The invention belongs to the field of titanium-based alloys, and particularly relates to a novel heat-resisting titanium alloy and a processing and manufacturing method and application thereof. The processing and manufacturing method comprises the composition elements of alloy components, smelting, heat processing, heat treatment and the like, wherein the alloy components are as follows (in percentage by weight): 5.4%-6.3% of Al, 3.0%-5.0% of Sn, 2.5%-6.4% of Zr, 0.0%-0.96% of Mo, 0.25%-0.5% of Si, 0.2%-0.5% of Nb, 0.3%-3.4% of Ta, 0.2%-1.6% of W, 0.0%-0.07% of C, less than or equal to 0.17% of O, less than or equal to 0.03% of Fe and the balance of Ti and inevitable impurity elements. The novel heat-resisting titanium alloy disclosed by the invention can obtain different matching of tensile strength, plasticity, permanence, creep strength and heat stability through the combination of different heat processing process and heat treatment processes, can be used for manufacturing parts, namely blades, coil assemblies and the like which are positioned on the high-temperature parts of an advanced aircraft engine, is used for a long time within a range of 600-650 DEG C, can also be used for manufacturing high temperature-resistant structural members, namely aerospace craft skin and the like, is used for a short time at about 700 DEG C and can be used as a material and the like used for high temperature-resistant corrosion-resistant valves of an automobile and a boiler.