 13% (W / V) cornstarch solution.

[0036] B. Measure 45ml of purified water, boil, add 85g of sucrose, stir, after dissolving, continue heating to 100°C, filter with refined cotton, wash the filter with an appropriate amount of hot distilled water, combine the lotion and filtrate, let cool, add Add appropriate amount of distilled water to make the whole volume into 100mL, stir well to obtain B solution.

[0037] C. Mix the solution obtained in step A with the solution obtained in step B, fully stir for 30 minutes, and then lower the solution to normal temperature to obtain a corn-sucrose solution.

[0038] D, take by weighing 15 grams of neostigmine bromide (calculated as 1000 tablets), add 1L corn-sucrose solution, and stir for 30 minutes.

[0039] E. After measuring the content of...

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Abstract

The invention provides a neostigmine bromide composition freeze-dried tablet and a preparation method thereof and relates to the technical field of medicines and medicine production. The neostigmine bromide composition freeze-dried tablet is prepared from the following components including neostigmine bromide, starch and sucrose. According to the neostigmine bromide composition freeze-dried tablet provided by the invention, with the starch and the sucrose as auxiliary materials, heating process treatment is carried out on common corn starch, so that the actions of adhesion and disintegration of the starch in a tablet and the formability of the tablet are improved, and the neostigmine bromide composition freeze-dried tablet only needs two of the starch and the sucrose serving as the auxiliary materials. The neostigmine bromide composition freeze-dried tablet is prepared by adopting the freeze drying technology with twice cooling and twice temperature raising, wherein with twice cooling and twice temperature raising, the formability of the tablet is good, the dissolution of the tablet is improved, and thus the bioavailability of the tablet is improved. With the adoption of the neostigmine bromide composition freeze-dried tablet, the disadvantages of the common neostigmine bromide tablet are overcome, the species and the dosages of the auxiliary materials in the neostigmine bromide tablet are reduced, the dissolution of the tablet is large, the bioavailability of the tablet is high, and the curative effect and the safety of clinical medication are ensured.

Description

technical field [0001] The invention relates to the technical field of medicine and medicine production, in particular to a freeze-dried tablet of neostigmine bromide composition and a preparation method thereof. Background technique [0002] This product is an anticholinesterase drug with anticholinesterase effect, which is characterized by a strong excitatory effect on skeletal muscle and a weak miotic effect. It is clinically used for myasthenia gravis, intestinal paralysis and urinary retention after abdominal surgery, and can resist excessive poisoning of competing muscle relaxants such as tubocurarine and triiodoquaternary ammonium. [0003] Neostigmine bromide, molecular formula: C 12 h 19 BrN 2 o 2 ; Molecular weight 303.20. [0004] In clinical application, 1. Myasthenia gravis is an autoimmune disease with nerve-muscle junction transmission disorder. Difficulty breathing. Neostigmine improves muscle weakness by stimulating skeletal muscles. 2. Abdominal blo...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/27A61P21/04A61P1/14A61P7/10A61P9/04A61P39/02
Inventor 江小红石金友汪金灿郝结兵吴函峰
Owner HAINAN WEI KANG PHARMA QIANSHAN
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